{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T14:55:53Z","timestamp":1782226553891,"version":"3.54.5"},"reference-count":344,"publisher":"Elsevier","isbn-type":[{"value":"9780120224760","type":"print"}],"license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001]]},"DOI":"10.1016\/s0065-2776(01)76020-8","type":"book-chapter","created":{"date-parts":[[2004,5,19]],"date-time":"2004-05-19T04:26:52Z","timestamp":1084940812000},"page":"179-226","source":"Crossref","is-referenced-by-count":31,"title":["Cell Death Control in Lymphocytes"],"prefix":"10.1016","author":[{"given":"Kim","family":"Newton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Strasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0065-2776(01)76020-8_bb0005","first-page":"293","article-title":"Collaboration of PIM-1 and BCL-2 in lymphomagenesis","volume":"182","author":"Acton","year":"1992","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0010","doi-asserted-by":"crossref","first-page":"19892","DOI":"10.1074\/jbc.273.31.19892","article-title":"Lack of release of cytochrome c from mitochondria into cytosol early in the course of Fas-mediated apoptosis of Jurkat cells","volume":"273","author":"Adachi","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0015","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.281.5381.1322","article-title":"The Bcl-2 protein family: Arbiters of cell survival","volume":"281","author":"Adams","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0020","first-page":"615","article-title":"CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL\/tumor necrosis factor receptor\u2013interacting protein RIP","volume":"57","author":"Ahmad","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0025","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0092-8674(00)80291-3","article-title":"Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor\u2013deficient mice","volume":"89","author":"Akashi","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0030","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1084\/jem.178.6.2231","article-title":"Fas transduces activation signals in normal human T lymphocytes","volume":"178","author":"Alderson","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0035","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1093\/intimm\/6.11.1799","article-title":"Regulation of apoptosis and T cell activation by Fas-specific mAb","volume":"6","author":"Alderson","year":"1994","journal-title":"Int. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0040","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1084\/jem.181.1.71","article-title":"Fas ligand mediates activation-induced cell death in human T lymphocytes","volume":"181","author":"Alderson","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0045","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0092-8674(00)81031-4","article-title":"Impaired negative selection of T cells in Hodgkin\u2019s disease antigen CD30-deficient mice","volume":"84","author":"Amakawa","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_rf0050","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1126\/science.277.5324.370","article-title":"Inhibition of Bax channel-forming activity by Bcl-2","volume":"277","author":"Antonsson","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0055","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0955-0674(99)80034-9","article-title":"Apoptosis control by death and decoy receptors","volume":"11","author":"Ashkenazi","year":"1999","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0060","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0092-8674(85)80070-2","article-title":"Cloning the chromosomal breakpoint of t(14;18) human lymphomas: Clustering around JH on chromosome 14 and near a transcriptional unit on 18","volume":"41","author":"Bakhshi","year":"1985","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0065","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0952-7915(99)80025-9","article-title":"B cell development: Signal transduction by antigen receptors and their surrogates","volume":"11","author":"Benschop","year":"1999","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0070","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1038\/sj.onc.1202586","article-title":"Mechanisms and control of programmed cell death in invertebrates","volume":"17","author":"Bergmann","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0075","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0960-9822(98)70302-1","article-title":"The kit receptor promoters cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser 136","volume":"8","author":"Blume-Jensen","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0080","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S1074-7613(00)80244-7","article-title":"TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas (Apo-1\/CD95)","volume":"6","author":"Bodmer","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0085","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/35008667","article-title":"TRAIL receptor 2 signals apoptosis through FADD and caspase 8","volume":"2","author":"Bodmer","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0090","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1101\/gad.10.5.553","article-title":"p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes","volume":"10","author":"Bogue","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0095","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0092-8674(93)90508-N","article-title":"bcl-x, abcl-2\u2013related gene that functions as a dominant regulator of apoptotic cell death","volume":"74","author":"Boise","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0100","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/1074-7613(95)90161-2","article-title":"CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-X(L)","volume":"3","author":"Boise","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0105","doi-asserted-by":"crossref","first-page":"7795","DOI":"10.1074\/jbc.270.14.7795","article-title":"A novel protein that interacts with the death domain of Fas\/APO1 contains a sequence motif related to the death domain","volume":"270","author":"Boldin","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0110","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0092-8674(00)81265-9","article-title":"Involvement of MACH, anovel MORT1\/FADD-interacting protease, in Fas\/APO-1\u2013and TNF receptor\u2013induced cell death","volume":"85","author":"Boldin","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0115","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.iy.09.040191.001543","article-title":"The scid mouse mutant: Definition, characterization, and potential uses","volume":"9","author":"Bosma","year":"1991","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0120","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/4779","article-title":"Degranulation plays an essential part in regulating cell surface expression of Fas ligandin T cells and natural killer cells","volume":"5","author":"Bossi","year":"1999","journal-title":"Nature Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/emboj\/17.1.37","article-title":"Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization","volume":"17","author":"Bossy-Wetzel","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_rf0130","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1126\/science.286.5445.1735","article-title":"Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity","volume":"286","author":"Bouillet","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0135","first-page":"1921","article-title":"Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins","volume":"11","author":"Boyd","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0140","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0092-8674(00)81992-3","article-title":"CAR1, a TNFR-related protein, is a cellular receptor for cytopathic avian leukosis\u2013sarcoma viruses and mediates apoptosis","volume":"87","author":"Brojatsch","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0145","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/373441a0","article-title":"Cell-autonomous Fas (CD95)\/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas","volume":"373","author":"Brunner","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0150","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/1074-7613(95)90047-0","article-title":"Defective lymphoid development in mice lacking expression of the common cytokine receptor \u03b3 chain","volume":"2","author":"Cao","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0155","doi-asserted-by":"crossref","first-page":"12522","DOI":"10.1073\/pnas.95.21.12522","article-title":"Kinetics of T cell receptor \u03b2, \u03b3, and \u03b4 rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44+CD25+ pro-T thymocytes","volume":"95","author":"Capone","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0160","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0092-8674(00)81732-8","article-title":"Apaf-1 (CED-4 homologue) regulates programmed cell death in mammalian development","volume":"94","author":"Cecconi","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0165","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1093\/emboj\/16.5.968","article-title":"Identification of a novel regulatory domain in Bcl-xL and Bcl-2","volume":"16","author":"Chang","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0170","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1093\/intimm\/9.9.1375","article-title":"BCL-XL\u2013regulated apoptosis in T cell development","volume":"9","author":"Chao","year":"1997","journal-title":"Int. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0175","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S1074-7613(00)80400-8","article-title":"Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-\u03baB pathway","volume":"7","author":"Chaudhary","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0180","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1093\/emboj\/16.8.1865","article-title":"Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis","volume":"16","author":"Cheng","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0185","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0092-8674(95)90071-3","article-title":"FADD, a novel death domain\u2013containing protein, interacts with the death domain of Fas and initiates apoptosis","volume":"81","author":"Chinnaiyan","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0190","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1126\/science.274.5289.990","article-title":"Signal transduction by DR3, a death domain\u2013containing receptor related to TNFR-1 and CD95","volume":"274","author":"Chinnaiyan","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0195","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1074\/jbc.271.9.4573","article-title":"Molecular ordering of the cell death pathway","volume":"271","author":"Chinnaiyan","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0200","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1074\/jbc.271.9.4961","article-title":"FADD\/MORT1 is a common mediator of CD95 (Fas\/APO-1) and tumor necrosis factor receptor\u2013induced apoptosis","volume":"271","author":"Chinnaiyan","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0205","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1126\/science.275.5303.1122","article-title":"Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death","volume":"275","author":"Chinnaiyan","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_rf0210","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/374733a0","article-title":"Induction of apoptosis by the Bcl-2 homologue Bak","volume":"374","author":"Chittenden","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0215","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1093\/emboj\/16.9.2282","article-title":"T-cell receptor ligation by peptide\/MHC induces activation of a caspase in immature thymocytes: The molecular basis of negative selection","volume":"16","author":"Clayton","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0220","doi-asserted-by":"crossref","first-page":"7439","DOI":"10.1073\/pnas.82.21.7439","article-title":"Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18","volume":"82","author":"Cleary","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0225","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0092-8674(86)90362-4","article-title":"Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2\/immunoglobulin transcript resulting from the t(14;18) translocation","volume":"47","author":"Cleary","year":"1986","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0230","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0167-5699(92)90066-G","article-title":"The lpr and gld genes in systemic autoimmunity: Life and death in the Fas lane","volume":"13","author":"Cohen","year":"1993","journal-title":"Immunol. Today"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0235","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0092-8674(00)81182-4","article-title":"The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2\u2013like protein CED-9","volume":"93","author":"Conradt","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0240","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0092-8674(00)80405-5","article-title":"Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery","volume":"91","author":"Datta","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0245","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/35385","article-title":"Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants","volume":"391","author":"Davidson","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0250","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1084\/jem.187.11.1825","article-title":"Spontaneous development of plasmacytoid tumors in mice with defective Fas\u2013Fas ligand interactions","volume":"187","author":"Davidson","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0255","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S1074-7613(00)80399-4","article-title":"The novel receptor TRAIL-R4 induces NF-\u03baB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain","volume":"7","author":"Degli-Esposti","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0260","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1084\/jem.186.7.1165","article-title":"Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family","volume":"186","author":"Degli-Esposti","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0265","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1126\/science.278.5338.687","article-title":"Interleukin-3\u2013induced phosphorylation of BAD through the protein kinase Akt","volume":"278","author":"del Peso","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0270","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S1074-7613(00)80194-6","article-title":"The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation","volume":"12","author":"Devin","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0275","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/373438a0","article-title":"Autocrine T-cell suicide mediated by APO-1\/(Fas\/CD95)","volume":"373","author":"Dhein","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0280","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/385086a0","article-title":"RAIDD is a new \u2018death\u2019 adaptor molecule","volume":"385","author":"Duan","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0285","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1101\/gad.11.21.2810","article-title":"CD30-dependent degradation of TRAF2: Implications for negative regulation of TRAF signaling and the control of cell survival","volume":"11","author":"Duckett","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0290","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(86)90004-8","article-title":"Genetic control of programmed cell death in the nematode C. elegans","volume":"44","author":"Ellis","year":"1986","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0295","doi-asserted-by":"crossref","first-page":"14363","DOI":"10.1074\/jbc.273.23.14363","article-title":"Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL","volume":"273","author":"Emery","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_rf0300","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/34112","article-title":"A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD","volume":"391","author":"Enari","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0305","doi-asserted-by":"crossref","first-page":"17601","DOI":"10.1074\/jbc.271.30.17601","article-title":"Activation of the CPP32 apoptotic protease by distinct signaling pathways with differential sensitivity to Bcl-xL","volume":"271","author":"Erhardt","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0310","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/sj.cdd.4400205","article-title":"Bcl-2 prevents activation of CPP32 cysteine protease and cleavage of poly (ADP-ribose) polymerase and U1-70 kD proteins in staurosporine-mediated apoptosis","volume":"4","author":"Estoppey","year":"1997","journal-title":"Cell Death Differ."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0315","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.4049\/jimmunol.148.7.2207","article-title":"Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages","volume":"148","author":"Fadok","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0320","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1074-7613(00)80437-9","article-title":"Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-xL transgene","volume":"4","author":"Fang","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0325","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1074-7613(00)80586-5","article-title":"Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing","volume":"9","author":"Fang","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0330","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/374731a0","article-title":"Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K","volume":"374","author":"Farrow","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0335","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/375795a0","article-title":"Crucial role of the pre\u2013T-cell receptor alpha gene in development of alpha\u2013beta but not gamma\u2013delta T cells","volume":"375","author":"Fehling","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0340","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S1074-7613(00)80446-X","article-title":"Restoration of thymopoiesis in pT\u03b1\u2212\/\u2212 mice by anti-CD3\u03b5 antibody treatment or with transgenes encoding activated Lck or Tailless pT\u03b1","volume":"6","author":"Fehling","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0345","doi-asserted-by":"crossref","first-page":"7464","DOI":"10.1073\/pnas.93.15.7464","article-title":"In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains","volume":"93","author":"Fernandes-Alnemri","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0350","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0092-8674(95)90013-6","article-title":"Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome","volume":"81","author":"Fisher","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0355","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1084\/jem.182.5.1377","article-title":"An essential role for gp39, the ligand for CD40, in thymic selection","volume":"182","author":"Foy","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0360","first-page":"665","article-title":"bcl-w, a novel member of the bcl-2 family, promotes cell survival","volume":"13","author":"Gibson","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0365","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0167-5699(93)90186-O","article-title":"Control points in early T-cell development","volume":"14","author":"Godfrey","year":"1993","journal-title":"Immunol. Today"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0370","doi-asserted-by":"crossref","first-page":"19641","DOI":"10.1074\/jbc.272.32.19641","article-title":"CASH, a novel caspase homologue with death effector domains","volume":"272","author":"Goltsev","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0375","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4049\/jimmunol.151.1.83","article-title":"bcl-2 proto-oncogene expression during human T cell development","volume":"151","author":"Gratiot-Deans","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_rf0380","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/(SICI)1521-4141(199801)28:01<257::AID-IMMU257>3.0.CO;2-G","article-title":"TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1","volume":"28","author":"Grell","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0385","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1093\/emboj\/18.11.3034","article-title":"Induction of cell death by tumor necrosis factor (TNF) receptor 2, CD40 and CD30\u2014A role for TNF-R1 activation by endogenous membrane-anchored TNF","volume":"18","author":"Grell","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0390","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1084\/jem.182.6.1973","article-title":"Bcl-xL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice","volume":"182","author":"Grillot","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0395","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1084\/jem.183.2.381","article-title":"bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice","volume":"183","author":"Grillot","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0400","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0092-8674(93)80070-U","article-title":"A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor \u03b2 chain and a 33 kd glycoprotein","volume":"75","author":"Groettrup","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0405","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1074\/jbc.274.2.1156","article-title":"Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor\u2013R1\/Fas death","volume":"274","author":"Gross","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0410","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1101\/gad.13.4.400","article-title":"Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis","volume":"13","author":"Grumont","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0415","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1101\/gad.10.16.2038","article-title":"V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors","volume":"10","author":"Guidos","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0420","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1002\/eji.1830171013","article-title":"Correlation of T cell receptor gene rearrangements to T cell surface antigen expression and to serum immunoglobulin level in scid mice","volume":"17","author":"Habu","year":"1987","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0425","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0092-8674(00)81477-4","article-title":"Differential requirement for caspase 9 in apoptotic pathways in vivo","volume":"94","author":"Hakem","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0430","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1074-7613(00)80084-9","article-title":"Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells","volume":"11","author":"Haks","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0435","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1073\/pnas.92.10.4507","article-title":"Inactivation of Bcl-2 by phosphorylation","volume":"92","author":"Haldar","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0440","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0960-9822(98)79298-X","article-title":"CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45","volume":"8","author":"Halenbeck","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0445","doi-asserted-by":"crossref","first-page":"5857","DOI":"10.1128\/MCB.16.10.5857","article-title":"Induction of apoptosis by human Nbk\/Bik, a BH3-containing protein that interacts with E1B 19K","volume":"16","author":"Han","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0450","doi-asserted-by":"crossref","first-page":"11333","DOI":"10.1073\/pnas.94.21.11333","article-title":"MRIT, a novel death-effector domain\u2013containing protein, interacts with caspases and BclXL and initiates cell death","volume":"94","author":"Han","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_rf0455","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1097-2765(00)80469-4","article-title":"Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A","volume":"3","author":"Harada","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0460","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0092-8674(93)90111-3","article-title":"Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death","volume":"72","author":"Hartley","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0465","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1126\/science.285.5424.113","article-title":"Positive selection of natural autoreactive B cells","volume":"285","author":"Hayakawa","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0470","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S1074-7613(00)80285-X","article-title":"Different nuclear signals are activated by the B cell receptor during positive versus negative signaling","volume":"6","author":"Healy","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0475","doi-asserted-by":"crossref","first-page":"7783","DOI":"10.1074\/jbc.273.14.7783","article-title":"Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist","volume":"273","author":"Hegde","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0480","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/35036","article-title":"Death cycle and Swiss army knives","volume":"391","author":"Hengartner","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0485","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0092-8674(94)90506-1","article-title":"C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2","volume":"76","author":"Hengartner","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0490","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0092-8674(95)90070-5","article-title":"The TNF receptor 1\u2013associated protein TRADD signals cell death and NF-\u03baB activation","volume":"81","author":"Hsu","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0495","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0092-8674(00)80984-8","article-title":"TRADD\u2013TRAF2 and TRADD\u2013FADD interactions define two distinct TNF receptor 1 signal transduction pathways","volume":"84","author":"Hsu","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0500","doi-asserted-by":"crossref","first-page":"12401","DOI":"10.1073\/pnas.94.23.12401","article-title":"Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members","volume":"94","author":"Hsu","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0505","doi-asserted-by":"crossref","first-page":"17255","DOI":"10.1074\/jbc.272.28.17255","article-title":"I-FLICE, a novel inhibitor of tumor necrosis factor receptor\u20131 and CD-95\u2013induced apoptosis","volume":"272","author":"Hu","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0510","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1073\/pnas.95.8.4386","article-title":"Bcl-XL interacts with Apaf-1 and inhibits Apaf-1\u2013dependent caspase-9 activation","volume":"95","author":"Hu","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0515","doi-asserted-by":"crossref","first-page":"33489","DOI":"10.1074\/jbc.273.50.33489","article-title":"WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation","volume":"273","author":"Hu","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0520","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/sj.onc.1200848","article-title":"Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death","volume":"14","author":"Huang","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0525","doi-asserted-by":"crossref","first-page":"14871","DOI":"10.1073\/pnas.96.26.14871","article-title":"Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-xL","volume":"96","author":"Huang","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0530","doi-asserted-by":"crossref","first-page":"18842","DOI":"10.1074\/jbc.272.30.18842","article-title":"Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death","volume":"272","author":"Imaizumi","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0535","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1093\/emboj\/16.7.1686","article-title":"harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-XL","volume":"16","author":"Inohara","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0540","doi-asserted-by":"crossref","first-page":"10717","DOI":"10.1073\/pnas.94.20.10717","article-title":"CLARP, a death effector domain\u2013containing protein interacts with caspase-8 and regulates apoptosis","volume":"94","author":"Inohara","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_rf0545","doi-asserted-by":"crossref","first-page":"32479","DOI":"10.1074\/jbc.273.49.32479","article-title":"Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death","volume":"273","author":"Inohara","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0550","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0014-5793(97)00271-8","article-title":"Direct physical interaction between the Caenorhabditis elegans death proteins ced-3 and ced-4","volume":"406","author":"Irmler","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0555","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/40657","article-title":"Inhibition of death receptor signals by cellular FLIP","volume":"388","author":"Irmler","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0560","doi-asserted-by":"crossref","first-page":"11671","DOI":"10.1074\/jbc.272.18.11671","article-title":"Bcl-2 phosphorylation required for anti-apoptosis function","volume":"272","author":"Ito","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0565","doi-asserted-by":"crossref","first-page":"10932","DOI":"10.1016\/S0021-9258(18)82075-0","article-title":"A novel protein domain required for apoptosis","volume":"268","author":"Itoh","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0570","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0092-8674(91)90614-5","article-title":"The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis","volume":"65","author":"Itoh","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0575","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/emboj\/18.1.156","article-title":"Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor","volume":"18","author":"Izquierdo","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0580","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/eji.1830240423","article-title":"CD3 components at the surface of pro-T cells can mediate pre\u2013T cell development in vivo","volume":"24","author":"Jacobs","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0585","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0960-9822(06)00120-5","article-title":"Ced-4 induces chromatin condensation in Schizosaccharomyces pombe and is inhibited by direct physical association with Ced-9","volume":"7","author":"James","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0590","first-page":"982","article-title":"Effect of a bcl-2 transgene on production and localization of precursor B cells in mouse bone marrow","volume":"26","author":"Janani","year":"1998","journal-title":"Exp. Hematol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0595","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1002\/j.1460-2075.1996.tb01089.x","article-title":"Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis","volume":"15","author":"J\u00e4nicke","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0600","doi-asserted-by":"crossref","first-page":"15540","DOI":"10.1074\/jbc.273.25.15540","article-title":"Caspase-3 is required for \u03b1-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis","volume":"273","author":"J\u00e4nicke","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0605","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1084\/jem.183.4.1923","article-title":"p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement","volume":"183","author":"Jiang","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0610","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1126\/science.283.5401.543","article-title":"Prevention of constitutive TNF receptor 1 signaling by silencer of death domains","volume":"283","author":"Jiang","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0615","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/373444a0","article-title":"Fas(CD95)\/FasL interactions required for programmed cell death after T-cell activation","volume":"373","author":"Ju","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0620","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0092-8674(94)90241-0","article-title":"The expression of Vpre-B\/\u03bb5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice","volume":"77","author":"Karasuyama","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0625","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1084\/jem.188.5.909","article-title":"Efficient peripheral clonal elimination of B lymphocytes in MRL\/lpr mice bearing autoantibody transgenes","volume":"188","author":"Kench","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0630","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/bjc.1972.33","article-title":"Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics","volume":"26","author":"Kerr","year":"1972","journal-title":"Br. J. Cancer"},{"key":"10.1016\/S0065-2776(01)76020-8_rf0635","doi-asserted-by":"crossref","first-page":"6939","DOI":"10.1073\/pnas.94.13.6939","article-title":"Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage\u2013induced apoptosis","volume":"94","author":"Kharbanda","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0640","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/374736a0","article-title":"Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak","volume":"374","author":"Kiefer","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0645","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1084\/jem.186.8.1269","article-title":"Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex\u2013encoded molecules","volume":"186","author":"Kirberg","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0650","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1002\/j.1460-2075.1995.tb00245.x","article-title":"Cytotoxicity-dependent APO-1 (Fas\/CD95)\u2013associated proteins form a death-inducing signaling complex (DISC) with the receptor","volume":"14","author":"Kischkel","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0655","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1074-7613(00)80212-5","article-title":"Apo2L\/TRAIL-dependent recruitment of endogenous FADD and caspase 8 to death receptors 4 and 5","volume":"12","author":"Kischkel","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0660","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/384372a0","article-title":"A death-domain\u2013containing receptor that mediates apoptosis","volume":"384","author":"Kitson","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0665","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1126\/science.275.5303.1132","article-title":"The release of cytochrome c from mitochondria\u2014A primary site for Bcl-2 regulation of apoptosis","volume":"275","author":"Kluck","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0670","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/ng0897-358","article-title":"Bcl-2 and Bax function independently to regulate cell death","volume":"16","author":"Knudson","year":"1997","journal-title":"Nature Genet."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0675","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1074-7613(00)80518-X","article-title":"Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common \u03b3 chain\u2013deficient mice","volume":"7","author":"Kondo","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0680","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1126\/science.278.5336.294","article-title":"Caspase-3\u2013generated fragment of gelsolin: Effector of morphological change in apoptosis","volume":"278","author":"Kothakota","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0685","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1073\/pnas.90.8.3516","article-title":"MCL1, a gene expressed in programmed.myeloid cell differentiation, has sequence similarity to bcl-2","volume":"90","author":"Kozopas","year":"1993","journal-title":"Proc. Natl. Acad. Sci USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0690","series-title":"J. Biol. Chem","article-title":"FADD is required for DR4- and DR5-mediated apoptosis: lack of TRAIL-induced apoptosis in FADD-deficient mouse embryo fibroblasts","author":"Kuang","year":"2000"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0695","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0092-8674(00)81476-2","article-title":"Reduced apoptosis and cytochrome c\u2013mediated caspase activation in mice lacking caspase 9","volume":"94","author":"Kuida","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0700","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1084\/jem.188.2.415","article-title":"The peripheral deletion of autoreactive CD8+ T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1)","volume":"188","author":"Kurts","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0705","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1084\/jem.183.4.1377","article-title":"Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1\/Fas-mediated apoptosis","volume":"183","author":"Lagresle","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0710","doi-asserted-by":"crossref","first-page":"13171","DOI":"10.1073\/pnas.95.22.13171","article-title":"Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo","volume":"95","author":"Lam","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_rf0715","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S0092-8674(00)80373-6","article-title":"In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death","volume":"90","author":"Lam","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0720","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1182\/blood.V90.11.4266","article-title":"Mutations in the Fas antigen in patients with multiple myeloma","volume":"90","author":"Landowski","year":"1997","journal-title":"Blood"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0725","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1084\/jem.186.9.1513","article-title":"Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells","volume":"186","author":"Lang","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0730","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/371346a0","article-title":"Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE","volume":"371","author":"Lazebnik","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0735","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1126\/science.7624775","article-title":"Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77)","volume":"269","author":"Lee","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0740","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S1074-7613(00)80390-8","article-title":"TRAF2 is essential for JNK but not NF-\u03baB activation and regulates lymphocyte proliferation and survival","volume":"7","author":"Lee","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0745","doi-asserted-by":"crossref","first-page":"11401","DOI":"10.1073\/pnas.90.23.11401","article-title":"Restoration of early thymocyte differentiation in T-cell receptor \u03b2-chain\u2013deficient mutant mice by transmembrane signaling through CD3e","volume":"90","author":"Levelt","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0750","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0092-8674(00)80434-1","article-title":"Cytochrome c and dATP-dependent formation of Apaf-1\/caspase-9 complex initiates an apoptotic protease cascade","volume":"91","author":"Li","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0755","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0092-8674(00)81590-1","article-title":"Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis","volume":"94","author":"Li","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0760","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/1074-7613(94)90098-1","article-title":"Bcl-2 is upregulated at the CD4+CD8+ stage during positive selection and promotes thymocyte differentiation at several control points","volume":"1","author":"Linette","year":"1994","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0765","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/367281a0","article-title":"Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77","volume":"367","author":"Liu","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0770","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0092-8674(00)80085-9","article-title":"Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c","volume":"86","author":"Liu","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0775","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0092-8674(00)80197-X","article-title":"DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis","volume":"89","author":"Liu","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0780","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0092-8674(00)81589-5","article-title":"Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors","volume":"94","author":"Luo","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0785","doi-asserted-by":"crossref","first-page":"4763","DOI":"10.1073\/pnas.92.11.4763","article-title":"Bclx regulates the survival of double-positive thymocytes","volume":"92","author":"Ma","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0790","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/1074-7613(95)90167-1","article-title":"Targeted disruption of the flk2\/flt3 gene leads to deficiencies in primitive hematopoietic progenitors","volume":"3","author":"Mackarehtschian","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0795","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.4049\/jimmunol.162.11.6322","article-title":"The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice","volume":"162","author":"Maldonado","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_rf0800","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1002\/j.1460-2075.1995.tb00146.x","article-title":"Altered T cell development in mice with a targeted mutation of the CD3-\u03b5 gene","volume":"14","author":"Malissen","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0805","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S0092-8674(00)80289-5","article-title":"Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor\u2013deficient mice but not in mutant rag-1\u2212\/\u2212 mice","volume":"89","author":"Maraskovsky","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0810","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/intimm\/10.9.1367","article-title":"Overexpression of Bcl-2 does not rescue impaired B lymphopoiesis in IL-7 receptor\u2013deficient mice but can enhance survival of mature B cells","volume":"10","author":"Maraskovsky","year":"1998","journal-title":"Int. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0815","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/S0960-9822(02)70791-4","article-title":"Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-\u03baB","volume":"6","author":"Marsters","year":"1996","journal-title":"Curr. Biol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0820","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/S0960-9822(06)00422-2","article-title":"A novel receptor for Apo2L\/TRAIL contains a truncated death domain","volume":"7","author":"Marsters","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0825","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1074\/jbc.273.8.4345","article-title":"Membrane oligomerization and cleavage activates the caspase-8 (FLICE\/MACHa1) death signal","volume":"273","author":"Martin","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0830","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1182\/blood.V89.3.853","article-title":"Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell","volume":"89","author":"Matsuzaki","year":"1997","journal-title":"Blood"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0835","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/349254a0","article-title":"Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)","volume":"349","author":"McDonnell","year":"1991","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0840","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1093\/emboj\/16.10.2794","article-title":"FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)","volume":"16","author":"Medema","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0845","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0092-8674(00)81760-2","article-title":"Dying like flies","volume":"95","author":"Meier","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0850","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/j.1460-2075.1994.tb06307.x","article-title":"Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes","volume":"13","author":"Merino","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0855","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0168-9525(98)01573-X","article-title":"Genetics of programmed cell death in C. elegans: Past, present and future","volume":"14","author":"Metzstein","year":"1998","journal-title":"Trends Genet"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0860","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1093\/intimm\/7.9.1451","article-title":"Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo","volume":"7","author":"Mogil","year":"1995","journal-title":"Int. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0865","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0092-8674(92)90030-G","article-title":"RAG-1\u2013deficient mice have no mature B and T lymphocytes","volume":"68","author":"Mombaerts","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0870","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4049\/jimmunol.160.1.3","article-title":"Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): A new receptor protecting lymphocytes from the death ligand TRAIL","volume":"160","author":"Mongkolsapaya","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0875","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1073\/pnas.96.17.9683","article-title":"Bcl-2 family members do not inhibit apoptosis by binding the caspase-activator Apaf-1","volume":"96","author":"Moriishi","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0880","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1126\/science.7878471","article-title":"Massive cell death of immature hematopoietic cells and neurons in Bcl-x deficient mice","volume":"267","author":"Motoyama","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_rf0885","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0092-8674(00)81266-0","article-title":"FLICE, a novel FADD homologous ICE\/CED-3\u2013like protease, is recruited to the CD95 (Fas\/Apo-1) death-inducing signaling complex","volume":"85","author":"Muzio","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0890","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1074\/jbc.272.5.2952","article-title":"FLICE induced apoptosis in a cell-free system","volume":"272","author":"Muzio","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0895","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1074\/jbc.273.5.2926","article-title":"An induced proximity model for caspase-8 activation","volume":"273","author":"Muzio","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0900","first-page":"131","article-title":"V(D)J recombination is not required for the development of lymphoma in p53-deficient mice","volume":"9","author":"Nacht","year":"1998","journal-title":"Cell Growth Differ."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0905","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1101\/gad.10.16.2055","article-title":"Mutations in the p53 and SCID genes cooperate in tumorigenesis","volume":"10","author":"Nacht","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0910","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1126\/science.7533326","article-title":"The Fas death factor","volume":"267","author":"Nagata","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0915","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1126\/science.8372353","article-title":"Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice","volume":"261","author":"Nakayama","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0920","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1073\/pnas.91.9.3700","article-title":"Targeted disruption of bcl-2\u03b1\u03b2 in mice: Occurrence of gray hair, polycystic kidney disease, and lymphocytopenia","volume":"91","author":"Nakayama","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0925","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/337562a0","article-title":"Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody gene","volume":"337","author":"Nemazee","year":"1989","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0930","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1093\/emboj\/17.3.706","article-title":"A dominant interfering mutant of FADD\/Mort1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes","volume":"17","author":"Newton","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0935","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/emboj\/19.5.931","article-title":"FADD\/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor","volume":"19","author":"Newton","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0940","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.4049\/jimmunol.154.9.4395","article-title":"Expression and function of mouse Fas antigen on immature and mature T cells","volume":"154","author":"Nishimura","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0945","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/emboj\/17.2.384","article-title":"Bim\u2014A novel member of the Bcl-2 family that promotes apoptosis","volume":"17","author":"O\u2019Connor","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0950","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1084\/jem.181.2.485","article-title":"Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody","volume":"181","author":"Ogasawara","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0955","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0092-8674(93)90509-O","article-title":"Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death","volume":"74","author":"Oltvai","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0960","doi-asserted-by":"crossref","first-page":"16443","DOI":"10.1074\/jbc.271.28.16443","article-title":"The CED-3\/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A","volume":"271","author":"Orth","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0965","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0167-5699(93)90322-C","article-title":"The turnover of B-cell populations","volume":"14","author":"Osmond","year":"1993","journal-title":"Immunol. Today"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0970","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4049\/jimmunol.160.1.120","article-title":"TNF receptor\u2013deficient mice reveal striking differences between several models of thymocyte negative selection","volume":"160","author":"Page","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0975","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1126\/science.277.5327.815","article-title":"An antagonist decoy receptor and a death domain\u2013containing receptor for TRAIL","volume":"277","author":"Pan","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0980","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1126\/science.276.5309.111","article-title":"The receptor for the cytotoxic ligand TRAIL","volume":"276","author":"Pan","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb0985","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0014-5793(98)00791-1","article-title":"Identification and functional characterization of DR6, a novel death domain\u2013containing TNF receptor","volume":"431","author":"Pan","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/S0065-2776(01)76020-8_rf0990","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0014-5793(98)00135-5","article-title":"TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signaling","volume":"424","author":"Pan","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/S0065-2776(01)76020-8_bb0995","doi-asserted-by":"crossref","first-page":"5841","DOI":"10.1074\/jbc.273.10.5841","article-title":"Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex","volume":"273","author":"Pan","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1000","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1084\/jem.184.3.1149","article-title":"A tumor-suppressor function for Fas (CD95) revealed in T cell\u2013deficient mice","volume":"184","author":"Peng","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1005","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.4049\/jimmunol.154.10.5103","article-title":"Cell expansion and growth arrest phases during the transition from precursor (CD4\u20138\u2013) to immature (CD4+8+) thymocytes in normal and genetically modified mice","volume":"154","author":"Penit","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1010","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1084\/jem.180.5.1955","article-title":"Early lymphocyte expansion is severely impaired in interleukin 7 receptor\u2013deficient mice","volume":"180","author":"Peschon","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1015","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1084\/jem.178.2.615","article-title":"Multiple rearangements in TCR-\u03b1 chain genes maximize the production of useful thymocytes","volume":"178","author":"Petrie","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1020","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/(SICI)1521-4141(199802)28:02<560::AID-IMMU560>3.0.CO;2-Q","article-title":"Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection","volume":"28","author":"Petschner","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1025","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0092-8674(93)90134-C","article-title":"Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection","volume":"73","author":"Pfeffer","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1030","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/25387","article-title":"Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer","volume":"396","author":"Pitti","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1035","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S1097-2765(00)80456-6","article-title":"The pro-apoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex","volume":"3","author":"Puthalakath","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1040","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/sj.cdd.4400370","article-title":"Cell death attentuation by \u2018Usurpin\u2019, a mammalian DED\u2013caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex","volume":"5","author":"Rasper","year":"1998","journal-title":"Cell Death Differ."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1045","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.4049\/jimmunol.153.6.2831","article-title":"Effects of the lpr mutation on elimination and inactivation of self-reactive B cells","volume":"153","author":"Rathmell","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1050","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/376181a0","article-title":"CD95 (Fas)\u2013dependent elimination of self-reactive B cells upon interaction with CD4+ T cells","volume":"376","author":"Rathmell","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1055","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0092-8674(00)81349-5","article-title":"Expansion or elimination of B cells in vivo: Dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor","volume":"87","author":"Rathmell","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1060","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1084\/jem.188.4.651","article-title":"Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow fas-mediated deletion by CD4+ T cells","volume":"188","author":"Rathmell","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_rf1065","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.4049\/jimmunol.155.11.5455","article-title":"bcl-2 transgenic Lpr mice show profound enhancement of lymphadenopathy","volume":"155","author":"Reap","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1070","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S1074-7613(00)80566-X","article-title":"Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis","volume":"8","author":"Refaeli","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1075","doi-asserted-by":"crossref","first-page":"6346","DOI":"10.1093\/emboj\/16.21.6346","article-title":"The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3\u2013like protease during Fas-mediated apoptosis","volume":"16","author":"Rh\u00e9aume","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1080","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1126\/science.7539157","article-title":"Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity","volume":"268","author":"Rieux-Laucat","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1085","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/1074-7613(95)90116-7","article-title":"Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo","volume":"3","author":"Rodewald","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1090","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1074-7613(00)80329-5","article-title":"Prothymocyte expansion by c-kit and the common cytokine receptor \u03b3 chain is essential for repertoire formation","volume":"6","author":"Rodewald","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1095","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/35160","article-title":"Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c","volume":"391","author":"Ross\u00e9","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1100","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/364798a0","article-title":"Mice lacking the tumor necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes","volume":"364","author":"Rothe","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1105","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/374163a0","article-title":"Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells","volume":"374","author":"Rothstein","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1110","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4049\/jimmunol.157.1.65","article-title":"Analysis of central B cell tolerance in autoimmune-prone MRL\/lpr mice bearing autoantibody transgenes","volume":"157","author":"Rubio","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1115","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1126\/science.276.5318.1571","article-title":"Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2","volume":"276","author":"Rudel","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1120","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1002\/eji.1830230951","article-title":"Autoimmune gld mutation uncouples suicide and cytokine\/proliferation pathways in activated, mature T cells","volume":"23","author":"Russell","year":"1993","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1125","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1073\/pnas.90.10.4409","article-title":"Mature T cells of autoimmune lpr\/lpr mice have a defect in antigen-stimulated suicide","volume":"90","author":"Russell","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1130","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0092-8674(93)80067-O","article-title":"Ulcerative colitis\u2013like disease in mice with a disrupted interleukin-2 gene","volume":"75","author":"Sadlack","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1135","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/43678","article-title":"Acinus is a caspase-3\u2013activated protein required for apoptotic chromatin condensation","volume":"401","author":"Sahara","year":"1999","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1140","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/34214","article-title":"Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis","volume":"391","author":"Sakahira","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1145","doi-asserted-by":"crossref","first-page":"17941","DOI":"10.1074\/jbc.274.25.17941","article-title":"Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation","volume":"274","author":"Saleh","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_rf1150","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1074\/jbc.274.3.1541","article-title":"The role of c-FLIP in modulation of CD95-induced apoptosis","volume":"274","author":"Scaffidi","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1155","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S1074-7613(00)80401-X","article-title":"TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-\u03baB","volume":"7","author":"Schneider","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1160","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1084\/jem.187.8.1205","article-title":"Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity","volume":"187","author":"Schneider","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1165","doi-asserted-by":"crossref","first-page":"664","DOI":"10.4049\/jimmunol.150.2.664","article-title":"Studies of T cell deletion and T cell anergy following in vivo administration of SEB to normal and lupus-prone mice","volume":"150","author":"Scott","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1170","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0960-9822(06)00297-1","article-title":"TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL","volume":"7","author":"Screaton","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1175","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1073\/pnas.94.9.4615","article-title":"LARD: A new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing","volume":"94","author":"Screaton","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1180","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0092-8674(91)90361-2","article-title":"bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes","volume":"67","author":"Sentman","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1185","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0960-9822(06)00216-8","article-title":"Caenorhabditis elegans Ced-4 stimulates Ced-3 processing and Ced-3-induced apoptosis","volume":"7","author":"Seshagiri","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1190","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1101\/gad.10.5.578","article-title":"Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities","volume":"10","author":"Shaham","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1195","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.277.5327.818","article-title":"Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors","volume":"277","author":"Sheridan","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1200","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/20959","article-title":"Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC","volume":"399","author":"Shimizu","year":"1999","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1205","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1093\/intimm\/6.7.995","article-title":"CD3 \u03b5-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2\u2212\/\u2212 mice in the absence of TCR \u03b2 chain expression","volume":"6","author":"Shinkai","year":"1994","journal-title":"Int. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1210","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(92)90029-C","article-title":"RAG-2\u2013deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangements","volume":"68","author":"Shinkai","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1215","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/eji.1830200111","article-title":"T cell receptor\u2013negative thymocytes from SCID mice can be induced to enter the CD4\/CD8 differentiation pathway","volume":"20","author":"Shores","year":"1990","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1220","doi-asserted-by":"crossref","first-page":"13973","DOI":"10.1073\/pnas.93.24.13973","article-title":"The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex","volume":"93","author":"Shu","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1225","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1074-7613(00)80450-1","article-title":"Casper is a FADD- and caspase-related inducer of apoptosis","volume":"6","author":"Shu","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1230","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/eji.1830220231","article-title":"Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice","volume":"22","author":"Sidman","year":"1992","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1235","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/1074-7613(94)90067-1","article-title":"The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice","volume":"1","author":"Singer","year":"1994","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_rf1240","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1083\/jcb.144.2.281","article-title":"Ordering the cytochrome c\u2013initiated caspase cascade: Hierarchical activation of caspases\u20132, \u22123, \u22126, \u22127, \u22128, and \u221210 in a caspase-9\u2013dependent manner","volume":"144","author":"Slee","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1245","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S1074-7613(94)80022-7","article-title":"BCL-2 increases memory B cell recruitment but does not perturb selection in germinal centers","volume":"1","author":"Smith","year":"1994","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1250","doi-asserted-by":"crossref","first-page":"11628","DOI":"10.1073\/pnas.92.25.11628","article-title":"FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen","volume":"92","author":"Smith","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1255","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.1002\/j.1460-2075.1996.tb00901.x","article-title":"CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas\/APO-1)\u2013transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease","volume":"15","author":"Smith","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1260","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/emboj\/18.1.167","article-title":"Boo, a novel negative regulator of cell death, interacts with Apaf-1","volume":"18","author":"Song","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1265","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/385653a0","article-title":"Interaction between the C. elegans cell-death regulators CED-9 and CED-4","volume":"385","author":"Spector","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1270","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1002\/eji.1830261235","article-title":"Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo","volume":"26","author":"Speiser","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1275","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S1074-7613(00)80211-3","article-title":"FADD\/MORT1 and caspase 8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2","volume":"12","author":"Sprick","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1280","doi-asserted-by":"crossref","first-page":"14486","DOI":"10.1073\/pnas.93.25.14486","article-title":"Molecular ordering of the Fas-apoptotic pathway: The Fas\/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3\/ICE-like cysteine proteases","volume":"93","author":"Srinivasula","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1285","doi-asserted-by":"crossref","first-page":"18542","DOI":"10.1074\/jbc.272.30.18542","article-title":"FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas\/ TNFR1-induced apoptosis","volume":"272","author":"Srinivasula","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1290","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S1097-2765(00)80095-7","article-title":"Autoactivation of procaspase-9 by Apaf-1\u2013mediated oligomerization","volume":"1","author":"Srinivasula","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1295","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/373385a0","article-title":"Death of a T cell","volume":"373","author":"Strasser","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1300","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nm0198-021","article-title":"Fas ligand\u2014Caught between Scylla and Charybdis","volume":"4","author":"Strasser","year":"1998","journal-title":"Nature Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1305","unstructured":"Strasser, A., O\u2019Connor, L., and Dixit, V. M. Apoptosis signalling. Annu. Rev. Biochem. in press."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1310","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/348331a0","article-title":"Novel primitive lymphoid tumors induced in trasgenic mice by cooperation between myc and bcl-2","volume":"348","author":"Strasser","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1315","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/0092-8674(91)90362-3","article-title":"Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship","volume":"67","author":"Strasser","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1320","doi-asserted-by":"crossref","first-page":"8661","DOI":"10.1073\/pnas.88.19.8661","article-title":"Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease","volume":"88","author":"Strasser","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1325","first-page":"1","article-title":"E\u03bc,\u2013bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells","volume":"8","author":"Strasser","year":"1993","journal-title":"Oncogene"},{"key":"10.1016\/S0065-2776(01)76020-8_rf1325","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/368457a0","article-title":"bcl-2 expression promotes B but not T lymphoid development in scid mice","volume":"368","author":"Strasser","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1335","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1073\/pnas.91.4.1376","article-title":"Positive and negative selection of T cells in T cell receptor transgenic mice expressing a bcl-2 transgene","volume":"91","author":"Strasser","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1340","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0092-8674(94)90201-1","article-title":"DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2","volume":"79","author":"Strasser","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1345","doi-asserted-by":"crossref","first-page":"6136","DOI":"10.1002\/j.1460-2075.1995.tb00304.x","article-title":"Bcl-2 and Fas\/APO-1 regulate distinct pathways to lymphocyte apoptosis","volume":"14","author":"Strasser","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1350","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/sj.cdd.4400451","article-title":"Death by a thousand cuts: An ever increasing list of caspase substrates","volume":"5","author":"Stroh","year":"1998","journal-title":"Cell Death Differ."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1355","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/0092-8674(93)90326-L","article-title":"Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis family","volume":"75","author":"Suda","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1360","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.4049\/jimmunol.157.9.3918","article-title":"Apoptosis of mouse native T cells induced by recombinant soluble Fas ligand and activation-induced resistance to Fas ligand","volume":"157","author":"Suda","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1365","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1084\/jem.186.12.2045","article-title":"Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing","volume":"186","author":"Suda","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1370","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/372100a0","article-title":"T-cell apoptosis detected in situ during positive and negative selection in the thymus","volume":"372","author":"Surh","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1375","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1126\/science.7770771","article-title":"Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor \u03b2","volume":"268","author":"Suzuki","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1380","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/intimm\/9.9.1367","article-title":"Normal thymic selection, superantigen-induced deletion and Fas-mediated apoptosis of T cells in IL-2 receptor \u03b2 chain\u2013deficient mice","volume":"9","author":"Suzuki","year":"1997","journal-title":"Int. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1385","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1074-7613(00)80306-4","article-title":"The roles of Fas\/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice","volume":"5","author":"Sytwu","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1390","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/cimm.1996.0069","article-title":"Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas\/Fas ligand\u2013defective mice","volume":"168","author":"Tamura","year":"1996","journal-title":"Cell. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1395","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nm0198-031","article-title":"Downregulation of Fas ligand by shedding","volume":"4","author":"Tanaka","year":"1998","journal-title":"Nature Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1400","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1126\/science.276.5321.2057","article-title":"Differential requirement for survival and proliferation of CD8 naive or memory T cells","volume":"276","author":"Tanchot","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1405","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1084\/jem.179.1.145","article-title":"The T cell receptor repertoire of CD4\u22128+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus","volume":"179","author":"Tao","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1410","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1093\/intimm\/9.10.1481","article-title":"Continued differentiation during B lymphopoiesis requires signals in addition to cell survival","volume":"9","author":"Tarlinton","year":"1997","journal-title":"Int. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1415","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/0092-8674(93)90464-2","article-title":"A novel domain within the 55 kd TNF receptor signals cell death","volume":"74","author":"Tartaglia","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1420","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/intimm\/8.5.675","article-title":"Fas (CD95)-independent regulation of immune responses by antigen-specific CD4\u2212CD8+ T cells","volume":"8","author":"Teh","year":"1996","journal-title":"Int. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_rf1420","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.281.5381.1312","article-title":"Caspases: Enemies within","volume":"281","author":"Thornberry","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1430","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/1074-7613(95)90125-6","article-title":"Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4","volume":"3","author":"Tivol","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1435","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1126\/science.2787530","article-title":"Monoclonal antibody\u2013mediated tumor regression by induction of apoptosis","volume":"245","author":"Trauth","year":"1989","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1440","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1073\/pnas.83.14.5214","article-title":"Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma","volume":"83","author":"Tsujimoto","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1445","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.6093263","article-title":"Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation","volume":"226","author":"Tsujimoto","year":"1984","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1450","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0092-8674(00)80450-X","article-title":"Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria","volume":"91","author":"VanderHeiden","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1455","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1074-7613(00)80440-9","article-title":"The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance","volume":"4","author":"Van Parijs","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1460","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.4049\/jimmunol.160.5.2065","article-title":"Functional roles of Fas and Bcl-2\u2013regulated apoptosis of T lymphocytes","volume":"160","author":"Van Parijs","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1465","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1074-7613(00)80478-1","article-title":"The Fas\/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens","volume":"8","author":"Van Parijs","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1470","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S1074-7613(00)80103-X","article-title":"Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death","volume":"11","author":"Van Parijs","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1475","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S1074-7613(00)80609-3","article-title":"Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas\/Apo1, and DR3 and is lethal prenatally","volume":"9","author":"Varfolomeev","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1480","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1126\/science.1470921","article-title":"Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2","volume":"258","author":"Vaux","year":"1992","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1485","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.4049\/jimmunol.151.5.2546","article-title":"Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes","volume":"151","author":"Veis","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1490","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0092-8674(93)80065-M","article-title":"Bcl-2\u2013deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair","volume":"75","author":"Veis","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1495","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1073\/pnas.95.7.3810","article-title":"Cytokine-induced survival of activated T cells in vitro and in vivo","volume":"95","author":"Vella","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1500","doi-asserted-by":"crossref","first-page":"6578","DOI":"10.1074\/jbc.272.10.6578","article-title":"Fas-associated death domain protein interleukin-1\u03b2\u2013converting enzyme 2 (FLICE2), an ICE\/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling","volume":"272","author":"Vincenz","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1505","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0092-8674(94)90330-1","article-title":"Positive selection of lymphocytes","volume":"76","author":"von Boehmer","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1510","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1084\/jem.181.4.1519","article-title":"Lymphopenia in interleukin (IL)-7 gene\u2013deleted mice identifies IL-7 as a nonredundant cytokine","volume":"181","author":"von Freeden-Jeffry","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1515","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1074-7613(00)80517-8","article-title":"The earliest T lineage\u2013committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression","volume":"7","author":"von Freeden-Jeffry","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_rf1515","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0960-9822(98)70042-9","article-title":"Dominant-negative FADD inhibits TNFR60-, Fas\/Apo1- and TRAIL-R\/Apo2\u2013mediated cell death but not gene induction","volume":"8","author":"Wajant","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1525","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.1093\/emboj\/16.17.5386","article-title":"TRAIL-R2: A novel apoptosis-mediating receptor for TRAIL","volume":"16","author":"Walczak","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1530","first-page":"144","article-title":"Exploring cell death mechanisms by analyzing signaling cascades of the TNF\/NGF receptor family","volume":"97","author":"Wallach","year":"1996","journal-title":"Behring Inst. Mitt."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1535","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S1074-7613(00)80549-X","article-title":"A role for FADD in T cell activation and development","volume":"8","author":"Walsh","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1540","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1101\/gad.10.22.2859","article-title":"BID: A novel BH3 domain-only death agonist","volume":"10","author":"Wang","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1545","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1126\/science.284.5412.339","article-title":"Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD","volume":"284","author":"Wang","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1550","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0092-8674(00)80605-4","article-title":"Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II","volume":"98","author":"Wang","year":"1999","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1555","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/1521-4141(200001)30:1<155::AID-IMMU155>3.0.CO;2-X","article-title":"Inhibition of Fas-mediated apoptosis by the B cell antigen receptor through c-FLIP","volume":"30","author":"Wang","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1560","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1126\/science.270.5238.985","article-title":"Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4","volume":"270","author":"Waterhouse","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1565","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/1074-7613(95)90180-9","article-title":"Interleukin-2 receptor \u03b1 chain regulates the size and content of the peripheral lymphoid compartment","volume":"3","author":"Willerford","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1570","doi-asserted-by":"crossref","first-page":"4909","DOI":"10.4049\/jimmunol.163.9.4909","article-title":"In vivo evidence that caspase-3 is required for Fas-mediated apoptosis of hepatocytes","volume":"163","author":"Woo","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1575","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/367277a0","article-title":"Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas","volume":"367","author":"Woronicz","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1580","doi-asserted-by":"crossref","first-page":"21449","DOI":"10.1074\/jbc.272.34.21449","article-title":"Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9","volume":"272","author":"Wu","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1585","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1126\/science.275.5303.1126","article-title":"Interaction and regulation of subcellular localization of CED-4 by CED-9","volume":"275","author":"Wu","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1590","first-page":"141","article-title":"KILLER\/DR5 is a DNA damage\u2013inducible p53-regulated death receptor gene","volume":"17","author":"Wu","year":"1997","journal-title":"Nature\/Genet."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1595","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1242\/dev.126.9.2021","article-title":"C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death","volume":"126","author":"Wu","year":"1999","journal-title":"Development"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1600","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0074-7696(08)62312-8","article-title":"Cell death: The significance of apoptosis","volume":"68","author":"Wyllie","year":"1980","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/S0065-2776(01)76020-8_rf1600","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1101\/gad.10.9.1073","article-title":"The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease","volume":"10","author":"Xue","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1610","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1073\/pnas.94.4.1441","article-title":"Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor","volume":"18","author":"Yamada","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1615","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0092-8674(95)90411-5","article-title":"Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces Bax and promotes cell death","volume":"80","author":"Yang","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1620","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1126\/science.275.5303.1129","article-title":"Prevention of apoptosis by Bcl-2\u2014Release of cytochrome c from mitochondria blocked","volume":"275","author":"Yang","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1625","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1097-2765(00)80032-5","article-title":"Autoproteolytic activation of pro-caspases by oligomerization","volume":"1","author":"Yang","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1630","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.4049\/jimmunol.158.10.4729","article-title":"The Fas-deficient SCID mouse exhibits the development of T cells in the thymus","volume":"158","author":"Yasutomo","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1635","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S1074-7613(00)80391-X","article-title":"Early lethality, functional NF-\u03baB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice","volume":"7","author":"Yeh","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1640","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1126\/science.279.5358.1954","article-title":"FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis","volume":"279","author":"Yeh","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1645","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S1074-7613(00)80214-9","article-title":"Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development","volume":"12","author":"Yeh","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1650","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/23730","article-title":"Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis","volume":"400","author":"Yin","year":"1999","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1655","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1084\/jem.169.5.1747","article-title":"A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor","volume":"169","author":"Yonehara","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1660","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0092-8674(00)81733-X","article-title":"Apaf1 is required for mitochondrial pathways of apoptosis and brain development","volume":"94","author":"Yoshida","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1665","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1074-7613(00)80239-3","article-title":"Constitutive Bcl-2 expression during immunoglobulin heavy chain\u2013promoted B cell differentiation expands novel precursor B cells","volume":"6","author":"Young","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1670","doi-asserted-by":"crossref","first-page":"13733","DOI":"10.1074\/jbc.274.20.13733","article-title":"A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis","volume":"274","author":"Yu","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1675","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0092-8674(93)90485-9","article-title":"The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1\u03b2\u2013converting enzyme","volume":"75","author":"Yuan","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1680","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0092-8674(00)81382-3","article-title":"Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-XL","volume":"87","author":"Zha","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_rf1680","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/32681","article-title":"Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD\/Mort1","volume":"392","author":"Zhang","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1690","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/377348a0","article-title":"Induction of apoptosis in mature T cells by tumor necrosis factor","volume":"377","author":"Zheng","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1695","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/35060","article-title":"Injected cytochrome c induces apoptosis","volume":"391","author":"Zhivotovsky","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1700","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1084\/jem.183.4.1879","article-title":"Inhibition of Nur77\/Nurr1 leads to inefficient clonal deletion of self-reactive T cells","volume":"183","author":"Zhou","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1705","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.4049\/jimmunol.156.8.2661","article-title":"Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor 1","volume":"156","author":"Zhou","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1710","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1002\/eji.1830261215","article-title":"Homeostatic regulation of CD8+ T cells after antigen challenge in the absence of Fas (CD95)","volume":"26","author":"Zimmermann","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S0065-2776(01)76020-8_bb1715","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0092-8674(00)80501-2","article-title":"Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c\u2013dependent activation of caspase-3","volume":"90","author":"Zou","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0065-2776(01)76020-8_bb1720","doi-asserted-by":"crossref","first-page":"11549","DOI":"10.1074\/jbc.274.17.11549","article-title":"An APAF-1\u00b7cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9","volume":"274","author":"Zou","year":"1999","journal-title":"J. Biol. Chem."}],"container-title":["Advances in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065277601760208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065277601760208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T18:03:36Z","timestamp":1682705016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065277601760208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"ISBN":["9780120224760"],"references-count":344,"URL":"https:\/\/doi.org\/10.1016\/s0065-2776(01)76020-8","relation":{},"ISSN":["0065-2776"],"issn-type":[{"value":"0065-2776","type":"print"}],"subject":[],"published":{"date-parts":[[2001]]}}}