{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:00:56Z","timestamp":1779343256776,"version":"3.51.4"},"reference-count":59,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1996,8,1]],"date-time":"1996-08-01T00:00:00Z","timestamp":838857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":6194,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1996,8]]},"DOI":"10.1016\/s0092-8674(00)80118-x","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T20:23:03Z","timestamp":1086812583000},"page":"453-463","source":"Crossref","is-referenced-by-count":244,"title":["Cdc53 Targets Phosphorylated G1 Cyclins for Degradation by the Ubiquitin Proteolytic Pathway"],"prefix":"10.1016","volume":"86","author":[{"given":"Andrew R","family":"Willems","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Lanker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.Elizabeth","family":"Patton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L","family":"Craig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy F","family":"Nason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal","family":"Mathias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuji","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curt","family":"Wittenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Tyers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)80118-X_BIB1","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/0092-8674(94)90443-X","article-title":"Closing the cell cycle circle in yeast","volume":"77","author":"Amon","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0092-8674(00)80098-7","article-title":"SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box","volume":"86","author":"Bai","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/371339a0","article-title":"Repression of growth-regulated G1 cyclin expression by cyclic AMP in budding yeast","volume":"371","author":"Baroni","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1101\/gad.9.4.399","article-title":"G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast","volume":"9","author":"Barral","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB5","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1126\/science.2538923","article-title":"A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein","volume":"243","author":"Chau","year":"1989","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB6","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1128\/MCB.8.11.4675","article-title":"DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae","volume":"8","author":"Cross","year":"1988","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB7","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/0955-0674(95)80062-X","article-title":"Starting the cell cycle","volume":"7","author":"Cross","year":"1995","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/j.1460-2075.1995.tb07004.x","article-title":"Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway","volume":"14","author":"Deshaies","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB9","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1002\/j.1460-2075.1995.tb00162.x","article-title":"Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae","volume":"14","author":"Dirick","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB10","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0092-8674(83)90420-8","article-title":"Cyclin","volume":"33","author":"Evans","year":"1983","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB11","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1091\/mbc.3.7.805","article-title":"Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae","volume":"3","author":"Fitch","year":"1992","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/349132a0","article-title":"Cyclin is degraded by the ubiquitin pathway","volume":"349","author":"Glotzer","year":"1991","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB13","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1126\/science.2842867","article-title":"The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme","volume":"241","author":"Goebl","year":"1988","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB14","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1128\/MCB.9.5.2034","article-title":"The Saccharomyces cerevisiae CKS1 gene, a homolog of the Schizosaccharomyces pombe suc1+ gene, encodes a subunit of the Cdc28 protein kinase complex","volume":"9","author":"Hadwiger","year":"1989","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB15","doi-asserted-by":"crossref","first-page":"6255","DOI":"10.1073\/pnas.86.16.6255","article-title":"A family of cyclin homologs that control the G1 phase in yeast","volume":"86","author":"Hadwiger","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB16","series-title":"Antibodies","author":"Harlow","year":"1988"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB17","doi-asserted-by":"crossref","first-page":"4940","DOI":"10.1016\/S0021-9258(17)37636-6","article-title":"Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase Cdc2","volume":"269","author":"Hershko","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0955-0674(95)80031-X","article-title":"Ubiquitin, proteasomes, and the regulation of intracellular protein degradation","volume":"7","author":"Hochstrasser","year":"1995","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB19","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1016\/S0021-9258(19)50351-9","article-title":"Expression of a ubiquitin derivative that conjugates to protein irreversibly produces phenotypes consistent with a ubiquitin deficiency","volume":"267","author":"Hodgins","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB20","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1073\/pnas.92.7.2563","article-title":"A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase","volume":"92","author":"Huibregtse","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB21","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0092-8674(94)90543-6","article-title":"Cyclins and cancer. II. Cyclin D and CDK inhibitors come of age","volume":"79","author":"Hunter","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0092-8674(95)90337-2","article-title":"Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast","volume":"81","author":"Irniger","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB23","series-title":"Methods in Yeast Genetics","author":"Kaiser","year":"1994"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB24","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0092-8674(95)90338-0","article-title":"A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B","volume":"81","author":"King","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB25","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0092-8674(00)81267-2","article-title":"cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family","volume":"85","author":"Kipreos","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB26","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/0076-6879(91)94038-E","article-title":"Epitope tagging and protein surveillance","volume":"194","author":"Kolodziej","year":"1991","journal-title":"Meth. Enzymol."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB27","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1002\/j.1460-2075.1994.tb06948.x","article-title":"Regulated degradation of the transcription factor Gcn4","volume":"13","author":"Kornitzer","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB28","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1126\/science.271.5255.1597","article-title":"Rapid degradation of the G1 cyclin Cln2 induced by CDK-dependent phosphorylation","volume":"271","author":"Lanker","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB29","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0092-8674(91)90042-W","article-title":"Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast","volume":"66","author":"Lew","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB30","doi-asserted-by":"crossref","first-page":"12046","DOI":"10.1016\/S0021-9258(19)50306-4","article-title":"N-recognin\/Ubc2 interactions in the N-end rule pathway","volume":"268","author":"Madura","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB31","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1101\/gad.7.5.833","article-title":"Negative regulation of FAR1 at the Start of the yeast cell cycle","volume":"7","author":"McKinney","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB32","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1126\/science.8421781","article-title":"An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae","volume":"259","author":"Mendenhall","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB33","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0092-8674(95)90322-4","article-title":"Cyclin ubiquitination","volume":"81","author":"Murray","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB34","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1002\/j.1460-2075.1988.tb03332.x","article-title":"The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog","volume":"7","author":"Nash","year":"1988","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB35","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0955-0674(93)90099-C","article-title":"Control of the yeast cell cycle by the Cdc28 protein kinase","volume":"5","author":"Nasmyth","year":"1993","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB36","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1128\/MCB.14.5.3320","article-title":"An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells","volume":"14","author":"Nugroho","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB37","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0065-230X(08)60254-7","article-title":"Cyclins and cyclin-dependent kinases","volume":"66","author":"Pines","year":"1995","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB38","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1101\/gad.6.11.2021","article-title":"Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2","volume":"6","author":"Richardson","year":"1992","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB39","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1126\/science.2876518","article-title":"Amino acid sequences common to rapidly degraded proteins","volume":"234","author":"Rogers","year":"1986","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB40","doi-asserted-by":"crossref","first-page":"7953","DOI":"10.1128\/MCB.14.12.7953","article-title":"G1 cyclin degradation","volume":"14","author":"Salama","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/373081a0","article-title":"Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade","volume":"373","author":"Scheffner","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB42","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/yea.320111306","article-title":"Use of polymerase chain reaction epitope tagging for protein tagging in Saccharomyces cerevisiae","volume":"11","author":"Schneider","year":"1995","journal-title":"Yeast"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB43","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1126\/science.272.5261.560","article-title":"Linkage of replication to Start by the Cdk inhibitor Sic1","volume":"272","author":"Schneider","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB44","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1073\/pnas.88.3.1004","article-title":"Specific initiation by RNA polymerase I in a whole-cell extract from yeast","volume":"88","author":"Schultz","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB45","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1101\/gad.7.7a.1160","article-title":"CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae","volume":"7","author":"Schwob","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB46","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0092-8674(94)90193-7","article-title":"The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae","volume":"79","author":"Schwob","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB47","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0092-8674(94)90540-1","article-title":"G1 phase progression","volume":"79","author":"Sherr","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB48","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/genetics\/122.1.19","article-title":"A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae","volume":"122","author":"Sikorski","year":"1989","journal-title":"Genetics"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB49","doi-asserted-by":"crossref","first-page":"10353","DOI":"10.1016\/S0021-9258(17)39255-4","article-title":"Isolation of three proteins that bind to mammalian RNA polymerase II","volume":"260","author":"Sopta","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB50","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1101\/gad.9.22.2780","article-title":"CLN3, not positive feedback, determines the timing of CLN2 transcription in cycling cells","volume":"9","author":"Stuart","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB51","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1091\/mbc.6.2.185","article-title":"The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis","volume":"6","author":"Sudakin","year":"1995","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB52","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/371342a0","article-title":"Inhibition of G1 cyclin activity by the Ras\/cAMP pathway in yeast","volume":"371","author":"Tokiwa","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB53","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.93.15.7772","article-title":"The cyclin-dependent kinase inhibitor p40SIC1 imposes the requirement for CLN G1 cyclin function at Start","author":"Tyers","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA, in press."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB54","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1002\/j.1460-2075.1992.tb05229.x","article-title":"The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation","volume":"11","author":"Tyers","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB55","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1002\/j.1460-2075.1993.tb05845.x","article-title":"Comparison of the Saccharomyces cerevisiae G1 cyclins","volume":"12","author":"Tyers","year":"1993","journal-title":"EMBO J."},{"issue":"CDC28 protein kinase. Cell 62","key":"10.1016\/S0092-8674(00)80118-X_BIB56","first-page":"225","article-title":"G1-specific cyclins of S","volume":"p.34","author":"Wittenberg","year":"1990","journal-title":"cerevisiae"},{"key":"10.1016\/S0092-8674(00)80118-X_BIB57","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1128\/MCB.15.2.731","article-title":"p34CDC28-mediated control of Cln3 cyclin degradation","volume":"15","author":"Yaglom","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB58","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0022-2836(87)90646-2","article-title":"Structural comparison of the yeast cell division cycle gene CDC4 and a related pseudogene","volume":"195","author":"Yochem","year":"1987","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0092-8674(00)80118-X_BIB59","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1128\/MCB.15.9.4835","article-title":"Genetic and biochemical interactions between an essential kinetochore protein, Cbf2p\/Ndc10p, and the CDC34 ubiquitin-conjugating enzyme","volume":"15","author":"Yoon","year":"1995","journal-title":"Mol. Cell. Biol."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286740080118X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286740080118X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T03:46:55Z","timestamp":1624420015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009286740080118X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,8]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,8]]}},"alternative-id":["S009286740080118X"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)80118-x","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1996,8]]}}}