{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:29:01Z","timestamp":1776785341232,"version":"3.51.2"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5280,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1999,2]]},"DOI":"10.1016\/s0092-8674(00)80545-0","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T16:23:03Z","timestamp":1086798183000},"page":"319-328","source":"Crossref","is-referenced-by-count":1773,"title":["A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin \u03b1v\u03b26 Binds and Activates Latent TGF \u03b21"],"prefix":"10.1016","volume":"96","author":[{"given":"John S","family":"Munger","sequence":"first","affiliation":[]},{"given":"Xiaozhu","family":"Huang","sequence":"additional","affiliation":[]},{"given":"Hisaaki","family":"Kawakatsu","sequence":"additional","affiliation":[]},{"given":"Mark J.D","family":"Griffiths","sequence":"additional","affiliation":[]},{"given":"Stephen L","family":"Dalton","sequence":"additional","affiliation":[]},{"given":"Jianfeng","family":"Wu","sequence":"additional","affiliation":[]},{"given":"Jean-Fran\u00e7ois","family":"Pittet","sequence":"additional","affiliation":[]},{"given":"Naftali","family":"Kaminski","sequence":"additional","affiliation":[]},{"given":"Chrystelle","family":"Garat","sequence":"additional","affiliation":[]},{"given":"Michael A","family":"Matthay","sequence":"additional","affiliation":[]},{"given":"Daniel B","family":"Rifkin","sequence":"additional","affiliation":[]},{"given":"Dean","family":"Sheppard","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)80545-0_BIB1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1006\/abio.1994.1042","article-title":"An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct","volume":"216","author":"Abe","year":"1994","journal-title":"Anal. Biochem."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB2","first-page":"1077","article-title":"Redox-mediated activation of latent transforming growth factor-beta 1","volume":"10","author":"Barcellos-Hoff","year":"1996","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB3","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1172\/JCI117045","article-title":"Transforming growth factor-beta activation in irradiated murine mammary gland","volume":"93","author":"Barcellos-Hoff","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB4","first-page":"1228","article-title":"Immunohistochemical detection of active transforming growth factor-beta in situ using engineered tissue","volume":"147","author":"Barcellos-Hoff","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/360361a0","article-title":"Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease","volume":"360","author":"Border","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80545-0_BIB6","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1242\/jcs.108.6.2241","article-title":"Expression of the \u03b2 6 integrin in development, neoplasia, and tissue repair suggests a role in epithelial remodeling","volume":"108","author":"Breuss","year":"1995","journal-title":"J. Cell Sci."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB7","doi-asserted-by":"crossref","first-page":"6642","DOI":"10.1073\/pnas.88.15.6642","article-title":"Transforming growth factor-beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis","volume":"88","author":"Broekelmann","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80545-0_BIB8","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1016\/S0021-9258(18)42622-1","article-title":"Characterization of the integrin \u03b1 v\u03b2 6 as a fibronectin-binding protein","volume":"267","author":"Busk","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/15419069409004430","article-title":"Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts","volume":"2","author":"Cone","year":"1994","journal-title":"Cell Adhes. Commun."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB10","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0092-8674(00)81460-9","article-title":"Thrombospondin-1 is a major activator of TGF-beta1 in vivo","volume":"93","author":"Crawford","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80545-0_BIB11","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1073\/pnas.88.2.580","article-title":"Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose-6-phosphate\/insulin-like growth factor type II receptor","volume":"88","author":"Dennis","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80545-0_BIB12","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1136\/thx.48.10.959","article-title":"Effect of antibody to transforming growth factor-beta on bleomycin induced accumulation of lung collagen in mice","volume":"48","author":"Giri","year":"1993","journal-title":"Thorax"},{"key":"10.1016\/S0092-8674(00)80545-0_BIB13","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nm0995-932","article-title":"Release and activation of platelet latent TGF-beta in blood clots during dissolution with plasmin","volume":"1","author":"Grainger","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB14","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1126\/science.2315700","article-title":"Requirement for activin A and transforming growth factor-beta 1 pro-region in homodimer assembly","volume":"247","author":"Gray","year":"1990","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80545-0_BIB15","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1083\/jcb.133.4.921","article-title":"Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin","volume":"133","author":"Huang","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB16","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1242\/jcs.111.15.2189","article-title":"The integrin alphavbeta6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin","volume":"111","author":"Huang","year":"1998","journal-title":"J. Cell Sci."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB17","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1165\/ajrcmb.19.4.3293","article-title":"Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout mice","volume":"19","author":"Huang","year":"1998","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB18","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/ng1295-415","article-title":"Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction","volume":"11","author":"Kaartinen","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1083\/jcb.121.2.439","article-title":"Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells","volume":"121","author":"Kojima","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB20","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1073\/pnas.90.2.770","article-title":"Transforming growth factor-beta 1 null mutation in mice causes excessive inflammatory response and early death","volume":"90","author":"Kulkarni","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80545-0_BIB21","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1083\/jcb.110.4.1361","article-title":"Mechanism of activation of latent recombinant transforming growth factor-beta 1 by plasmin","volume":"110","author":"Lyons","year":"1990","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB22","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1042\/bj3130343","article-title":"Structural characterization of the latent complex between transforming growth factor beta 1 and beta 1-latency-associated peptide","volume":"313","author":"McMahon","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB23","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1091\/mbc.4.9.953","article-title":"The extracellular matrix as a cell survival factor","volume":"4","author":"Meredith","year":"1993","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/S0092-8674(00)80545-0_BIB24","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1091\/mbc.9.9.2627","article-title":"Interactions between growth factors and integrins","volume":"9","author":"Munger","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/S0092-8674(00)80545-0_BIB25","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1083\/jcb.136.5.1151","article-title":"Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta","volume":"136","author":"Nunes","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB26","doi-asserted-by":"crossref","first-page":"10154","DOI":"10.1073\/pnas.90.21.10154","article-title":"Multiple integrins mediate cell attachment to cytotactin\/tenascin","volume":"90","author":"Prieto","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80545-0_BIB27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0092-8674(85)90322-8","article-title":"Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor","volume":"40","author":"Pytela","year":"1985","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80545-0_BIB28","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1242\/dev.124.13.2659","article-title":"TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes","volume":"124","author":"Sanford","year":"1997","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)80545-0_BIB29","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1083\/jcb.111.2.757","article-title":"Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells","volume":"111","author":"Sato","year":"1990","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB30","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1083\/jcb.122.4.923","article-title":"Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism","volume":"122","author":"Schultz-Cherry","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB31","doi-asserted-by":"crossref","first-page":"26783","DOI":"10.1016\/S0021-9258(18)47087-1","article-title":"The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta","volume":"269","author":"Schultz-Cherry","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB32","doi-asserted-by":"crossref","first-page":"7304","DOI":"10.1074\/jbc.270.13.7304","article-title":"Regulation of transforming growth factor-beta activation by discrete sequences of thrombospondin 1","volume":"270","author":"Schultz-Cherry","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB33","doi-asserted-by":"crossref","first-page":"17409","DOI":"10.1016\/S0021-9258(18)41941-2","article-title":"Transforming growth factor beta differentially regulates expression of integrin subunits in guinea pig airway epithelial cells","volume":"267","author":"Sheppard","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB34","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/359693a0","article-title":"Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease","volume":"359","author":"Shull","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80545-0_BIB35","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1172\/JCI119590","article-title":"Adenovector-mediated gene transfer of active transforming growth factor-\u03b2 1 induces prolonged severe fibrosis in rat lung","volume":"100","author":"Sime","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB36","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1177\/44.8.8756760","article-title":"Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils","volume":"44","author":"Taipale","year":"1996","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB37","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0065-230X(08)60740-X","article-title":"Extracellular matrix-associated transforming growth factor-beta","volume":"75","author":"Taipale","year":"1998","journal-title":"Adv. Cancer. Res."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB38","doi-asserted-by":"crossref","first-page":"7741","DOI":"10.1016\/S0021-9258(18)68561-8","article-title":"Transforming growth factor-beta1 positively regulates its own expression in normal and transformed cells","volume":"263","author":"Van Obberghen-Schilling","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB39","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1165\/ajrcmb.15.5.8918373","article-title":"Differential regulation of airway epithelial integrins by growth factors","volume":"15","author":"Wang","year":"1996","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB40","doi-asserted-by":"crossref","first-page":"6940","DOI":"10.1016\/S0021-9258(17)37465-3","article-title":"Role of the integrin alphaVbeta6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor","volume":"269","author":"Weinacker","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB41","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1083\/jcb.109.2.877","article-title":"Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression","volume":"109","author":"Werb","year":"1989","journal-title":"J. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80545-0_BIB42","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/0003-9861(61)90291-0","article-title":"The determination of hydroxyproline in tissue and protein samples containing small proportions of this amino acid","volume":"93","author":"Woessner","year":"1961","journal-title":"Arch. Biochem. Biophys."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400805450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400805450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T23:48:33Z","timestamp":1624405713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400805450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,2]]}},"alternative-id":["S0092867400805450"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)80545-0","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717970989.793469382","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1999,2]]}}}