{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T14:30:57Z","timestamp":1771597857940,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropharmacology"],"published-print":{"date-parts":[[1998,1]]},"DOI":"10.1016\/s0028-3908(97)00188-3","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T22:55:58Z","timestamp":1027637758000},"page":"25-36","source":"Crossref","is-referenced-by-count":150,"title":["Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat"],"prefix":"10.1016","volume":"37","author":[{"given":"Rosa Maria A.","family":"Simmons","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic L.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken H.","family":"Hoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Deverill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul L.","family":"Ornstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smriti","family":"Iyengar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0028-3908(97)00188-3_BIB1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0304-3959(94)00095-V","article-title":"The formalin test: scoring properties of the first and second phases of the pain response in rats","volume":"60","author":"Abbott","year":"1995","journal-title":"Pain"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB2","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/S0028-3908(96)00156-6","article-title":"Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereopsecificity and selectivity profiles","volume":"35","author":"Bleakman","year":"1996","journal-title":"Neuropharmacology"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB3","first-page":"581","article-title":"Pharmacological discrimination of GluR5 and GluR6 kainate receptor subtypes by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquin oline-3 carboxylic-acid","volume":"49","author":"Bleakman","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB4","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0960-894X(97)00185-6","article-title":"Structure-activity studies of aryl-spaced decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists","volume":"7","author":"Bleisch","year":"1997","journal-title":"Biomed. Chem. Lett."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB5","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1476-5381.1994.tb13156.x","article-title":"A comparison of intravenous NBQX and GYKI 53655 as AMPA antagonists in the rat spinal cord","volume":"112","author":"Chizh","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB6","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1523\/JNEUROSCI.12-09-03665.1992","article-title":"The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury","volume":"12","author":"Coderre","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0304-3959(93)90161-H","article-title":"Contribution of central plasticity to to pathological pain: review of clinical and experimental evidence","volume":"52","author":"Coderre","year":"1993","journal-title":"Pain"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0304-3959(93)90098-A","article-title":"The formalin test: a validation of the weighted-scores method of the behavioral pain rating","volume":"54","author":"Coderre","year":"1993","journal-title":"Pain"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB9","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1111\/j.1460-9568.1994.tb00323.x","article-title":"Intracelullar messengers contributing to persistent nociception and hyperalgesia induced by l-glutamate and substance P in the rat formalin pain model","volume":"6","author":"Coderre","year":"1994","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB10","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1097\/00001756-199404000-00006","article-title":"AMPA receptors have an equal role in spinal nociceptive and non-nociceptive transmission","volume":"5","author":"Cumberbatch","year":"1994","journal-title":"Neuroreport"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB11","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/0006-8993(87)91487-9","article-title":"Evidence for the involvement of N-methylaspartate receptors in wind-up of class 2 neurons in the dorsal horn of rat","volume":"424","author":"Davies","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB12","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/0028-3908(87)90275-9","article-title":"Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurons following C fibre stimulation","volume":"26","author":"Dickenson","year":"1987","journal-title":"Neuropharmacology"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0896-6273(93)90241-I","article-title":"GYKI 52466, a 2,3-benzodiazepine, is a highly selective non-competitive antagonist of AMPA\/Kainate receptor responses","volume":"10","author":"Donevan","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0304-3959(77)90130-0","article-title":"The formalin test: a quantitative study of the analgesic effects of morphine, meperidin and brain stem stimulation in rats and cat","volume":"4","author":"Dubuisson","year":"1977","journal-title":"Pain"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB15","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2307\/2528490","article-title":"New tables for multiple comparisons with a control","volume":"20","author":"Dunnett","year":"1964","journal-title":"Biometrics"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0304-3940(89)90690-3","article-title":"Primary afferent depolarization in the rat spinal cord is mediated by pathways utilizing NMDA and non-NMDA receptors","volume":"100","author":"Evans","year":"1989","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB17","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1476-5381.1987.tb11246.x","article-title":"A comparison of excitatory amino acid antagonists acting at primary afferent C fibers and motoneurons of the isolated spinal cord of the rat","volume":"91","author":"Evans","year":"1987","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB18","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0006-8993(90)90975-H","article-title":"Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat","volume":"518","author":"Haley","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB19","first-page":"164P","article-title":"Afferent C-fiber and A-delta activity in models of inflammation","volume":"90","author":"Heapy","year":"1987","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev.ne.17.030194.000335","article-title":"Cloned glutamate receptors","volume":"17","author":"Hollmann","year":"1994","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB21","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1126\/science.2899909","article-title":"Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists","volume":"241","author":"Honore","year":"1988","journal-title":"Science"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0896-6273(90)90163-A","article-title":"Glutamate receptor channels in DRG neurons: activation of kainate and quisqualate and blockade of desensitization by concavalin","volume":"5","author":"Huettner","year":"1990","journal-title":"A. Neuron"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0304-3959(87)90088-1","article-title":"The formalin test: dissociation between inflammatory and non-inflammatory pain","volume":"30","author":"Hunskaar","year":"1987","journal-title":"Pain"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB24","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0304-3940(94)90025-6","article-title":"Role of excitatory amino acid receptors in the mediation of the nociceptive response to formalin in the rat","volume":"174","author":"Hunter","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB25","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1021\/jm00066a016","article-title":"3SR, 4aRS, 6RS, 8aRS)-6-[2-(1H-tetrazol-5-yl) ethyl-decahydroisoquinoline-3-carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist","volume":"36","author":"Ornstein","year":"1993","journal-title":"J. Med. Chem."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB26","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1021\/jm950912p","article-title":"Structure-activity studies of 6-(tetrazolylalkyl)-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists, 1. effects of stereochemistry, chain length and chain substitution","volume":"39","author":"Ornstein","year":"1996","journal-title":"J. Med. Chem."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB27","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1021\/jm950913h","article-title":"Structure-activity studies of 6-substituted decahydroisoquinoline-3-carboxylic Acid AMPA receptor antagonists. 2. Effects of distal acid bioisosteric substitution, absolute stereochemical preferences and in vivo activity","volume":"39","author":"Ornstein","year":"1996","journal-title":"J. Med. Chem."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0922-4106(93)90027-7","article-title":"Cyclothiazide reverses AMPA receptor antagonism of the 2,3-benzodiazepine, GYKI 53655","volume":"244","author":"Palmer","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB29","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/0896-6273(93)90220-L","article-title":"Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin","volume":"11","author":"Partin","year":"1993","journal-title":"A. Neuron"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB30","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0896-6273(95)90253-8","article-title":"Selective antagonism of AMPA receptors unmasks kainate receptor\u2013mediated responses in hippocampal neurons","volume":"14","author":"Paternain","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB31","first-page":"1015","article-title":"Analgesic effects of AMPA\/kainate antagonist LY293558 in humans: reduction of capsaicin-evoked allodynia and hyperalgesia but not pain sensations in normal skin","volume":"23","author":"Sang","year":"1997","journal-title":"Soc. Neurosci. Abstr."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB32","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/0028-3908(95)00099-R","article-title":"In vitro and in vivo antagonism of AMPA receptor activation by (3S,4aR,6R,8aR)-6-[2-(1(2)H-Tetrazyl)-5-yl)ethyl]decahydro-isoqui noline-3-carboxylic acid","volume":"34","author":"Schoepp","year":"1995","journal-title":"Neuropharmacology"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB33","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0166-2236(93)90093-2","article-title":"The molecular biology of mammalian glutamate receptor channels","volume":"16","author":"Seeburg","year":"1993","journal-title":"Trends Neurosci."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB34","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1126\/science.2154034","article-title":"2:3-dihydroxy-6-nitro-7-sulfamoyl-benzo (F)quinoxaline:a neuroprotectant for cerebral ischemia","volume":"247","author":"Sheardown","year":"1990","journal-title":"Science"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB35","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0304-3959(89)90222-4","article-title":"Modified formalin test: Characteristic biphasic pain response","volume":"38","author":"Shibata","year":"1989","journal-title":"Pain"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0960-894X(00)80100-6","article-title":"Structure-activity relationships of 2,3, benzodiazepine compounds with glutamate antagonistic action","volume":"3","author":"Tarnawa","year":"1993","journal-title":"Biorganic Med. Chem. Lett."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB37","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/0166-2236(94)90018-3","article-title":"Modulation of spinal excitability; co-operation between neurokinin and excitatory amino-acid neurotransmitters","volume":"17","author":"Urban","year":"1994","journal-title":"Trends Neurosci."},{"key":"10.1016\/S0028-3908(97)00188-3_BIB38","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0304-3959(90)90073-M","article-title":"The rat paw formalin test: comparison of noxious agents","volume":"40","author":"Wheeler-Aceto","year":"1990","journal-title":"Pain"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB39","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0304-3959(91)90100-C","article-title":"The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation: implications for post-injury pain hypersensitivity states","volume":"44","author":"Woolf","year":"1991","journal-title":"Pain"},{"key":"10.1016\/S0028-3908(97)00188-3_BIB40","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0896-6273(93)90242-J","article-title":"A benzodiazepine recognition site associated with the non-NMDA glutamate receptor","volume":"10","author":"Zorumski","year":"1993","journal-title":"Neuron"}],"container-title":["Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390897001883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028390897001883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:50:43Z","timestamp":1580259043000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028390897001883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["S0028390897001883"],"URL":"https:\/\/doi.org\/10.1016\/s0028-3908(97)00188-3","relation":{},"ISSN":["0028-3908"],"issn-type":[{"value":"0028-3908","type":"print"}],"subject":[],"published":{"date-parts":[[1998,1]]}}}