{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T19:03:28Z","timestamp":1775329408606,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4702,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1016\/s0092-8674(00)00061-1","type":"journal-article","created":{"date-parts":[[2004,4,15]],"date-time":"2004-04-15T09:36:43Z","timestamp":1082021803000},"page":"721-729","source":"Crossref","is-referenced-by-count":216,"title":["Binding of Inositol Phosphate to DNA-PK and Stimulation of Double-Strand Break Repair"],"prefix":"10.1016","volume":"102","author":[{"given":"Les A","family":"Hanakahi","sequence":"first","affiliation":[]},{"given":"Michael","family":"Bartlet-Jones","sequence":"additional","affiliation":[]},{"given":"Claire","family":"Chappell","sequence":"additional","affiliation":[]},{"given":"Darryl","family":"Pappin","sequence":"additional","affiliation":[]},{"given":"Stephen C","family":"West","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)00061-1_BIB1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0008-6215(96)00250-9","article-title":"Conformational studies of myo-inositol phosphates","volume":"296","author":"Barrientos","year":"1996","journal-title":"Carbohydr. Res."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB2","doi-asserted-by":"crossref","first-page":"14066","DOI":"10.1073\/pnas.95.24.14066","article-title":"DNA end-joining catalyzed by human cell-free extracts","volume":"95","author":"Baumann","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)00061-1_BIB3","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/0092-8674(95)90360-7","article-title":"Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation","volume":"80","author":"Blunt","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00061-1_BIB4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1126\/science.282.5387.293","article-title":"Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK","volume":"282","author":"Bondeva","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)00061-1_BIB5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0955-0674(96)80060-3","article-title":"Phosphoinositide kinases","volume":"2","author":"Carpenter","year":"1996","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB6","doi-asserted-by":"crossref","first-page":"26196","DOI":"10.1074\/jbc.M000491200","article-title":"Interactions of the DNA ligase IV\/Xrcc4 complex with DNA ends and the DNA-dependent protein kinase","volume":"275","author":"Chen","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB7","doi-asserted-by":"crossref","first-page":"24097","DOI":"10.1074\/jbc.272.39.24097","article-title":"Double-strand break repair","volume":"272","author":"Chu","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0008-6215(00)84287-1","article-title":"31P nuclear magnetic resonance-pH titrations of myo-inositol hexaphosphate","volume":"46","author":"Costello","year":"1976","journal-title":"Carbohydr. Res."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB9","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S0968-0004(98)01284-5","article-title":"DNA end-joining","volume":"23","author":"Critchlow","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB10","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/S0960-9822(06)00258-2","article-title":"Mammalian DNA double-strand break repair protein Xrcc4 interacts with DNA ligase IV","volume":"7","author":"Critchlow","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB11","doi-asserted-by":"crossref","first-page":"10440","DOI":"10.1016\/S0021-9258(18)82219-0","article-title":"Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II","volume":"268","author":"Dvir","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/03086648108077394","article-title":"The structure of myo-inositol hexaphosphate in solution","volume":"10","author":"Emsley","year":"1981","journal-title":"Phosphorus and Sulfur"},{"key":"10.1016\/S0092-8674(00)00061-1_BIB13","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1093\/emboj\/19.7.1703","article-title":"Homologous and non-homologous recombination differentially affect DNA damage repair in mice","volume":"19","author":"Essers","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/bies.950190710","article-title":"The function of inositol high polyphosphate binding proteins","volume":"19","author":"Fukuda","year":"1997","journal-title":"BioEssays"},{"key":"10.1016\/S0092-8674(00)00061-1_BIB15","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/41358","article-title":"Activity of DNA ligase IV stimulated by complex formation with Xrcc4 protein in mammalian cells","volume":"388","author":"Grawunder","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00061-1_BIB16","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/0092-8674(95)90482-4","article-title":"DNA-dependent protein kinase catalytic subunit","volume":"82","author":"Hartley","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00061-1_BIB17","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1042\/bj2940929","article-title":"Inhibition of iron-catalyzed hydroxy radical formation by inositol polyphosphates","volume":"294","author":"Hawkins","year":"1993","journal-title":"Biochem. J."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0092-8674(95)90225-2","article-title":"When is a lipid kinase not a lipid kinase? When it is a protein kinase","volume":"83","author":"Hunter","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00061-1_BIB19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.270.5233.50","article-title":"PIK-related kinases","volume":"270","author":"Keith","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)00061-1_BIB20","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1126\/science.278.5337.471","article-title":"Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate","volume":"278","author":"Larsson","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)00061-1_BIB21","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1074\/jbc.273.3.1794","article-title":"The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase","volume":"273","author":"Leber","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB22","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1126\/science.7855602","article-title":"Absence of p350 subunit of DNA activated protein kinase from a radiosensitive human cell line","volume":"267","author":"Lees-Miller","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)00061-1_BIB23","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1093\/emboj\/18.7.2008","article-title":"DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity","volume":"18","author":"Modesti","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB24","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1126\/science.287.5460.2026","article-title":"A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control","volume":"287","author":"Odom","year":"2000","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)00061-1_BIB25","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/emboj\/17.2.609","article-title":"Ku protein stimulates DNA end joining by mammalian DNA ligases","volume":"17","author":"Ramsden","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB26","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1006\/jmbi.1999.2848","article-title":"Polyanionic inhibitors of phosphoglycerate mutase","volume":"289","author":"Rigden","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB27","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0960-9822(00)80055-X","article-title":"Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases","volume":"9","author":"Saiardi","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB28","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0014-5793(00)01194-7","article-title":"Inositol polyphosphate multikinase (ArgRIII) determines nuclear mRNA export in Saccharomyces cerevisiae","volume":"468","author":"Saiardi","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB29","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1101\/gad.13.8.916","article-title":"The DNA-dependent protein kinase","volume":"13","author":"Smith","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB30","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/0006-291X(87)90489-X","article-title":"Observation of inositol pentakis- and hexakis-phosphates in mammalian tissues by 31P NMR","volume":"149","author":"Szwergold","year":"1987","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1126\/science.8469973","article-title":"Impairment of V(D)J recombination in double-strand break repair mutants","volume":"260","author":"Taccioli","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)00061-1_BIB32","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1093\/emboj\/17.18.5497","article-title":"Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells","volume":"17","author":"Takata","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB33","doi-asserted-by":"crossref","first-page":"9071","DOI":"10.1016\/S0021-9258(19)50390-8","article-title":"Photoaffinity labeling and characterization of isolated inositol 1,3,4,5-tetrakisphosphate- and inositol hexakisphosphate-binding proteins","volume":"267","author":"Theibert","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB34","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1615\/CritRevEukarGeneExpr.v6.i4.20","article-title":"Regulation and repair of double-strand DNA breaks","volume":"6","author":"Weaver","year":"1996","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/S0092-8674(00)00061-1_BIB35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0005-2760(98)00139-8","article-title":"Structure and function of phosphoinositide 3-kinases","volume":"1436","author":"Wymann","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0092-8674(00)00061-1_BIB36","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1126\/science.285.5424.96","article-title":"A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export","volume":"285","author":"York","year":"1999","journal-title":"Science"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400000611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400000611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T16:33:01Z","timestamp":1623774781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400000611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S0092867400000611"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)00061-1","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}