{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:10:16Z","timestamp":1777115416109,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[1998,12,1]],"date-time":"1998-12-01T00:00:00Z","timestamp":912470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1998,12,1]],"date-time":"1998-12-01T00:00:00Z","timestamp":912470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2001,4,11]],"date-time":"2001-04-11T00:00:00Z","timestamp":986947200000},"content-version":"vor","delay-in-days":862,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[1998,12]]},"DOI":"10.1016\/s0092-8674(00)81716-x","type":"journal-article","created":{"date-parts":[[2004,4,10]],"date-time":"2004-04-10T05:39:29Z","timestamp":1081575569000},"page":"917-926","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":489,"title":["Identification of Ligands for Olfactory Receptors by Functional Expression of a Receptor Library"],"prefix":"10.1016","volume":"95","author":[{"given":"Dietmar","family":"Krautwurst","sequence":"first","affiliation":[]},{"given":"King-Wai","family":"Yau","sequence":"additional","affiliation":[]},{"given":"Randall R","family":"Reed","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(00)81716-X_BIB1","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1126\/science.2255909","article-title":"Identification of a specialized adenylyl cyclase that may mediate odorant detection","volume":"250","author":"Bakalyar","year":"1990","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0896-6273(00)80435-3","article-title":"Mice deficient in G(olf) are anosmic","volume":"20","author":"Belluscio","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/hmg\/3.2.229","article-title":"Olfactory receptor gene cluster on human chromosome 17","volume":"3","author":"Ben-Arie","year":"1994","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0092-8674(00)81716-X_BIB4","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1002\/j.1460-2075.1990.tb07422.x","article-title":"Rapid activation of alternative second messenger pathways in olfactory cilia from rats by different odorants","volume":"9","author":"Boekhoff","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(00)81716-X_BIB5","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0896-6273(00)80200-7","article-title":"General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel","volume":"17","author":"Brunet","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0092-8674(91)90418-X","article-title":"A novel multigene family may encode odorant receptors","volume":"65","author":"Buck","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0092-8674(91)90177-Z","article-title":"The cyclophilin homolog ninaA is required in the secretory pathway","volume":"67","author":"Colley","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/347184a0","article-title":"Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons","volume":"347","author":"Dhallan","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB9","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0092-8674(00)81173-3","article-title":"Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein","volume":"93","author":"Dwyer","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1126\/science.2704991","article-title":"Odor-induced membrane currents in vertebrate-olfactory receptor neurons","volume":"244","author":"Firestein","year":"1989","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1993.sp019756","article-title":"The relation between stimulus and response in olfactory receptor cells of the tiger salamander","volume":"468","author":"Firestein","year":"1993","journal-title":"J. Physiol. (Lond)"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB12","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81716-X_BIB13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0014-4835(86)90030-8","article-title":"Rhodopsin's amino terminus is a principal antigenic site","volume":"42","author":"Hargrave","year":"1986","journal-title":"Exp. Eye Res."},{"key":"10.1016\/S0092-8674(00)81716-X_BIB14","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1126\/science.2499043","article-title":"Golf","volume":"244","author":"Jones","year":"1989","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1113\/jphysiol.1989.sp017868","article-title":"Activation by odorants of cation-selective conductance in the olfactory receptor cell isolated from the newt","volume":"419","author":"Kurahashi","year":"1989","journal-title":"J. Physiol. (Lond)"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB16","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0092-8674(92)90185-F","article-title":"The Drosophila learning and memory gene rutabaga encodes a Ca2+\/Calmodulin-responsive adenylyl cyclase","volume":"68","author":"Levin","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB17","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0960-0760(91)90262-4","article-title":"Signal transduction in olfactory neurons","volume":"39","author":"Levy","year":"1991","journal-title":"J. Steroid Biochem Mol. Biol."},{"key":"10.1016\/S0092-8674(00)81716-X_BIB18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/0014-5793(90)81226-E","article-title":"Primary structure of cAMP-gated channel from bovine olfactory epithelium","volume":"270","author":"Ludwig","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1016\/S0092-8674(00)81716-X_BIB19","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0169-328X(97)00099-5","article-title":"Functional expression of olfactory-adrenergic receptor chimeras and intracellular retention of heterologously expressed olfactory receptors","volume":"48","author":"McClintock","year":"1997","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/S0092-8674(00)81716-X_BIB20","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1751-1097.1993.tb04956.x","article-title":"Role of hydroxyl-bearing amino acids in differentially tuning the absorption spectra of the human red and green cone pigments","volume":"58","author":"Merbs","year":"1993","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/S0092-8674(00)81716-X_BIB21","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/325442a0","article-title":"A cyclic nucleotide-gated conductance in olfactory receptor cilia","volume":"325","author":"Nakamura","year":"1987","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB22","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1073\/pnas.81.15.4851","article-title":"Isolation and nucleotide sequence of the gene encoding human rhodopsin","volume":"81","author":"Nathans","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB23","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/0092-8674(93)90395-7","article-title":"The family of genes encoding odorant receptors in the channel catfish","volume":"72","author":"Ngai","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB24","doi-asserted-by":"crossref","first-page":"15175","DOI":"10.1074\/jbc.270.25.15175","article-title":"G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C","volume":"270","author":"Offermanns","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(00)81716-X_BIB25","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0026-895X(25)10203-4","article-title":"Transfected muscarinic acetylcholine receptors selectively couple to Gi- type G proteins and Gq\/11","volume":"45","author":"Offermanns","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0092-8674(00)81716-X_BIB26","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1126\/science.3388043","article-title":"Molecular cloning of odorant-binding protein","volume":"241","author":"Pevsner","year":"1988","journal-title":"Science"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1523\/JNEUROSCI.18-01-00227.1998","article-title":"Tissue and zonal-specific expression of an olfactory receptor transgene","volume":"18","author":"Qasba","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/S0092-8674(00)81716-X_BIB28","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/361353a0","article-title":"Cloning and expression of odorant receptors","volume":"361","author":"Raming","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0896-6273(92)90287-N","article-title":"Signaling pathways in odorant detection","volume":"8","author":"Reed","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0092-8674(93)90145-G","article-title":"A zonal organization of odorant receptor gene expression in the olfactory epithelium","volume":"73","author":"Ressler","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB31","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1152\/jn.1995.73.2.862","article-title":"InsP3 causes an increase in apical [Ca2+]i by activating two distinct current components in vertebrate olfactory receptor cells","volume":"73","author":"Schild","year":"1995","journal-title":"J. Neurophysiol."},{"key":"10.1016\/S0092-8674(00)81716-X_BIB32","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0092-8674(00)81068-5","article-title":"odr-10 encodes a seven transmembrane domain olfactory receptor required for responses to the odorant diacetyl","volume":"84","author":"Sengupta","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB33","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0092-8674(91)90156-S","article-title":"The cyclophilin homolog ninaA is a tissue-specific integral membrane protein required for the proper synthesis of a subset of Drosophila rhodopsins","volume":"65","author":"Stamnes","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB34","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1146\/annurev.bi.63.070194.000533","article-title":"Structure and function of G protein-coupled receptors","volume":"63","author":"Strader","year":"1994","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/S0092-8674(00)81716-X_BIB35","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1073\/pnas.93.2.884","article-title":"The chromosomal distribution of mouse odorant receptor genes","volume":"93","author":"Sullivan","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB36","doi-asserted-by":"crossref","first-page":"8840","DOI":"10.1073\/pnas.88.19.8840","article-title":"Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa","volume":"88","author":"Sung","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB37","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0092-8674(93)90422-M","article-title":"Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium","volume":"74","author":"Vassar","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB38","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/0092-8674(94)90029-9","article-title":"Topographic organization of sensory projections to the olfactory bulb","volume":"79","author":"Vassar","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB39","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/chemse\/22.4.467","article-title":"Functional expression of odorant receptors of the zebrafish Danio rerio and of the nematode C. elegans in HEK293 cells","volume":"22","author":"Wellerdieck","year":"1997","journal-title":"Chem. Senses"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB40","doi-asserted-by":"crossref","first-page":"12162","DOI":"10.1073\/pnas.94.22.12162","article-title":"The Caenorhabditis elegans seven-transmembrane protein ODR-10 functions as an odorant receptor in mammalian cells","volume":"94","author":"Zhang","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(00)81716-X_BIB41","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1126\/science.279.5348.237","article-title":"Functional expression of a mammalian odorant receptor [see comments]","volume":"279","author":"Zhao","year":"1998","journal-title":"Science"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286740081716X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286740081716X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:39:34Z","timestamp":1758796774000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009286740081716X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,12]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1998,12]]}},"alternative-id":["S009286740081716X"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(00)81716-x","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1998,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of Ligands for Olfactory Receptors by Functional Expression of a Receptor Library","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0092-8674(00)81716-X","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1998 Cell Press. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}