{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:00:50Z","timestamp":1767848450070,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1996,3,1]],"date-time":"1996-03-01T00:00:00Z","timestamp":825638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1996,3,1]],"date-time":"1996-03-01T00:00:00Z","timestamp":825638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2001,4,11]],"date-time":"2001-04-11T00:00:00Z","timestamp":986947200000},"content-version":"vor","delay-in-days":1867,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[1996,3]]},"DOI":"10.1016\/s0092-8674(00)81052-1","type":"journal-article","created":{"date-parts":[[2004,4,10]],"date-time":"2004-04-10T05:39:29Z","timestamp":1081575569000},"page":"745-755","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":450,"title":["Inactivation of NMDA Receptors by Direct Interaction of Calmodulin with the NR1 Subunit"],"prefix":"10.1016","volume":"84","author":[{"given":"Michael D","family":"Ehlers","sequence":"first","affiliation":[]},{"given":"Su","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Jeffrey P","family":"Bernhardt","sequence":"additional","affiliation":[]},{"given":"Richard L","family":"Huganir","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)81052-1_BIB1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0092-8674(92)90546-O","article-title":"The MARCKS brothers","volume":"71","author":"Aderem","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0896-6273(95)90056-X","article-title":"Mechanism for a sliding synaptic modification threshold","volume":"15","author":"Bear","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB3","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1111\/j.1471-4159.1992.tb09370.x","article-title":"Biochemical characterization and localization of a non-N-methyl-D-aspartate glutamate receptor subunit in rat brain","volume":"58","author":"Blackstone","year":"1992","journal-title":"J. Neurochem."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","article-title":"A synaptic model of memory","volume":"361","author":"Bliss","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB5","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/368545a0","article-title":"Direct modulation by Ca2+-calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons","volume":"368","author":"Chen","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0166-2236(95)80018-W","article-title":"Calcium","volume":"18","author":"Choi","year":"1995","journal-title":"Trends Neurosci."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0031-6997(25)00025-0","article-title":"Excitatory amino acid receptors in the vertebrate central nervous system","volume":"41","author":"Collingridge","year":"1989","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.ne.13.030190.001021","article-title":"Patterned activity, synaptic convergence, and the NMDA receptor in developing visual pathways","volume":"13","author":"Constantine-Paton","year":"1990","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB9","doi-asserted-by":"crossref","first-page":"9359","DOI":"10.1073\/pnas.89.19.9359","article-title":"Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C","volume":"89","author":"Durand","year":"1992","journal-title":"Proc. Natl. Aca. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB10","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1126\/science.7569904","article-title":"Regulated subcellular distribution of the NR1 subunit of the NMDA receptor","volume":"269","author":"Ehlers","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB11","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/0896-6273(93)90209-A","article-title":"Zinc potentiates agonist-induced currents at certain splice variants of the NMDA receptor","volume":"10","author":"Hollmann","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev.ne.17.030194.000335","article-title":"Cloned glutamate receptors","volume":"17","author":"Hollmann","year":"1994","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0968-0004(00)88949-5","article-title":"Calmodulin-binding domains","volume":"20","author":"James","year":"1995","journal-title":"Trends Biochem."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB14","doi-asserted-by":"crossref","first-page":"10638","DOI":"10.1016\/S0021-9258(18)33870-5","article-title":"Ca2+-dependent interaction of 5-dimethylaminonaphthalene-1-sulfonyl-calmodulin with cyclic nucleotide phosphodiesterase, calcineurin, and troponin I","volume":"257","author":"Kincaid","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/358036a0","article-title":"Molecular diversity of the NMDA receptor channel","volume":"358","author":"Kutsuwada","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB16","doi-asserted-by":"crossref","first-page":"20036","DOI":"10.1074\/jbc.270.34.20036","article-title":"Differential tyrosine phosphorylation of N-methyl-D-aspartate receptor subunits","volume":"270","author":"Lau","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB17","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1523\/JNEUROSCI.14-05-03180.1994","article-title":"Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA","volume":"14","author":"Laurie","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB18","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1523\/JNEUROSCI.13-02-00674.1993","article-title":"Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium","volume":"13","author":"Legendre","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB19","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/369235a0","article-title":"Regulation of NMDA channel function by endogenous Ca2+-dependent phosphatase","volume":"369","author":"Lieberman","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB20","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1126\/science.266.5189.1348","article-title":"Calcium-calmodulin modulation of the olfactory cyclic nucleotide\u2013gated cation channel","volume":"266","author":"Liu","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB21","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/321519a0","article-title":"NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurons","volume":"321","author":"MacDermott","year":"1986","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/309261a0","article-title":"Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurons","volume":"309","author":"Mayer","year":"1984","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1113\/jphysiol.1985.sp015633","article-title":"The action of N-methyl-D-aspartic acid on mouse spinal neurones in culture","volume":"361","author":"Mayer","year":"1985","journal-title":"J. Physiol."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB24","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1113\/jphysiol.1995.sp020540","article-title":"Calcium-dependent inactivation of heteromeric NMDA receptor-channels expressed in human embryonic kidney cells","volume":"482","author":"Medina","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/357070a0","article-title":"Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs","volume":"357","author":"Meguro","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB26","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1126\/science.256.5060.1217","article-title":"Heteromeric NMDA receptors - molecular and functional distinction of subtypes","volume":"256","author":"Monyer","year":"1992","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/354031a0","article-title":"Molecular cloning and characterization of the rat NMDA receptor","volume":"354","author":"Moriyoshi","year":"1991","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB28","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1523\/JNEUROSCI.14-02-00667.1994","article-title":"Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody","volume":"14","author":"Petralia","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB29","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1126\/science.1703661","article-title":"ACh receptor-rich membrane domains organized in fibroblasts by recombinant 43-kilodalton protein","volume":"251","author":"Phillips","year":"1991","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB30","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0959-4388(94)90100-7","article-title":"Glutamate receptor phosphorylation and synaptic plasticity","volume":"4","author":"Roche","year":"1994","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB31","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1113\/jphysiol.1993.sp019884","article-title":"Rundown of N-methyl-D-aspartate channels during whole-cell recording in rat hippocampal neurons","volume":"470","author":"Rosenmund","year":"1993","journal-title":"J. Physiol."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB32","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0896-6273(93)90197-Y","article-title":"Calcium-induced actin depolymerization reduces NMDA channel activity","volume":"10","author":"Rosenmund","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB33","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0166-2236(93)90093-2","article-title":"The TINS\/TiPS lecture","volume":"16","author":"Seeburg","year":"1993","journal-title":"Trends Neurosci."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB34","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/368144a0","article-title":"Changing subunit compostion of heteromeric NMDA receptors during development of rat cortex","volume":"368","author":"Sheng","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB35","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/0006-291X(92)91701-Q","article-title":"Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing","volume":"185","author":"Sugihara","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB36","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/364070a0","article-title":"Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain","volume":"364","author":"Tingley","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB37","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1126\/science.7878472","article-title":"Synaptic desensitization of NMDA receptors by calcineurin","volume":"267","author":"Tong","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB38","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1126\/science.7754371","article-title":"Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines","volume":"268","author":"Traynelis","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81052-1_BIB39","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1113\/jphysiol.1993.sp019876","article-title":"Calcium-mediated modulation of N-methyl-D-aspartate (NMDA) responses in cultured rat hippocampal neurones","volume":"470","author":"Vyklicky","year":"1993","journal-title":"J. Physiol."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB40","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0959-4388(93)90120-N","article-title":"Mammalian ionotropic glutamate receptors","volume":"3","author":"Wisden","year":"1993","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/S0092-8674(00)81052-1_BIB41","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF00711446","article-title":"Calcium- dependent, slow desensitization distinguishes different types of glutamate receptors","volume":"9","author":"Zorumski","year":"1989","journal-title":"Cell. Mol. Neurobiol."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400810521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400810521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:42:11Z","timestamp":1758796931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400810521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["S0092867400810521"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)81052-1","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1996,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inactivation of NMDA Receptors by Direct Interaction of Calmodulin with the NR1 Subunit","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0092-8674(00)81052-1","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1996 Cell Press.  All rights reserved.","name":"copyright","label":"Copyright"}]}}