{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:56:03Z","timestamp":1782820563273,"version":"3.54.5"},"reference-count":57,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5280,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[1999,2]]},"DOI":"10.1016\/s0092-8674(00)80658-3","type":"journal-article","created":{"date-parts":[[2004,8,10]],"date-time":"2004-08-10T15:55:49Z","timestamp":1092153349000},"page":"541-551","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":584,"title":["Putative Mammalian Taste Receptors"],"prefix":"10.1016","volume":"96","author":[{"given":"Mark A.","family":"Hoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Lindemeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Battey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.P.","family":"Ryba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Zuker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)80658-3_BIB1","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1126\/science.3194756","article-title":"A bitter substance induces a rise in intracellular calcium in a subpopulation of rat taste cells","volume":"242","author":"Akabas","year":"1988","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/331351a0","article-title":"Transduction in taste receptor cells requires cAMP-dependent protein kinase","volume":"331","author":"Avenet","year":"1988","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB3","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1126\/science.282.5396.2028","article-title":"Neurobiology of the Caenorhabditis elegans genome","volume":"282","author":"Bargmann","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB4","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/0031-9384(94)90361-1","article-title":"PTC\/PROP tasting","volume":"56","author":"Bartoshuk","year":"1994","journal-title":"Physiol. Behav"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB5","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1085\/jgp.96.5.1061","article-title":"Membrane currents in taste cells of the rat fungiform papilla. Evidence for two types of Ca currents and inhibition of K currents by saccharin","volume":"96","author":"B\u00e9h\u00e9","year":"1990","journal-title":"J. Gen. Physiol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1113\/jphysiol.1996.sp021147","article-title":"Changes in IP3 and cytosolic Ca2+ in response to sugars and non-sugar sweeteners in transduction of sweet taste in the rat","volume":"490","author":"Bernhardt","year":"1996","journal-title":"J. Physiol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/ar.1092120305","article-title":"Age does not affect numbers of taste buds and papillae in adult rhesus monkeys","volume":"212","author":"Bradley","year":"1985","journal-title":"Anat. Rec"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0006-8993(85)90212-4","article-title":"Inhibition by amiloride of chorda tympani responses evoked by monovalent salts","volume":"334","author":"Brand","year":"1985","journal-title":"Brain Res"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB9","series-title":"Physiologie du Go\u00f9t, ou M\u00e9ditations de Gastronomie Transcendante","author":"Brillat-Savarin","year":"1826"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB10","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/366575a0","article-title":"Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid","volume":"366","author":"Brown","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB11","doi-asserted-by":"crossref","first-page":"11987","DOI":"10.1073\/pnas.95.20.11987","article-title":"Cloning and localization of two multigene receptor families in goldfish olfactory epithelium","volume":"95","author":"Cao","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB12","doi-asserted-by":"crossref","first-page":"11067","DOI":"10.1073\/pnas.88.24.11067","article-title":"Isolation of Drosophila genes encoding G protein-coupled receptor kinases","volume":"88","author":"Cassill","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB13","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1523\/JNEUROSCI.16-12-03817.1996","article-title":"The taste of monosodium glutamate","volume":"16","author":"Chaudhari","year":"1996","journal-title":"J. Neurosci"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB14","doi-asserted-by":"crossref","unstructured":"Corey, D., and Zuker, C. (1996). Sensory systems. In Curr. Opin. Neurobiol., A. Aguayo and M. Raff, eds: Curr. Biol. 6, 437\u2013546.","DOI":"10.1016\/S0959-4388(96)80046-8"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB15","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/cne.902610411","article-title":"Ultrastructure of apical specializations of taste cells in the mudpuppy, Necturus maculosus","volume":"261","author":"Cummings","year":"1987","journal-title":"J. Comp. Neurol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB16","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1152\/jn.1996.75.3.1256","article-title":"Sweet taste transduction in hamster","volume":"75","author":"Cummings","year":"1996","journal-title":"J. Neurophysiol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB17","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1085\/jgp.107.4.545","article-title":"Distribution and characterization of functional amiloride-sensitive sodium channels in rat tongue","volume":"107","author":"Doolin","year":"1996","journal-title":"J. Gen. Physiol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0092-8674(95)90161-2","article-title":"A novel family of genes encoding putative pheromone receptors in mammals","volume":"83","author":"Dulac","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB19","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1152\/jn.1991.65.6.1452","article-title":"Taste-responsive neurons of the glossopharyngeal nerve of the rat","volume":"65","author":"Frank","year":"1991","journal-title":"J. Neurophysiol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB20","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1152\/jn.1983.50.4.941","article-title":"Nerve fibers sensitive to ionic taste stimuli in chorda tympani of the rat","volume":"50","author":"Frank","year":"1983","journal-title":"J. Neurophysiol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0006-8993(97)00974-8","article-title":"In situ tight-seal recordings of taste substance-elicited action currents and voltage-gated Ba currents from single taste bud cells in the peeled epithelium of mouse tongue","volume":"776","author":"Furue","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0165-0270(98)00104-6","article-title":"A method for in-situ tight-seal recordings from single taste bud cells of mice","volume":"84","author":"Furue","year":"1998","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB23","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1085\/jgp.100.5.803","article-title":"Proton currents through amiloride-sensitive Na channels in hamster taste cells. Role in acid transduction","volume":"100","author":"Gilbertson","year":"1992","journal-title":"J. Gen. Physiol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB24","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1126\/science.6691151","article-title":"Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway","volume":"223","author":"Heck","year":"1984","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB25","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0092-8674(00)80536-X","article-title":"A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution","volume":"90","author":"Herrada","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB26","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/BF01928657","article-title":"\u03c8ber die Verbreitung der Geschmackknospen beim Menchen","volume":"62","author":"Hoffmann","year":"1875","journal-title":"Arch. Pathol. Anat. Physiol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB27","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1177\/00220345970760040301","article-title":"Analysis and comparison of partial sequences of clones from a taste-bud-enriched cDNA library","volume":"76","author":"Hoon","year":"1997","journal-title":"J. Dent. Res"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB28","series-title":"Introduction to Umami","author":"Kawamura","year":"1987"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB29","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev.ph.54.030192.003435","article-title":"Chemosensory transduction mechanisms in taste","volume":"54","author":"Kinnamon","year":"1992","journal-title":"Annu. Rev. Physiol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB30","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0959-4388(96)80057-2","article-title":"Mechanisms of taste transduction","volume":"6","author":"Kinnamon","year":"1996","journal-title":"Curr. Opin. Neurobiol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB31","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/cne.902350105","article-title":"Ultrastructure of mouse vallate taste buds. I. taste cells and their associated synapses","volume":"235","author":"Kinnamon","year":"1985","journal-title":"J. Comp. Neurol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB32","doi-asserted-by":"crossref","first-page":"7023","DOI":"10.1073\/pnas.85.18.7023","article-title":"Apical localization of K+ channels in taste cells provides the basis for sour taste transduction","volume":"85","author":"Kinnamon","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.902700102","article-title":"Ultrastructure of mouse vallate taste buds","volume":"270","author":"Kinnamon","year":"1988","journal-title":"J. Comp. Neurol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB34","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0092-8674(00)81716-X","article-title":"Identification of ligands for olfactory receptors by functional expression of a receptor library","volume":"95","author":"Krautwurst","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB35","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0031-9384(87)90086-2","article-title":"The effect of bilateral sectioning of the chorda tympani and the greater superficial petrosal nerves on the sweet taste in the rat","volume":"41","author":"Krimm","year":"1987","journal-title":"Physiol. Behav"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB36","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1152\/physrev.1996.76.3.719","article-title":"Taste reception","volume":"76","author":"Lindemann","year":"1996","journal-title":"Physiol. Rev"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB37","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/S0960-9822(96)00704-X","article-title":"Chemoreception","volume":"6","author":"Lindemann","year":"1996","journal-title":"Curr. Biol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB38","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1017\/S0016672300020425","article-title":"The genetics of tasting in mice. I. sucrose octaacetate","volume":"38","author":"Lush","year":"1981","journal-title":"Genet. Res"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB39","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1017\/S0016672300026355","article-title":"The genetics of tasting in mice. III. quinine","volume":"44","author":"Lush","year":"1984","journal-title":"Genet. Res"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB40","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1017\/S0016672300027968","article-title":"The genetics of tasting in mice. VI. saccharin, acesulfame, dulcin and sucrose","volume":"53","author":"Lush","year":"1989","journal-title":"Genet. Res"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB41","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0092-8674(00)80537-1","article-title":"A multigene family encoding a diverse array of putative pheromone receptors in mammals","volume":"90","author":"Matsunami","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB42","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/357563a0","article-title":"Gustducin is a taste-cell-specific G protein closely related to the transducins","volume":"357","author":"McLaughlin","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB43","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/0031-9384(90)90374-D","article-title":"Variations in human taste bud density and taste intensity perception","volume":"47","author":"Miller","year":"1990","journal-title":"Physiol. Behav"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB44","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1101\/SQB.1996.061.01.016","article-title":"The molecular biology of olfactory perception","volume":"61","author":"Mombaerts","year":"1996","journal-title":"Cold Spring Harb. Symp. Quant. Biol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB45","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.1073\/pnas.95.9.5178","article-title":"Putative pheromone receptors related to the Ca2+-sensing receptor in Fugu","volume":"95","author":"Naito","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB46","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1126\/science.1329206","article-title":"Molecular diversity of glutamate receptors and implications for brain function","volume":"258","author":"Nakanishi","year":"1992","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB47","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/chemse\/11.3.283","article-title":"The neural activities of the greatersuperficial petrosal nerve of the rat in response to chemical stimulation of the palate","volume":"11","author":"Nejad","year":"1986","journal-title":"Chem. Senses"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB48","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF01206895","article-title":"Immunocytochemical localization of the L1 and N-CAM cell adhesion molecules and their shared carbohydrate epitope L2\/HNK-1 in the developing and differentiated gustatory papillae of the mouse tongue","volume":"21","author":"Nolte","year":"1992","journal-title":"J. Neurocytol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB49","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1523\/JNEUROSCI.17-10-03580.1997","article-title":"Bitter taste transduction of denatonium in the mudpuppy Necturus maculosus","volume":"17","author":"Ogura","year":"1997","journal-title":"J. Neurosci"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/cne.902700103","article-title":"Ultrastructure of mouse foliate taste buds","volume":"270","author":"Royer","year":"1988","journal-title":"J. Comp. Neurol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB51","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0896-6273(00)80946-0","article-title":"A new multigene family of putative pheromone receptors","volume":"19","author":"Ryba","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB52","first-page":"307","article-title":"The diversity of bitter taste signal transduction mechanisms","volume":"47","author":"Spielman","year":"1992","journal-title":"Soc. Gen. Physiol. Ser"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/ajpcell.1997.272.1.C1","article-title":"New perspectives in a gustatory physiology","volume":"272","author":"Stewart","year":"1997","journal-title":"Am. J. Physiol"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB54","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1042\/bj2600121","article-title":"Sweet tastants stimulate adenylate cyclase coupled to GTP-binding protein in rat tongue membranes","volume":"260","author":"Striem","year":"1989","journal-title":"Biochem. J"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB55","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0092-8674(95)90162-0","article-title":"Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans","volume":"83","author":"Troemel","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB56","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0092-8674(00)80399-2","article-title":"Reprogramming chemotaxis responses","volume":"91","author":"Troemel","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80658-3_BIB57","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/381796a0","article-title":"Transduction of bitter and sweet taste by gustducin","volume":"381","author":"Wong","year":"1996","journal-title":"Nature"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400806583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400806583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:50:31Z","timestamp":1758797431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400806583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,2]]}},"alternative-id":["S0092867400806583"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)80658-3","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1999,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Putative Mammalian Taste Receptors","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0092-8674(00)80658-3","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1999 Cell Press. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}