{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:45:32Z","timestamp":1771001132911,"version":"3.50.1"},"reference-count":60,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1996,10,1]],"date-time":"1996-10-01T00:00:00Z","timestamp":844128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":6133,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1996,10]]},"DOI":"10.1016\/s0092-8674(00)81346-x","type":"journal-article","created":{"date-parts":[[2004,6,30]],"date-time":"2004-06-30T12:27:59Z","timestamp":1088598479000},"page":"287-296","source":"Crossref","is-referenced-by-count":190,"title":["Interaction between the Origin Recognition Complex and the Replication Licensing Systemin Xenopus"],"prefix":"10.1016","volume":"87","author":[{"given":"Alison","family":"Rowles","sequence":"first","affiliation":[]},{"given":"James P.J","family":"Chong","sequence":"additional","affiliation":[]},{"given":"Lamorna","family":"Brown","sequence":"additional","affiliation":[]},{"given":"Mike","family":"Howell","sequence":"additional","affiliation":[]},{"given":"Gerard I","family":"Evan","sequence":"additional","affiliation":[]},{"given":"J.Julian","family":"Blow","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)81346-X_BIB1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/357128a0","article-title":"ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex","volume":"357","author":"Bell","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB2","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1126\/science.8266072","article-title":"Yeast origin recognition complex functions in transcription silencing and DNA replication","volume":"262","author":"Bell","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB3","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0092-8674(95)90096-9","article-title":"The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing","volume":"83","author":"Bell","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB4","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1083\/jcb.122.5.993","article-title":"Preventing rereplication of DNA in a single cell cycle","volume":"122","author":"Blow","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB5","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0092-8674(86)90622-7","article-title":"Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs","volume":"47","author":"Blow","year":"1986","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB6","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1002\/j.1460-2075.1987.tb02463.x","article-title":"Nuclei act as independent and integrated units of replication in a Xenopus cell-free system","volume":"6","author":"Blow","year":"1987","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB7","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/332546a0","article-title":"A role for the nuclear envelope in controlling DNA replication within the cell cycle","volume":"332","author":"Blow","year":"1988","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB8","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(90)90261-C","article-title":"A cdc2-like protein is involved in the initiation of DNA replication in Xenopus egg extracts","volume":"62","author":"Blow","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1242\/jcs.95.3.383","article-title":"Replication of purified DNA in Xenopus egg extracts is dependent on nuclear assembly","volume":"95","author":"Blow","year":"1990","journal-title":"J. Cell Sci."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/379357a0","article-title":"Role for a Xenopus orc2-related protein in controlling DNA replication","volume":"379","author":"Carpenter","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB11","doi-asserted-by":"crossref","first-page":"10459","DOI":"10.1073\/pnas.89.21.10459","article-title":"CDC46\/MCM5, a yeast protein whose subcellular localization is cell cycle\u2013regulated, is involved in DNA replication at autonomously replicating sequences","volume":"89","author":"Chen","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB12","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1242\/jcs.108.5.1831","article-title":"Both cdc2 and cdk2 promote S-phase initiation in Xenopus egg extracts","volume":"108","author":"Chevalier","year":"1995","journal-title":"J. Cell Sci."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB13","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/375418a0","article-title":"Purification of an Mcm-containing complex as a component of the DNA replication licensing system","volume":"375","author":"Chong","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0968-0004(96)10013-X","article-title":"The role of MCM\/P1 proteins in the licensing of DNA replication","volume":"21","author":"Chong","year":"1996","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB15","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.1073\/pnas.91.12.5247","article-title":"Herpes simplex virus 1 gamma(1)34.5 gene function, which blocks the host response to infection, maps in the homologous domain of the genes expressed during growth arrest and DNA damage","volume":"91","author":"Chou","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB16","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/379180a0","article-title":"An essential role for the cdc6 protein in forming the prereplicative complexes of budding yeast","volume":"379","author":"Cocker","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/357169a0","article-title":"Protein\u2013DNA interactions at a yeast replication origin","volume":"357","author":"Diffley","year":"1992","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB18","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0092-8674(94)90299-2","article-title":"Two steps in the assembly of complexes at yeast replication origins in vivo","volume":"78","author":"Diffley","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB19","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1099\/0022-1317-73-4-971","article-title":"Status of the ICP34.5 gene in herpes simplex virus type 1 strain 17","volume":"73","author":"Dolan","year":"1992","journal-title":"J. Gen. Virol."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB20","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1101\/gad.7.4.555","article-title":"The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit","volume":"7","author":"Durfee","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB21","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/0092-8674(91)90117-H","article-title":"Evidence that the G1\u2013S and G2\u2013M transitions are controlled by different cdc2 proteins in higher eukaryotes","volume":"66","author":"Fang","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB22","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1126\/science.8266071","article-title":"Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae","volume":"262","author":"Foss","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB23","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1101\/gad.9.8.911","article-title":"The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication","volume":"9","author":"Fox","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB24","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1126\/science.270.5242.1667","article-title":"Conserved initiator proteins in eukaryotes","volume":"270","author":"Gavin","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB25","doi-asserted-by":"crossref","first-page":"5707","DOI":"10.1128\/MCB.10.11.5707","article-title":"The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication","volume":"10","author":"Gibson","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB26","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1126\/science.270.5242.1674","article-title":"A Drosophila homolog of the yeast origin recognition complex","volume":"270","author":"Gossen","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB27","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0092-8674(80)90439-0","article-title":"Regulated DNA replication of DNA microinjected into eggs of Xenopus laevis","volume":"21","author":"Harland","year":"1980","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB28","unstructured":"Harlow, E., and Lane, D. (1988). Antibodies: A Laboratory Manual (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press)."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB29","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/nar\/20.7.1463","article-title":"Plasmid replication in Xenopus eggs and egg extracts","volume":"20","author":"Hyrien","year":"1992","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB30","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1002\/j.1460-2075.1993.tb06140.x","article-title":"Chromosomal replication initiates and terminates at random sequences but at regular intervals in the ribosomal DNA of Xenopus early embryos","volume":"12","author":"Hyrien","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB31","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1126\/science.270.5238.994","article-title":"Transition in specification of embryonic metazoan DNA replication origins","volume":"270","author":"Hyrien","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB32","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1083\/jcb.130.4.755","article-title":"Early events in DNA replication require cyclin E and are blocked by p21CIP1","volume":"130","author":"Jackson","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB33","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1083\/jcb.123.6.1321","article-title":"Determination of initiation of DNA replication before and after nuclear formation in Xenopus egg cell-free extracts","volume":"123","author":"Kubota","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB34","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/0092-8674(95)90081-0","article-title":"Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor","volume":"81","author":"Kubota","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB35","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1098\/rstb.1993.0024","article-title":"The role of nucleoplasmin in chromatin assembly and disassembly","volume":"339","author":"Laskey","year":"1993","journal-title":"Phil. Trans. Roy. Soc. (Lond.) B."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB36","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/379360a0","article-title":"Interaction of cdc2 and cdc18 with a fission yeast orc2-like protein","volume":"379","author":"Leatherwood","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB37","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1126\/science.8266075","article-title":"Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system","volume":"262","author":"Li","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB38","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/0092-8674(95)90528-6","article-title":"ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome","volume":"81","author":"Liang","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB39","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1091\/mbc.6.6.741","article-title":"The origin recognition complex in silencing, cell cycle progression, and DNA replication","volume":"6","author":"Loo","year":"1995","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB40","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/375421a0","article-title":"MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells","volume":"375","author":"Madine","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB41","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/S0960-9822(95)00253-3","article-title":"Nuclear envelope prevents rereplication by restricting binding of MCM3 to chromatin","volume":"5","author":"Madine","year":"1995","journal-title":"Curr. Biol."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB42","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1093\/nar\/20.7.1457","article-title":"DNA replication initiates at multiple sites on plasmid DNA in Xenopus egg extracts","volume":"20","author":"Mahbubani","year":"1992","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB43","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/genetics\/106.3.365","article-title":"Mutants of S. cerevisiae defective in the maintenance of minichromosomes","volume":"106","author":"Maine","year":"1984","journal-title":"Genetics"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB44","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0022-2836(92)90543-S","article-title":"The mcm2 mutation of yeast affects replication, rather than segregation or amplification of the two- micron plasmid","volume":"224","author":"Maiti","year":"1992","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB45","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0092-8674(84)90526-9","article-title":"Lack of specific sequence requirement for DNA replication in Xenopus eggs compared with high sequence specificity in yeast","volume":"38","author":"M\u00e9chali","year":"1984","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB46","doi-asserted-by":"crossref","unstructured":"Messing, J. (1983). New M13 vectors for cloning. In Methods in Enzymology, Volume 101C, R. Wu, L. Grossman, and K. Moldave, eds. (London: Academic Press Inc., Ltd.), pp. 20\u201378.","DOI":"10.1016\/0076-6879(83)01005-8"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB47","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/366087a0","article-title":"Yeast origin recognition complex is involved in DNA replication and transcriptional silencing","volume":"366","author":"Micklem","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB48","doi-asserted-by":"crossref","first-page":"12475","DOI":"10.1073\/pnas.92.26.12475","article-title":"Orp1, a member of the cdc18\/cdc6 family of s-phase regulators, is homologous to a component of the origin recognition complex","volume":"92","author":"Muzi-Falconi","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB49","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0092-8674(87)90424-7","article-title":"Nuclear reconstitution in vitro","volume":"48","author":"Newport","year":"1987","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB50","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/0092-8674(91)90089-H","article-title":"Sperm decondensation in Xenopus egg cytoplasm is mediated by nucleoplasmin","volume":"65","author":"Philpott","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB51","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0167-4781(94)90283-6","article-title":"Recent developments in the initiation of chromosomal DNA replication","volume":"1217","author":"Rowley","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB52","series-title":"Molecular Cloning","author":"Sambrook","year":"1989"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB53","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0022-2836(86)90030-6","article-title":"A mutant that affects the function of autonomously replicating sequences in yeast","volume":"192","author":"Sinha","year":"1986","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB54","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/S0960-9822(00)00196-2","article-title":"Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases","volume":"4","author":"Strausfeld","year":"1994","journal-title":"Curr. Biol."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB55","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1242\/jcs.109.6.1555","article-title":"Both cyclin A and cyclin E have S phase promoting factor (SPF) activity in Xenopus egg extracts","volume":"109","author":"Strausfeld","year":"1996","journal-title":"J. Cell Sci."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB56","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0022-2836(86)90385-2","article-title":"Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes","volume":"189","author":"Studier","year":"1986","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB57","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/geno.1996.0018","article-title":"Mouse and human homologs of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L","volume":"31","author":"Takahara","year":"1996","journal-title":"Genomics"},{"key":"10.1016\/S0092-8674(00)81346-X_BIB58","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1432-1033.1994.00771.x","article-title":"Inhibition of cyclin-dependent kinases by purine analogues","volume":"224","author":"Vesely","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB59","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1101\/gad.5.6.944","article-title":"Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function","volume":"5","author":"Yan","year":"1991","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81346-X_BIB60","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1101\/gad.7.11.2149","article-title":"Cell cycle\u2013regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast","volume":"7","author":"Yan","year":"1993","journal-title":"Genes Dev."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286740081346X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286740081346X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T21:45:32Z","timestamp":1624484732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009286740081346X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,10]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,10]]}},"alternative-id":["S009286740081346X"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)81346-x","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1996,10]]}}}