{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:57:15Z","timestamp":1783605435254,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4276,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[2001,11]]},"DOI":"10.1016\/s0092-8674(01)00589-x","type":"journal-article","created":{"date-parts":[[2004,4,17]],"date-time":"2004-04-17T14:47:25Z","timestamp":1082213245000},"page":"591-603","source":"Crossref","is-referenced-by-count":562,"title":["Drosophila Fragile X-Related Gene Regulates the MAP1B Homolog Futsch to Control Synaptic Structure and Function"],"prefix":"10.1016","volume":"107","author":[{"given":"Yong Q.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adina M.","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich J.G.","family":"Matthies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Renden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean D.","family":"Speese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald M.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendal","family":"Broadie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(01)00589-X_BIB1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1126\/science.7692601","article-title":"FMR1 protein","volume":"262","author":"Ashley","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0092-8674(01)00589-X_BIB2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/ng0793-244","article-title":"Human and murine FMR-1","volume":"4","author":"Ashley","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/scientificamerican1273-24","article-title":"Genetic dissection of behavior","volume":"229","author":"Benzer","year":"1973","journal-title":"Sci. Am."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB4","doi-asserted-by":"crossref","first-page":"5833","DOI":"10.1242\/dev.126.24.5833","article-title":"A role for PS integrins in morphological growth and synaptic function at the postembryonic neuromuscular junction of Drosophila","volume":"126","author":"Beumer","year":"1999","journal-title":"Development"},{"key":"10.1016\/S0092-8674(01)00589-X_BIB5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","author":"Brand","year":"1993","journal-title":"Development"},{"key":"10.1016\/S0092-8674(01)00589-X_BIB6","series-title":"Drosophila Protocols","article-title":"Functional assays of the peripheral and central nervous system","author":"Broadie","year":"2000"},{"key":"10.1016\/S0092-8674(01)00589-X_BIB7","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1523\/JNEUROSCI.13-01-00144.1993","article-title":"Development of the embryonic neuromuscular synapse of Drosophila melanogaster","volume":"13","author":"Broadie","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB8","doi-asserted-by":"crossref","first-page":"15521","DOI":"10.1074\/jbc.273.25.15521","article-title":"Purified recombinant Fmrp exhibits selective RNA binding as an intrinsic property of the fragile X mental retardation protein","volume":"273","author":"Brown","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB9","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.1073\/pnas.94.10.5401","article-title":"Abnormal dendritic spines in fragile X knockout mice","volume":"94","author":"Comery","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(01)00589-X_BIB10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/ng0893-335","article-title":"The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation","volume":"4","author":"Devys","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB11","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/hmg\/5.8.1083","article-title":"The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals","volume":"5","author":"Eberhart","year":"1996","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1097-2765(00)80012-X","article-title":"FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association","volume":"1","author":"Feng","year":"1997","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(01)00589-X_BIB13","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1523\/JNEUROSCI.17-05-01539.1997","article-title":"Fragile X mental retardation protein","volume":"17","author":"Feng","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB14","doi-asserted-by":"crossref","first-page":"5847","DOI":"10.1523\/JNEUROSCI.19-14-05847.1999","article-title":"The stoned proteins regulate synaptic vesicle recycling in the presynaptic terminal","volume":"19","author":"Fergestad","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/ajmg.1320410306","article-title":"Analysis of neocortex in three males with the fragile X syndrome","volume":"41","author":"Hinton","year":"1991","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0896-6273(00)81169-1","article-title":"Drosophila Futsch\/22C10 is a MAP1B-like protein required for dendritic and axonal development","volume":"26","author":"Hummel","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/S0092-8674(01)00589-X_BIB17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3109\/01677069409167279","article-title":"The central complex of Drosophila melanogaster is involved in flight control","volume":"9","author":"Ilius","year":"1994","journal-title":"J. Neurogenet."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/1096-8628(20010115)98:2<161::AID-AJMG1025>3.0.CO;2-B","article-title":"Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome","volume":"98","author":"Irwin","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB19","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/hmg\/9.6.901","article-title":"Understanding the molecular basis of fragile X syndrome","volume":"9","author":"Jin","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/ng0196-91","article-title":"The fragile X mental retardation protein is associated with ribosomes","volume":"12","author":"Khandjian","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/hmg\/10.4.329","article-title":"Evidence that fragile X mental retardation protein is a negative regulator of translation","volume":"10","author":"Laggerbauer","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB22","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1093\/nar\/29.11.2276","article-title":"The fragile X mental retardation protein inhibits translation via interacting with mRNA","volume":"29","author":"Li","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB23","series-title":"The Genome of Drosophila melanogaster","author":"Lindsley","year":"1992"},{"key":"10.1016\/S0092-8674(01)00589-X_BIB24","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.1523\/JNEUROSCI.21-14-05139.2001","article-title":"Abnormal development of dendritic spines in FMR1 knock-out mice","volume":"21","author":"Nimchinsky","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB25","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1093\/hmg\/9.8.1145","article-title":"Over)correction of FMR1 deficiency with YAC transgenics","volume":"9","author":"Peier","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB26","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1097\/00001756-200012180-00002","article-title":"Genetic studies in Drosophila","volume":"11","author":"Rodesch","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/S0092-8674(01)00589-X_BIB27","doi-asserted-by":"crossref","first-page":"6868","DOI":"10.1523\/JNEUROSCI.20-18-06868.2000","article-title":"Integrin-mediated regulation of synaptic morphology, transmission, and plasticity","volume":"20","author":"Rohrbough","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB28","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0896-6273(00)81170-8","article-title":"Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growth","volume":"26","author":"Roos","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/S0092-8674(01)00589-X_BIB29","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1242\/dev.125.6.1049","article-title":"Systematic gain-of-function genetics in Drosophila","volume":"125","author":"Rorth","year":"1998","journal-title":"Development"},{"key":"10.1016\/S0092-8674(01)00589-X_BIB30","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1093\/emboj\/20.17.4803","article-title":"The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif","volume":"20","author":"Schaeffer","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0092-8674(93)90420-U","article-title":"The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein","volume":"74","author":"Siomi","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(01)00589-X_BIB32","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/hmg\/5.6.809","article-title":"FMRP is associated to the ribosomes via RNA","volume":"5","author":"Tamanini","year":"1996","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB33","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1093\/hmg\/6.8.1315","article-title":"Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis","volume":"6","author":"Tamanini","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB34","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/363722a0","article-title":"Characterization and localization of the FMR-1 gene product associated with fragile X syndrome","volume":"363","author":"Verheij","year":"1993","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(01)00589-X_BIB35","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0092-8674(91)90397-H","article-title":"Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome","volume":"65","author":"Verkerk","year":"1991","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(01)00589-X_BIB36","doi-asserted-by":"crossref","first-page":"8536","DOI":"10.1128\/MCB.20.22.8536-8547.2000","article-title":"Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein","volume":"20","author":"Wan","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(01)00589-X_BIB37","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1073\/pnas.94.10.5395","article-title":"Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation","volume":"94","author":"Weiler","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286740100589X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286740100589X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T17:25:31Z","timestamp":1623777931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009286740100589X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["S009286740100589X"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(01)00589-x","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1002353.27366","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1002353.31462","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2001,11]]}}}