{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T07:27:55Z","timestamp":1779348475608,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5617,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1998,3]]},"DOI":"10.1016\/s0092-8674(00)81132-0","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T16:23:03Z","timestamp":1086798183000},"page":"645-656","source":"Crossref","is-referenced-by-count":488,"title":["Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes"],"prefix":"10.1016","volume":"92","author":[{"given":"Kazuaki","family":"Takaku","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F","family":"Seldin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto M","family":"Taketo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)81132-0_BIB1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s003359900465","article-title":"Sequence and chromosomal mapping of the mouse homolog (Madh4) of the human DPC4\/MADH4 gene","volume":"8","author":"Anna","year":"1997","journal-title":"Mammal. Genome"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB2","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1001\/archsurg.1991.01410310035004","article-title":"Prognosis of symptomatic duodenal adenomas in familial adenomatous polyposis","volume":"126","author":"Beckwith","year":"1991","journal-title":"Arch. Surg."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB3","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1101\/SQB.1986.051.01.096","article-title":"Molecular genetics of human familial cancer","volume":"51","author":"Cavenee","year":"1986","journal-title":"Cold Spring Harbor Symp. Quant. Biol."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB4","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1172\/JCI113130","article-title":"Hepatic processing of transforming growth factor \u03b2 in the rat","volume":"80","author":"Coffey","year":"1987","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0092-8674(00)81335-5","article-title":"Nomenclature","volume":"87","author":"Derynck","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB6","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0092-8674(00)80128-2","article-title":"MADR2 maps to 18q21 and encodes a TGF\u03b2-regulated MAD-related protein that is functionally mutated in colorectal carcinoma","volume":"86","author":"Eppert","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB7","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/386796a0","article-title":"Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene","volume":"386","author":"Fazeli","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB8","series-title":"Tumors of the Intestines","author":"Fenoglio-Preiser","year":"1990"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB9","first-page":"123","article-title":"Development of resistance mechanisms to the growth-inhibitory effects of transforming growth factor-\u03b2 during tumor progression","volume":"5","author":"Filmus","year":"1993","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB10","first-page":"521","article-title":"Overexpression of H-ras oncogene induces resistance to the growth inhibitory action of transforming growth factor beta-1 (TGF-\u03b21) and alters the number and type of TGF-\u03b21 receptors in rat intestinal epithelial cell clones","volume":"7","author":"Filmus","year":"1992","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB11","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1016\/0016-5085(93)91084-U","article-title":"Enhanced expression of transforming growth factor \u03b2 isoforms in pancreatic cancer correlates with decreased survival","volume":"105","author":"Friess","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB12","first-page":"493","article-title":"Resistance to inhibition of cell growth by transforming growth factor-\u03b2 and its role in oncogenesis","volume":"4","author":"Fynan","year":"1993","journal-title":"Crit. Rev. Onc."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB50","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/BF00352361","article-title":"Mapping of the Hmg1 gene and of seven related sequences in the mouse","volume":"6","author":"Gariboldi","year":"1995","journal-title":"Mammal. Genome"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB13","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0092-8674(81)90021-0","article-title":"Identification and characterization of the familial adenomatous polyposis coli gene","volume":"66","author":"Groden","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB14","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1126\/science.271.5247.350","article-title":"DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1","volume":"271","author":"Hahn","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB15","first-page":"6696","article-title":"Frequent somatic mutations of the APC gene in human pancreatic cancer","volume":"52","author":"Horii","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB16","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/j.1349-7006.1992.tb02753.x","article-title":"Physical ordering of three polymorphic DNA markers spanning the regions containing a tumor suppressor gene of renal cell carcinoma by three-color fluorescent in situ hybridization","volume":"83","author":"Inazawa","year":"1992","journal-title":"Jpn. J. Cancer Res."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB17","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0140-6736(88)91962-9","article-title":"Upper gastrointestinal cancer in familial adenomatous polyposis","volume":"1","author":"Jagelman","year":"1988","journal-title":"Lancet"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ijc.2910490124","article-title":"TGF\u03b21 and TGF\u03b22 are potential growth regulators for low-grade and malignant gliomas in vitro","volume":"49","author":"Jennings","year":"1991","journal-title":"Int. J. Cancer"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB19","doi-asserted-by":"crossref","first-page":"S295","DOI":"10.1007\/s003359900330","article-title":"Mouse chromosome 18","volume":"7","author":"Johnson","year":"1997","journal-title":"Mammal. Genome"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB20","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1126\/science.2895499","article-title":"Absence of TGF-\u03b2 receptors and growth inhibitory responses in retinoblastoma cells","volume":"240","author":"Kimchi","year":"1988","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)81333-1","article-title":"Lessons from hereditary colorectal cancer","volume":"87","author":"Kinzler","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB22","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1126\/science.1651562","article-title":"Identification of FAP locus genes from chromosome 5q21","volume":"253","author":"Kinzler","year":"1991","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB23","unstructured":"Kloppel, G. (1993). Pathology of nonendocrine pancreatic tumors. In The Pancreas: Biology, Pathobiology, and Disease, V.L.W. Go, E.P. DiMagno, J.D. Gardner, E. Lebenthal, H.A. Reber, and G.A. Scheele, eds. (New York: Raven Press), pp. 871\u2013897."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB24","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/383832a0","article-title":"Partnership between DPC4 and SMAD proteins in TGF-\u03b2 signaling pathways","volume":"383","author":"Lagna","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB25","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1006\/bbrc.1995.2644","article-title":"Mutations of the transforming growth factor-\u03b2 type II receptor gene and genomic instability in hereditary nonpolyposis colorectal cancer","volume":"216","author":"Lu","year":"1995","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1006\/geno.1993.1002","article-title":"Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse","volume":"15","author":"Luongo","year":"1993","journal-title":"Genomics"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB27","first-page":"5947","article-title":"Loss of Apc+ in intestinal adenomas from Min mice","volume":"54","author":"Luongo","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB28","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1172\/JCI117048","article-title":"A benign cultured colon adenoma bears three genetically altered colon cancer oncogenes, but progresses to tumorigenicity and transforming growth factor-beta independence without inactivating the p53 tumor suppressor gene","volume":"93","author":"Markowitz","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB29","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1126\/science.7761852","article-title":"Inactivation of the type II TGF-\u03b2 receptor in colon cancer cells with microsatellite instability","volume":"268","author":"Markowitz","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0962-8924(97)01036-2","article-title":"TGF-\u03b2 signaling through the Smad pathway","volume":"7","author":"Massague","year":"1997","journal-title":"Trends Cell Biol."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB31","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1101\/gad.9.24.3027","article-title":"Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis","volume":"9","author":"Mishina","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB32","first-page":"M31","article-title":"Cancer gets Mad","volume":"1288","author":"Moskaluk","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB33","first-page":"7120","article-title":"Characterization of transforming growth factor-\u03b2-resistant subclones isolated from a transforming growth factor-\u03b2-sensitive human colon carcinoma cell line","volume":"48","author":"Mulder","year":"1988","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB51","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0888-7543(91)90317-8","article-title":"Genomic organization of adrenergic and serotonin receptors in the mouse","volume":"10","author":"Oakey","year":"1991","journal-title":"Genomics"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB34","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1073\/pnas.92.10.4482","article-title":"Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncation Apc gene","volume":"92","author":"Oshima","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB35","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0092-8674(00)81988-1","article-title":"Suppression of intestinal polyposis in Apc\u0394716 knockout mice by inhibition of cyclooxygenase-2 (COX-2)","volume":"87","author":"Oshima","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB36","first-page":"1644","article-title":"Morphological and molecular polyp formation in Apc\u0394716 knockout mice","volume":"57","author":"Oshima","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB37","first-page":"185","article-title":"Negative regulation of cell growth by TGF\u03b2","volume":"1242","author":"Polyak","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/ng0796-347","article-title":"Mad- related genes in the human","volume":"13","author":"Riggins","year":"1996","journal-title":"Nature Genet."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB39","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0002-9610(99)80088-9","article-title":"Familial segregation in the occurrence and severity of periampullary neoplasms in familial adenomatous polyposis","volume":"171","author":"Sanabria","year":"1996","journal-title":"Amer. J. Surgery"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB40","first-page":"490","article-title":"DPC4 gene in various tumor types","volume":"56","author":"Schutte","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB41","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1084\/jem.167.2.688","article-title":"Genetic analysis of autoimmune gld mice. I. Identification of a restriction fragment length polymorphism closely linked to the gld mutation within a conserved linkage group","volume":"167","author":"Seldin","year":"1988","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB42","first-page":"4479","article-title":"N-ethyl-N-nitrosourea treatment of multiple intestinal neoplasia (Min) mice","volume":"55","author":"Shoemaker","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB43","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/359693a0","article-title":"Targeted disruption of the mouse transforming growth factor-\u03b21 gene results in multifocal inflammatory disease","volume":"359","author":"Shull","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB44","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/carcin\/18.2.321","article-title":"Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis","volume":"18","author":"Smits","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB45","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0092-8674(91)90499-O","article-title":"Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice","volume":"64","author":"Soriano","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB46","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1007\/BF02553308","article-title":"Gardner's syndrome associated with periampullary carcinoma, duodenal and gastric adenomatosis. Report of a case","volume":"25","author":"Sugihara","year":"1982","journal-title":"Dis. Colon Rectum"},{"key":"10.1016\/S0092-8674(00)81132-0_BIB47","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ng0796-343","article-title":"Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers","volume":"13","author":"Thiagalingam","year":"1996","journal-title":"Nature Genet."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB48","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1056\/NEJM198809013190901","article-title":"Genetic alterations during colorectal-tumor development","volume":"319","author":"Vogelstein","year":"1988","journal-title":"New Engl. J. Med."},{"key":"10.1016\/S0092-8674(00)81132-0_BIB49","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/383168a0","article-title":"Receptor-associated Mad homologues synergize as effectors of the TGF-\u03b2 response","volume":"383","author":"Zhang","year":"1996","journal-title":"Nature"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400811320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400811320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T03:57:28Z","timestamp":1549511848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400811320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["S0092867400811320"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)81132-0","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1998,3]]}}}