{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:52:49Z","timestamp":1779353569600,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1999,3,1]],"date-time":"1999-03-01T00:00:00Z","timestamp":920246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":5251,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1999,3]]},"DOI":"10.1016\/s0092-8674(00)80574-7","type":"journal-article","created":{"date-parts":[[2004,4,10]],"date-time":"2004-04-10T09:39:29Z","timestamp":1081589969000},"page":"635-644","source":"Crossref","is-referenced-by-count":845,"title":["A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly"],"prefix":"10.1016","volume":"96","author":[{"given":"Manfred","family":"Koegl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Hoppe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Schlenker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helle D","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas U","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Jentsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)80574-7_BIB1","series-title":"Current Protocols in Molecular Biology","author":"Ausubel","year":"1994"},{"key":"10.1016\/S0092-8674(00)80574-7_BIB2","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1083\/jcb.133.6.1331","article-title":"Yeast ubiquitin-like genes are involved in duplication of the microtubule organizing center","volume":"133","author":"Biggins","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80574-7_BIB3","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1126\/science.2538923","article-title":"A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein","volume":"243","author":"Chau","year":"1989","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80574-7_BIB4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1006\/jmbi.1994.1169","article-title":"Structure of tetraubiquitin shows how multiubiquitin chains can be formed","volume":"236","author":"Cook","year":"1994","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0092-8674(00)80574-7_BIB5","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1074\/jbc.273.6.3562","article-title":"Involvement of valosin-containing protein, an ATPase co-purified with I \u03ba B \u03b1 and the 26S proteasome, in ubiquitin-proteasome-mediated degradation of I \u03ba B \u03b1","volume":"273","author":"Dai","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80574-7_BIB6","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0092-8674(87)90711-2","article-title":"The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses","volume":"48","author":"Finley","year":"1985","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80574-7_BIB7","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1083\/jcb.114.3.443","article-title":"Yeast cell cycle protein Cdc48p shows full length homology to the mammalian protein VCP and is a member of a protein family involved in secretion, peroxisome formation, and gene expression","volume":"114","author":"Fr\u00f6hlich","year":"1991","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80574-7_BIB8","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1002\/j.1460-2075.1996.tb00869.x","article-title":"Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin-mediated proteolysis in Saccharomyces cerevisiae","volume":"15","author":"Ghislain","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80574-7_BIB9","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.genet.30.1.405","article-title":"Ubiquitin-dependent protein degradation","volume":"30","author":"Hochstrasser","year":"1996","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/S0092-8674(00)80574-7_BIB10","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/0092-8674(95)90021-7","article-title":"Selective protein degradation","volume":"82","author":"Jentsch","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80574-7_BIB11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/329131a0","article-title":"The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme","volume":"329","author":"Jentsch","year":"1987","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80574-7_BIB12","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/j.1460-2075.1992.tb05080.x","article-title":"Ubiquitin as a degradation signal","volume":"11","author":"Johnson","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80574-7_BIB13","doi-asserted-by":"crossref","first-page":"17442","DOI":"10.1074\/jbc.270.29.17442","article-title":"A proteolytic pathway that recognizes ubiquitin as a degradation signal","volume":"270","author":"Johnson","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80574-7_BIB14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/361369a0","article-title":"Resistance to cadmium mediated by ubiquitin-dependent proteolysis","volume":"361","author":"Jungmann","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80574-7_BIB15","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","article-title":"Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism","volume":"392","author":"Kitada","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80574-7_BIB16","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1002\/j.1460-2075.1994.tb06452.x","article-title":"Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23","volume":"13","author":"Masutani","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80574-7_BIB17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/j.1460-2075.1991.tb07940.x","article-title":"UBA1","volume":"10","author":"McGrath","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80574-7_BIB18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/bms.1200230503","article-title":"Identification of proteins in polyacrylamide gels by mass spectrometric peptide mapping combined with database search","volume":"23","author":"Mortz","year":"1994","journal-title":"Biol. Mass. Spectrom."},{"key":"10.1016\/S0092-8674(00)80574-7_BIB19","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0168-9525(98)01473-5","article-title":"Combinatorial control in ubiquitin-dependent proteolysis","volume":"14","author":"Patton","year":"1998","journal-title":"Trends Genet."},{"key":"10.1016\/S0092-8674(00)80574-7_BIB20","doi-asserted-by":"crossref","first-page":"24131","DOI":"10.1074\/jbc.273.37.24131","article-title":"A novel component involved in ubiquitination is required for development of Dictyostelium discoideum","volume":"273","author":"Pukatzki","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80574-7_BIB21","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/35661","article-title":"Rad23 links DNA repair to the ubiquitin\/proteasome pathway","volume":"391","author":"Schauber","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80574-7_BIB22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/373081a0","article-title":"Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade","volume":"373","author":"Scheffner","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80574-7_BIB23","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/j.1460-2075.1990.tb08141.x","article-title":"Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins","volume":"9","author":"Seufert","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80574-7_BIB24","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1002\/j.1460-2075.1992.tb05379.x","article-title":"In vivo function of the proteasome in the ubiquitin pathway","volume":"11","author":"Seufert","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80574-7_BIB25","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1101\/gad.2.11.1476","article-title":"The RAD6 protein of Saccharomyces cerevisiae polyubiquitinates histones, and its acidic domain mediates this activity","volume":"2","author":"Sung","year":"1988","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)80574-7_BIB26","doi-asserted-by":"crossref","first-page":"6020","DOI":"10.1128\/MCB.16.11.6020","article-title":"The multiubiquitin-chain-binding protein Mcb1 is a component of the 26S proteasome in Saccharomyces cerevisiae and plays a nonessential, substrate-specific role in protein turnover","volume":"16","author":"van Nocker","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)80574-7_BIB27","doi-asserted-by":"crossref","first-page":"7757","DOI":"10.1128\/MCB.13.12.7757","article-title":"The Saccharomyces cerevisiae DNA repair gene RAD23 encodes a nuclear protein containing a ubiquitin-like domain required for biological function","volume":"13","author":"Watkins","year":"1993","journal-title":"Mol. Cell. Biol."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400805747?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400805747?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T23:07:36Z","timestamp":1585696056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400805747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1999,3]]}},"alternative-id":["S0092867400805747"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)80574-7","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1999,3]]}}}