{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T13:25:25Z","timestamp":1764681925379,"version":"3.46.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"published-print":{"date-parts":[[2001,6]]},"DOI":"10.1016\/s0027-5107(01)00109-9","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T18:06:51Z","timestamp":1027620411000},"page":"79-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice"],"prefix":"10.1016","volume":"477","author":[{"given":"Frank J.","family":"Gonzalez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shioko","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0027-5107(01)00109-9_BIB1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00008571-199602000-00002","article-title":"P450 super family \u2014 update on new sequences, gene mapping, accession numbers and nomenclature","volume":"6","author":"Nelson","year":"1996","journal-title":"Pharmacogenetics"},{"key":"10.1016\/S0027-5107(01)00109-9_BIB2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0168-9525(90)90174-5","article-title":"Evolution of the P450 gene superfamily \u2014 animal-plant \u2018warfare\u2019, molecular drive and human genetic differences in drug oxidation","volume":"6","author":"Gonzalez","year":"1990","journal-title":"Trends Genet."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0009-2797(97)00068-9","article-title":"Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species","volume":"106","author":"Guengerich","year":"1997","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB4","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/carcin\/15.4.725","article-title":"Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells","volume":"15","author":"Christou","year":"1994","journal-title":"Carcinogenesis"},{"key":"10.1016\/S0027-5107(01)00109-9_BIB5","unstructured":"F.P. Guengerich, W.G. Humphreys, C.H. Yun, G.J. Hammons, F.F. Kadlubar, Y. Seto, O. Okazaki, M.V. Martin, Mechanisms of cytochrome P450 1A2-mediated formation of N-hydroxy arylamines and heterocyclic amines and their reaction with guanyl residues, in: Proceedings of the Princess Takamatsu Symposium, Vol. 23, 1995 pp. 78\u201384."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00008571-199510000-00001","article-title":"Role of cytochrome P4501A2 in chemical carcinogenesis \u2014 implications for human variability in expression and enzyme activity","volume":"5","author":"Eaton","year":"1995","journal-title":"Pharmacogenetics"},{"key":"10.1016\/S0027-5107(01)00109-9_BIB7","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1021\/tx00020a008","article-title":"Role of human cytochrome P450 IIE1 in the oxidation of many low molecular weight cancer suspects","volume":"4","author":"Guengerich","year":"1991","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-3-642-46870-4_4","article-title":"Polymorphisms of N-acetyltransferases, glutathione Stransferases, microsomal epoxide hydrolase and sulfotransferases \u2014 influence on cancer susceptibility","volume":"154","author":"Hengstler","year":"1998","journal-title":"Recent Results Cancer Res."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB9","first-page":"5","article-title":"Epoxide hydrolase \u2014 properties and metabolic roles","volume":"4","author":"Guengerich","year":"1982","journal-title":"Rev. Biochem. Toxicol."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/carcin\/15.2.171","article-title":"Studies on the importance of microsomal epoxide hydrolase in the detoxification of arene oxides using the heterologous expression of the enzyme in mammalian cells","volume":"15","author":"Friedberg","year":"1994","journal-title":"Carcinogenesis"},{"key":"10.1016\/S0027-5107(01)00109-9_BIB11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3109\/03602539409029808","article-title":"Polycyclic hydrocarbon activation \u2014 bay regions and beyond","volume":"26","author":"Phillips","year":"1994","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2165\/00003088-199426010-00005","article-title":"Pharmacogenetic phenotyping and genotyping. Present status and future potential","volume":"26","author":"Gonzalez","year":"1994","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/00008571-199504000-00001","article-title":"Cancer genes: single and susceptibility \u2014 exposing the difference","volume":"5","author":"Caporaso","year":"1995","journal-title":"Pharmacogenetics"},{"key":"10.1016\/S0027-5107(01)00109-9_BIB14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0006-2952(88)90756-3","article-title":"Interactions of hepatic cytochromes P450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P450 enzyme expression","volume":"37","author":"Waxman","year":"1988","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB15","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1210\/edrv-17-6-670","article-title":"Steroid sulfotransferases","volume":"17","author":"Strott","year":"1996","journal-title":"Endocr. Rev."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB16","doi-asserted-by":"crossref","first-page":"5134","DOI":"10.1073\/pnas.92.11.5134","article-title":"Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2","volume":"92","author":"Pineau","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB17","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.96.5.1977","article-title":"Cytochrome P450 CYP1B1 determines susceptibility to 7,12-dimethylbenz[a]anthracene-induced lymphomas","volume":"96","author":"Buters","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB18","doi-asserted-by":"crossref","first-page":"12063","DOI":"10.1074\/jbc.271.20.12063","article-title":"Role of CYP2E1 in the hepatotoxicity of acetaminophen","volume":"271","author":"Lee","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB19","first-page":"7696","article-title":"Human cytochrome P450PA (P450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines","volume":"86","author":"Butler","year":"1989","journal-title":"Biochemistry"},{"key":"10.1016\/S0027-5107(01)00109-9_BIB20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00008571-199204000-00004","article-title":"Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1","volume":"2","author":"Gu","year":"1992","journal-title":"Pharmacogenetics"},{"key":"10.1016\/S0027-5107(01)00109-9_BIB21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/00008571-199608000-00002","article-title":"Role of CYP1A2 in caffeine pharmacokinetics and metabolism \u2014 studies using mice deficient in CYP1A2.","volume":"6","author":"Buters","year":"1996","journal-title":"Pharmacogenetics"},{"key":"10.1016\/S0027-5107(01)00109-9_BIB22","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/00008571-199206000-00003","article-title":"Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites","volume":"2","author":"Butler","year":"1992","journal-title":"Pharmacogenetics"},{"key":"10.1016\/S0027-5107(01)00109-9_BIB23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0076-6879(96)72015-3","article-title":"Assays for CYP1A2 by testing in vivo metabolism of caffeine in humans","volume":"272","author":"Tang","year":"1996","journal-title":"Methods Enzymol."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB24","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/03602539509029827","article-title":"The role of covalent binding to microsomal proteins in the hepatotoxicity of acetaminophen","volume":"27","author":"Holtzman","year":"1995","journal-title":"Drug. Metab. Rev."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB25","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/0006-2952(90)90228-D","article-title":"Effects of ethanol and inhibitors on the binding and metabolism of acetaminophen and N-acetyl-p-benzoquinone imine by hepatic microsomes from control and ethanol-treated rats","volume":"40","author":"Prasad","year":"1990","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/taap.1998.8501","article-title":"Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double- null mice","volume":"152","author":"Zaher","year":"1998","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0041-008X(96)80026-3","article-title":"Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression","volume":"141","author":"Valentine","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/S0027-5107(01)00109-9_BIB28","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1093\/carcin\/20.9.1825","article-title":"CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice","volume":"20","author":"Kimura","year":"1999","journal-title":"Carcinogenesis"},{"key":"10.1016\/S0027-5107(01)00109-9_BIB29","doi-asserted-by":"crossref","first-page":"23963","DOI":"10.1074\/jbc.274.34.23963","article-title":"Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene","volume":"274","author":"Miyata","year":"1999","journal-title":"J. Biol. Chem."}],"container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510701001099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510701001099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T13:22:52Z","timestamp":1764681772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0027510701001099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":29,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["S0027510701001099"],"URL":"https:\/\/doi.org\/10.1016\/s0027-5107(01)00109-9","relation":{},"ISSN":["1386-1964"],"issn-type":[{"type":"print","value":"1386-1964"}],"subject":[],"published":{"date-parts":[[2001,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice","name":"articletitle","label":"Article Title"},{"value":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0027-5107(01)00109-9","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}