{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:57:58Z","timestamp":1778885878840,"version":"3.51.4"},"reference-count":165,"publisher":"Elsevier","isbn-type":[{"value":"9780120066865","type":"print"}],"license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002]]},"DOI":"10.1016\/s0065-230x(02)86001-8","type":"book-chapter","created":{"date-parts":[[2004,5,19]],"date-time":"2004-05-19T00:26:52Z","timestamp":1084926412000},"page":"1-39","source":"Crossref","is-referenced-by-count":161,"title":["Coordinate regulation of translation by the PI 3-kinase and mTOR pathways"],"prefix":"10.1016","member":"78","reference":[{"key":"10.1016\/S0065-230X(02)86001-8_BIB1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1042\/bj3350417","article-title":"Atypical protein kinase Clambda binds and regulates p70 S6 kinase","volume":"335","author":"Akimoto","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0960-9822(98)70037-5","article-title":"3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro","volume":"8","author":"Alessi","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB3","first-page":"136","article-title":"A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt","volume":"98","author":"Aoki","year":"2001"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB4","doi-asserted-by":"crossref","first-page":"12,466","DOI":"10.1074\/jbc.M009939200","article-title":"Disruption of 3-phosphoinositide-dependent kinase 1 (PDK1) signaling by the anti-tumorigenic and anti-proliferative agent n-alpha-tosyl-l-phenylalanyl chloromethyl ketone","volume":"276","author":"Ballif","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB5","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0960-9822(01)00369-4","article-title":"Identification of the NIMA family kinases NEK6\/7 as regulators of the p70 ribosomal S6 kinase","volume":"11","author":"Belham","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB6","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1046\/j.1440-1711.2000.00928.x","article-title":"Cellular function of p70S6K: A role in regulating cell motility","volume":"78","author":"Berven","year":"2000","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB7","first-page":"1733","article-title":"Stimulation of ribosomal protein S6 kinase activity by pp60v-src or by serum: Dissociation from phorbol ester-stimulated activity","volume":"83","author":"Blenis","year":"1986"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB8","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ncb1101-1014","article-title":"Akt\/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo","volume":"3","author":"Bodine","year":"2001","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB9","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0092-8674(00)80799-0","article-title":"Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4","volume":"97","author":"Bohni","year":"1999","journal-title":"Cell"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1126\/science.282.5387.293","article-title":"Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK","volume":"282","author":"Bondeva","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB11","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1128\/MCB.19.7.4729","article-title":"p70(s6k) integrates phos-phatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes","volume":"19","author":"Brennan","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB12","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/369756a0","article-title":"A mammalian protein targeted by G1-arresting rapamycin-receptor complex","volume":"369","author":"Brown","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB13","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/377441a0","article-title":"Control of p70 S6 kinase by kinase activity of FRAP in vivo","volume":"377","author":"Brown","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.277.5322.99","article-title":"Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin","volume":"277","author":"Brunn","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB15","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.1002\/j.1460-2075.1996.tb00911.x","article-title":"Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002","volume":"15","author":"Brunn","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0955-0674(99)00078-2","article-title":"Signal transduction: Hanging on a scaffold","volume":"12","author":"Burack","year":"2000","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB17","first-page":"1432","article-title":"RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1","volume":"95","author":"Burnett","year":"1998"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB18","first-page":"8351","article-title":"Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton","volume":"95","author":"Burnett","year":"1998"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB19","first-page":"4240","article-title":"New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase\/AKT pathway","volume":"96","author":"Cantley","year":"1999"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB20","first-page":"11,696","article-title":"Structural and functional analysis of p70 S6 kinase","volume":"92","author":"Cheatham","year":"1995"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB21","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1210\/endo.137.3.8603594","article-title":"The Drosophila insulin receptor is required for normal growth","volume":"137","author":"Chen","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB22","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1006\/bbrc.1998.8792","article-title":"Alpha 4 associates with protein phosphatases 2A, 4, and 6","volume":"247","author":"Chen","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB23","first-page":"12,574","article-title":"RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12\/rapamycin complex","volume":"91","author":"Chiu","year":"1994"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB24","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0092-8674(00)81257-X","article-title":"The 70kD S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1","volume":"85","author":"Chou","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB25","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/370071a0","article-title":"PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase","volume":"370","author":"Chung","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB26","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/0092-8674(92)90643-Q","article-title":"Rapamycin-FKBP specifically blocks growth-dependent activation of and signalling by the 70kD S6 protein kinases","volume":"69","author":"Chung","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB27","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1432-1033.1991.tb16305.x","article-title":"Molecular cloning and characterization of a novel putative protein serine kinase related to the cAMP-dependent and protein kinase C families","volume":"201","author":"Coffer","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB28","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1128\/MCB.20.8.2880-2889.2000","article-title":"Atypical protein kinases Clambda and -zeta associate with the GTP-binding protein Cdc42 and mediate stress fiber loss","volume":"20","author":"Coghlan","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB29","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/378785a0","article-title":"Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B","volume":"378","author":"Cross","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/bbrc.1997.6419","article-title":"Regulation of thrombin-induced sress fibre formation in Swiss 3T3 cells by the 70-kDa S6 kinase","volume":"233","author":"Crouch","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0092-8674(94)90402-2","article-title":"Positive Regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: An alternative route to mitogen-induced gene expression","volume":"79","author":"de Groot","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB32","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1126\/science.1063518","article-title":"Mammalian TOR: A homeostatic ATP sensor","volume":"294","author":"Dennis","year":"2001","journal-title":"Science"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB33","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1101\/gad.10.15.1904","article-title":"Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases","volume":"10","author":"Di Como","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB34","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0955-0674(98)80149-X","article-title":"Mechanisms and consequences of activation of protein kinase B\/Akt","volume":"10","author":"Downward","year":"1998","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB35","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1128\/MCB.19.6.4525","article-title":"Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation","volume":"19","author":"Dufner","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB36","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1006\/excr.1999.4683","article-title":"Ribosomal S6 kinase signaling and the control of translation","volume":"253","author":"Dufner","year":"1999","journal-title":"Exp. Cell Res."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0955-0674(00)00192-7","article-title":"Multiple roles for Cdc42 in cell regulation","volume":"13","author":"Erickson","year":"2001","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB38","doi-asserted-by":"crossref","first-page":"10,240","DOI":"10.1074\/jbc.272.15.10240","article-title":"Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes","volume":"272","author":"Fadden","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB39","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1126\/science.1066015","article-title":"Phosphatidic acid-mediated mitogenic activation of mTOR signaling","volume":"294","author":"Fang","year":"2001","journal-title":"Science"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB40","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1101\/gad.995802","article-title":"Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1\/eIF4E","volume":"16","author":"Fingar","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB41","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/00007890-199202010-00045","article-title":"Inhibition of liver, kidney, and intestine regeneration by rapamycin","volume":"53","author":"Francavilla","year":"1992","journal-title":"Transplantation"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB42","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/81715","article-title":"Hypoglycemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha","volume":"26","author":"Fruman","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB43","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1101\/gad.901101","article-title":"TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth","volume":"15","author":"Gao","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB44","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0955-0674(99)80028-3","article-title":"Organization and regulation of mitogen-activated protein kinase signaling pathways","volume":"11","author":"Garrington","year":"1999","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB45","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1101\/gad.13.11.1422","article-title":"Regulation of 4E-BP1 phosphorylation: A novel two-step mechanism","volume":"13","author":"Gingras","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB46","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1101\/gad.12.4.502","article-title":"4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway","volume":"12","author":"Gingras","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB47","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1101\/gad.912401","article-title":"Hierarchical phosphorylation of the translation inhibitor 4E-BP1","volume":"15","author":"Gingras","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB48","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1101\/gad.887201","article-title":"Regulation of translation initiation by FRAP\/mTOR","volume":"15","author":"Gingras","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB49","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1101\/gad.13.24.3244","article-title":"Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico\/PI3-kinase signaling pathway","volume":"13","author":"Goberdhan","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB50","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M202678200","article-title":"Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation: A role for the TSC2 tumor suppressor gene in pulmonary lymphangi-oleiomyomatosis (LAM)","author":"Goncharova","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB51","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1074\/jbc.M103808200","article-title":"A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation","volume":"277","author":"Gonzalez-Garcia","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB52","doi-asserted-by":"crossref","first-page":"30,061","DOI":"10.1074\/jbc.273.46.30061","article-title":"Molecular cloning and characterization of a novel S6 kinase, p70 S6 kinase beta containing a proline-rich region","volume":"273","author":"Gout","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB53","doi-asserted-by":"crossref","first-page":"23,650","DOI":"10.1074\/jbc.271.39.23650","article-title":"The serine protease inhibitors, tosylphenylalanine chloromethyl ketone and tosyllysine chloromethyl ketone, potently inhibit pp70S6k activation","author":"Grammer","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB54","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.4049\/jimmunol.162.6.3491","article-title":"Differential regulation of 4E-BP1 and 4E-BP2, two repressors of translation initiation, during human myeloid cell differentiation","volume":"162","author":"Grolleau","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB55","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1002\/j.1460-2075.1995.tb00257.x","article-title":"Repression of cap-dependent translation by 4E-binding protein 1: Competition with p220 for binding to eukaryotic initiation factor-4E","volume":"14","author":"Haghighat","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB56","doi-asserted-by":"crossref","first-page":"14,484","DOI":"10.1074\/jbc.273.23.14484","article-title":"Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism","volume":"273","author":"Hara","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB57","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0014-5793(99)01094-7","article-title":"Dissociation of the eukaryotic initiation factor-4E\/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase","volume":"457","author":"Heesom","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB58","first-page":"13,796","article-title":"FRAP\/mTOR is required for proliferation and patterning during embryonic development in the mouse","volume":"98","author":"Hentges","year":"2001"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB59","doi-asserted-by":"crossref","first-page":"11,249","DOI":"10.1074\/jbc.275.15.11249","article-title":"Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells","volume":"275","author":"Herbert","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB60","doi-asserted-by":"crossref","first-page":"11,591","DOI":"10.1074\/jbc.M110367200","article-title":"The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites","volume":"277","author":"Herbert","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB61","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0959-437X(97)80125-6","article-title":"Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family","volume":"7","author":"Hoekstra","year":"1997","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB62","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1006\/bbrc.2000.4044","article-title":"Rapid activation of protein kinase B\/Akt has a key role in antipoptotic signaling during liver regeneration","volume":"279","author":"Hong","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB63","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1124\/mol.54.5.815","article-title":"Studies on the mechanism of resistance to rapamycin in human cancer cells","volume":"54","author":"Hosoi","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB64","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1074\/jbc.274.2.1092","article-title":"Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation","volume":"274","author":"Iiboshi","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB65","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1093\/emboj\/16.12.3693","article-title":"Rapamycin suppresses 5 TOP mRNA translation through inhibition of p70s6k","volume":"16","author":"Jefferies","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB66","first-page":"4441","article-title":"Rapamycin selectively represses translation of the \u201cpolypryimidine tract\u201d nRNA family","volume":"91","author":"Jefferies","year":"1994"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB67","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1093\/emboj\/18.10.2782","article-title":"Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast","volume":"18","author":"Jiang","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB68","doi-asserted-by":"crossref","first-page":"10,943","DOI":"10.1074\/jbc.M007758200","article-title":"Rapamycin-insensitive regulation of 4E-BP1 in regenerating rat liver","volume":"276","author":"Jiang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB69","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0014-4827(77)90154-9","article-title":"Coordination of growth with cell division in the yeast Saccharomyces cerevisiae","volume":"105","author":"Johnston","year":"1977","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB70","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1093\/hmg\/6.12.2155","article-title":"Molecular genetic and phenotypic analysis reveals differences between TSC1 and TSC2 associated familial and sporadic tuberous sclerosis","volume":"6","author":"Jones","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB71","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0962-8924(00)01741-4","article-title":"Why cytoplasmic signalling proteins should be recruited to cell membranes","volume":"10","author":"Kholodenko","year":"2000","journal-title":"Trends Cell Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB72","first-page":"14,340","article-title":"Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation","volume":"97","author":"Kim","year":"2000"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB73","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1038\/sj.onc.1202895","article-title":"Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt","volume":"18","author":"Koh","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB74","first-page":"7365","article-title":"Cloning of the mitogen-activated S6 kinase from the rat liver reveals an enzyme of the second messanger subfamily","volume":"87","author":"Kozma","year":"1990"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB75","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/emboj\/19.5.1087","article-title":"Functional interaction betwen RAFT1\/FRAP\/mTOR and protein kinase C in the regulation of cap-dependent initiation of translation","volume":"19","author":"Kumar","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB76","doi-asserted-by":"crossref","first-page":"10,779","DOI":"10.1074\/jbc.275.15.10779","article-title":"Regulation of the rapamycin and FKBP-target 1\/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase","volume":"275","author":"Kumar","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB77","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/hmg\/11.5.525","article-title":"A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6K kinase activity in Tsc1 null cells","volume":"11","author":"Kwiatkowski","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB78","doi-asserted-by":"crossref","first-page":"24,610","DOI":"10.1074\/jbc.273.38.24610","article-title":"Differential activation of p70 and p85 S6 kinase isoforms during cardiac hypertrophy in the adult mammal","volume":"273","author":"Laser","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB79","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1038\/sj.onc.1202894","article-title":"Characterization of S6K2, a novel kinase homologous to S6K1","volume":"18","author":"Lee-Fruman","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB80","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1126\/science.285.5436.2082","article-title":"All creatures great and small","volume":"285","author":"Leevers","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB81","doi-asserted-by":"crossref","first-page":"6584","DOI":"10.1002\/j.1460-2075.1996.tb01049.x","article-title":"The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth","volume":"15","author":"Leevers","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB82","doi-asserted-by":"crossref","first-page":"15,762","DOI":"10.1074\/jbc.271.26.15762","article-title":"Oncogenic Raf-1 activates p70 S6 kinase via a mitogen-activated protein kinase-independent pathway","volume":"271","author":"Lenormand","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB83","doi-asserted-by":"crossref","first-page":"9812","DOI":"10.1074\/jbc.274.14.9812","article-title":"Suboptimal cross-linking of antigen receptor induces Syk-dependent activation of p70S6 kinase through protein kinase C and phosphoinositol 3-kinase","volume":"274","author":"Li","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB84","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/S0960-9822(06)00338-1","article-title":"A novel Cdc42Hs mutant induces cellular transformation","volume":"7","author":"Lin","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB85","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1126\/science.7939721","article-title":"PHAS-1 as a link between mitogen-activated protein kinase and translation initiation","volume":"266","author":"Lin","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB86","first-page":"503","article-title":"The zinc finger protein GLI induces cellular sensitivity to the mTOR inhibitor rapamycin","volume":"10","author":"Louro","year":"1999","journal-title":"Cell. Growth Differ."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB87","doi-asserted-by":"crossref","first-page":"861S","DOI":"10.1093\/jn\/131.3.861S","article-title":"Role of leucine in the regulation of mTOR by amino acids: Revelations from structure-activity studies","volume":"131","author":"Lynch","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB88","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0092-8674(00)80280-9","article-title":"Cocrystal structure of the messenger RNA 5 cap-binding protein (eIF4E) bound to 7-methyl-GDP","volume":"89","author":"Marcotrigiano","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB89","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/hmg\/8.8.1461","article-title":"PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome","volume":"8","author":"Marsh","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB90","doi-asserted-by":"crossref","first-page":"7884","DOI":"10.1074\/jbc.M006969200","article-title":"Regulation of S6K2 by effectors of the PI3-kinase pathway","volume":"276","author":"Martin","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB91","doi-asserted-by":"crossref","first-page":"7892","DOI":"10.1074\/jbc.M009972200","article-title":"Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation","volume":"276","author":"Martin","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB92","doi-asserted-by":"crossref","first-page":"6321","DOI":"10.1046\/j.1432-1327.2000.01719.x","article-title":"Synthesis of the translational apparatus is regulated at the translational level","volume":"267","author":"Meyuhas","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB93","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1126\/science.276.5309.60","article-title":"Liver regeneration","volume":"276","author":"Michalopoulos","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB94","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1046\/j.1365-2443.2001.00479.x","article-title":"Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha","volume":"6","author":"Minami","year":"2001","journal-title":"Genes Cells"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB95","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/35078571","article-title":"The translational inhibitor 4E-BP is an effector of PI(3)K\/Akt signalling and cell growth in Drosophila","volume":"3","author":"Miron","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB96","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1128\/MCB.15.1.326","article-title":"Activation of pp70\/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP","volume":"15","author":"Monfar","year":"1995","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB97","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1126\/science.285.5436.2126","article-title":"Drosophila S6 kinase: A regulator of cell size","volume":"285","author":"Montagne","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB98","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/0300-9084(93)90149-M","article-title":"Stimulation of translation in 3T3-L1 cells in response to insulin and phorbol ester is directly correlated with increased phosphate labelling of initiation factor (eIF-) 4F and ribosomal protein S6","volume":"75","author":"Morley","year":"1993","journal-title":"Biochimie"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB99","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1128\/MCB.17.9.5648","article-title":"Dual requirement for a newly identified phosphorylation site in p70s6k","volume":"17","author":"Moser","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB100","doi-asserted-by":"crossref","first-page":"33,836","DOI":"10.1074\/jbc.M006005200","article-title":"Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S\/T)P sites detected by phospho-specific antibodies","volume":"275","author":"Mothe-Satney","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB101","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1128\/MCB.20.10.3558-3567.2000","article-title":"Multiple mechanisms control phosphorylation of PHAS-I in five (S\/T)P sites that govern translational repression","volume":"20","author":"Mothe-Satney","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB102","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1016\/S0021-9258(19)50735-9","article-title":"An array of insulin-activated, proline-directed serine\/threonine protein kinases phosphorylate the p70 S6 kinase","volume":"267","author":"Mukhopadhyay","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB103","first-page":"10,624","article-title":"B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A","volume":"94","author":"Murata","year":"1997"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB104","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1042\/bj3440427","article-title":"Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation","volume":"344","author":"Nave","year":"1999","journal-title":"Biochem. J."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB105","first-page":"10,314","article-title":"Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP\/mTOR","volume":"98","author":"Neshat","year":"2001"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB106","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1101\/gad.845700","article-title":"Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin","volume":"14","author":"Oldham","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB107","doi-asserted-by":"crossref","first-page":"7731","DOI":"10.1074\/jbc.273.13.7731","article-title":"A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regneration","volume":"273","author":"Ono","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB108","doi-asserted-by":"crossref","first-page":"34,758","DOI":"10.1074\/jbc.274.49.34758","article-title":"Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon","volume":"274","author":"Parekh","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB109","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/371762a0","article-title":"Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5\u2032-cap function","volume":"371","author":"Pause","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB110","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/35050135","article-title":"Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice","volume":"408","author":"Pende","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB111","doi-asserted-by":"crossref","first-page":"7416","DOI":"10.1074\/jbc.275.10.7416","article-title":"FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions","volume":"275","author":"Peterson","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB112","first-page":"4438","article-title":"Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycin associated protein","volume":"96","author":"Peterson","year":"1999"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB113","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/152692480101100105","article-title":"Use of sirolimus in kidney transplantation","volume":"11","author":"Podbielski","year":"2001","journal-title":"Prog. Transplant"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB114","first-page":"10,320","article-title":"An inhibitor of mTOR reduces neoplasia and normalizes p70\/S6 kinase activity in Pten+\/\u2212 mice","volume":"98","author":"Podsypanina","year":"2001"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB115","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0092-8674(01)00333-6","article-title":"Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size","volume":"105","author":"Potter","year":"2001","journal-title":"Cell"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB116","doi-asserted-by":"crossref","first-page":"14,002","DOI":"10.1074\/jbc.273.22.14002","article-title":"4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family","volume":"273","author":"Poulin","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB117","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/0300-9084(94)90079-5","article-title":"The guanine nucleotide-exchange factor, eIF-2B","volume":"76","author":"Price","year":"1994","journal-title":"Biochimie"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB118","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1126\/science.279.5351.707","article-title":"Phosphorylation and activation of p70s6k by PDK1","volume":"279","author":"Pullen","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB119","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0959-437X(00)00150-7","article-title":"Cell-cycle-dependent translational control","volume":"11","author":"Pyronnet","year":"2001","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB120","doi-asserted-by":"crossref","first-page":"8347","DOI":"10.1074\/jbc.274.13.8347","article-title":"The role of phosphoinositide 3-kinase lipid products in cell function","volume":"274","author":"Rameh","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB121","doi-asserted-by":"crossref","first-page":"12,925","DOI":"10.1074\/jbc.274.18.12925","article-title":"A potential role for extracellular signal-regulated kinases in prostaglandin F2alpha-induced protein synthesis in smooth muscle cells","volume":"274","author":"Rao","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB122","doi-asserted-by":"crossref","first-page":"8983","DOI":"10.1074\/jbc.271.15.8983","article-title":"A reevaluation of the cap-binding protein, eIF4E, as a rate-limiting factor for initiation of translation in reticulocyte lysate","volume":"271","author":"Rau","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB123","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/emboj\/19.3.434","article-title":"Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI","volume":"19","author":"Raught","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB124","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1002\/j.1460-2075.1994.tb06418.x","article-title":"Nuclear localization of p85s6k: functional requirement for entry into S phase","volume":"13","author":"Reinhard","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB125","doi-asserted-by":"crossref","first-page":"9583","DOI":"10.1074\/jbc.R000034200","article-title":"The TOR kinases link nutrient sensing to cell growth","volume":"276","author":"Rohde","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB126","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1128\/MCB.19.4.2921","article-title":"p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex","volume":"19","author":"Romanelli","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB127","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/ncb1101-1009","article-title":"Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K\/Akt\/mTOR and PI(3)K\/Akt\/GSK3 pathways","volume":"3","author":"Rommel","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB128","first-page":"1065","article-title":"Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E","volume":"93","author":"Rousseau","year":"1996"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB129","first-page":"1134","article-title":"Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F","volume":"10","author":"Rozen","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB130","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1126\/science.284.5417.1161","article-title":"Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling","volume":"284","author":"Sabatini","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB131","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0092-8674(94)90570-3","article-title":"RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs","volume":"78","author":"Sabatini","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB132","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1074\/jbc.270.2.815","article-title":"Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells","volume":"270","author":"Sabers","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB133","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0960-9822(02)00762-5","article-title":"Identification of conserved motif required for mTOR signaling","volume":"12","author":"Schalm","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB134","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1128\/MCB.21.3.743-754.2001","article-title":"The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells","volume":"21","author":"Scheper","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB135","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1038\/sj.onc.1202751","article-title":"The role of c-myc in cellular growth control","volume":"18","author":"Schmidt","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB136","doi-asserted-by":"crossref","first-page":"35,786","DOI":"10.1074\/jbc.M102479200","article-title":"The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival","volume":"276","author":"Schwartzbauer","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB137","first-page":"7772","article-title":"Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway","volume":"95","author":"Scott","year":"1998"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB138","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0014-5793(97)00500-0","article-title":"Insulin activates a PD 098059-sensitive kinase that is involved in the regulation of p70S6K and PHAS-I","volume":"409","author":"Scott","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB139","first-page":"3504","article-title":"A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells","volume":"60","author":"Sekulic","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB140","doi-asserted-by":"crossref","first-page":"6649","DOI":"10.1093\/emboj\/17.22.6649","article-title":"Disruption of the p70(s6k)\/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase","volume":"17","author":"Shima","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB141","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1093\/emboj\/19.11.2537","article-title":"The conserved phosphoinositide 3-kinase pathway determines heart size in mice","volume":"19","author":"Shioi","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB142","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.4049\/jimmunol.166.5.3201","article-title":"Uncoupling p70(s6) kinase activation and proliferation: Rapamycin-resistant proliferation of human CD8(+) T lymphocytes","volume":"166","author":"Slavik","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB143","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0955-0674(98)80150-6","article-title":"The mRNA 5 cap-binding protein eIF4E and control of cell growth","volume":"10","author":"Sonenberg","year":"1998","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB144","doi-asserted-by":"crossref","first-page":"20,611","DOI":"10.1074\/jbc.274.29.20611","article-title":"Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)","volume":"274","author":"Takata","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB145","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.22.13.4803-4814.2002","article-title":"Myogenic Akt signaling regulates blood vessel recruitment during myofiber growth","author":"Takehashi","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB146","doi-asserted-by":"crossref","first-page":"8671","DOI":"10.1128\/MCB.21.24.8671-8683.2001","article-title":"Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation","volume":"21","author":"Tang","year":"2001","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB147","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0092-8674(01)00332-4","article-title":"The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation","volume":"105","author":"Tapon","year":"2001","journal-title":"Cell"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB148","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1128\/MCB.22.6.1674-1683.2002","article-title":"Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif","volume":"22","author":"Tee","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB149","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1038\/sj.onc.1203622","article-title":"DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling","volume":"19","author":"Tee","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB150","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/70293","article-title":"Cell-autonomous regulation of cell and organ growth in Drosophila by Akt\/PKB","volume":"1","author":"Verdu","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB151","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1083\/jcb.133.1.5","article-title":"A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleo-protein particle during nuclear export","volume":"133","author":"Visa","year":"1996","journal-title":"J. Cell. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB152","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S1471-4914(01)02161-X","article-title":"PI 3-kinase, mTOR, protein synthesis and cancer","volume":"7","author":"Vogt","year":"2001","journal-title":"Trends Mol. Med."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB153","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.288.5473.2045","article-title":"Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6","volume":"288","author":"Volarevic","year":"2000","journal-title":"Science"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB154","doi-asserted-by":"crossref","first-page":"5426","DOI":"10.1128\/MCB.17.9.5426","article-title":"The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k","volume":"17","author":"von Manteuffel","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB155","doi-asserted-by":"crossref","first-page":"32,670","DOI":"10.1074\/jbc.M102776200","article-title":"Cross-talk between the ERK and p70 S6 kinase (S6K) signaling pathways. MEK-dependent activation of S6K2 in cardiomyocytes","volume":"276","author":"Wang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB156","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1093\/emboj\/16.8.1909","article-title":"Mitogen-activated protein kinases activate the serine\/threonine kinases Mnk1 and Mnk2","volume":"16","author":"Waskiewicz","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB157","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0960-9822(99)80450-3","article-title":"Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor","volume":"9","author":"Weinkove","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB158","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0014-5793(97)01548-2","article-title":"Regulation of eukaryotic initiation factor eIF2B: Glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin","volume":"421","author":"Welsh","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB159","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1128\/MCB.15.5.2333","article-title":"Multiple independent inputs are required for activation of the p70 S6 kinase","volume":"15","author":"Weng","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB160","doi-asserted-by":"crossref","first-page":"16,621","DOI":"10.1074\/jbc.273.26.16621","article-title":"Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies","volume":"273","author":"Weng","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB161","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0960-9822(00)00441-3","article-title":"The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells","volume":"10","author":"Williams","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB162","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1074\/jbc.274.7.4166","article-title":"The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction","volume":"274","author":"Wilson","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB163","doi-asserted-by":"crossref","first-page":"37,307","DOI":"10.1074\/jbc.C000482200","article-title":"Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex","volume":"275","author":"Wilson","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-230X(02)86001-8_BIB164","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2337\/diabetes.50.2.353","article-title":"Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells","volume":"50","author":"Xu","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/S0065-230X(02)86001-8_BIB165","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1101\/gad.835000","article-title":"Regulation of cellular growth by the Drosophila target of rapamycin dTOR","volume":"14","author":"Zhang","year":"2000","journal-title":"Genes Dev."}],"container-title":["Advances in Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065230X02860018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065230X02860018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T18:30:16Z","timestamp":1758738616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065230X02860018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"ISBN":["9780120066865"],"references-count":165,"URL":"https:\/\/doi.org\/10.1016\/s0065-230x(02)86001-8","relation":{},"ISSN":["0065-230X"],"issn-type":[{"value":"0065-230X","type":"print"}],"subject":[],"published":{"date-parts":[[2002]]}}}