{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:24:03Z","timestamp":1771014243201,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[2000,10]]},"DOI":"10.1016\/s0028-3908(00)00051-4","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T14:12:37Z","timestamp":1027606357000},"page":"2139-2146","source":"Crossref","is-referenced-by-count":133,"title":["The anticonvulsant, lamotrigine decreases spontaneous glutamate release but increases spontaneous GABA release in the rat entorhinal cortex in vitro"],"prefix":"10.1016","volume":"39","author":[{"given":"Mark O.","family":"Cunningham","sequence":"first","affiliation":[]},{"given":"Roland S.G.","family":"Jones","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0028-3908(00)00051-4_BIB1","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1152\/jn.1996.76.2.1089","article-title":"A comparison of spontaneous synaptic EPSCs in layer V and layer II neurones in the rat entorhinal cortex in vitro","volume":"76","author":"Berretta","year":"1996","journal-title":"J. Neurophysiol."},{"issue":"Suppl","key":"10.1016\/S0028-3908(00)00051-4_BIB2","first-page":"89","article-title":"Use of the \u201cmonolog\u201d spike and wave monitor to evaluate lamotrigine for absence seizures","volume":"32","author":"Besag","year":"1991","journal-title":"Epilepsia"},{"key":"10.1016\/S0028-3908(00)00051-4_BIB3","series-title":"Clinical Update on Lamotrigine: A Novel Antiepileptic Agent","first-page":"81","article-title":"An overview: efficacy of lamotrigine","author":"Binnie","year":"1992"},{"key":"10.1016\/S0028-3908(00)00051-4_BIB4","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/sj.bjp.0702361","article-title":"An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons","volume":"126","author":"Calabresi","year":"1999","journal-title":"Brit. J. Pharm."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0920-1211(92)90065-2","article-title":"An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels","volume":"13","author":"Cheung","year":"1992","journal-title":"Epilepsy Res."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB6","first-page":"205P","article-title":"Effects of lamotrigine (LamictalTM) in an animal model of anxiety","volume":"111","author":"Critchley","year":"1994","journal-title":"Brit. J. Pharm."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB7","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1528-1157.1987.tb03661.x","article-title":"Common anticonvulsants inhibit Ca++ uptake and amino acid neurotransmitter release in vitro","volume":"28","author":"Crowder","year":"1987","journal-title":"Epilepsia"},{"key":"10.1016\/S0028-3908(00)00051-4_BIB8","first-page":"126P","article-title":"Phenytoin modifies spontaneous transmitter release at glutamate terminals in rat medial entorhinal cortex","volume":"511","author":"Cunningham","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB9","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0306-4522(99)00468-6","article-title":"Reciprocal modulation of glutamate and GABA release may underlie the anticonvulsant effect of phenytoin","volume":"95","author":"Cunningham","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/S0028-3908(00)00051-4_BIB10","first-page":"49P","article-title":"Phenytoin enhances spontaneous GABA mediated inhibition in the rat entorhinal cortex","volume":"127","author":"Cunningham","year":"1999","journal-title":"Brit. J. Pharm."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB11","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/(SICI)1096-9861(19990614)408:4<449::AID-CNE1>3.0.CO;2-R","article-title":"Newly formed excitatory pathways for hyperexcitability in experimental temporal lobe epilepsy","volume":"408","author":"Esclapez","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1213\/00000539-199908000-00047","article-title":"The combined effects of halothane and lamotrigine on excitatory postsynaptic potentials and use-dependent block in the rat dentate gyrus in vitro","volume":"89","author":"Frizelle","year":"1999","journal-title":"Anesth. Analg."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2165\/00003495-199346010-00009","article-title":"Lamotrigine: a review of its pharmacological properties and clinical efficacy in epilepsy","volume":"46","author":"Goa","year":"1993","journal-title":"Drugs"},{"key":"10.1016\/S0028-3908(00)00051-4_BIB14","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0006-8993(98)00180-2","article-title":"Lamotrigine may limit pathological excitation in the hippocampus by modulating a transient potassium outward current","volume":"791","author":"Grunze","year":"1998","journal-title":"Brain Res."},{"issue":"Suppl. 7","key":"10.1016\/S0028-3908(00)00051-4_BIB15","first-page":"16","article-title":"Chronic lamotrigine treatment increases hippocampal GABA shunt activity and elevates cerebral taurine levels in rats","volume":"40","author":"Hassel","year":"1999","journal-title":"Epilpesia"},{"key":"10.1016\/S0028-3908(00)00051-4_BIB16","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/9142","article-title":"Deficit of quanta1 release of GABA in experimental models of temporal lobe epilepsy","volume":"2","author":"Hirsch","year":"1999","journal-title":"Nature Neurosci."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0166-2236(93)90018-H","article-title":"Entorhinal-hippocampal connections: a speculative view of their function","volume":"16","author":"Jones","year":"1993","journal-title":"Trends Neurosci."},{"issue":"Suppl. 7","key":"10.1016\/S0028-3908(00)00051-4_BIB18","first-page":"244","article-title":"Effects of topiramate, lamotrigine and gabapentin on cerebral GABA in healthy humans","volume":"40","author":"Kuzniecky","year":"1999","journal-title":"Epilepsia"},{"key":"10.1016\/S0028-3908(00)00051-4_BIB19","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0006-8993(93)91660-K","article-title":"Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neuroglial cultures from rat cortex","volume":"612","author":"Lees","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB20","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1528-1157.1986.tb03573.x","article-title":"Pharmacological studies of lamotrigine, a novel potential antiepileptic drug. 2. Neurochemical studies on the mechanism of action","volume":"27","author":"Leach","year":"1986","journal-title":"Epilepsia"},{"issue":"Supp 1","key":"10.1016\/S0028-3908(00)00051-4_BIB21","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1177\/0883073897012001081","article-title":"Lamotrigine in absence and primary generalized epilepsies","volume":"12","author":"Mikati","year":"1997","journal-title":"J. Child Neurol."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB22","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1528-1157.1986.tb03572.x","article-title":"Pharmacological studies on lamotrigine, a novel potential antiepileptic drug. 1 Anticonvulsant profile in mice and rats","volume":"27","author":"Miller","year":"1986","journal-title":"Epilepsia"},{"key":"10.1016\/S0028-3908(00)00051-4_BIB23","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0014-2999(97)01291-0","article-title":"Weak blockade of AMPA receptor-mediated depolarizations in the rat cortical wedge by phenytoin but not lamotrigine or carbamazepine","volume":"337","author":"Phillips","year":"1997","journal-title":"Eur. J. Pharmac."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB24","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/BF02427571","article-title":"Psychotic disorder after lamotrigine","volume":"19","author":"Polselli","year":"1998","journal-title":"Ital. J. Neurol. Sci."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB25","first-page":"1151","article-title":"Biochemical and electrophysiological studies on the mechanism of action of PNU-15 1774E, a novel antiepileptic compound","volume":"288","author":"Salvati","year":"1999","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB26","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1152\/jn.1998.80.2.638","article-title":"Mechanisms underlying the enhancement of excitatory synaptic transmission in basolateral amygdala neurones of the kindling rat","volume":"80","author":"Shoji","year":"1998","journal-title":"J. Neurophysiol."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB27","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/BF00966587","article-title":"A review of evidence for GABAergic predominance\/glutamatergic deficit as a common etiological factor in both schizophrenia and affective psychoses: more support for a continuum hypothesis of `functional' psychosis","volume":"16","author":"Squires","year":"1991","journal-title":"Neurochem. Res."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/exnr.1997.6554","article-title":"Differential inhibition by riluzole, lamotrigine and phenytoin of sodium and calcium currents in cortical neurones: implications for neuroprotective strategies","volume":"147","author":"Stefani","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB29","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/0140-6736(92)92922-3","article-title":"Lamotrigine in primary generalised epilepsy","volume":"340","author":"Stewart","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/S0028-3908(00)00051-4_BIB30","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/0028-3908(95)00104-E","article-title":"Effect of lamotrigine on the electrically-evoked release of endogenous ammo acids from slices of dorsal horn of the rat spinal cord","volume":"34","author":"Teoh","year":"1995","journal-title":"Neuropharmacology"},{"key":"10.1016\/S0028-3908(00)00051-4_BIB31","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/0140-6736(92)91632-I","article-title":"Lamotrigine for generalized epilepsies","volume":"339","author":"Timmings","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/S0028-3908(00)00051-4_BIB32","first-page":"456","article-title":"Mechanism of action of new antiepileptic drugs: rational design and serendipitous findings","volume":"15","author":"Upton","year":"1994","journal-title":"Trends Neurosci."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB33","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1212\/WNL.45.10.1907","article-title":"Similar potency of carbamazepine, oxcarbamazepine and lamotrigine in inhibiting the release of glutamate and other neurotransmitters","volume":"45","author":"Waldmeier","year":"1995","journal-title":"Neurology."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB34","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF00178716","article-title":"Effect of carbamazepine, oxcarbamazepine and lamotrigine on the increase in extracellular glutamate elicited by veratridine in rat cortex and striatum","volume":"354","author":"Waldmeier","year":"1996","journal-title":"N. S. Arch. Pharm."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB35","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/(SICI)1098-2396(199611)24:3<248::AID-SYN7>3.0.CO;2-E","article-title":"Presynaptic inhibition of excitatory neurotransmission by lamotrigine in the rat amygdalar neurons","volume":"24","author":"Wang","year":"1996","journal-title":"Synapse"},{"key":"10.1016\/S0028-3908(00)00051-4_BIB36","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1097\/00001756-199611250-00048","article-title":"Inhibition of N-type calcium currents by lamotrigine in rat amygdalar neurones","volume":"7","author":"Wang","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/S0028-3908(00)00051-4_BIB37","first-page":"120P","article-title":"A comparison of characteristics of spontaneous IPSCs in layers II and V of the rat entorhinal cortex in vitro","volume":"515","author":"Wood","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/S0028-3908(00)00051-4_BIB38","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/BF00373920","article-title":"Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurones","volume":"430","author":"Xie","year":"1995","journal-title":"Eur. J. Physiol."}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390800000514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390800000514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T02:27:51Z","timestamp":1578536871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390800000514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["S0028390800000514"],"URL":"https:\/\/doi.org\/10.1016\/s0028-3908(00)00051-4","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}