{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:46:50Z","timestamp":1777319210542,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5798,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[1997,9]]},"DOI":"10.1016\/s0092-8674(00)80369-4","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T13:47:39Z","timestamp":1088084859000},"page":"1031-1039","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":767,"title":["The Transmembrane Kinase Ire1p Is a Site-Specific Endonuclease That Initiates mRNA Splicing in the Unfolded Protein Response"],"prefix":"10.1016","volume":"90","author":[{"given":"Carmela","family":"Sidrauski","sequence":"first","affiliation":[]},{"given":"Peter","family":"Walter","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)80369-4_BIB1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0014-5793(93)81701-Z","article-title":"A hybrid protein kinase-RNase in an interferon-induced pathway?","volume":"334","author":"Bork","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB2","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1083\/jcb.105.4.1515","article-title":"The subnuclear localization of tRNA ligase in yeast","volume":"105","author":"Clark","year":"1987","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB3","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0092-8674(93)90648-A","article-title":"Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase","volume":"73","author":"Cox","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80369-4_BIB4","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0092-8674(00)81360-4","article-title":"A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response","volume":"87","author":"Cox","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80369-4_BIB5","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1074\/jbc.270.8.4133","article-title":"2\u20135A-dependent RNase molecules dimerize during activation by 2\u20135A*","volume":"270","author":"Dong","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB6","doi-asserted-by":"crossref","first-page":"14153","DOI":"10.1016\/S0021-9258(17)36767-4","article-title":"Intrinsic molecular activities of the interferon-induced 2\u20135A-dependent RNase","volume":"269","author":"Dong","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB7","first-page":"635","article-title":"Assembly of a tRNA splicing complex","volume":"6","author":"Greer","year":"1986","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB8","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0092-8674(83)90473-7","article-title":"Mechanism of action of a yeast RNA ligase in tRNA splicing","volume":"32","author":"Greer","year":"1983","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80369-4_BIB9","first-page":"76","article-title":"Substrate recognition and identification of splice sites by the tRNA-splicing endonuclease and ligase from Saccharomyces cerevisiae","volume":"7","author":"Greer","year":"1987","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB10","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1002\/j.1460-2075.1993.tb05999.x","article-title":"A dominant negative mutant of 2\u20135A-dependent RNase suppresses antiproliferative and antiviral effects of interferon","volume":"12","author":"Hassel","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB11","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0092-8674(00)80269-X","article-title":"Properties of H. volcanii tRNA intron endonuclease reveal a relationship between the archaeal and eucaryal intron processing systems","volume":"89","author":"Kleman-Leyer","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80369-4_BIB12","first-page":"877","article-title":"The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum","volume":"13","author":"Kohno","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB13","doi-asserted-by":"crossref","first-page":"6836","DOI":"10.1016\/S0021-9258(19)62691-8","article-title":"Activation of 2\u20135A-dependent RNase by analogs of 2\u20135A","volume":"261","author":"Krause","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB14","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1002\/pro.5560031209","article-title":"Three-dimensional structure of Schistosoma japonicum glutathione-S-transferase fused with a six-amino acid conserved neutralizing epitope of gp41 from HIV","volume":"3","author":"Lim","year":"1994","journal-title":"Prot. Sci."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB15","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/0092-8674(88)90231-0","article-title":"Site-selection by the tRNA splicing endonuclease of Xenopus laevis","volume":"55","author":"Mattoccia","year":"1988","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80369-4_BIB16","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/0958-1669(94)90071-X","article-title":"The cellular response to unfolded proteins","volume":"5","author":"McMillan","year":"1994","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB17","unstructured":"Moore, M.J., Query, C.C., and Sharp, P.A. (1993). Splicing of precursors to mRNAs by the spliceosome. In the RNA World. R.F. Gesteland and J.F. Atkins, eds. (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press), pp. 303\u2013357."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB18","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1046\/j.1365-2443.1996.d01-274.x","article-title":"Signalling from endoplasmic reticulum to nucleus","volume":"1","author":"Mori","year":"1996","journal-title":"Genes to Cells"},{"key":"10.1016\/S0092-8674(00)80369-4_BIB19","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/0092-8674(93)90521-Q","article-title":"A transmembrane protein with a cdc2+\/CDC28-related kinase activity is required for signaling from the ER to the nucleus","volume":"74","author":"Mori","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80369-4_BIB20","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1002\/j.1460-2075.1992.tb05323.x","article-title":"A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins","volume":"11","author":"Mori","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB21","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1093\/nar\/24.21.4222","article-title":"Saccharomyces cerevisiae IRE2\/HAC1 is involved in IRE1-mediated KAR2 expression","volume":"24","author":"Nikawa","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB22","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1128\/MCB.11.1.425","article-title":"In vivo pre-tRNA processing in Saccharomyces cerevisiae","volume":"11","author":"O'Connor","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB23","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0092-8674(83)90472-5","article-title":"Precise excision of intervening sequences from precursor transfer RNA by a membrane associated endonuclease","volume":"32","author":"Peebles","year":"1983","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80369-4_BIB24","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/0092-8674(88)90230-9","article-title":"Substrate recognition and splice site determination in yeast tRNA splicing","volume":"55","author":"Reyes","year":"1988","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80369-4_BIB25","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/349494a0","article-title":"PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome","volume":"349","author":"Schwer","year":"1991","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80369-4_BIB26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0962-8924(94)90011-6","article-title":"The unfolded-protein-response pathway in yeast","volume":"4","author":"Shamu","year":"1994","journal-title":"Trends Cell Biol."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB27","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1002\/j.1460-2075.1996.tb00666.x","article-title":"Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus","volume":"15","author":"Shamu","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB28","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0092-8674(00)81361-6","article-title":"tRNA ligase is required for regulated mRNA splicing in the unfolded protein response","volume":"87","author":"Sidrauski","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80369-4_BIB29","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0076-6879(88)64064-X","article-title":"Structural analysis of RNA using chemical and enzymatic probing monitored by primer extension","volume":"164","author":"Stern","year":"1986","journal-title":"Meth. Enzymol."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB30","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/0960-9822(93)90014-F","article-title":"A kinase that responds to stress","volume":"3","author":"Sweet","year":"1993","journal-title":"Curr. Biol."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB31","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0092-8674(00)80270-6","article-title":"The yeast tRNA splicing endonuclease","volume":"89","author":"Trotta","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80369-4_BIB32","doi-asserted-by":"crossref","first-page":"18181","DOI":"10.1074\/jbc.271.30.18181","article-title":"The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-autophosphorylation of Ire1p (Ern1p) are required for kinase activation","volume":"271","author":"Welihinda","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80369-4_BIB33","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/0092-8674(93)90403-D","article-title":"Expression cloning of 2\u20135A-dependent RNAse","volume":"72","author":"Zhou","year":"1993","journal-title":"Cell"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400803694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400803694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:50:49Z","timestamp":1758797449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400803694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1997,9]]}},"alternative-id":["S0092867400803694"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)80369-4","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1997,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Transmembrane Kinase Ire1p Is a Site-Specific Endonuclease That Initiates mRNA Splicing in the Unfolded Protein Response","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0092-8674(00)80369-4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1997 Cell Press. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}