{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:17:59Z","timestamp":1779344279309,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1996,6,1]],"date-time":"1996-06-01T00:00:00Z","timestamp":833587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1996,6,1]],"date-time":"1996-06-01T00:00:00Z","timestamp":833587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2002,4,11]],"date-time":"2002-04-11T00:00:00Z","timestamp":1018483200000},"content-version":"vor","delay-in-days":2140,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[1996,6]]},"DOI":"10.1016\/s0092-8674(00)81273-8","type":"journal-article","created":{"date-parts":[[2004,4,10]],"date-time":"2004-04-10T05:39:29Z","timestamp":1081575569000},"page":"899-909","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":185,"title":["Daughter of Sevenless Is a Substrate of the Phosphotyrosine Phosphatase Corkscrew and Functions during Sevenless Signaling"],"prefix":"10.1016","volume":"85","author":[{"given":"Ronald","family":"Herbst","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela M","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D","family":"Allard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Schilling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Raabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)81273-8_BIB1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0968-0004(94)90005-1","article-title":"Raf meets Ras","volume":"19","author":"Avruch","year":"1994","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0092-8674(00)81273-8_BIB2","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/0092-8674(91)90262-W","article-title":"Ligand-independent activation of the Sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye","volume":"64","author":"Basler","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB3","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.1073\/pnas.91.15.7335","article-title":"Protein\u2013tyrosine phosphatase SHPTP2 couples platelet-derived growth factor receptor \u03b2 to Ras","volume":"91","author":"Bennett","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB4","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1002\/j.1460-2075.1994.tb06426.x","article-title":"The Drosophila rolled locus encodes a MAP kinase required in the Sevenless signal transduction pathway","volume":"13","author":"Biggs","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)81273-8_BIB5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1126\/science.1736363","article-title":"The Son of Sevenless gene product","volume":"255","author":"Bonfini","year":"1992","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB6","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/370386a0","article-title":"The ETS domain protein pointed-P2 is a target of MAP kinase in the Sevenless signal transduction pathway","volume":"370","author":"Brunner","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB7","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0092-8674(94)90362-X","article-title":"A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor kinase signaling pathways","volume":"76","author":"Brunner","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0092-8674(91)90639-G","article-title":"Oncogenes and signal transduction","volume":"64","author":"Cantley","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB9","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0092-8674(95)90497-2","article-title":"phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila","volume":"80","author":"Chang","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB10","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/360600a0","article-title":"Raf functions downstream of Ras1 in the Sevenless signal transduction pathway","volume":"360","author":"Dickson","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB11","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0092-8674(95)90496-4","article-title":"Control of Drosophila photoreceptor cell fates by Phyllopod, a novel nuclear protein acting downstream of the Raf kinase","volume":"80","author":"Dickson","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB12","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/365781a0","article-title":"The pathway to signal achievement","volume":"365","author":"Egan","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB13","doi-asserted-by":"crossref","first-page":"8864","DOI":"10.1021\/bi00448a027","article-title":"Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase","volume":"28","author":"Fantus","year":"1989","journal-title":"Biochemistry"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB14","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1126\/science.8096088","article-title":"SH2-containing phosphotyrosine phosphatase as a target of protein\u2013tyrosine kinases","volume":"259","author":"Feng","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB15","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1002\/j.1460-2075.1995.tb07343.x","article-title":"The Drosophila insulin receptor homolog","volume":"14","author":"Fernandez","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)81273-8_BIB16","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/355559a0","article-title":"Signalling by the Sevenless protein\u2013tyrosine kinase is mimicked by Ras1 activation","volume":"355","author":"Fortini","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB17","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0968-0004(94)90108-2","article-title":"PH domain","volume":"19","author":"Gibson","year":"1994","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0092-8674(00)81273-8_BIB18","doi-asserted-by":"crossref","first-page":"17026","DOI":"10.1016\/S0021-9258(19)47335-3","article-title":"Evidence for protein\u2013tyrosine phosphatase catalysis proceeding via a cysteine\u2013phosphate intermediate","volume":"266","author":"Guan","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81273-8_BIB19","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1016\/S0021-9258(19)39885-0","article-title":"The insulinomimetic agents H2O2 and vanadate stimulate protein\u2013tyrosine phosphorylation in intact cells","volume":"265","author":"Heffetz","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81273-8_BIB20","first-page":"369","article-title":"Oncogenic activation of v-kit involves deletion of a putative tyrosine-substrate interaction site","volume":"10","author":"Herbst","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB21","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1101\/gad.8.18.2176","article-title":"A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases","volume":"8","author":"Hsu","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81273-8_BIB22","doi-asserted-by":"crossref","first-page":"13434","DOI":"10.1016\/S0021-9258(19)38668-5","article-title":"Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homolog, SH\u2013PTP2","volume":"268","author":"Lechleider","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81273-8_BIB23","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1128\/mcb.14.1.509-517.1994","article-title":"A new function for a phosphotyrosine phosphatase","volume":"14","author":"Li","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)81273-8_BIB24","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1101\/gad.7.4.621","article-title":"Control of cell fate determination by p21ras\/Ras1, an essential component of torso signaling in Drosophila","volume":"7","author":"Lu","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81273-8_BIB25","doi-asserted-by":"crossref","first-page":"23634","DOI":"10.1016\/S0021-9258(19)49509-4","article-title":"Sequence specificity in recognition of the epidermal growth factor receptor by protein\u2013tyrosine phosphatase 1B","volume":"268","author":"Milarski","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81273-8_BIB26","doi-asserted-by":"crossref","first-page":"21239","DOI":"10.1016\/S0021-9258(17)31954-3","article-title":"Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin","volume":"269","author":"Milarski","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81273-8_BIB27","first-page":"6674","article-title":"Role of SH\u2013PTP2, a protein\u2013tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation","volume":"14","author":"Noguchi","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)81273-8_BIB28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0092-8674(94)90580-0","article-title":"The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras\/MAPK pathway","volume":"78","author":"O'Neill","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0092-8674(93)90170-U","article-title":"A Drosophila SH2\u2013SH3 adaptor protein implicated in coupling the Sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos","volume":"73","author":"Olivier","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB30","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/373573a0","article-title":"Protein modules and signalling networks","volume":"373","author":"Pawson","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB31","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0092-8674(92)90098-W","article-title":"corkscrew encodes a putative protein\u2013tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase Torso","volume":"70","author":"Perkins","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB32","doi-asserted-by":"crossref","DOI":"10.1016\/S0092-8674(00)81274-X","article-title":"DOS, a novel pleckstrin homology domain\u2013containing protein required for signal transduction between Sevenless and Ras1 in Drosophila","volume":"85","author":"Raabe","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB33","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0896-6273(92)90177-F","article-title":"Growth factor signaling by receptor tyrosine kinases","volume":"9","author":"Schlessinger","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB34","doi-asserted-by":"crossref","first-page":"8333","DOI":"10.1073\/pnas.86.21.8333","article-title":"Structure and activity of the Sevenless protein","volume":"86","author":"Simon","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB35","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0092-8674(91)90065-7","article-title":"Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the Sevenless protein tyrosine kinase","volume":"67","author":"Simon","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB36","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0092-8674(93)90169-Q","article-title":"An SH3\u2013SH2\u2013SH3 protein is required for p21Ras1 activation and binds to Sevenless and SOS proteins in vitro","volume":"73","author":"Simon","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB37","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0092-8674(93)90383-2","article-title":"MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo","volume":"75","author":"Sun","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB38","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0092-8674(95)90498-0","article-title":"The SH2-containing protein\u2013tyrosine phosphatase SH\u2013PTP2 is required upstream of MAP kinase for early Xenopus development","volume":"80","author":"Tang","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB39","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0092-8674(95)90204-X","article-title":"KSR, a novel protein kinase required for RAS signal transduction","volume":"83","author":"Therrien","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB40","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0092-8674(93)90117-9","article-title":"A protein kinase similar to MAP kinase activator acts downstream of the Raf kinase in Drosophila","volume":"72","author":"Tsuda","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB41","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1126\/science.7681217","article-title":"Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation","volume":"259","author":"Vogel","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81273-8_BIB42","doi-asserted-by":"crossref","first-page":"17716","DOI":"10.1074\/jbc.270.30.17716","article-title":"Identification of the major SHPTP2-binding protein that is tyrosine-phosphorylated in response to insulin","volume":"270","author":"Yamauchi","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81273-8_BIB43","doi-asserted-by":"crossref","first-page":"11765","DOI":"10.1074\/jbc.270.20.11765","article-title":"Altered expression of protein\u2013tyrosine phosphatase 2C in 293 cells affects protein\u2013tyrosine phosphorylation and mitogen-activated protein kinase activation","volume":"270","author":"Zhao","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81273-8_BIB44","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev.ne.17.030194.002105","article-title":"Determination of neuronal cell fate","volume":"17","author":"Zipursky","year":"1994","journal-title":"Annu. Rev. Neurosci."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400812738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400812738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:43:41Z","timestamp":1758797021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400812738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,6]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,6]]}},"alternative-id":["S0092867400812738"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)81273-8","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1996,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Daughter of Sevenless Is a Substrate of the Phosphotyrosine Phosphatase Corkscrew and Functions during Sevenless Signaling","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0092-8674(00)81273-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1996 Cell Press.  All rights reserved.","name":"copyright","label":"Copyright"}]}}