{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T21:01:00Z","timestamp":1774645260610,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1996,5,1]],"date-time":"1996-05-01T00:00:00Z","timestamp":830908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1996,5,1]],"date-time":"1996-05-01T00:00:00Z","timestamp":830908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2001,4,11]],"date-time":"2001-04-11T00:00:00Z","timestamp":986947200000},"content-version":"vor","delay-in-days":1806,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[1996,5]]},"DOI":"10.1016\/s0092-8674(00)81238-6","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T16:23:03Z","timestamp":1086798183000},"page":"721-732","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1020,"title":["Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27"],"prefix":"10.1016","volume":"85","author":[{"given":"Hiroaki","family":"Kiyokawa","sequence":"first","affiliation":[]},{"given":"Rhonda D","family":"Kineman","sequence":"additional","affiliation":[]},{"given":"Katia O","family":"Manova-Todorova","sequence":"additional","affiliation":[]},{"given":"Vera C","family":"Soares","sequence":"additional","affiliation":[]},{"given":"Eric S","family":"Hoffman","sequence":"additional","affiliation":[]},{"given":"Masao","family":"Ono","sequence":"additional","affiliation":[]},{"given":"Dilruba","family":"Khanam","sequence":"additional","affiliation":[]},{"given":"Adrian C","family":"Hayday","sequence":"additional","affiliation":[]},{"given":"Lawrence A","family":"Frohman","sequence":"additional","affiliation":[]},{"given":"Andrew","family":"Koff","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)81238-6_BIB1","first-page":"595","article-title":"Characterization of p21 Cip1\/Waf1 peptide domains required for cyclin E\/Cdk2 and PCNA interaction","volume":"12","author":"Chen","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/362849a0","article-title":"Thymoycte apoptosis induced by p53-dependent and independent pathways","volume":"362","author":"Clarke","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB3","article-title":"Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle","author":"Coats","year":"1996","journal-title":"Science, in press."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/1074-7613(94)90102-3","article-title":"T cell receptor \u03b2 chain gene rearrangment and selection during thymocyte development in adult mice","volume":"1","author":"Dudley","year":"1994","journal-title":"Immunity"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB5","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/0092-8674(93)90723-4","article-title":"TGF\u03b2 inhibition of CDK4 synthesis is linked to cell cycle arrest","volume":"74","author":"Ewen","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB6","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.119.3.493","article-title":"Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation","volume":"119","author":"Gavrieli","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB7","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/366707a0","article-title":"Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit","volume":"366","author":"Gu","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB8","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0092-8674(93)90499-G","article-title":"The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases","volume":"75","author":"Harper","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1091\/mbc.6.4.387","article-title":"Inhibition of cyclin-dependent kinases by p21","volume":"6","author":"Harper","year":"1995","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB10","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/0092-8674(92)90249-C","article-title":"Regulation of retinoblastoma functions by ectopic expression of human cyclins","volume":"70","author":"Hinds","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB11","first-page":"1021","article-title":"Heterozygous Rb-1\u039420\/+ mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance","volume":"9","author":"Hu","year":"1994","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/359295a0","article-title":"Effects of an Rb mutation in the mouse","volume":"359","author":"Jacks","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB13","doi-asserted-by":"crossref","unstructured":"Koff, A., and Polyak, K. (1995). p27KIP1, an inhibitor of cyclin-dependent kinases. In Progress in Cell Cycle Research, Volume 1, L. Meijer, S. Guidet, and H.Y.L. Tung, eds. (New York: Plenum Press), pp. 141\u2013147.","DOI":"10.1007\/978-1-4615-1809-9_11"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB14","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1083\/jcb.131.1.227","article-title":"Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells","volume":"131","author":"Kranenburg","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB15","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1101\/gad.9.6.639","article-title":"Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with a unique domain structure and tissue distribution","volume":"9","author":"Lee","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB16","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1101\/gad.10.2.142","article-title":"Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937","volume":"10","author":"Liu","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB17","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/362847a0","article-title":"p53 is required for radiation-induced apoptosis in mouse thymocytes","volume":"362","author":"Lowe","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/375159a0","article-title":"Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1","volume":"375","author":"Luo","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB19","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/336348a0","article-title":"Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells","volume":"366","author":"Mansour","year":"1988","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB20","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1210\/endo-123-6-2827","article-title":"Growth enhancement of transgenic mice expressing human insulin-like growth factor I","volume":"123","author":"Mathews","year":"1988","journal-title":"Endocrinology"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB21","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1101\/gad.9.6.650","article-title":"p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene","volume":"9","author":"Matsuoka","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/374131a0","article-title":"Principles of CDK regulation","volume":"374","author":"Morgan","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB23","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1172\/JCI111145","article-title":"Bromodeoxyuridine in tumors and chromosomes detected with a monoclonal antibody","volume":"72","author":"Morstyn","year":"1983","journal-title":"J. Clin. Invest."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB24","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/j.1460-2075.1995.tb07031.x","article-title":"Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1\/CIP1\/WAF1","volume":"14","author":"Nakanishi","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB44","doi-asserted-by":"crossref","DOI":"10.1016\/S0092-8674(00)81237-4","article-title":"Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors","volume":"85","author":"Nakayama","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB25","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1095\/biolreprod27.2.327","article-title":"A longitudinal study of estrous cyclicity in aging C57BL\/6J mice. I. Cycle frequency, length, and vaginal cytology","volume":"27","author":"Nelson","year":"1982","journal-title":"Biol. Reprod."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB26","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1126\/science.8384376","article-title":"Cyclin-dependent regulation of G1 in mammalian fibroblasts","volume":"259","author":"Ohtsubo","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB27","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/300611a0","article-title":"Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes","volume":"300","author":"Palmiter","year":"1982","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB28","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1126\/science.2683075","article-title":"G1 events and the regulation of cell proliferation","volume":"246","author":"Pardee","year":"1989","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1101\/gad.8.1.9","article-title":"p27KIP1, a cyclin-Cdk inhibitor, links transforming growth factor-\u03b2 and contact inhibition to cell cycle arrest","volume":"8","author":"Polyak","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0092-8674(94)90572-X","article-title":"Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals","volume":"78","author":"Polyak","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB31","series-title":"Reproduction of Eukaryotic Cells","author":"Prescott","year":"1976"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB32","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1101\/gad.7.8.1559","article-title":"Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts","volume":"7","author":"Quelle","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB33","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1128\/MCB.15.7.3463","article-title":"Different roles for cyclin D1 and E in regulation of the G1-to-S transition","volume":"15","author":"Resnitzky","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB34","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1101\/gad.9.15.1831","article-title":"Kip\/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-\u03b2","volume":"9","author":"Reynisdottir","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB35","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/0092-8674(93)90636-5","article-title":"Mammalian G1 cyclins","volume":"73","author":"Sherr","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB36","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1101\/gad.9.10.1149","article-title":"Inhibitors of mammalian G1 cyclin-dependent kinases","volume":"9","author":"Sherr","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB37","first-page":"3683","article-title":"A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor \u03b2-arrested epithelial cells","volume":"14","author":"Slingerland","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB38","first-page":"135","article-title":"Formation of p27-CDK complexes during the human cell cycle","volume":"7","author":"Soos","year":"1996","journal-title":"Cell Growth Differ."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB39","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1101\/gad.7.11.2071","article-title":"Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20","volume":"7","author":"Swiatek","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0092-8674(94)90573-8","article-title":"p27, a novel inhibitor of G1 cyclin\u2013Cdk protein kinase activity, is related to p21","volume":"78","author":"Toyoshima","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB41","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.4049\/jimmunol.140.5.1461","article-title":"Subpopulations of early thymocytes","volume":"140","author":"Wilson","year":"1988","journal-title":"J. Immunol."},{"key":"10.1016\/S0092-8674(00)81238-6_BIB42","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/366701a0","article-title":"p21 is a universal inhibitor of cyclin kinases","volume":"366","author":"Xiong","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81238-6_BIB43","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1101\/gad.8.15.1750","article-title":"p21-containing cyclin kinases exist in both active and inactive states","volume":"8","author":"Zhang","year":"1994","journal-title":"Genes Dev."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400812386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400812386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:44:08Z","timestamp":1758797048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400812386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,5]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,5]]}},"alternative-id":["S0092867400812386"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)81238-6","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1996,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27Kip1","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0092-8674(00)81238-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1996 Cell Press. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}