{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T12:41:41Z","timestamp":1779021701199,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1999,5,1]],"date-time":"1999-05-01T00:00:00Z","timestamp":925516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5191,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1999,5]]},"DOI":"10.1016\/s0092-8674(00)80769-2","type":"journal-article","created":{"date-parts":[[2004,4,10]],"date-time":"2004-04-10T09:39:29Z","timestamp":1081589969000},"page":"575-586","source":"Crossref","is-referenced-by-count":442,"title":["Induction of GADD45 and JNK\/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1"],"prefix":"10.1016","volume":"97","author":[{"given":"D.Paul","family":"Harkin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M","family":"Bean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Miklos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Han","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivi B","family":"Truong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Englert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred C","family":"Christians","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leif W","family":"Ellisen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyamala","family":"Maheswaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D","family":"Oliner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A","family":"Haber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)80769-2_BIB1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/930","article-title":"BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A","volume":"19","author":"Anderson","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)80769-2_BIB2","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/382678a0","article-title":"Transcriptional activation by BRCA1","volume":"382","author":"Chapman","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB3","doi-asserted-by":"crossref","first-page":"31929","DOI":"10.1074\/jbc.271.50.31929","article-title":"The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation","volume":"271","author":"Chen","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80769-2_BIB4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1097-2765(00)80114-8","article-title":"A genome-wide transcriptional analysis of the mitotic cell cycle","volume":"2","author":"Cho","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB5","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(93)90500-P","article-title":"WAF1, a potential mediator of p53 tumor suppression","volume":"75","author":"El-Deiry","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB6","doi-asserted-by":"crossref","first-page":"8800","DOI":"10.1073\/pnas.85.23.8800","article-title":"DNA damage-inducible transcripts in mammalian cells","volume":"85","author":"Fornace","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB7","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.1073\/pnas.89.12.5547","article-title":"Tight control of gene expression in mammalian cells by tetracylcline-responsive promoters","volume":"89","author":"Gossen","year":"1992","journal-title":"Proc. Natl. Acad. Sci USA"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB8","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0092-8674(00)81302-1","article-title":"The tumor suppressor gene BRCA1 is required for embryonic cellular proliferation in the mouse","volume":"85","author":"Hakem","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB9","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/ng0797-298","article-title":"Partial rescue of a BRCA15-6 early embryonic lethality by p53 or p21 null mutation","volume":"16","author":"Hakem","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)80769-2_BIB10","doi-asserted-by":"crossref","first-page":"24385","DOI":"10.1016\/S0021-9258(20)80537-7","article-title":"Analysis of the mammalian gadd45 gene and its reponse to DNA damage","volume":"268","author":"Hollander","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80769-2_BIB11","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/ng0396-298","article-title":"Growth retardation and tumour inhibition by BRCA1","volume":"12","author":"Holt","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)80769-2_BIB12","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/bjc.1998.99","article-title":"Prognostic role of clinical, pathological and biological characteristics in patients with locally advanced breast cancer","volume":"77","author":"Honkoop","year":"1998","journal-title":"Br. J. Cancer"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB13","doi-asserted-by":"crossref","first-page":"12983","DOI":"10.1073\/pnas.95.22.12983","article-title":"BRCA1 is associated with the centrosome during mitosis","volume":"95","author":"Hsu","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.283.5398.83","article-title":"The transcriptional program in the response of human fibroblasts to serum","volume":"283","author":"Iyer","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB15","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0165-4608(97)00267-7","article-title":"Loss of nuclear BRCA1 expression in breast cancers is associated with a highly proliferative tumor phenotype","volume":"101","author":"Jarvis","year":"1998","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/S0092-8674(00)80769-2_BIB16","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0092-8674(92)90593-2","article-title":"A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia","volume":"71","author":"Kastan","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB17","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1101\/gad.9.21.2712","article-title":"Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice","volume":"9","author":"Lane","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)80769-2_BIB18","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1038\/sj.onc.1201834","article-title":"Stress-induced immediate-early gene, EGR1, involves activation of p38\/JNK1","volume":"4","author":"Lim","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB19","first-page":"2112","article-title":"Inactivation of the mouse BRCA1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development","volume":"90","author":"Liu","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)80769-2_BIB20","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1038\/nbt1296-1675","article-title":"Expression monitoring by hybridization to high-density oligonucleotide arrays","volume":"14","author":"Lockhart","year":"1996","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/S0092-8674(00)80769-2_BIB21","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1101\/gad.11.10.1226","article-title":"Targeted mutations of breast cancer susceptibility gene homologs in mice","volume":"11","author":"Ludwig","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)80769-2_BIB22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng0995-17","article-title":"The developmental pattern of BRCA1 expression implies a role in differentiation of the breast and other tissues","volume":"11","author":"Marquis","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)80769-2_BIB23","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.7545954","article-title":"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1","volume":"266","author":"Miki","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB24","doi-asserted-by":"crossref","first-page":"13595","DOI":"10.1073\/pnas.93.24.13595","article-title":"Evidence for a transcriptional activation function of BRCA1 C-terminal region Proc","volume":"93","author":"Monteiro","year":"1996","journal-title":"Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB25","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1073\/pnas.95.5.2302","article-title":"BRCA1 regulates p53-dependent gene expression","volume":"95","author":"Ouichi","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB26","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1126\/science.274.5290.1194","article-title":"Ultraviolet light and osmotic stress","volume":"275","author":"Rosette","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB27","doi-asserted-by":"crossref","first-page":"7138","DOI":"10.1073\/pnas.94.14.7138","article-title":"BRCA1 is a cell cycle-regulated nuclear phosphoprotein","volume":"94","author":"Ruffner","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB28","doi-asserted-by":"crossref","first-page":"5605","DOI":"10.1073\/pnas.94.11.5605","article-title":"BRCA1 is a component of the RNA polymerase II holoenzyme","volume":"94","author":"Scully","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0092-8674(00)81847-4","article-title":"Association of BRCA1 with Rad51 in mitotic and meiotic cells","volume":"88","author":"Scully","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB30","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0092-8674(00)80503-6","article-title":"Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage","volume":"90","author":"Scully","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB31","first-page":"1","article-title":"Induction of apoptosis by the tumor suppressor protein BRCA1","volume":"13","author":"Shao","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/38291","article-title":"Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1\/CIP1","volume":"389","author":"Somasundaram","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB33","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0092-8674(00)81619-0","article-title":"A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1\/MEKK4 MAPKKK","volume":"95","author":"Takekawa","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB34","first-page":"801","article-title":"Induction of phosphorylation on BRCA1 during the cell cycle and after DNA damage","volume":"8","author":"Thomas","year":"1997","journal-title":"Cell Growth Differ."},{"key":"10.1016\/S0092-8674(00)80769-2_BIB35","first-page":"3237","article-title":"Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier","volume":"58","author":"Tomlinson","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)80769-2_BIB36","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1126\/science.270.5235.484","article-title":"Serial analysis of gene expression","volume":"270","author":"Velculescu","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB37","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1038\/sj.onc.1202403","article-title":"BRCA1 binds c-myc and inhibits its transcriptional and transforming activity in cells","volume":"17","author":"Wang","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.onc.1200924","article-title":"Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-D11b","volume":"14","author":"Wilson","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB39","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/nbt1297-1359","article-title":"Genome-wide expression monitoring in Saccharomyces cerevisiae","volume":"15","author":"Wodicka","year":"1997","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/S0092-8674(00)80769-2_BIB40","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/ng1296-430","article-title":"Identification of a RING protein that can interact in vivo with the BRCA1 gene product","volume":"14","author":"Wu","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(00)80769-2_BIB41","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S1097-2765(00)80466-9","article-title":"Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells","volume":"3","author":"Xu","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB42","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/372798a0","article-title":"Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1","volume":"372","author":"Yan","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)80769-2_BIB43","doi-asserted-by":"crossref","first-page":"25388","DOI":"10.1074\/jbc.273.39.25388","article-title":"The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression","volume":"273","author":"Yu","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)80769-2_BIB44","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1038\/sj.onc.1201932","article-title":"BRCA1 physically associates ewith p53 and stimulates its transcriptional activity","volume":"16","author":"Zhang","year":"1998","journal-title":"Oncogene"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400807692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400807692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T13:46:27Z","timestamp":1623764787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400807692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1999,5]]}},"alternative-id":["S0092867400807692"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)80769-2","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1999,5]]}}}