{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:31:12Z","timestamp":1780392672722,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4702,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1016\/s0092-8674(00)00103-3","type":"journal-article","created":{"date-parts":[[2004,4,15]],"date-time":"2004-04-15T09:36:43Z","timestamp":1082021803000},"page":"41-50","source":"Crossref","is-referenced-by-count":634,"title":["The Osteoclast Differentiation Factor Osteoprotegerin-Ligand Is Essential for Mammary Gland Development"],"prefix":"10.1016","volume":"103","author":[{"given":"Jimmie E","family":"Fata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Yun","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Irie-Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A","family":"Moorehead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Scully","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn B","family":"Voura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L","family":"Lacey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rama","family":"Khokha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef M","family":"Penninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)00103-3_BIB1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/36593","article-title":"A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function","volume":"390","author":"Anderson","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00103-3_BIB2","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1101\/gad.14.6.650","article-title":"Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling","volume":"14","author":"Brisken","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s001090050244","article-title":"Exploring the role of sex steroids through studies of receptor deficient mice","volume":"76","author":"Couse","year":"1998","journal-title":"J. Mol. Med."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB4","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1101\/gad.13.18.2412","article-title":"RANK is essential for osteoclast and lymph node development","volume":"13","author":"Dougall","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1023\/A:1018700502518","article-title":"Parathyroid hormone-related protein","volume":"4","author":"Dunbar","year":"1999","journal-title":"J. Mamm. Gland. Biol. Neoplasia."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB6","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1006\/dbio.1999.9313","article-title":"Timp-1 is important for epithelial proliferation and branching morphogenesis during mouse mammary development","volume":"211","author":"Fata","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB7","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1242\/dev.127.11.2269","article-title":"Postnatal mammary gland development requires macrophages and eosinophils","volume":"127","author":"Gouon-Evans","year":"2000","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)00103-3_BIB8","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/74999","article-title":"Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord","volume":"6","author":"Honore","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1023\/A:1018708704335","article-title":"Prolactin and mammary gland development","volume":"4","author":"Horseman","year":"1999","journal-title":"J. Mamm. Gland. Biol. Neoplasia."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB10","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1073\/pnas.96.7.3540","article-title":"Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand","volume":"96","author":"Hsu","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)00103-3_BIB11","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1101\/gad.13.23.3037","article-title":"The genetic transformation of bone biology","volume":"13","author":"Karsenty","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/16852","article-title":"OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis","volume":"397","author":"Kong","year":"1999","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00103-3_BIB13","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/46303","article-title":"Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand","volume":"402","author":"Kong","year":"1999","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00103-3_BIB14","first-page":"832","article-title":"Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation","volume":"18","author":"Kovacs","year":"1997","journal-title":"Endocr. Rev."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB15","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1172\/JCI8489","article-title":"Osteoclasts expressing the measles virus nucliocapsid gene display a pagetic phenotype","volume":"105","author":"Kurihara","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation","volume":"93","author":"Lacey","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00103-3_BIB17","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0092-8674(00)80290-1","article-title":"Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op\/op mice","volume":"89","author":"Lagasse","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00103-3_BIB18","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1073\/pnas.97.4.1566","article-title":"RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism","volume":"97","author":"Li","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)00103-3_BIB19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1101\/gad.11.2.179","article-title":"Stat5a is mandatory for adult mammary gland development and lactogenesis","volume":"11","author":"Liu","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB20","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1101\/gad.9.18.2266","article-title":"Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities","volume":"9","author":"Lydon","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB21","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0095-5108(18)30053-8","article-title":"Physiology of lactation","volume":"26","author":"Neville","year":"1999","journal-title":"Clin. Perinatol."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1101\/gad.11.2.167","article-title":"Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse","volume":"11","author":"Ormandy","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB23","doi-asserted-by":"crossref","first-page":"9312","DOI":"10.1073\/pnas.91.20.9312","article-title":"Colony stimulating factor 1 is required for mammary gland development during pregnancy","volume":"91","author":"Pollard","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)00103-3_BIB24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1023\/A:1018748418447","article-title":"Regulation of mammary gland development by tissue interaction","volume":"4","author":"Robinson","year":"1999","journal-title":"J. Mamm. Gland Biol. Neoplasia"},{"key":"10.1016\/S0092-8674(00)00103-3_BIB25","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1101\/gad.14.8.889","article-title":"Side-branching in the mammary gland","volume":"14","author":"Robinson","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB26","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0301-472X(99)00061-2","article-title":"Cell biology of the osteoclast","volume":"27","author":"Roodman","year":"1999","journal-title":"Exp. Hematol."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB27","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1172\/JCI9557","article-title":"RANKing the importance of measles virus in Paget's disease","volume":"105","author":"Ross","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","article-title":"Osteoprotegerin","volume":"89","author":"Simonet","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00103-3_BIB29","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1210\/endo.140.10.7037","article-title":"Breast cancer cells interact with osteoblasts to support osteoclast formation","volume":"140","author":"Thomas","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/S0092-8674(00)00103-3_BIB30","doi-asserted-by":"crossref","first-page":"25190","DOI":"10.1074\/jbc.272.40.25190","article-title":"TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells","volume":"272","author":"Wong","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00103-3_BIB31","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S1097-2765(00)80232-4","article-title":"TRANCE, a TNF family member, activates Akt\/PKB through a signaling complex involving TRAF6 and c-Src","volume":"4","author":"Wong","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(00)00103-3_BIB32","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","article-title":"Osteoclast differentiation factor is a ligand for osteoprotegerin\/osteoclastogenesis-inhibitory factor and is identical to TRANCE\/RANKL","volume":"95","author":"Yasuda","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400001033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400001033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T22:40:03Z","timestamp":1705099203000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400001033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S0092867400001033"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)00103-3","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}