{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T19:28:07Z","timestamp":1773948487263,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4946,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[2000,1]]},"DOI":"10.1016\/s0092-8674(00)81561-5","type":"journal-article","created":{"date-parts":[[2004,4,10]],"date-time":"2004-04-10T09:39:29Z","timestamp":1081589969000},"page":"229-240","source":"Crossref","is-referenced-by-count":369,"title":["OAZ Uses Distinct DNA- and Protein-Binding Zinc Fingers in Separate BMP-Smad and Olf Signaling Pathways"],"prefix":"10.1016","volume":"100","author":[{"given":"Akiko","family":"Hata","sequence":"first","affiliation":[]},{"given":"Joan","family":"Seoane","sequence":"additional","affiliation":[]},{"given":"Giorgio","family":"Lagna","sequence":"additional","affiliation":[]},{"given":"Ermelinda","family":"Montalvo","sequence":"additional","affiliation":[]},{"given":"Ali","family":"Hemmati-Brivanlou","sequence":"additional","affiliation":[]},{"given":"Joan","family":"Massagu\u00e9","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)81561-5_BIB1","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/383691a0","article-title":"A transcriptional partner of MAD proteins in TGF-\u03b2 signaling","volume":"383","author":"Chen","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB2","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1101\/gad.12.14.2144","article-title":"Determinants of specificity in TGF-\u03b2 signal transduction","volume":"12","author":"Chen","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1749-6632.1999.tb09513.x","article-title":"Sp1 and its likes","volume":"880","author":"Cook","year":"1999","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB4","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1093\/emboj\/17.11.3091","article-title":"Direct binding of Smad3 and Smad4 to critical TGF\u03b2-inducible elements in the promoter of human plasminogen activator inhibitor-type1 gene","volume":"17","author":"Dennler","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB5","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/374464a0","article-title":"Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo","volume":"374","author":"Frasch","year":"1995","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB6","doi-asserted-by":"crossref","first-page":"6268","DOI":"10.1002\/j.1460-2075.1995.tb00317.x","article-title":"Antagonizing the Spemann organizer","volume":"14","author":"Gawantka","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB7","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1101\/gad.7.5.760","article-title":"Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression","volume":"7","author":"Hagman","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB8","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/40424","article-title":"Mutations increasing autoinhibition inactivate the tumour suppressors Smad2 and Smad4","volume":"388","author":"Hata","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB9","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1101\/gad.12.2.186","article-title":"Smad6 inhibits BMP\/Smad1 signaling by specifically competing with the Smad4 tumor suppressor","volume":"12","author":"Hata","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB10","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/37284","article-title":"TGF-\u03b2 signaling from cell membrane to nucleus through SMAD proteins","volume":"390","author":"Heldin","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1146\/annurev.neuro.20.1.43","article-title":"Vertebrate neural induction","volume":"20","author":"Hemmati-Brivanlou","year":"1997","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB12","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1101\/gad.10.13.1580","article-title":"Bone morphogenetic proteins","volume":"10","author":"Hogan","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB13","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1101\/gad.12.19.3084","article-title":"Synergistic cooperation of TFE3 and smad proteins in TGF-\u03b2-induced transcription of the plasminogen activator inhibitor-1 gene","volume":"12","author":"Hua","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB14","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1083\/jcb.127.6.1755","article-title":"Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage","volume":"127","author":"Katagiri","year":"1994","journal-title":"Cell Biol."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0925-4773(96)00539-4","article-title":"Five years on the wings of fork head","volume":"57","author":"Kaufmann","year":"1996","journal-title":"Mech. Dev."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/jmbi.1999.3007","article-title":"Zinc finger peptides for the regulation of gene expression","volume":"293","author":"Klug","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1097-2765(00)80119-7","article-title":"Smad2 and Smad3 positively and negatively regulate TGF\u03b2-dependent transcription through the forkhead DNA-binding protein FAST2","volume":"2","author":"Labb\u00e9","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB18","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/383832a0","article-title":"Partnership between DPC4 and SMAD proteins in TGF\u03b2 signaling pathways","volume":"383","author":"Lagna","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB19","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/381620a0","article-title":"A human Mad protein acting as a BMP-regulated transcriptional activator","volume":"381","author":"Liu","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB20","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1101\/gad.11.23.3157","article-title":"Dual role of the Smad4\/DPC4 tumor suppressor in TGF\u03b2-inducible transcriptional responses","volume":"11","author":"Liu","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB21","doi-asserted-by":"crossref","first-page":"25628","DOI":"10.1074\/jbc.273.40.25628","article-title":"Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2","volume":"273","author":"Macias-Silva","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB22","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev.biochem.67.1.753","article-title":"TGF\u03b2 signal transduction","volume":"67","author":"Massagu\u00e9","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0166-2236(96)01046-6","article-title":"Bone morphogenetic proteins in the nervous system","volume":"20","author":"Mehler","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/dbio.1998.9197","article-title":"A BMP-inducible gene, dlx5, regulates osteoblast differentiation and mesoderm induction","volume":"208","author":"Miyama","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB25","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/dnares\/5.5.277","article-title":"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro","volume":"5","author":"Nagase","year":"1998","journal-title":"DNA Res."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB26","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1242\/dev.122.10.3045","article-title":"The Xvent-2 homeobox gene is part of the BMP-4 signaling pathway controlling dorsoventral patterning of Xenopus mesoderm","volume":"122","author":"Onichtchouk","year":"1996","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB27","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1242\/dev.125.8.1447","article-title":"Requirement for Xvent-1 and Xvent-2 gene function in dorsoventral patterning of Xenopus mesoderm","volume":"125","author":"Onichtchouk","year":"1998","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB44","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1126\/science.8378770","article-title":"Crystal structure of a five-finger GLI-DNA complex","volume":"261","author":"Pavletich","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB45","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1126\/science.2028256","article-title":"Zinc finger-DNA recognition","volume":"252","author":"Pavletich","year":"1991","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB28","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1242\/dev.110.4.1041","article-title":"A Drosophila growth factor homolog, decapentaplegic, regulates homeotic gene expression within and across germ layers during midgut morphogenesis","volume":"110","author":"Panganiban","year":"1990","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0168-9525(98)01662-X","article-title":"Teeth. Where and how to make them","volume":"15","author":"Peters","year":"1999","journal-title":"Trends Genet."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0925-4773(98)00239-1","article-title":"Transcriptional regulation of Xvent homeobox genes","volume":"81","author":"Rastegar","year":"1999","journal-title":"Mech. Dev."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB31","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0092-8674(00)81600-1","article-title":"Crystal structure of a Smad MH1 domain bound to DNA","volume":"94","author":"Shi","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB32","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/7251","article-title":"BMPs inhibit neurogenesis by a mechanism involving degradation of a transcription factor","volume":"2","author":"Shou","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB33","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1242\/dev.124.16.3037","article-title":"Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4","volume":"124","author":"Suzuki","year":"1997","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB34","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1242\/dev.125.10.1877","article-title":"The Tlx-2 homeobox gene is a downstream target of BMP signaling and is required for mouse mesoderm development","volume":"125","author":"Tang","year":"1998","journal-title":"Development"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB35","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1523\/JNEUROSCI.17-11-04159.1997","article-title":"Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O\/E-1 to regulate gene expression","volume":"17","author":"Tsai","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB36","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.1128\/MCB.18.11.6447","article-title":"Identification of DNA recognition sequences and protein interaction domains of the multiple-Zn-finger protein Roaz","volume":"18","author":"Tsai","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB37","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0968-0004(99)01406-1","article-title":"Mammalian Kr\u00fcppel-like transcription factors","volume":"24","author":"Turner","year":"1999","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB38","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.1128\/MCB.13.9.5805","article-title":"Genes encoding components of the olfactory signal transduction cascade contain a DNA binding site that may direct neuronal expression","volume":"13","author":"Wang","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB39","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0960-9822(00)00152-4","article-title":"Mesodermal patterning by an inducer gradient depends on secondary cell\u2013cell communication","volume":"4","author":"Wilson","year":"1994","journal-title":"Curr. Biol."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB46","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0092-8674(00)80712-6","article-title":"A Smad transcriptional Corepressor","volume":"97","author":"Wotton","year":"1999","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB40","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.3201241","article-title":"Novel regulators of bone formation","volume":"242","author":"Wozney","year":"1988","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB41","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1101\/gad.12.15.2354","article-title":"Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm","volume":"12","author":"Xu","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(00)81561-5_BIB42","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1097-2765(00)80061-1","article-title":"Human Smad3 and Smad4 are sequence-specific transcription activators","volume":"1","author":"Zawel","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB43","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/29814","article-title":"Smad3 and Smad4 cooperate with c-Jun\/c-Fos to mediate TGF-\u03b2-induced transcription","volume":"394","author":"Zhang","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81561-5_BIB47","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1097-2765(00)80120-3","article-title":"Characterization of human FAST-1, a TGF\u03b2 and activin signal transducer","volume":"2","author":"Zhou","year":"1998","journal-title":"Mol. Cell"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400815615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867400815615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T13:45:52Z","timestamp":1623764752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867400815615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["S0092867400815615"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)81561-5","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}