{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:28:56Z","timestamp":1777436936315,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1999,3,1]],"date-time":"1999-03-01T00:00:00Z","timestamp":920246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5252,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1999,3]]},"DOI":"10.1016\/s0092-8674(00)80595-4","type":"journal-article","created":{"date-parts":[[2004,6,30]],"date-time":"2004-06-30T12:27:59Z","timestamp":1088598479000},"page":"857-868","source":"Crossref","is-referenced-by-count":5356,"title":["Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor"],"prefix":"10.1016","volume":"96","author":[{"given":"Anne","family":"Brunet","sequence":"first","affiliation":[]},{"given":"Azad","family":"Bonni","sequence":"additional","affiliation":[]},{"given":"Michael J","family":"Zigmond","sequence":"additional","affiliation":[]},{"given":"Michael Z","family":"Lin","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Juo","sequence":"additional","affiliation":[]},{"given":"Linda S","family":"Hu","sequence":"additional","affiliation":[]},{"given":"Michael J","family":"Anderson","sequence":"additional","affiliation":[]},{"given":"Karen C","family":"Arden","sequence":"additional","affiliation":[]},{"given":"John","family":"Blenis","sequence":"additional","affiliation":[]},{"given":"Michael E","family":"Greenberg","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)80595-4_BIB1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0014-5793(96)01370-1","article-title":"Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase","volume":"399","author":"Alessi","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/geno.1997.5122","article-title":"Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily","volume":"47","author":"Anderson","year":"1998","journal-title":"Genomics"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB3","doi-asserted-by":"crossref","first-page":"31515","DOI":"10.1074\/jbc.272.50.31515","article-title":"Role of translocation in the activation and function of protein kinase B","volume":"272","author":"Andjelkovic","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB4","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1126\/science.281.5381.1305","article-title":"Death receptors","volume":"281","author":"Ashkenazi","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/sj.onc.1200814","article-title":"Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)","volume":"14","author":"Borkhardt","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB6","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.282.5392.1318","article-title":"Regulation of cell death protease caspase-9 by phosphorylation","volume":"282","author":"Cardone","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB7","doi-asserted-by":"crossref","first-page":"6482","DOI":"10.1074\/jbc.273.11.6482","article-title":"Protein kinase B\/Akt mediates effects of insulin on hepatic insulin-like growth factor-binding protein-1 gene expression through a conserved insulin response sequence","volume":"273","author":"Cichy","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/B978-012312411-1\/50010-X","article-title":"Molecular mechanisms of neuronal survival and apoptosis","volume":"1","author":"Datta","year":"1998","journal-title":"Horm. Signaling"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0092-8674(00)80405-5","article-title":"Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery","volume":"91","author":"Datta","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB10","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1126\/science.278.5338.687","article-title":"Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt","volume":"278","author":"del Peso","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB11","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0955-0674(98)80149-X","article-title":"Mechanisms and consequences of activation of protein kinase B\/Akt","volume":"10","author":"Downward","year":"1998","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB12","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1126\/science.275.5300.661","article-title":"Regulation of neuronal survival by the serine-threonine protein kinase Akt","volume":"275","author":"Dudek","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB13","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/0092-8674(86)90786-5","article-title":"Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose","volume":"45","author":"Ellis","year":"1986","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB14","doi-asserted-by":"crossref","first-page":"134","DOI":"10.4049\/jimmunol.160.1.134","article-title":"The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression","volume":"160","author":"Faris","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB15","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/nm0596-574","article-title":"Involvement of the CD95 (APO-1\/FAS) receptor\/ligand system in drug-induced apoptosis in leukemia cells","volume":"2","author":"Friesen","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB16","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.biochem.67.1.481","article-title":"Phosphoinositide kinases","volume":"67","author":"Fruman","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB17","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/ng1193-230","article-title":"Fusion of a forkhead domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma","volume":"5","author":"Galili","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB18","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1182\/blood.V90.9.3714","article-title":"AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily","volume":"90","author":"Hillion","year":"1997","journal-title":"Blood"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB19","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1074\/jbc.273.8.4416","article-title":"Transcriptional regulation of the human FasL promoter-enhancer region","volume":"273","author":"Holtz-Heppelmann","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0092-8674(00)81873-5","article-title":"Programmed cell death in animal development","volume":"88","author":"Jacobson","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB21","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S1097-2765(00)80054-4","article-title":"DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-\u03baB and AP-1","volume":"1","author":"Kasibhatla","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB22","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/385544a0","article-title":"Suppression of the c-Myc-induced apoptosis by Ras signaling through PI(3)K and PKB","volume":"385","author":"Kauffmann-Zeh","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0022-2836(95)80047-6","article-title":"DNA recognition site analysis of Xenopus winged helix proteins","volume":"248","author":"Kaufmann","year":"1995","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB24","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1101\/gad.11.6.701","article-title":"The PI 3-kinase\/Akt signaling pathway delivers an anti-apoptotic signal","volume":"11","author":"Kennedy","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB25","first-page":"3307","article-title":"Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells","volume":"8","author":"Khanna","year":"1993","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB26","doi-asserted-by":"crossref","first-page":"31427","DOI":"10.1074\/jbc.272.50.31427","article-title":"Two NFAT transcription factor binding sites participate in the regulation of CD95 (Fas) ligand expression in activated human T cells","volume":"272","author":"Latinis","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB27","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1128\/MCB.19.1.751","article-title":"Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death","volume":"19","author":"Le-Niculescu","year":"1999","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB28","doi-asserted-by":"crossref","first-page":"27320","DOI":"10.1074\/jbc.273.42.27320","article-title":"Activation of protein kinase B\/Akt is sufficient to repress the glucocorticoid and cAMP induction of phosphoenolpyruvate carboxykinase gene","volume":"273","author":"Liao","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB29","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1126\/science.278.5341.1319","article-title":"daf-16","volume":"278","author":"Lin","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB30","series-title":"Molecular Cloning","author":"Maniatis","year":"1989"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB31","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1128\/MCB.18.7.3744","article-title":"Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression","volume":"18","author":"Mittelstadt","year":"1998","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB32","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0092-8674(95)90412-3","article-title":"Tumor suppressor p53 is a direct transcriptional activator of the human bax gene","volume":"80","author":"Miyashita","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0092-8674(00)81874-7","article-title":"Apoptosis by death factor","volume":"88","author":"Nagata","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB34","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1128\/MCB.15.3.1747","article-title":"Hepatic nuclear factor 3- and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes","volume":"15","author":"O\u2019Brien","year":"1995","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB35","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/40194","article-title":"The Forkhead transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans","volume":"389","author":"Ogg","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB36","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1002\/j.1460-2075.1994.tb06599.x","article-title":"Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1)","volume":"13","author":"Pag\u00e8s","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB37","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1101\/gad.12.16.2488","article-title":"Caenorhabditis elegans Akt\/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor","volume":"12","author":"Paradis","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB38","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1002\/j.1460-2075.1994.tb06827.x","article-title":"Cloning and characterization of seven human forkhead proteins","volume":"13","author":"Pierrou","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB39","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1046\/j.1432-1327.1998.2530399.x","article-title":"Molecular cloning and characterization of mouse caspase-8","volume":"253","author":"Sakamaki","year":"1998","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB40","doi-asserted-by":"crossref","first-page":"11345","DOI":"10.1073\/pnas.94.21.11345","article-title":"Interleukin 3-dependent survival by the Akt protein kinase","volume":"94","author":"Songyang","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB41","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1126\/science.7878463","article-title":"Mechanisms and genes of cellular suicide","volume":"267","author":"Steller","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB42","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.4049\/jimmunol.147.6.2047","article-title":"Tumor necrosis factor-alpha mRNA accumulation in human myelomonocytic cell lines. Role of transcriptional regulation by DNA sequence motifs and mRNA stabilization","volume":"147","author":"Sung","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/S0092-8674(00)80595-4_BIB43","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0092-8674(00)80487-0","article-title":"The structural basis for 14-3-3:phosphopeptide binding specificity","volume":"91","author":"Yaffe","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80595-4_BIB44","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/25147","article-title":"Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway","volume":"396","author":"Yano","year":"1998","journal-title":"Nature"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400805954?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400805954?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T22:47:50Z","timestamp":1682722070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400805954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,3]]}},"alternative-id":["S0092867400805954"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)80595-4","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1999,3]]}}}