{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T02:07:30Z","timestamp":1787710050381,"version":"build-2784847793"},"reference-count":40,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[1997,12,1]],"date-time":"1997-12-01T00:00:00Z","timestamp":880934400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1997,12,1]],"date-time":"1997-12-01T00:00:00Z","timestamp":880934400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5707,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[1997,12]]},"DOI":"10.1016\/s0092-8674(00)80480-8","type":"journal-article","created":{"date-parts":[[2004,4,10]],"date-time":"2004-04-10T05:39:29Z","timestamp":1081575569000},"page":"881-891","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":500,"title":["The Eye-Specification Proteins So and Eya Form a Complex and Regulate Multiple Steps in Drosophila Eye Development"],"prefix":"10.1016","volume":"91","author":[{"given":"Francesca","family":"Pignoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenton H","family":"Zavitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A","family":"Garrity","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.Lawrence","family":"Zipursky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)80480-8_BIB1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0076-6879(95)54018-0","article-title":"Analyzing protein-protein interactions using two-hybrid systems","volume":"254","author":"Bartel","year":"1995","journal-title":"Methods Enzymol."},{"key":"10.1016\/S0092-8674(00)80480-8_BIB2","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1242\/dev.111.3.657","article-title":"An extensive 3\u2032 cis-regulatory region directs the imaginal disc expression of decapentaplegic, a member of the TGF-\u03b2 family in Drosophila","volume":"111","author":"Blackman","year":"1991","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0092-8674(93)90115-7","article-title":"The eyes absent gene","volume":"72","author":"Bonini","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB4","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0092-8674(95)90497-2","article-title":"Phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila","volume":"80","author":"Chang","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB5","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1242\/dev.124.2.559","article-title":"Role of decapentaplegic in initiation and progression of the morphogenetic furrow in the developing Drosophila retina","volume":"124","author":"Chanut","year":"1997","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB6","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0092-8674(00)80481-X","article-title":"Dachshund and Eyes Absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila","volume":"91","author":"Chen","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB7","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0896-6273(94)90308-5","article-title":"The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system","volume":"12","author":"Cheyette","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB8","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0092-8674(95)90496-4","article-title":"Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase","volume":"80","author":"Dickson","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB9","doi-asserted-by":"crossref","first-page":"7929","DOI":"10.1073\/pnas.79.24.7929","article-title":"Monoclonal antibodies against the Drosophila nervous system","volume":"79","author":"Fujita","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB10","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/ng0894-463","article-title":"PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects","volume":"7","author":"Glaser","year":"1994","journal-title":"Nature Genet."},{"key":"10.1016\/S0092-8674(00)80480-8_BIB11","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1126\/science.7892602","article-title":"Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila","volume":"267","author":"Halder","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0168-9525(96)10051-2","article-title":"The world according to hedgehog","volume":"13","author":"Hammerschmidt","year":"1997","journal-title":"Trends Genet."},{"key":"10.1016\/S0092-8674(00)80480-8_BIB13","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1242\/dev.120.8.2121","article-title":"Expression of baculovirus P35 prevents cell death in Drosophila","volume":"120","author":"Hay","year":"1994","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB14","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/0092-8674(93)90535-X","article-title":"The TGF\u03b2 homolog dpp and the segment polarity gene hedgehog are required for propagation of the morphogenetic wave in the Drosophila retina","volume":"75","author":"Heberlein","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB15","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/373709a0","article-title":"Growth and differentiation in the Drosophila eye coordinated by hedgehog","volume":"373","author":"Heberlein","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB16","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/354522a0","article-title":"Mouse small eye results from mutations in a paired-like homeobox-containing gene","volume":"354","author":"Hill","year":"1991","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB17","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1128\/MCB.15.7.3813","article-title":"Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system","volume":"15","author":"Hollenberg","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80480-8_BIB18","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/nar\/24.2.303","article-title":"Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development","volume":"24","author":"Kawakami","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0092-8674(00)80480-8_BIB19","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0014-5793(96)00899-X","article-title":"Identification and expression of six family genes in mouse retina","volume":"393","author":"Kawakami","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/S0092-8674(00)80480-8_BIB20","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/40906","article-title":"Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic","volume":"388","author":"Kim","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1101\/gad.8.2.133","article-title":"The TGF-\u03b2 superfamily","volume":"8","author":"Kingsley","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)80480-8_BIB22","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0092-8674(93)90536-Y","article-title":"The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye","volume":"75","author":"Ma","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB23","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1242\/dev.120.12.3473","article-title":"dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila","volume":"120","author":"Mardon","year":"1994","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB24","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1242\/dev.121.3.693","article-title":"Homeobox genes and connective tissue patterning","volume":"121","author":"Oliver","year":"1995","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB25","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1242\/dev.121.12.4045","article-title":"Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development","volume":"121","author":"Oliver","year":"1995","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB26","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1242\/dev.124.2.271","article-title":"Induction of Drosophila eye development by decapentaplegic","volume":"124","author":"Pignoni","year":"1997","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB27","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1126\/science.7914031","article-title":"Homology of the eyeless gene of Drosophila to the small eye gene in mice and aniridia in humans","volume":"265","author":"Quiring","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB28","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0092-8674(88)90055-4","article-title":"Cell-cell interaction in the Drosophila retina","volume":"55","author":"Reinke","year":"1988","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB29","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/neu.480220503","article-title":"Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development","volume":"22","author":"Robinow","year":"1991","journal-title":"J. Neurobiol."},{"key":"10.1016\/S0092-8674(00)80480-8_BIB30","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/genetics\/138.4.1137","article-title":"Sine oculis is a homeobox gene required for Drosophila visual system development","volume":"138","author":"Serikaku","year":"1994","journal-title":"Genetics"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1242\/dev.124.1.45","article-title":"Ectopic eye development in Drosophila induced by directed dachshund expression","volume":"124","author":"Shen","year":"1997","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB32","first-page":"220","article-title":"Purification of glutathione-S-transferase fusion proteins","volume":"4","author":"Smith","year":"1983","journal-title":"Methods Mol. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80480-8_BIB33","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1242\/dev.124.2.343","article-title":"The Drosophila TGF alpha homolog Spitz acts in photoreceptor recruitment in the developing retina","volume":"124","author":"Tio","year":"1997","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB34","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/0092-8674(91)90284-6","article-title":"Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region","volume":"67","author":"Ton","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB35","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1242\/dev.122.7.2153","article-title":"Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye","volume":"122","author":"Wiersdorff","year":"1996","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB36","unstructured":"Wolff, T., and Ready, D.F. (1993). Pattern formation in the Drosophila retina. In The Development of Drosophila melanogaster, A. Martinez Arias and M. Bate, eds. (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory), pp. 1277\u20131325."},{"key":"10.1016\/S0092-8674(00)80480-8_BIB37","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1242\/dev.117.4.1223","article-title":"Analysis of genetic mosaics in developing and adult Drosophila tissues","volume":"117","author":"Xu","year":"1993","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB38","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1242\/dev.124.1.219","article-title":"Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode","volume":"124","author":"Xu","year":"1997","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB39","doi-asserted-by":"crossref","first-page":"11974","DOI":"10.1073\/pnas.94.22.11974","article-title":"Mouse Eya genes are expressed during limbs tendon development and encode a transcriptional activation function","volume":"94","author":"Xu","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80480-8_BIB40","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1101\/gr.7.2.128","article-title":"Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene","volume":"7","author":"Zimmerman","year":"1997","journal-title":"Genome Res."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400804808?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400804808?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:42:26Z","timestamp":1758796946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400804808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,12]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1997,12]]}},"alternative-id":["S0092867400804808"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)80480-8","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1997,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Eye-Specification Proteins So and Eya Form a Complex and Regulate Multiple Steps in Drosophila Eye Development","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0092-8674(00)80480-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1997 Cell Press.  All rights reserved.","name":"copyright","label":"Copyright"}]}}