{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:02:19Z","timestamp":1774566139683,"version":"3.50.1"},"reference-count":148,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4672,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[2000,10]]},"DOI":"10.1016\/s0092-8674(00)00121-5","type":"journal-article","created":{"date-parts":[[2004,4,15]],"date-time":"2004-04-15T09:36:43Z","timestamp":1082021803000},"page":"295-309","source":"Crossref","is-referenced-by-count":1971,"title":["TGF\u03b2 Signaling in Growth Control, Cancer, and Heritable Disorders"],"prefix":"10.1016","volume":"103","author":[{"given":"Joan","family":"Massagu\u00e9","sequence":"first","affiliation":[]},{"given":"Stacy W","family":"Blain","sequence":"additional","affiliation":[]},{"given":"Roger S","family":"Lo","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)00121-5_BIB1","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1093\/hmg\/9.8.1227","article-title":"Analysis of ALK-1 and endoglin in newborns from families with hereditary hemorrhagic telangiectasia type 2","volume":"9","author":"Abdalla","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0016-5085(97)70216-6","article-title":"Transforming growth factor beta type II receptor gene mutations in adenomas from hereditary nonpolyposis colorectal cancer","volume":"112","author":"Akiyama","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB3","first-page":"1452","article-title":"Transforming growth factor \u03b2 and cell cycle regulation","volume":"55","author":"Alexandrow","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB4","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1242\/dev.127.15.3349","article-title":"Molecular mechanisms of hormone-mediated M\u00fcllerian duct regression","volume":"127","author":"Allard","year":"2000","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB5","first-page":"3363","article-title":"The S387Y mutations of the transforming growth factor-beta receptor type I gene is uncommon in metastases of breast cancer and other common types of adenocarcinoma","volume":"59","author":"Anbazhagan","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/dbio.1999.9534","article-title":"Endoglin, an ancillary TGF\u03b2 receptor, is required for extraembryonic angiogenesis and plays a key role in heart development","volume":"217","author":"Arthur","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/bcr40","article-title":"Transforming growth factor-\u03b2 and breast cancer","volume":"2","author":"Barcellos-Hoff","year":"2000","journal-title":"Breast Cancer Res."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/(SICI)1096-8628(19991229)89:4<218::AID-AJMG6>3.0.CO;2-E","article-title":"Persistence of M\u00fcllerian derivatives in males","volume":"89","author":"Belville","year":"1999","journal-title":"Am. J. Med.Genet."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1006\/dbio.2000.9670","article-title":"BMP type II receptor is required for gastrulation and early development of mouse embryos","volume":"221","author":"Beppu","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB10","article-title":"Different sensitivity of the TGF-beta cell cycle arrest pathway to c-Myc and MDM-2","volume":"in press","author":"Blain","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB11","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM200005043421807","article-title":"Role of transforming growth factor beta in human disease","volume":"342","author":"Blobe","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB12","first-page":"5564","article-title":"Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene","volume":"57","author":"Bottinger","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB13","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI8088","article-title":"A murine model of hereditary hemorrhagic telangiectasia","volume":"104","author":"Bourdeau","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB14","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1126\/science.280.5368.1455","article-title":"Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton","volume":"280","author":"Brunet","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB15","first-page":"2856","article-title":"Expression of transforming growth factor beta type II receptor reduces tumorigenicity in human gastric cancer cells","volume":"57","author":"Chang","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB16","first-page":"821","article-title":"Involvement of caspase family proteases in transforming growth factor-beta induced apoptosis","volume":"8","author":"Chen","year":"1997","journal-title":"Cell Growth Differ."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB17","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1074\/jbc.274.6.3672","article-title":"Smad1 recognition and activation by the ALK1 group of transforming growth factor-beta family receptors","volume":"274","author":"Chen","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB18","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1101\/gad.12.14.2144","article-title":"Determinants of specificity in TGF-\u03b2 signal transduction","volume":"12","author":"Chen","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB19","first-page":"4805","article-title":"Transforming growth factor \u03b2 type I receptor kinase mutant associated with metastatic breast cancer","volume":"58","author":"Chen","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB20","doi-asserted-by":"crossref","first-page":"9498","DOI":"10.1073\/pnas.150006697","article-title":"A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta-induced cell-cycle arrest","volume":"97","author":"Claassen","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB21","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0092-8674(00)80127-0","article-title":"TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice","volume":"86","author":"Cui","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/(SICI)1098-2744(199909)26:1<37::AID-MC5>3.0.CO;2-6","article-title":"Transforming growth factor-beta responsiveness in DPC4\/SMAD4-null cancer cells","volume":"26","author":"Dai","year":"1999","journal-title":"Mol. Carcinog."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MCB.19.1.1","article-title":"c-Myc target genes involved in cell growth, apoptosis, and metabolism","volume":"19","author":"Dang","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB24","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1086\/303059","article-title":"Familial primary pulmonary hypertension (Gene PPH1) is caused by mutations in the bone Morphogenetic Protein Receptor-II Gene","volume":"67","author":"Deng","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB25","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(00)81696-7","article-title":"Smads","volume":"95","author":"Derynck","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB26","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1242\/dev.121.6.1845","article-title":"Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knockout mice","volume":"121","author":"Dickson","year":"1995","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB27","doi-asserted-by":"crossref","first-page":"37413","DOI":"10.1074\/jbc.274.52.37413","article-title":"Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription","volume":"274","author":"Engel","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB28","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0092-8674(00)80128-2","article-title":"MADR2 maps to 18q21 and encodes a TGF\u03b2-regulated MAD-related protein that is functionally mutated in colorectal carcinoma","volume":"86","author":"Eppert","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB29","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1101\/gad.9.2.204","article-title":"p53-dependent repression of CDK4 translation in TGF\u03b2-induced G1 cell cycle arrest","volume":"9","author":"Ewen","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB30","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1096\/fasebj.12.9.633","article-title":"The molecular role of Myc in growth and transformation","volume":"12","author":"Facchini","year":"1998","journal-title":"FASEB J."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB31","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1242\/dev.126.6.1305","article-title":"Mechanisms of GDF-5 action during skeletal development","volume":"126","author":"Francis-West","year":"1999","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB32","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/382511a0","article-title":"Cdc25 cell cycle phosphatase as a target of c-myc","volume":"382","author":"Galaktionov","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/72835","article-title":"A role for smad6 in development and homeostasis of the cardiovascular system","volume":"24","author":"Galvin","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB34","doi-asserted-by":"crossref","first-page":"10315","DOI":"10.1073\/pnas.90.21.10315","article-title":"Transforming growth factor \u03b2 effects on expression of G1 cyclins and cyclin-dependent protein kinases","volume":"90","author":"Geng","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB35","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1101\/gad.14.4.435","article-title":"Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif","volume":"14","author":"Germain","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB36","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1038\/sj.onc.1203701","article-title":"Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGFbetaRII","volume":"19","author":"Go","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB37","first-page":"5329","article-title":"Genetic alterations of the transforming growth factor \u03b2 receptor genes in pancreatic and biliary adenocarcinomas","volume":"58","author":"Goggins","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB38","first-page":"303","article-title":"The role for transforming growth factor\u03b2 (TGF-\u03b2) in human cancer","volume":"10","author":"Gold","year":"1999","journal-title":"Crit. Rev. Oncog."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB39","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/6821","article-title":"Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis","volume":"21","author":"Gong","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB40","doi-asserted-by":"crossref","first-page":"27973","DOI":"10.1074\/jbc.M002704200","article-title":"Engagement of bone morphogenetic protein type IB receptor and Smad1 signaling by anti-M\u00fcllerian hormone and its type II receptor","volume":"275","author":"Gouedard","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB41","first-page":"253","article-title":"Functional analysis of the TGF\u03b2 receptor\/Smad pathway through gene ablation in mice","volume":"44","author":"Goumans","year":"2000","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB42","first-page":"320","article-title":"Mutational inactivation of transforming growth factor \u03b2 receptor type II in microsatelite stable colon cancers","volume":"59","author":"Grady","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB43","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1006\/mcne.1996.0046","article-title":"Neural crest apoptosis and the establishment of craniofacial pattern","volume":"8","author":"Graham","year":"1996","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB44","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/4887","article-title":"Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase","volume":"6","author":"Greenwald","year":"1999","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB45","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/76074","article-title":"Mutations in TGIF cause holoprosencephaly and link nodal signalling to human neural axis determination","volume":"25","author":"Gripp","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB46","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1056\/NEJM199510053331407","article-title":"Hereditary hemorrhagic telangiectasia","volume":"333","author":"Guttmacher","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB47","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1126\/science.271.5247.350","article-title":"DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1","volume":"271","author":"Hahn","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB147","doi-asserted-by":"crossref","first-page":"27161","DOI":"10.1074\/jbc.274.38.27161","article-title":"Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression","volume":"274","author":"Hanafusa","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB48","doi-asserted-by":"crossref","first-page":"31577","DOI":"10.1074\/jbc.274.44.31577","article-title":"Interaction and functional cooperation of PEBP2\/CBF with Smads. Synergistic induction of the immunoglobulin germline C\u03b1 promoter","volume":"274","author":"Hanai","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB49","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/371257a0","article-title":"p15INK4B is a potential effector of TGF-\u03b2-induced cell cycle arrest","volume":"371","author":"Hannon","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB50","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1101\/gad.12.2.186","article-title":"Smad6 inhibits BMP\/Smad1 signaling by specifically competing with the Smad4 tumor suppressor","volume":"12","author":"Hata","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB51","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/37284","article-title":"TGF-\u03b2 signalling from cell membrane to nucleus through SMAD proteins","volume":"390","author":"Heldin","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB52","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1093\/emboj\/18.5.1345","article-title":"TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway","volume":"18","author":"Hocevar","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB53","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1101\/gad.10.13.1580","article-title":"Bone morphogenetic proteins","volume":"10","author":"Hogan","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB54","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1126\/science.280.5366.1086","article-title":"Mutations in the SMAD4\/DPC4 gene in juvenile polyposis","volume":"280","author":"Howe","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB55","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1006\/dbio.1999.9430","article-title":"Xenopus Smad4beta is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes","volume":"214","author":"Howell","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB56","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0092-8674(00)80555-3","article-title":"Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12","volume":"96","author":"Huse","year":"1999","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB57","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/387417a0","article-title":"Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-\u03b2 in cells lacking the CDK inhibitor p15","volume":"387","author":"Iavarone","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB58","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1128\/MCB.19.1.916","article-title":"E2F and histone deacetlyase mediate transforming growth factor \u03b2 repression of cdc25A during keratinocyte cell cycle arrest","volume":"19","author":"Iavarone","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB59","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0304-3835(96)04583-1","article-title":"Microsatellite instability and mutated type II transforming growth factor-beta receptor gene in gliomas","volume":"112","author":"Izumoto","year":"1997","journal-title":"Cancer Lett."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB60","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/40906","article-title":"Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic","volume":"388","author":"Kim","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB61","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1093\/emboj\/19.13.3314","article-title":"BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II","volume":"19","author":"Kirsch","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB62","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/75903","article-title":"Crystal structure of the BMP-2-BRIA ectodomain complex","volume":"7","author":"Kirsch","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB63","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0092-8674(00)80258-5","article-title":"Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts","volume":"89","author":"Komori","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB148","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1101\/gad.13.7.804","article-title":"A mechanism of repression of TGF\u03b2\/Smad signaling by oncogenic Ras","volume":"13","author":"Kretzschmar","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB64","doi-asserted-by":"crossref","first-page":"8358","DOI":"10.1073\/pnas.150152697","article-title":"Association of smads with lymphoid enhancer binding factor 1\/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways","volume":"97","author":"Labbe","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB65","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1093\/emboj\/19.13.3496","article-title":"Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis","volume":"19","author":"Latres","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB66","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/ng0797-307","article-title":"Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2\/CBFA1 in cleidocranial dysplasia","volume":"16","author":"Lee","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB67","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/35006129","article-title":"Betaglycan binds inhibin and can mediate functional antagonism of activin signalling","volume":"404","author":"Lewis","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB68","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/0092-8674(93)90368-Z","article-title":"Betaglycan presents ligand to the TGF-\u03b2 signaling receptor","volume":"73","author":"L\u00f3pez-Casillas","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB69","first-page":"4595","article-title":"Genomic structure of the transforming growth factor \u03b2 type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers","volume":"56","author":"Lu","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB70","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1101\/gad.13.17.2196","article-title":"The ski oncoprotein interacts with the smad proteins to repress TGFbeta signaling","volume":"13","author":"Luo","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB71","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1093\/hmg\/9.5.745","article-title":"Expression analysis of endoglin missense and truncation mutations","volume":"9","author":"Lux","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB72","doi-asserted-by":"crossref","first-page":"25628","DOI":"10.1074\/jbc.273.40.25628","article-title":"Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2","volume":"273","author":"Macias-Silva","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB73","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1126\/science.7761852","article-title":"Inactivation of the type II TGF-\u03b2 receptor in colon cancer cells with microsatellite instability","volume":"268","author":"Markowitz","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB74","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/S0955-0674(99)00044-7","article-title":"How do small GTPase signal transduction pathways regulate cell cycle entry?","volume":"11","author":"Marshall","year":"1999","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB75","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev.biochem.67.1.753","article-title":"TGF\u03b2 signal transduction","volume":"67","author":"Massagu\u00e9","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB76","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1101\/gad.14.6.627","article-title":"Controlling TGF\u03b2 signaling","volume":"14","author":"Massagu\u00e9","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB77","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/emboj\/19.8.1745","article-title":"Transcriptional control by the TGF-\u03b2\/Smad signaling system","volume":"19","author":"Massagu\u00e9","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB78","doi-asserted-by":"crossref","first-page":"12163","DOI":"10.1074\/jbc.274.17.12163","article-title":"Identification of two Smad4 proteins in Xenopus. Their common and distinct properties","volume":"274","author":"Masuyama","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB79","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1101\/gad.12.10.1438","article-title":"Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite","volume":"12","author":"McMahon","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB80","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1210\/endo.140.5.6705","article-title":"High specificity of M\u00fcllerian-inhibiting substance signaling in vivo","volume":"140","author":"Mishina","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB81","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1038\/sj.onc.1202642","article-title":"Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis","volume":"18","author":"Miyaki","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB82","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0959-437X(00)00084-8","article-title":"Genetics of ventral forebrain development and holoprosencephaly","volume":"10","author":"Muenke","year":"2000","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB83","first-page":"177","article-title":"Cleidocranial dysplasia","volume":"36","author":"Mundlos","year":"1999","journal-title":"J. Med. Genet."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB84","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0092-8674(00)80260-3","article-title":"Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia","volume":"89","author":"Mundlos","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB85","first-page":"5545","article-title":"A transforming growth factor \u03b2 receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability","volume":"55","author":"Myeroff","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB86","doi-asserted-by":"crossref","first-page":"14961","DOI":"10.1073\/pnas.96.26.14961","article-title":"Transforming growth factor beta targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity","volume":"96","author":"Nagahara","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB87","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0092-8674(00)81237-4","article-title":"Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors","volume":"85","author":"Nakayama","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB88","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1242\/dev.127.14.3107","article-title":"Transforming growth factor \u03b23 induces cell death during the first stage of mammary gland involution","volume":"127","author":"Nguyen","year":"2000","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB89","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/35001602","article-title":"Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer","volume":"403","author":"Nishita","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB90","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0960-9822(07)00533-7","article-title":"TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis","volume":"8","author":"Oft","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB91","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1073\/pnas.97.6.2626","article-title":"Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis","volume":"97","author":"Oh","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB92","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0092-8674(00)80259-7","article-title":"Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development","volume":"89","author":"Otto","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB93","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/(SICI)1521-1878(199805)20:5<382::AID-BIES5>3.0.CO;2-Q","article-title":"TGF-beta signaling, Smads, and tumor suppressors","volume":"20","author":"Padgett","year":"1998","journal-title":"Bioessays"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB94","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1074\/jbc.275.5.3552","article-title":"Smad and AML proteins synergistically confer Transforming Growth Factor beta1 responsiveness to human germ-line IgA genes","volume":"275","author":"Pardali","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB95","first-page":"5548","article-title":"Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer","volume":"55","author":"Parsons","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB96","first-page":"5678","article-title":"TbetaR-I(6A) is a candidate tumor susceptibility allele","volume":"59","author":"Pasche","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB97","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1006\/jmbi.1999.2640","article-title":"Mechanisms of cyclin-dependent kinase regulation","volume":"287","author":"Pavletich","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB98","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1136\/thx.54.12.1107","article-title":"Primary pulmonary hypertension","volume":"54","author":"Peacock","year":"1999","journal-title":"Thorax"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB99","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1093\/hmg\/8.12.2171","article-title":"Expression analysis of four endoglin missense mutations suggests that haploinsufficiency is the predominant mechanism for hereditary hemorrhagic telangiectasia type 1","volume":"8","author":"Pece-Barbara","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB100","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/jmg.33.6.441","article-title":"Hereditary haemorrhagic telangiectasia with extensive liver involvement is not caused by either HHT1 or HHT2","volume":"33","author":"Piantanida","year":"1996","journal-title":"J. Med. Genet."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB101","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/ng0997-18","article-title":"Mutations in CDMP1 cause autosomal dominant brachydactyly type C","volume":"17","author":"Polinkovsky","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB102","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/dbio.1999.9282","article-title":"TGF-beta family signal transduction in Drosophila development","volume":"210","author":"Raftery","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB103","first-page":"447","article-title":"Transforming growth factor-beta and cancer","volume":"9","author":"Reiss","year":"1997","journal-title":"Oncol. Res."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB104","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1101\/gad.11.4.492","article-title":"The subcellular location of p15Ink4b and p27Kip1 coordinate their inhibitory interactions with cdk4 and cdk2","volume":"11","author":"Reynisd\u00f3ttir","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB105","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1101\/gad.9.15.1831","article-title":"Kip\/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arest in response to TGF-\u03b2","volume":"9","author":"Reynisd\u00f3ttir","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB106","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/excr.1998.4096","article-title":"Transforming growth factor-beta-mediated apoptosis in the Ramos B-lymphoma cell line is accompanied by caspase activation and Bcl-XL downregulation","volume":"242","author":"Saltzman","year":"1998","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB107","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1128\/MCB.17.5.2458","article-title":"Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells","volume":"17","author":"Sandhu","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB108","doi-asserted-by":"crossref","first-page":"8949","DOI":"10.1074\/jbc.274.13.8949","article-title":"ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling","volume":"274","author":"Sano","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB109","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1182\/blood.V94.8.2854.420k07_2854_2861","article-title":"A deletion in the gene for transforming growth factor beta type I receptor abolishes growth regulation by transforming growth factor beta in a cutaneous T-cell lymphoma","volume":"94","author":"Schiemann","year":"1999","journal-title":"Blood"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB110","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/35000126","article-title":"Nodal signalling in vertebrate development","volume":"403","author":"Schier","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB111","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1101\/gad.13.12.1501","article-title":"CDK inhibitors","volume":"13","author":"Sherr","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB112","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/40431","article-title":"A structural basis for mutational inactivation of the tumour suppressor Smad4","volume":"388","author":"Shi","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB113","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0092-8674(00)81600-1","article-title":"Crystal structure of a Smad MH1 domain bound to DNA","volume":"94","author":"Shi","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB114","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1074\/jbc.275.3.2063","article-title":"Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling","volume":"275","author":"Sirard","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB115","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1242\/dev.122.12.3969","article-title":"Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family","volume":"122","author":"Storm","year":"1996","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB116","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/dbio.1999.9241","article-title":"GDF5 coordinates bone and joint formation during digit development","volume":"209","author":"Storm","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB117","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/368639a0","article-title":"Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily","volume":"368","author":"Storm","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB118","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1126\/science.282.5397.2270","article-title":"p53-independent role of MDM-2 in TGF-\u03b2 resistance","volume":"282","author":"Sun","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB119","doi-asserted-by":"crossref","first-page":"12442","DOI":"10.1073\/pnas.96.22.12442","article-title":"SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling","volume":"96","author":"Sun","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB120","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0092-8674(00)81132-0","article-title":"Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and APC genes","volume":"92","author":"Takaku","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB121","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1128\/MCB.20.9.3015-3026.2000","article-title":"TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development","volume":"20","author":"Takatsu","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB122","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/sj.onc.1200938","article-title":"Mutation analysis of coding sequences of the entire transforming growth factor beta type II receptor gene in sporadic human colon cancer using genomic DNA and intron primers","volume":"14","author":"Takenoshita","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB123","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nm0798-802","article-title":"Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency","volume":"4","author":"Tang","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB124","article-title":"Heterozygous germline mutations in BMPR2, encoding a TGF-\u03b2 receptor, cause familial primary pulmonary hypertension","volume":"in press","author":"The International PPH Consortium","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB125","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/ng0396-315","article-title":"A human chondrodysplasia due to a mutation in a TGF-beta superfamily member","volume":"12","author":"Thomas","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB126","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/ng0997-58","article-title":"Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1","volume":"17","author":"Thomas","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB127","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1242\/dev.127.14.3079","article-title":"Formation of the definitive endoderm in mouse is a Smad2-dependent process","volume":"127","author":"Tremblay","year":"2000","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB128","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0092-8674(00)81701-8","article-title":"SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor","volume":"95","author":"Tsukazaki","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB129","first-page":"5583","article-title":"Somatic in vivo alterations of the JV18\u20131 gene at 18q21 in human lung cancers","volume":"56","author":"Uchida","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB130","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1038\/sj.onc.1202118","article-title":"Disruption of the antiproliferative TGF-beta signaling pathways in human pancreatic cancer cells","volume":"17","author":"Villanueva","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB131","first-page":"4507","article-title":"Analysis of specific gene mutations in the Transforming Growth Factor-\u03b2 signal transduction pathway in human ovarian cancer","volume":"60","author":"Wang","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB132","doi-asserted-by":"crossref","first-page":"22044","DOI":"10.1074\/jbc.270.37.22044","article-title":"Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells","volume":"270","author":"Wang","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB133","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1128\/MCB.19.9.5913","article-title":"Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G1 arrest pathway","volume":"19","author":"Warner","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB134","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/embo-reports\/kvd029","article-title":"Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal","volume":"1","author":"Watanabe","year":"2000","journal-title":"EMBO Reports"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB135","doi-asserted-by":"crossref","unstructured":"Westendorf, J.J., and Hiebert, S.W. (1999). Mammalian runt-domain proteins and their roles in hematopoiesis, osteogenesis, and leukemia. J. Cell. Biochem. (Suppl), 51\u201358.","DOI":"10.1002\/(SICI)1097-4644(1999)75:32+<51::AID-JCB7>3.0.CO;2-S"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB136","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1101\/gad.12.16.2445","article-title":"Smads and early developmental signaling by the TGFbeta superfamily","volume":"12","author":"Whitman","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB137","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1128\/MCB.19.3.1821","article-title":"Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta","volume":"19","author":"Wong","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB138","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0092-8674(00)80712-6","article-title":"A Smad Transcriptional Corepressor","volume":"97","author":"Wotton","year":"1999","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB139","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1073\/pnas.97.9.4820","article-title":"Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway","volume":"97","author":"Xu","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB140","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/35010529","article-title":"The nuclear import function of Smad2 is masked by SARA and unmasked by TGF\u03b2-dependent phosphorylation","volume":"2","author":"Xu","year":"2000","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB141","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1038\/sj.onc.1203504","article-title":"Haploid loss of the tumor suppressor Smad4\/Dpc4 initiates gastric polyposis and cancer in mice","volume":"19","author":"Xu","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB142","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1172\/JCI3523","article-title":"TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development","volume":"103","author":"Yin","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0092-8674(00)00121-5_BIB143","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1097-2765(00)80061-1","article-title":"Human Smad3 and Smad4 are sequence-specific transcription activators","volume":"1","author":"Zawel","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB144","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/29814","article-title":"Smad3 and Smad4 cooperate with c-Jun\/c-Fos to mediate TGF-beta-induced transcription","volume":"394","author":"Zhang","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB145","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)81730-4","article-title":"Smad3 mutant mice develop metastatic colorectal carcinoma","volume":"94","author":"Zhu","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)00121-5_BIB146","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1101\/SQB.1997.062.01.033","article-title":"BMP signaling and vertebrate limb development","volume":"62","author":"Zou","year":"1997","journal-title":"Cold Spring Harb. Symp. Quant. Biol."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400001215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400001215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T21:12:02Z","timestamp":1734297122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400001215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":148,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["S0092867400001215"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)00121-5","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}