{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:14:47Z","timestamp":1771636487717,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T00:00:00Z","timestamp":1376697600000},"content-version":"vor","delay-in-days":4521,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[2001,4]]},"DOI":"10.1016\/s0092-8674(01)00301-4","type":"journal-article","created":{"date-parts":[[2004,4,17]],"date-time":"2004-04-17T18:47:25Z","timestamp":1082227645000},"page":"115-126","source":"Crossref","is-referenced-by-count":316,"title":["Dynamic Coupling between the SH2 and SH3 Domains of c-Src and Hck Underlies Their Inactivation by C-Terminal Tyrosine Phosphorylation"],"prefix":"10.1016","volume":"105","author":[{"given":"Matthew A.","family":"Young","sequence":"first","affiliation":[]},{"given":"Stefania","family":"Gonfloni","sequence":"additional","affiliation":[]},{"given":"Giulio","family":"Superti-Furga","sequence":"additional","affiliation":[]},{"given":"Benoit","family":"Roux","sequence":"additional","affiliation":[]},{"given":"John","family":"Kuriyan","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(01)00301-4_BIB1","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1101\/gad.10.11.1341","article-title":"Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin","volume":"10","author":"Alexandropoulos","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB2","article-title":"The role of the SH3\u2013SH2 interface in the regulation of Src kinases","volume":"in press","author":"Arold","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB3","doi-asserted-by":"crossref","first-page":"15400","DOI":"10.1021\/bi9814991","article-title":"Calorimetric investigation of proton linkage by monitoring both the enthalpy and association constant of binding","volume":"37","author":"Bradshaw","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/S0092-8674(01)00301-4_BIB4","article-title":"Mutagenic analysis of the regulatory function of the c-Able Src homology 3 domain","volume":"in press","author":"Brasher","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(01)00301-4_BIB5","doi-asserted-by":"crossref","first-page":"17899","DOI":"10.1074\/jbc.272.29.17899","article-title":"SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1","volume":"272","author":"Briggs","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcc.540040211","article-title":"Charmm","volume":"4","author":"Brooks","year":"1983","journal-title":"J. Comput. Chem."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0959-440X(95)80078-6","article-title":"Methodological advances in molecular dynamics simulations of biological systems","volume":"5","author":"Brooks","year":"1995","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB8","unstructured":"Case, D.A., Pearlman, D.A., Caldwell, J.W., Cheatham, T.E., III, Ross, W.S., Simmerling, C., Darden, T., Merz, K.M., Stanton, R.V., Cheng, A., et al. (1997). AMBER 5.0 (San Francisco, CA, UCSF)."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB9","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/jcc.540161106","article-title":"Application of the multimolecule and multiconformational RESP methodology to biopolymers","volume":"16","author":"Cieplak","year":"1995","journal-title":"J. Comput. Chem."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB10","doi-asserted-by":"crossref","first-page":"5179","DOI":"10.1021\/ja00124a002","article-title":"A second generation force field for the simulation of proteins, nucleic acids, and organic molecules","volume":"117","author":"Cornell","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB11","doi-asserted-by":"crossref","first-page":"10089","DOI":"10.1063\/1.464397","article-title":"Particle mesh ewald","volume":"98","author":"Darden","year":"1995","journal-title":"J. Chem. Phys."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB12","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/368764a0","article-title":"Structure of the regulatory domains of the Src-family tyrosine kinase Lck","volume":"368","author":"Eck","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(01)00301-4_BIB13","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1006\/jmbi.1999.2619","article-title":"Comparison of SH3 and SH2 domain dynamics when expressed alone or in an SH(3+2) construct","volume":"287","author":"Engen","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB14","doi-asserted-by":"crossref","first-page":"7261","DOI":"10.1093\/emboj\/16.24.7261","article-title":"The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src","volume":"16","author":"Gonfloni","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/74041","article-title":"Crosstalk between the catalytic and regulatory domains allows bidirectional regulation of Src","volume":"7","author":"Gonfloni","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB16","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0010-4655(95)00052-H","article-title":"A method to explore transition paths in macromolecules. Applications to hemoglobin and phosphoglycerate kinase","volume":"91","author":"Guilbert","year":"1995","journal-title":"Comp. Phys. Comm."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0092-8674(87)90745-8","article-title":"A tail of two src's","volume":"49","author":"Hunter","year":"1987","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(01)00301-4_BIB18","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1021\/ja00392a016","article-title":"Transferable intermolecular potential functions for water, alcohols and ethers. Application to liquid water","volume":"103","author":"Jorgensen","year":"1981","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB19","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/347631a0","article-title":"Molecular dynamics simulations in biology","volume":"347","author":"Karplus","year":"1990","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(01)00301-4_BIB20","doi-asserted-by":"crossref","first-page":"32129","DOI":"10.1074\/jbc.273.48.32129","article-title":"Intramolecular regulatory interactions in the Src family kinase Hck probed by mutagenesis of a conserved tryptophan residue","volume":"273","author":"LaFevre-Bernt","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB21","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1006\/jmbi.1999.3406","article-title":"DNA-induced alpha-helix capping in conserved linker sequences is a determinant of binding affinity in Cys(2)-His(2) zinc fingers","volume":"295","author":"Laity","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB22","first-page":"1119","article-title":"Regulation of c-Src tyrosine kinase activity by the Src SH2 domain","volume":"8","author":"Liu","year":"1993","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(01)00301-4_BIB23","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1128\/MCB.9.6.2648","article-title":"Structural differences between repressed and derepressed forms of p60c-src","volume":"9","author":"MacAuley","year":"1989","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB24","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1126\/science.1694307","article-title":"Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins","volume":"248","author":"Matsuda","year":"1990","journal-title":"Science"},{"key":"10.1016\/S0092-8674(01)00301-4_BIB25","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/385650a0","article-title":"Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement","volume":"385","author":"Moarefi","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(01)00301-4_BIB26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/351069a0","article-title":"Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src","volume":"351","author":"Nada","year":"1991","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(01)00301-4_BIB27","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1074\/jbc.275.4.2721","article-title":"Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligand","volume":"275","author":"Porter","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB28","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1002\/j.1460-2075.1987.tb02512.x","article-title":"Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus","volume":"6","author":"Reynolds","year":"1987","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB29","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0021-9991(77)90098-5","article-title":"Numerical integration of the Cartesian equations of motion of a system with constraints","volume":"23","author":"Ryckaert","year":"1977","journal-title":"J. Comput. Phys."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB30","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S1097-2765(00)80357-3","article-title":"Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor","volume":"3","author":"Schindler","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(01)00301-4_BIB31","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0959-440X(97)80146-7","article-title":"Structures of Src-family tyrosine kinases","volume":"7","author":"Sicheri","year":"1997","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB32","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/385602a0","article-title":"Crystal structure of the Src family tyrosine kinase Hck","volume":"385","author":"Sicheri","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(01)00301-4_BIB33","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1002\/j.1460-2075.1993.tb05923.x","article-title":"Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src","volume":"12","author":"Superti-Furga","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB34","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/0092-8674(83)90073-9","article-title":"Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus","volume":"32","author":"Takeya","year":"1983","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(01)00301-4_BIB35","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev.cellbio.13.1.513","article-title":"Cellular functions regulated by Src family kinases","volume":"13","author":"Thomas","year":"1997","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB36","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1006\/jmbi.1996.0112","article-title":"Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution","volume":"256","author":"Tong","year":"1996","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB37","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1021\/bi002342n","article-title":"Molecular Determinants for Csk-Catalyzed Tyrosine Phosphorylation of the Src Tail","volume":"40","author":"Wang","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/S0092-8674(01)00301-4_BIB38","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1006\/jmbi.1997.1426","article-title":"The 2.35 A crystal structure of the inactivated form of chicken Src","volume":"274","author":"Williams","year":"1997","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0092-8674(01)00301-4_BIB39","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/385595a0","article-title":"Three-dimensional structure of the tyrosine kinase c-Src","volume":"385","author":"Xu","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(01)00301-4_BIB40","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1097-2765(00)80356-1","article-title":"Crystal structures of c-Src reveal features of its autoinhibitory mechanism","volume":"3","author":"Xu","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(01)00301-4_BIB41","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/384484a0","article-title":"Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation","volume":"384","author":"Yamaguchi","year":"1996","journal-title":"Nature"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867401003014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867401003014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T03:03:13Z","timestamp":1585710193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867401003014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["S0092867401003014"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(01)00301-4","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}