{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T03:56:47Z","timestamp":1776052607173,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1996,12,1]],"date-time":"1996-12-01T00:00:00Z","timestamp":849398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[1996,12]]},"DOI":"10.1016\/s0031-9384(96)00323-x","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T23:33:33Z","timestamp":1027640013000},"page":"1495-1500","source":"Crossref","is-referenced-by-count":46,"title":["Differential Ontogenesis of Three DOI-Induced Behaviors in Mice"],"prefix":"10.1016","volume":"60","author":[{"given":"NISSAR A","family":"DARMANI","sequence":"first","affiliation":[]},{"given":"JAMES","family":"SHADDY","sequence":"additional","affiliation":[]},{"given":"CHARLES F","family":"GERDES","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0031-9384(96)00323-X_BIB1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0024-3205(91)90579-Z","article-title":"Fetal brain serotonin synthesis and catabolism is under control by mother intake of tryptophan","volume":"49","author":"Arevalo","year":"1991","journal-title":"Life Sci."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0006-8993(93)90286-V","article-title":"Effect of aging in human cortical pre and postsynaptic serotonin binding sites","volume":"620","author":"Arranz","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0014-2999(91)90643-5","article-title":"Age dependence of 5-methoxytryptamine-induced hindlimb scratching in rats","volume":"199","author":"Berendsen","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0014-2999(91)90106-Z","article-title":"A peripheral 5-HT1D-like receptor involved in serotonergic induced hindlimbs scratching in rats","volume":"194","author":"Berendsen","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0028-3908(94)90059-0","article-title":"Molecular biology of 5-HT receptors","volume":"33","author":"Boess","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1016\/S0031-9384(96)00323-X_BIB6","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/BF00172108","article-title":"In vivo evidence for a greater brain tryptophan hydroxylase capacity in female than in male rats","volume":"338","author":"Carlsson","year":"1988","journal-title":"Naunyn-Schmied. Arch Pharmacol."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB7","first-page":"1051","article-title":"Pharmacological characterization of serotonin-stimulated phosphoinositide turnover in brain regions of the immature rat","volume":"244","author":"Claustre","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0968-0004(87)90035-1","article-title":"Polyphosphoinositide phosphodiesterase: regulation by a novel guanine nucleotide binding protein","volume":"12","author":"Crockroft","year":"1987","journal-title":"Gp. Trends Biochem. Sci."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB9","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/0091-3057(92)90406-6","article-title":"Further evidence for enigmas in adaptation mechanisms for the DOI-induced behaviors","volume":"43","author":"Darmani","year":"1992","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB10","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0091-3057(94)00340-8","article-title":"Temporal differential adaptation of head-twitch and ear-scratch responses following administration of challenge doses of DOI","volume":"50","author":"Darmani","year":"1995","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB11","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/0091-3057(90)90098-3","article-title":"Do functional relationships exist between 5-HT1A and 5-HT2 receptors?","volume":"36","author":"Darmani","year":"1990","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0091-3057(90)90047-L","article-title":"Pharmacological characterization of ear-scratch response in mice as a behavioral model for selective 5-HT2-receptor agonists and evidence for 5-HT1B- and 5-HT2-receptor interactions","volume":"37","author":"Darmani","year":"1990","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB13","first-page":"692","article-title":"Behavioral evidence for differential adaptation of the serotonergic system after acute and chronic treatment with (\u00b1)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) or ketanserin","volume":"262","author":"Darmani","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0091-3057(94)90542-8","article-title":"The head-twitch response in the least shrew (Cryptotis parva) is a 5-HT2- and not a 5-HT1C-mediated phenomenon","volume":"48","author":"Darmani","year":"1994","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0091-3057(96)00072-X","article-title":"The mechanism by which the selective 5-HT1A receptor antagonist S-(\u2212)UH 301 produces head-twitches in mice","volume":"55","author":"Darmani","year":"1996","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0031-9384(87)90129-6","article-title":"The maturational onset of the 5-HT mediated head twitch in mice","volume":"41","author":"Eble","year":"1987","journal-title":"Physiol. Behav."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0091-3057(92)90649-Z","article-title":"5-HT1A and 5-HT2 receptors mediate discrete behaviors in the Mongolian gerbil","volume":"43","author":"Eison","year":"1992","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF01251004","article-title":"Hippocampal 5-HT synthesis is greater in female rats than in males and more decreased by the 5-HT1A agonist 8-OH DPAT","volume":"79","author":"Haleem","year":"1990","journal-title":"J. Neural Trans. Gen. Sect."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0006-8993(95)00143-E","article-title":"Developmental switch in the hippocampal serotonin receptor linked to phosphoinositide hydrolysis","volume":"678","author":"Ike","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB20","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/physrev.1992.72.1.165","article-title":"Structure and function of the brain serotonin system","volume":"72","author":"Jacobs","year":"1992","journal-title":"Physiol. Revs."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB21","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/j.1476-5381.1994.tb14808.x","article-title":"In vivo properties of SB 20046A, a 5-HT2C\/2B receptor antagonist","volume":"111","author":"Kennett","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB22","first-page":"155","article-title":"Effect of 1-(m-chlorophenyl) piperazine and 1-(m-trifluoromethylphenyl) piperazine on locomotor activity","volume":"249","author":"Lucki","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0006-8993(84)91397-0","article-title":"Serotonin-2 binding sites in human frontal cortex and hippocampus:selective loss of S-2A sites with age","volume":"311","author":"Marcusson","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB24","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0028-3908(94)90058-2","article-title":"Receptors for 5-hydroxytryptamine: current perspectives on classification and nomenclature","volume":"33","author":"Martin","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1016\/S0031-9384(96)00323-X_BIB25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF02316866","article-title":"Dissociation of multiple effects of acute LSD on exploratory behavior in rats by ritanserin and proprandol","volume":"195","author":"Mittman","year":"1991","journal-title":"Psychopharmacology"},{"key":"10.1016\/S0031-9384(96)00323-X_BIB26","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF02244617","article-title":"5-HT2 mediation of acute behavioral effects of hallucinogens in rats","volume":"100","author":"Mittman","year":"1990","journal-title":"Psychopharmacology"},{"key":"10.1016\/S0031-9384(96)00323-X_BIB27","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0306-4522(93)90447-N","article-title":"Ontogeny of 5-hydroxytryptamine2 receptor immunoreactivity in the developing rat brain","volume":"55","author":"Morilak","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/S0031-9384(96)00323-X_BIB28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/sj.npp.1380102","article-title":"Neurons expressing 5-HT2 receptors in the rat brain: Neurochemical identification of cell types by immunocytochemistry","volume":"11","author":"Morilak","year":"1994","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/S0031-9384(96)00323-X_BIB29","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/0024-3205(94)00320-3","article-title":"Changes in muscarinic cholinergic, PCP, GABAA, D1 and 5-HT2A receptor binding, but not in benzodiazepine receptor binding in the rat brains of aged rats","volume":"55","author":"Nabeshima","year":"1994","journal-title":"Life Sci."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB30","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/0304-3940(90)90520-J","article-title":"Evidence for involvement of 5-HT2 and 5-HT1C receptors in the behavioral effects of the 5-HT agonist 1-(2,5-dimethoxy-4-iodophenylaminopropane)-2 (DOI)","volume":"115","author":"Pranzatelli","year":"1990","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB31","first-page":"759","article-title":"Biochemical and pharmacological properties of SR 46349B, a new and selective 5-hydroxytryptamine2 receptor antagonist","volume":"262","author":"Rinaldi-Carmona","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0165-3806(91)90236-C","article-title":"Developmental regulation of 5-HT2A and 5-HT1C mRNA and receptor levels","volume":"58","author":"Roth","year":"1991","journal-title":"Dev. Brain Res."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB33","first-page":"101","article-title":"(1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT)2A receptors: modulation by novel 5-HT2A\/2C antagonists, D1 antagonists and 5-HT1A agonists","volume":"273","author":"Schreiber","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB34","first-page":"684","article-title":"Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies","volume":"266","author":"Sorensen","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB35","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF02244617","article-title":"5-HT-2 mediation of acute behavioral effects of hallucinogens in rats","volume":"100","author":"Wing","year":"1990","journal-title":"Psychopharmacology"},{"key":"10.1016\/S0031-9384(96)00323-X_BIB36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0091-3057(90)90234-9","article-title":"8-OH DPAT and buspirone analogs inhibit the ketanserin sensitive quipazine-induced head-shake response in rats","volume":"35","author":"Yocca","year":"1990","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB37","unstructured":"Zar, J.H. Biostatistical analysis. Englewood Cliffs, NJ: Prentice Hall Inc.; 1984."},{"key":"10.1016\/S0031-9384(96)00323-X_BIB38","first-page":"401","article-title":"5-Hydroxytryptamine receptors","volume":"44","author":"Zifa","year":"1992","journal-title":"Pharmacol. Rev."}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003193849600323X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003193849600323X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T20:18:10Z","timestamp":1540498690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003193849600323X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,12]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,12]]}},"alternative-id":["S003193849600323X"],"URL":"https:\/\/doi.org\/10.1016\/s0031-9384(96)00323-x","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[1996,12]]}}}