{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:58:02Z","timestamp":1780444682741,"version":"3.54.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4702,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1016\/s0092-8674(00)00073-8","type":"journal-article","created":{"date-parts":[[2004,4,15]],"date-time":"2004-04-15T05:36:43Z","timestamp":1082007403000},"page":"849-862","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":929,"title":["p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53"],"prefix":"10.1016","volume":"102","author":[{"given":"Katsutoshi","family":"Oda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chizu","family":"Tanikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nishimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Tamai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Tokino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Taya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)00073-8_BIB1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB2","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1126\/science.2144057","article-title":"Suppression of human colorectal carcinoma cell growth by wild-type p53","volume":"249","author":"Baker","year":"1990","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB3","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1093\/emboj\/18.23.6845","article-title":"Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation","volume":"18","author":"Bulavin","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB4","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1006\/jmbi.1997.0951","article-title":"Prediction of complete gene structures in human genomic DNA","volume":"268","author":"Burge","year":"1997","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB5","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1101\/gad.14.3.278","article-title":"Chk2\/hCds1 functions as a DNA damage checkpoint in G1 by stabilizing p53","volume":"14","author":"Chehab","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB6","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1128\/MCB.16.9.4961","article-title":"A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis","volume":"16","author":"Friedlander","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB7","first-page":"1965","article-title":"Isolation of a novel GPI-anchored gene specifically regulated by p53; correlation between its expression and anti-cancer drug sensitivity","volume":"13","author":"Furuhata","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB8","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1101\/gad.12.19.2973","article-title":"The complexity of p53 modulation","volume":"12","author":"Giaccia","year":"1998","journal-title":"Genes. Dev."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB9","first-page":"694","article-title":"Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis","volume":"56","author":"Gomez-Manzano","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB10","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB11","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/hmg\/7.6.1039","article-title":"CSR, a scavenger receptor-like protein with a protective role against cellular damage caused by UV irradiation and oxidative stress","volume":"7","author":"Han","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0092-8674(00)80924-1","article-title":"Eukaryotic transcription","volume":"92","author":"Kadonaga","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB13","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1101\/gad.10.9.1054","article-title":"p53","volume":"10","author":"Ko","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB14","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/nm0697-614","article-title":"The proto-oncogene Bcl-2 and its role in regulating apoptosis","volume":"3","author":"Kroemer","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB15","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(00)81871-1","article-title":"p53, the cellular gatekeeper for growth and division","volume":"88","author":"Levine","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB16","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1093\/emboj\/18.21.6027","article-title":"p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c\u2013independent apoptosis blocked by Bcl-2","volume":"18","author":"Li","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB17","first-page":"171","article-title":"p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features","volume":"7","author":"Mitsudomi","year":"1992","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB18","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0092-8674(95)90412-3","article-title":"Tumor suppressor p53 is a direct transcriptional activator of the human bax gene","volume":"80","author":"Miyashita","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB19","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0888-7543(05)80111-9","article-title":"A knowledge base for predicting protein localization sites in eukaryotic cells","volume":"14","author":"Nakai","year":"1992","journal-title":"Genomics"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB20","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/(SICI)1098-2264(199912)26:4<329::AID-GCC7>3.0.CO;2-C","article-title":"Isolation and characterization of a novel TP53-inducible gene, TP53TG3","volume":"26","author":"Ng","year":"1999","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB21","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1038\/sj.onc.1201542","article-title":"A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis","volume":"15","author":"Nishimori","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0378-1119(91)90434-D","article-title":"Efficient selection for high-expression transfectants with a novel eukaryotic vector","volume":"108","author":"Niwa","year":"1991","journal-title":"Gene"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0076-6879(90)83007-V","article-title":"Rapid and sensitive sequence comparison with FASTP and FASTA","volume":"183","author":"Pearson","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB24","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1126\/science.288.5468.1053","article-title":"Noxa, a BH3-only member of the bcl-2 family and candidate mediator of p53-induced apoptosis","volume":"288","author":"Oda","year":"2000","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB25","first-page":"221","article-title":"Relationship of p53 to the control of apoptotic cell death","volume":"5","author":"Oren","year":"1994","journal-title":"Cancer Biol."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB26","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/38525","article-title":"A model for p53-induced apoptosis","volume":"389","author":"Polyak","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0092-8674(00)81774-2","article-title":"Signaling to p53","volume":"95","author":"Prives","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/ijc.2910620302","article-title":"Molecular events underlying schistosomiasis-related bladder cancer","volume":"62","author":"Ramchurren","year":"1995","journal-title":"Int. J. Cancer"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB29","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1101\/gad.12.14.2102","article-title":"Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53","volume":"12","author":"Resnick-Silverman","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB30","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1128\/MCB.18.7.3692","article-title":"Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest","volume":"18","author":"Ryan","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB31","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1093\/emboj\/18.16.4424","article-title":"Increased apoptosis induction by 121F mutant p53","volume":"18","author":"Saller","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB45","first-page":"2464","article-title":"A role for p38MAPK pathway in the transcriptional activation of p53 upon genotoxic stress by chemotherapeutic agents","volume":"60","author":"Sanchez-Prietro","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB32","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0092-8674(00)80416-X","article-title":"DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2","volume":"91","author":"Shieh","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1101\/gad.14.3.289","article-title":"The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites","volume":"14","author":"Shieh","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB34","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1101\/gad.11.24.3471","article-title":"DNA damage induces phosphorylation of the amino terminus of p53","volume":"11","author":"Siliciano","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB35","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.1093\/nar\/22.24.5156","article-title":"Predicting internal exons by oligonucleotide composition and discriminant analysis of spliceable open reading frames","volume":"22","author":"Solovyev","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1098-2264(199809)23:1<1::AID-GCC1>3.0.CO;2-Y","article-title":"Isolation of a novel TP53 target gene from a colon cancer cell line carrying a highly regulated wild-type TP53 expression system","volume":"23","author":"Takei","year":"1998","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB37","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/35003506","article-title":"A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage","volume":"404","author":"Tanaka","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB38","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1093\/hmg\/3.9.1537","article-title":"p53 tagged sites from human genomic DNA","volume":"3","author":"Tokino","year":"1994","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB39","first-page":"3281","article-title":"Cloning of P2XM, a novel human P2X receptor gene regulated by p53","volume":"57","author":"Urano","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB40","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.1093\/emboj\/17.16.4668","article-title":"The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression","volume":"17","author":"Venot","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB41","doi-asserted-by":"crossref","first-page":"15335","DOI":"10.1073\/pnas.93.26.15335","article-title":"Identification of a novel p53 functional domain that is necessary for efficient growth suppression","volume":"93","author":"Walker","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB42","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/376088a0","article-title":"Increased and altered DNA binding of human p53 by S and G2\/M but not G1 cyclin-dependent kinases","volume":"376","author":"Wang","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00073-8_BIB43","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI116435","article-title":"P53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines","volume":"91","author":"Yeargin","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0092-8674(00)00073-8_BIB44","doi-asserted-by":"crossref","first-page":"13030","DOI":"10.1074\/jbc.273.21.13030","article-title":"Identification of a novel p53 functional domain that is necessary for mediating apoptosis","volume":"273","author":"Zhu","year":"1998","journal-title":"J. Biol. Chem."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400000738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400000738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:38:25Z","timestamp":1758796705000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400000738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S0092867400000738"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)00073-8","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0092-8674(00)00073-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 Cell Press.  All rights reserved.","name":"copyright","label":"Copyright"}]}}