{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:55:50Z","timestamp":1771232150977,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1997,4,1]],"date-time":"1997-04-01T00:00:00Z","timestamp":859852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5951,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1997,4]]},"DOI":"10.1016\/s0092-8674(00)80184-1","type":"journal-article","created":{"date-parts":[[2004,4,10]],"date-time":"2004-04-10T09:39:29Z","timestamp":1081589969000},"page":"73-82","source":"Crossref","is-referenced-by-count":884,"title":["cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway"],"prefix":"10.1016","volume":"89","author":[{"given":"Mark R","family":"Vossler","sequence":"first","affiliation":[]},{"given":"Hong","family":"Yao","sequence":"additional","affiliation":[]},{"given":"Randall D","family":"York","sequence":"additional","affiliation":[]},{"given":"Ming-Gui","family":"Pan","sequence":"additional","affiliation":[]},{"given":"Caroline S","family":"Rim","sequence":"additional","affiliation":[]},{"given":"Philip J.S","family":"Stork","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)80184-1_BIB1","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1002\/j.1460-2075.1994.tb06424.x","article-title":"Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1","volume":"13","author":"Alessi","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB2","doi-asserted-by":"crossref","first-page":"7527","DOI":"10.1016\/S0021-9258(18)53207-5","article-title":"Mutational analysis of the cAMP-dependent protein kinase\u2013mediated phosphorylation site of Raf1b","volume":"268","author":"Altschuler","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB3","doi-asserted-by":"crossref","first-page":"10373","DOI":"10.1074\/jbc.270.18.10373","article-title":"Cyclic AMP\u2013dependent activation of Rap1b","volume":"270","author":"Altschuler","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB4","doi-asserted-by":"crossref","first-page":"23381","DOI":"10.1074\/jbc.270.40.23381","article-title":"The mouse B-raf gene encodes multiple protein isoforms with tissue-specific expression","volume":"270","author":"Barnier","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0968-0004(00)88944-6","article-title":"Regulation of Ras-mediated signalling","volume":"20","author":"Burgering","year":"1995","journal-title":"Trends Biol. Sci."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB6","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1126\/science.7694367","article-title":"Inhibition by cAMP ras-dependent activation of raf","volume":"262","author":"Cook","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80184-1_BIB7","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1002\/j.1460-2075.1993.tb06022.x","article-title":"RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts","volume":"12","author":"Cook","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB8","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(94)90133-3","article-title":"Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells","volume":"77","author":"Cowley","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80184-1_BIB9","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/0092-8674(94)90380-8","article-title":"JNK1","volume":"76","author":"D\u00e9rijard","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80184-1_BIB10","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.1128\/MCB.15.10.5524","article-title":"Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC12 cells","volume":"15","author":"Erhardt","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB11","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1091\/mbc.6.8.1025","article-title":"Differential effects of cAMP on the MAP kinase cascade","volume":"6","author":"Faure","year":"1995","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/S0092-8674(00)80184-1_BIB12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1126\/science.2164710","article-title":"Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product","volume":"246","author":"Frech","year":"1990","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80184-1_BIB13","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1016\/S0021-9258(17)37589-0","article-title":"Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells","volume":"269","author":"Frodin","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB14","doi-asserted-by":"crossref","first-page":"6746","DOI":"10.1128\/MCB.15.12.6746","article-title":"Identification of Rap1 as a target for the Crk SH3 domain\u2013binding guanine nucleotide-\u2013releasing factor C3G","volume":"15","author":"Gotoh","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB15","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1016\/S0021-9258(17)41718-2","article-title":"Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation","volume":"269","author":"Hallberg","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB16","doi-asserted-by":"crossref","first-page":"6571","DOI":"10.1016\/S0021-9258(18)38155-9","article-title":"Enhancement of the actions of smg p21 GDP\/GTP exchange protein by the protein kinase A\u2013catalyzed phosphorylation of smg p21","volume":"266","author":"Hata","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB17","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1083\/jcb.100.3.916","article-title":"Synergistic effects of cyclic AMP and NGF on neurite outgrowth and MT stability of PC12 cells","volume":"100","author":"Heidemann","year":"1985","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB18","doi-asserted-by":"crossref","first-page":"23626","DOI":"10.1074\/jbc.271.39.23626","article-title":"Nerve growth factor\u2013mediated activation of the mitogen-activated protein (MAP kinase cascade involves a signaling complex containing B-Raf and HSP90)","volume":"271","author":"Jaiswal","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB19","doi-asserted-by":"crossref","first-page":"4284","DOI":"10.1073\/pnas.87.11.4284","article-title":"Genetic analysis of the Krsten-ras-revertant 1 gene","volume":"87","author":"Kitayama","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80184-1_BIB20","doi-asserted-by":"crossref","first-page":"14680","DOI":"10.1074\/jbc.271.25.14680","article-title":"Different effects of various phospholipids on Ki-ras-, Ha-ras-, and rap1B-induced B-raf activation","volume":"271","author":"Kuroda","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1126\/science.8385802","article-title":"A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf","volume":"260","author":"Lange-Carter","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80184-1_BIB22","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/369411a0","article-title":"Requirement for ras in raf activation is overcome by targeting raf to the plasma membrane","volume":"369","author":"Leevers","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80184-1_BIB23","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0092-8674(93)90237-K","article-title":"The SRF accessory protein Elk-1 contains a growth factor\u2013regulated transcriptional activation domain","volume":"73","author":"Marais","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80184-1_BIB24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0092-8674(95)90401-8","article-title":"Specificity of receptor tyrosine kinase signaling","volume":"80","author":"Marshall","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80184-1_BIB25","doi-asserted-by":"crossref","first-page":"14587","DOI":"10.1074\/jbc.270.24.14587","article-title":"A novel mitogen-activated protein kinase phosphatase","volume":"270","author":"Misra-Press","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB26","doi-asserted-by":"crossref","first-page":"7153","DOI":"10.1128\/MCB.14.11.7153","article-title":"Association of MEK1 with p21ras\u2022GMPPNP is dependent on B-Raf","volume":"14","author":"Moodie","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB27","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nsb0896-723","article-title":"Ras\/Rap effector specificity determined by charge reversal","volume":"3","author":"Nassar","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB28","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1074\/jbc.271.3.1258","article-title":"Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein","volume":"271","author":"Ohtsuka","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB29","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1074\/jbc.271.9.4671","article-title":"Post-translational modification of H-ras is required for activation of, but not for association with, B-raf","volume":"271","author":"Okada","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB30","doi-asserted-by":"crossref","first-page":"23753","DOI":"10.1016\/S0021-9258(18)54347-7","article-title":"The phosphorylation and activation of B-raf in PC12 cells stimulated by nerve growth factor","volume":"266","author":"Oshima","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB31","first-page":"2005","article-title":"The Wnt-1 proto-oncogene regulates MAP kinase activation by multiple growth factors in PC12 cells","volume":"11","author":"Pan","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)80184-1_BIB32","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1074\/jbc.271.10.5871","article-title":"Regulation of epidermal growth factor receptor signaling by phosphorylation of the ras exchange factor hSOS1","volume":"271","author":"Porfiri","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB33","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1021\/bi00008a027","article-title":"Determination of v-mos-catalyzed phosphorylation sites and autophosphorylation on MAP kinase kinase by ESI\/MS","volume":"34","author":"Resing","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/S0092-8674(00)80184-1_BIB34","doi-asserted-by":"crossref","first-page":"7644","DOI":"10.1074\/jbc.270.13.7644","article-title":"Biochemical analysis of MEK activation in NIH 3T3 fibroblasts","volume":"270","author":"Reuter","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB35","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1073\/pnas.88.7.2643","article-title":"Phosphorylation of a Ras-related GTP-binding protein, Rap-1b, by a neuronal Ca2+\/calmodulin-dependent protein kinase, CaM kinase Gr","volume":"88","author":"Sahyoun","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80184-1_BIB36","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1128\/MCB.11.8.4053","article-title":"Dominant inhibitory ras mutants selectively inhibit the activity of either cellular or oncogenic ras","volume":"11","author":"Stacy","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB37","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/j.1460-2075.1996.tb00416.x","article-title":"Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation","volume":"15","author":"Urano","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB38","doi-asserted-by":"crossref","first-page":"6522","DOI":"10.1128\/MCB.14.10.6522","article-title":"B-Raf dependent regulation of the MEK-1\/MAP kinase pathway in PC12 cells and regulation by cAMP","volume":"14","author":"Vaillancourt","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB39","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/364352a0","article-title":"Direct interaction of ras and the amino-terminal region of raf-1 in vitro","volume":"364","author":"Warne","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80184-1_BIB40","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1126\/science.7694366","article-title":"Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3\u2032, 5\u2032-monophosphate","volume":"262","author":"Wu","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80184-1_BIB41","doi-asserted-by":"crossref","first-page":"11723","DOI":"10.1074\/jbc.270.20.11723","article-title":"Purification of a ras-dependent mitogen-activated protein kinase kinase kinase from bovine brain cytosol and its identification as a complex of B-raf and 14\u20133\u20133 proteins","volume":"270","author":"Yamamori","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB42","doi-asserted-by":"crossref","first-page":"20748","DOI":"10.1074\/jbc.270.35.20748","article-title":"Cyclic adenosine monophosphate can convert epidermal growth factor into a differentiating factor in neuronal cells","volume":"270","author":"Yao","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB43","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1128\/MCB.12.8.3407","article-title":"Microinjection of smg\/rap1\/Krev-1 p21 into swiss 3T3 cells induces DNA synthesis and morphological changes","volume":"12","author":"Yoshida","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80184-1_BIB44","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0014-5793(94)80367-6","article-title":"Differentiation of PC12 cells in response to a cAMP analogue is accompanied by sustained activation of mitogen-activated protein kinase. Comparison with the effects of insulin, growth factors and phorbol esters","volume":"338","author":"Young","year":"1994","journal-title":"FEBS Lett."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400801841?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400801841?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T13:50:05Z","timestamp":1623765005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400801841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,4]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,4]]}},"alternative-id":["S0092867400801841"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)80184-1","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1997,4]]}}}