{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T04:58:23Z","timestamp":1772513903934,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4521,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2001,3]]},"DOI":"10.1016\/s0092-8674(01)00283-5","type":"journal-article","created":{"date-parts":[[2004,4,15]],"date-time":"2004-04-15T05:36:43Z","timestamp":1082007403000},"page":"861-873","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":328,"title":["Groucho-Mediated Transcriptional Repression Establishes Progenitor Cell Pattern and Neuronal Fate in the Ventral Neural Tube"],"prefix":"10.1016","volume":"104","author":[{"given":"Jonas","family":"Muhr","sequence":"first","affiliation":[]},{"given":"Elisabet","family":"Andersson","sequence":"additional","affiliation":[]},{"given":"Madelen","family":"Persson","sequence":"additional","affiliation":[]},{"given":"Thomas M.","family":"Jessell","sequence":"additional","affiliation":[]},{"given":"Johan","family":"Ericson","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(01)00283-5_BIB1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0959-4388(00)00172-0","article-title":"Specification of neuronal fates in the ventral neural tube","volume":"11","author":"Briscoe","year":"2001","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/19315","article-title":"Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling","volume":"398","author":"Briscoe","year":"1999","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB3","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0092-8674(00)80853-3","article-title":"A homeodomain code specifies progenitor cell identity and neuronal fate in the ventral neural tube","volume":"101","author":"Briscoe","year":"2000","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB4","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/383407a0","article-title":"Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function","volume":"383","author":"Chiang","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB5","doi-asserted-by":"crossref","first-page":"33194","DOI":"10.1074\/jbc.274.47.33194","article-title":"The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription","volume":"274","author":"Choi","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB6","doi-asserted-by":"crossref","first-page":"31534","DOI":"10.1074\/jbc.274.44.31543","article-title":"The homeodomain transcription factor NK-4 acts as either a transcriptional activator or repressor and interacts with the p300 coactivator and the Groucho corepressor","volume":"274","author":"Choi","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB7","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1093\/emboj\/19.10.2292","article-title":"Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family","volume":"19","author":"Eberhard","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0092-8674(00)80323-2","article-title":"Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling","volume":"90","author":"Ericson","year":"1997","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB9","doi-asserted-by":"crossref","first-page":"8355","DOI":"10.1016\/S0021-9258(17)37201-0","article-title":"Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes","volume":"269","author":"Epstein","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1006\/excr.1999.4717","article-title":"Vertebrate bHLH genes and the determination of neuronal fates","volume":"253","author":"Guillemot","year":"1999","journal-title":"Exp. Cell Res."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)81747-X","article-title":"Cells' perception of position in a concentration gradient","volume":"95","author":"Gurdon","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB12","doi-asserted-by":"crossref","first-page":"18749","DOI":"10.1074\/jbc.271.31.18749","article-title":"mRNA profiling of rat islet tumors reveals nkx 6.1 as a beta-cell-specific homeodomain transcription factor","volume":"271","author":"Jensen","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB13","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1101\/gad.11.22.3072","article-title":"Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed","volume":"11","author":"Jim\u00e9nez","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0014-5793(99)01436-2","article-title":"Cloning and DNA-binding properties of the rat pancreatic \u03b2-cell-specific factor Nkx6.1","volume":"461","author":"Jorgensen","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB15","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0925-4773(96)00582-5","article-title":"Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development","volume":"59","author":"Koop","year":"1996","journal-title":"Mech. Dev."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB16","first-page":"2662","article-title":"The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP","volume":"12","author":"Kozmik","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/(SICI)1097-0177(199701)208:1<11::AID-AJA2>3.0.CO;2-4","article-title":"Grg3, a murine Groucho-related gene, is expressed in the developing nervous system and in mesenchyme-induced epithelial structures","volume":"208","author":"Leon","year":"1997","journal-title":"Dev. Dyn."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB18","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1242\/dev.119.2.419","article-title":"Nkx-2.5","volume":"119","author":"Lints","year":"1993","journal-title":"Development"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB19","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0896-6273(00)80729-1","article-title":"Specification of neurotransmitter identity by Phox2 proteins in neural crest stem cells","volume":"22","author":"Lo","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB20","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1523\/JNEUROSCI.17-10-03644.1997","article-title":"Mash1 and neurogenin1 expression patterns define complementary domains of neuroepithelium in the developing CNS and are correlated with regions expressing notch ligands","volume":"17","author":"Ma","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0925-4773(93)90099-J","article-title":"Cloning and developmental expression of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex","volume":"42","author":"Mallo","year":"1993","journal-title":"Mech. Dev."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB22","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1126\/science.284.5414.606","article-title":"Transcriptional coregulators in development","volume":"284","author":"Mannervik","year":"1999","journal-title":"Science"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB23","doi-asserted-by":"crossref","first-page":"9346","DOI":"10.1073\/pnas.93.18.9346","article-title":"Regulation of patched by sonic hedgehog in the developing neural tube","volume":"93","author":"Marigo","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB24","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1242\/dev.127.11.2357","article-title":"Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2","volume":"127","author":"Matsunaga","year":"2000","journal-title":"Development"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB25","doi-asserted-by":"crossref","first-page":"14743","DOI":"10.1074\/jbc.275.19.14743","article-title":"Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains","volume":"275","author":"Mirmira","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1432-1033.1993.tb18151.x","article-title":"Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein","volume":"216","author":"Miyasaka","year":"1993","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB27","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/44076","article-title":"Commitment to the B-lymphoid lineage depends on the transcription factor Pax5","volume":"401","author":"Nutt","year":"1999","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/PL00008188","article-title":"NKX2 gene expression in neuroectoderm but not in mesendodermally derived structures depends on sonic hedgehog in mouse embryos","volume":"210","author":"Pabst","year":"2000","journal-title":"Dev. Genes Evol."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB29","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0092-8674(94)90070-1","article-title":"Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins","volume":"79","author":"Paroush","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB30","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1101\/gad.9.7.769","article-title":"A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and Nurr1","volume":"9","author":"Perlmann","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB31","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80985-X","article-title":"Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation","volume":"84","author":"Pfaff","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB32","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0092-8674(00)80802-8","article-title":"A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord","volume":"97","author":"Pierani","year":"1999","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB33","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0896-6273(01)00212-4","article-title":"Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1","volume":"29","author":"Pierani","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB34","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0925-4773(98)00018-5","article-title":"Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development","volume":"72","author":"Qiu","year":"1998","journal-title":"Mech. Dev."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB35","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1101\/gad.13.1.125","article-title":"PRDI-BF1\/Blimp1 repression is mediated by corepressors of the Groucho family of proteins","volume":"13","author":"Ren","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB36","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/44164","article-title":"Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors","volume":"401","author":"Rolink","year":"1999","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB37","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/26989","article-title":"The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors","volume":"395","author":"Roose","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB38","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1101\/gad.820400","article-title":"Ventral neural patterning by Nkx homeobox genes","volume":"17","author":"Sander","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB39","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0092-8674(00)81704-3","article-title":"LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons","volume":"95","author":"Sharma","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB40","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1242\/dev.122.10.3141","article-title":"A conserved region of engrailed, shared among all en-, gsc-, NK1, Nk2-, and msh-class homeoproteins, mediates active transcriptional repression in vivo","volume":"122","author":"Smith","year":"1996","journal-title":"Development"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB41","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/mcne.1996.0060","article-title":"Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS","volume":"8","author":"Sommer","year":"1996","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB42","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1006\/dbio.2000.9643","article-title":"Antagonizing activity of chick Grg4 against tectum-organizing activity","volume":"221","author":"Sugiyama","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB43","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0092-8674(00)81783-3","article-title":"Specification of motor neuron identity by the MNR2 homeodomain protein","volume":"95","author":"Tanabe","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB44","doi-asserted-by":"crossref","first-page":"9443","DOI":"10.1073\/pnas.97.17.9443","article-title":"Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins","volume":"97","author":"Watada","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(01)00283-5_BIB45","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1101\/gad.12.22.3591","article-title":"Dorsoventral patterning in the Drosophila central nervous system","volume":"12","author":"Weiss","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(01)00283-5_BIB46","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1073\/pnas.93.5.1764","article-title":"A role of the Msx1 homeodomain in transcriptional regulation","volume":"93","author":"Zhang","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867401002835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867401002835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:39:25Z","timestamp":1758796765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867401002835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,3]]}},"alternative-id":["S0092867401002835"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(01)00283-5","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2001,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Groucho-Mediated Transcriptional Repression Establishes Progenitor Cell Pattern and Neuronal Fate in the Ventral Neural Tube","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0092-8674(01)00283-5","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2001 Cell Press. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}