{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T17:49:03Z","timestamp":1774806543733,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transactions of the Royal Society of Tropical Medicine and Hygiene"],"published-print":{"date-parts":[[1998,7]]},"DOI":"10.1016\/s0035-9203(98)91083-5","type":"journal-article","created":{"date-parts":[[2004,10,4]],"date-time":"2004-10-04T19:02:24Z","timestamp":1096916544000},"page":"437-440","source":"Crossref","is-referenced-by-count":21,"title":["An open randomized clinical study of intrarectal versus infused Quinimax\u00ae for the treatment of childhood cerebral malaria in Niger"],"prefix":"10.1093","volume":"92","author":[{"given":"H.","family":"Barennes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Munjakazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Verdier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Clavier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Pussard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"10.1016\/S0035-9203(98)91083-5_BIB1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0035-9203(90)90012-4","article-title":"A randomized comparative study of artemisinine [sic] (quinghaosu) suppositories and oral quinine in acute falciparum malaria","volume":"84","author":"Arnold","year":"1990","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1177\/004947559402400115","article-title":"Is intrarectal quinine a safe alternative to intramuscular injectable quinine?","volume":"24","author":"Barennes","year":"1994","journal-title":"Tropical Doctor"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB3","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/0035-9203(95)90036-5","article-title":"Intrarectal Quinimax (an association of Cinchona alkaloids) for the treatment of Plasmodium falciparum malaria in children in Niger: efficacy and pharmacokinetics","volume":"89","author":"Barennes","year":"1995","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB4","doi-asserted-by":"crossref","first-page":"154","DOI":"10.2165\/00044011-199611030-00005","article-title":"Intrarectal Quinimax\u00ae (a Cinchona alkaloids association) administered at three progressive doses to Plasmodium falciparum malaria children in Niger","volume":"22","author":"Barennes","year":"1996","journal-title":"Clinical Drug Investigation"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB5","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1046\/j.1365-2125.1996.03246.x","article-title":"Efficacy and pharmacokinetics of a new intrarectal quinine formulation in children with Plasmodium falciparum malaria","volume":"41","author":"Barennes","year":"1996","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB6","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/0035-9203(89)90317-9","article-title":"Efficacy of a 3-day oral regimen of a quinine-quinidine-cinchonine association (Quinimax\u00ae for treatment of falciparum malaria in Madagascar","volume":"83","author":"Deloron","year":"1989","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB7","first-page":"89","article-title":"Report of chloroquine resistance malaria in Niger","volume":"46","author":"Gay","year":"1991","journal-title":"Th\u00e9rapie"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0022-3476(61)80158-3","article-title":"Post injection sciatic nerve paralysis in infants and children","volume":"58","author":"Gilles","year":"1961","journal-title":"Journal of Pediatrics"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB9","first-page":"67","article-title":"In vivo chloroquine sensitivity of Plasmodium falciparum in south-west Niger","volume":"67","author":"Haegeman","year":"1987","journal-title":"Annales de la Soci\u00e9t\u00e9 Belge de M\u00e9decine Tropicale"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB10","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/0035-9203(92)90137-2","article-title":"Comparison of artemisinin suppositories with artesunate and intravenous quinine in the treatment of cerebral malaria","volume":"86","author":"Hien","year":"1992","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB11","first-page":"441","article-title":"Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 1341 comatose Malawian children","volume":"71","author":"Molyneux","year":"1989","journal-title":"Quarterly Journal of Medicine"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB12","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0035-9203(97)90099-7","article-title":"Comparison of artemisinin suppositories, intramuscular artesunate and intravenous quinine for the treatment of severe childhood malaria","volume":"91","author":"Phuong","year":"1997","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB13","first-page":"319","article-title":"Intrarectal administration of antimalarial drugs for the treatment of Plasmodium falciparum malaria","volume":"1","author":"Pussard","year":"1996","journal-title":"Recent Research and Development in Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0035-9203(93)90136-E","article-title":"Comparison of intramuscular and intravenous quinine for the treatment of severe and complicated malaria in children","volume":"87","author":"Schapira","year":"1993","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1542\/peds.19.2.261","article-title":"Sciatic neuropathy in infants related to antibiotic injections","volume":"19","author":"Scheinberg","year":"1957","journal-title":"Pediatrics"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00034983.1992.11812625","article-title":"Evaluation of the relative efficacy of various antimalarial drugs in Nigerian children under five years of age suffering from acute uncomplicated falciparum malaria","volume":"86","author":"Sowunmi","year":"1992","journal-title":"Annals of Tropical Medicine and Parasitology"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1056\/NEJM199607113350201","article-title":"A trial of artemether or quinine in children with cerebral malaria","volume":"335","author":"Van Hensbroek","year":"1996","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2165\/00003088-199121010-00002","article-title":"Pharmacokinetics of rectal drug administration. Part I","volume":"21","author":"Van Hoogdalen","year":"1991","journal-title":"Clinical Pharmacokinetics"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB19","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/0035-9203(90)90009-4","article-title":"The pharmacokinetic properties of intramuscular quinine in Gambian children with severe falciparum malaria","volume":"84","author":"Waller","year":"1990","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB20","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/0035-9203(94)90429-4","article-title":"Rectal administration of chloroquine for treatment of children with malaria","volume":"88","author":"Westman","year":"1994","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2125.1992.tb04100.x","article-title":"Antimalarial pharmacokinetics and treatment regimens","volume":"34","author":"White","year":"1992","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB22","first-page":"309","article-title":"Controversies in the management of severe falciparum malaria","volume":"2","author":"White","year":"1995","journal-title":"Bailli\u00e8re's Clinical Infectious Diseases: Malaria"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB23","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/0002-9343(82)90337-0","article-title":"Quinine pharmacokinetics and toxicity in cerebral and uncomplicated falciparum malaria","volume":"73","author":"White","year":"1982","journal-title":"American Journal of Medicine"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB24","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0140-6736(89)91918-1","article-title":"Open comparison of intramuscular chloroquine and quinine in children with severe chloroquine sensitive falciparum malaria","volume":"ii","author":"White","year":"1989","journal-title":"Lancet"},{"issue":"supplement 2","key":"10.1016\/S0035-9203(98)91083-5_BIB25","article-title":"Severe and complicated malaria","volume":"84","author":"WHO","year":"1990","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0035-9203(93)90494-B","article-title":"Towards optimal regimens of parenteral quinine for young African children with cerebral malaria: the importance of unbound quinine concentration","volume":"87","author":"Winstanley","year":"1993","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/004947558601600301","article-title":"Injections and aids","volume":"16","author":"Wyatt","year":"1986","journal-title":"Tropical Doctor"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB28","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/0035-9203(92)90104-K","article-title":"Unnecessary injections and paralytic poliomyelitis in India","volume":"86","author":"Wyatt","year":"1992","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"10.1016\/S0035-9203(98)91083-5_BIB29","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0140-6736(94)92342-6","article-title":"Role of quinine in the high mortality of intramuscular injection tetanus","volume":"ii","author":"Yen","year":"1994","journal-title":"Lancet"}],"container-title":["Transactions of the Royal Society of Tropical Medicine and Hygiene"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/trstmh\/article-pdf\/92\/4\/437\/5325139\/92-4-437.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T12:36:17Z","timestamp":1682771777000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/trstmh\/article-lookup\/doi\/10.1016\/S0035-9203(98)91083-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,7]]}},"alternative-id":["S0035920398910835"],"URL":"https:\/\/doi.org\/10.1016\/s0035-9203(98)91083-5","relation":{},"ISSN":["0035-9203"],"issn-type":[{"value":"0035-9203","type":"print"}],"subject":[],"published":{"date-parts":[[1998,7]]}}}