{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:28:29Z","timestamp":1776263309034,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1996,3,1]],"date-time":"1996-03-01T00:00:00Z","timestamp":825638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":6347,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1996,3]]},"DOI":"10.1016\/s0092-8674(00)81069-7","type":"journal-article","created":{"date-parts":[[2004,4,10]],"date-time":"2004-04-10T09:39:29Z","timestamp":1081589969000},"page":"911-921","source":"Crossref","is-referenced-by-count":870,"title":["Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth"],"prefix":"10.1016","volume":"84","author":[{"given":"Chuxia","family":"Deng","sequence":"first","affiliation":[]},{"given":"Anthony","family":"Wynshaw-Boris","sequence":"additional","affiliation":[]},{"given":"Fen","family":"Zhou","sequence":"additional","affiliation":[]},{"given":"Ann","family":"Kuo","sequence":"additional","affiliation":[]},{"given":"Philip","family":"Leder","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)81069-7_BIB1","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1083\/jcb.126.6.1611","article-title":"Parathyroid hormone-related peptide- depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation","volume":"126","author":"Amizuka","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(05)80085-6","article-title":"Role of insulin-like growth factors in embryonic and postnatal growth","volume":"75","author":"Baker","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB3","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0092-8674(86)90779-8","article-title":"Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185","volume":"45","author":"Bargmann","year":"1986","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0065-230X(08)60305-X","article-title":"The FGF family of growth factors and oncogenes","volume":"59","author":"Basilico","year":"1992","journal-title":"Adv. Canc. Res."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB5","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng0795-357","article-title":"A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia","volume":"10","author":"Bellus","year":"1995","journal-title":"Nature Genet."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB6","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.bi.58.070189.003043","article-title":"The heparin-binding (fibroblast) growth factor family of proteins","volume":"58","author":"Burgess","year":"1989","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB7","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1126\/science.2660260","article-title":"Altering the genome by homologous recombination","volume":"244","author":"Capecchi","year":"1989","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB8","doi-asserted-by":"crossref","first-page":"11620","DOI":"10.1016\/S0021-9258(19)78170-8","article-title":"Fibroblast growth factor receptor (FGFR-) 3","volume":"269","author":"Chellaiah","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/ajmg.1320550203","article-title":"Syndrome of proximal interstitial deletion 4p15","volume":"55","author":"Chitayat","year":"1995","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB10","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1128\/MCB.12.8.3365","article-title":"Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus","volume":"12","author":"Deng","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB11","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1101\/gad.8.24.3045","article-title":"Murine FGFR-1 is required for early post-implantation growth and axial organization","volume":"8","author":"Deng","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB12","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0092-8674(95)90487-5","article-title":"Toward a molecular understanding of skeletal development","volume":"80","author":"Erlebacher","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB13","unstructured":"Gilbert, S.F. (1994). Osteogenesis: The Development of Bones. Developmental Biology, Fourth Ed. (Sunderland, MA: Sinauer Associates)."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB14","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/365056a0","article-title":"Spondylometaphyseal dysplasia in mice carrying a dominant negative mutation in a matrix protein specific for cartilage-to-bone transition","volume":"365","author":"Jacenko","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1101\/gad.8.3.277","article-title":"Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene","volume":"8","author":"Karaplis","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0092-8674(92)90510-J","article-title":"The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF\u03b2 superfamily","volume":"71","author":"Kingsley","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0092-8674(95)90492-1","article-title":"A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis","volume":"80","author":"Li","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB18","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1073\/pnas.90.1.60","article-title":"Activation of glucose transport by a natural mutation in the human insulin receptor","volume":"90","author":"Longo","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB19","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/0168-9525(91)90221-B","article-title":"The DVR gene family in embryonic development","volume":"7","author":"Lyons","year":"1991","journal-title":"Trends Genet."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB20","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/336348a0","article-title":"Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells","volume":"336","author":"Mansour","year":"1988","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB21","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0092-8674(94)90520-7","article-title":"The ins and outs of fibroblast growth factors","volume":"78","author":"Mason","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/jmg.10.1.11","article-title":"Observations suggesting allelism of the hypochondroplasia and achondroplasia genes","volume":"10","author":"McKusick","year":"1973","journal-title":"J. Med. Genet."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/tera.1420220306","article-title":"Differential staining of cartilage and bone in whole mouse fetuses by alsian blue and alizarin red S","volume":"22","author":"McLeod","year":"1980","journal-title":"Teratol."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB24","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0168-9525(00)89088-5","article-title":"Fibroblast-growth-factor receptor mutations in human skeletal disorders","volume":"11","author":"Muenke","year":"1995","journal-title":"Trends Genet."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB25","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1126\/science.3523759","article-title":"Regulation by growth hormone of a number of chondrocytes containing IGF-I in rat growth plate","volume":"233","author":"Nilsson","year":"1986","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB26","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1136\/jmg.16.2.140","article-title":"Achondroplasia and hypochondroplasia","volume":"16","author":"Oberklaid","year":"1979","journal-title":"J. Med. Genet."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB27","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1136\/jmg.23.4.328","article-title":"The birth prevalence rates for the skeletal dysplasias","volume":"23","author":"Orioli","year":"1979","journal-title":"J. Med. Genet."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB28","doi-asserted-by":"crossref","first-page":"16305","DOI":"10.1016\/S0021-9258(18)42001-7","article-title":"Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3","volume":"267","author":"Ornitz","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB29","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1242\/dev.113.4.1419","article-title":"Developmental expression of two murine fibroblast growth factor receptors and bek","volume":"113","author":"Orr-Urtreger","year":"1991","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB30","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/j.1460-2075.1991.tb07654.x","article-title":"FGFR-1, a novel acidic fibroblast growth factor receptor with a distinct expression pattern","volume":"10","author":"Partanen","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1242\/dev.114.1.233","article-title":"Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse","volume":"114","author":"Peters","year":"1992","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB32","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1006\/dbio.1993.1040","article-title":"Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis","volume":"155","author":"Peters","year":"1993","journal-title":"Dev. Biol."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB33","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0168-9525(92)90197-C","article-title":"The BMP proteins in bone formation and repair","volume":"8","author":"Rosen","year":"1992","journal-title":"Trends Genet."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB34","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/371252a0","article-title":"Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia","volume":"371","author":"Rousseau","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/ng0595-11","article-title":"Stop codon FGFR-3 mutations in thanatophoric, dwarfism type 1","volume":"10","author":"Rousseau","year":"1995","journal-title":"Nature Genet."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB36","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0092-8674(94)90302-6","article-title":"Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia","volume":"78","author":"Shiang","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB37","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1242\/dev.113.2.641","article-title":"FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse","volume":"113","author":"Stark","year":"1991","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB38","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/368639a0","article-title":"Limb alterations in brachypodism mice due to mutations in a new member of the TGF\u03b2-superfamily","volume":"368","author":"Storm","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB39","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/ng0395-321","article-title":"Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3","volume":"9","author":"Tavormina","year":"1995","journal-title":"Nature Genet."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB40","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1073\/pnas.89.11.5128","article-title":"Highly efficient targeting in embryonic stem cells via homologous recombination with isogenic DNA constructs","volume":"89","author":"teRiele","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB41","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/0092-8674(91)90011-M","article-title":"Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene","volume":"65","author":"Tybulewicz","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81069-7_BIB42","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1096\/fasebj.5.13.1916105","article-title":"Collagen family of proteins","volume":"5","author":"van der Rest","year":"1991","journal-title":"FASEB J."},{"key":"10.1016\/S0092-8674(00)81069-7_BIB43","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1101\/gad.1.7.693","article-title":"Localized expression of the arterial factor gene during cardiac embryogenesis","volume":"1","author":"Zeller","year":"1987","journal-title":"Genes Dev."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400810697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400810697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T13:53:45Z","timestamp":1623765225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400810697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["S0092867400810697"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)81069-7","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1996,3]]}}}