{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:14:43Z","timestamp":1772792083364,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4215,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1016\/s0092-8674(02)00611-6","type":"journal-article","created":{"date-parts":[[2004,4,17]],"date-time":"2004-04-17T14:47:25Z","timestamp":1082213245000},"page":"261-269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":387,"title":["Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila"],"prefix":"10.1016","volume":"108","author":[{"given":"Thomas E.","family":"Lloyd","sequence":"first","affiliation":[]},{"given":"Richard","family":"Atkinson","sequence":"additional","affiliation":[]},{"given":"Mark N.","family":"Wu","sequence":"additional","affiliation":[]},{"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[]},{"given":"Giuseppa","family":"Pennetta","sequence":"additional","affiliation":[]},{"given":"Hugo J.","family":"Bellen","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(02)00611-6_BIB1","doi-asserted-by":"crossref","first-page":"32785","DOI":"10.1074\/jbc.272.52.32785","article-title":"Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth","volume":"272","author":"Asao","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB2","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/385826a0","article-title":"Hrs-2 is an ATPase implicated in calcium-regulated secretion","volume":"385","author":"Bean","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB3","doi-asserted-by":"crossref","first-page":"15271","DOI":"10.1074\/jbc.275.20.15271","article-title":"Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15","volume":"275","author":"Bean","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB4","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0896-6273(00)80196-8","article-title":"Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlg","volume":"17","author":"Budnik","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1097-2765(00)80125-2","article-title":"Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains","volume":"2","author":"Burd","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB6","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0955-0674(99)00077-0","article-title":"Regulation of signal transduction by endocytosis","volume":"12","author":"Ceresa","year":"2000","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB7","doi-asserted-by":"crossref","first-page":"7069","DOI":"10.1074\/jbc.M004129200","article-title":"Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor","volume":"276","author":"Chin","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB8","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1242\/dev.119.4.1359","article-title":"Autosomal P[ovoD1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras","volume":"119","author":"Chou","year":"1993","journal-title":"Development"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB9","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/0092-8674(93)90356-U","article-title":"Synaptic transmission persists in synaptotagmin mutants of Drosophila","volume":"73","author":"DiAntonio","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB10","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1101\/gad.7.4.633","article-title":"Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila","volume":"7","author":"Doyle","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB11","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0092-8674(90)90474-S","article-title":"Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body","volume":"61","author":"Felder","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB12","doi-asserted-by":"crossref","first-page":"5847","DOI":"10.1523\/JNEUROSCI.19-14-05847.1999","article-title":"The stoned proteins regulate synaptic vesicle recycling in the presynaptic terminal","volume":"19","author":"Fergestad","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB13","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1083\/jcb.132.6.1011","article-title":"Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes","volume":"132","author":"Futter","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB14","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1242\/dev.122.11.3355","article-title":"EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm","volume":"122","author":"Gabay","year":"1996","journal-title":"Development"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB15","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1242\/dev.124.18.3535","article-title":"MAP kinase in situ activation atlas during Drosophila embryogenesis","volume":"124","author":"Gabay","year":"1997","journal-title":"Development"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1006\/dbio.1998.9102","article-title":"Quantitative variations in the level of MAPK activity control patterning of the embryonic termini in Drosophila.","volume":"205","author":"Ghiglione","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB17","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1242\/dev.122.11.3363","article-title":"The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm","volume":"122","author":"Golembo","year":"1996","journal-title":"Development"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB18","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0092-8674(01)00485-8","article-title":"A new ticket for entry into budding vesicles\u2014ubiquitin","volume":"106","author":"Hicke","year":"2001","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0968-0004(01)01835-7","article-title":"A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems","volume":"26","author":"Hofman","year":"2001","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB20","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1083\/jcb.110.5.1541","article-title":"Separate endocytic pathways of kinase-defective and -active EGF receptor mutants expressed in same cells","volume":"110","author":"Honegger","year":"1990","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/BF00309878","article-title":"Transformational process of the endosomal compartment in nephrocytes of Drosophila melanogaster.","volume":"262","author":"Koenig","year":"1990","journal-title":"Cell Tissue Res."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB22","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.1128\/MCB.15.11.6213","article-title":"Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115- kilodalton protein with a structurally conserved putative zinc finger domain","volume":"15","author":"Komada","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB23","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1006\/bbrc.2001.4441","article-title":"Hrs and hbp","volume":"281","author":"Komada","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB24","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1101\/gad.13.11.1475","article-title":"Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis","volume":"13","author":"Komada","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB25","doi-asserted-by":"crossref","first-page":"20538","DOI":"10.1074\/jbc.272.33.20538","article-title":"Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes","volume":"272","author":"Komada","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB26","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1083\/jcb.97.2.499","article-title":"Reversible blockage of membrane retrieval and endocytosis in the garland cell of the temperature-sensitive mutant of Drosophila melanogaster, shibirets1.","volume":"97","author":"Kosaka","year":"1983","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB27","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1242\/jcs.113.12.2273","article-title":"Hrs interacts with SNAP-25 and regulates Ca2+-dependent exocytosis","volume":"113","author":"Kwong","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB28","doi-asserted-by":"crossref","unstructured":"Leptin, M., Casal, J., Grunewald, B., and Reuter, R. (1992). Mechanisms of early Drosophila mesoderm formation. Development (Suppl.), 23\u201332.","DOI":"10.1242\/dev.116.Supplement.23"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/dbio.1998.9121","article-title":"Several levels of EGF receptor signaling during photoreceptor specification in wild-type, ellipse, and null mutant Drosophila.","volume":"205","author":"Lesokhin","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB30","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/genetics\/138.1.111","article-title":"Genetic and phenotypic analysis of thirteen essential genes in cytological interval 22F1\u20132; 23B1\u20132 reveals novel genes required for neural development in Drosophila.","volume":"138","author":"Littleton","year":"1994","journal-title":"Genetics"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0014-5793(98)01401-X","article-title":"VHS domain marks a group of proteins involved in endocytosis and vesicular trafficking","volume":"440","author":"Lohi","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB32","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0092-8674(00)80680-7","article-title":"Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction","volume":"100","author":"Mao","year":"2000","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB33","doi-asserted-by":"crossref","first-page":"9346","DOI":"10.1128\/MCB.20.24.9346-9355.2000","article-title":"Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA","volume":"20","author":"Miura","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB34","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/jcp.1041410220","article-title":"Membrane pinch-off and reinsertion observed in living cells of Drosophila.","volume":"141","author":"Narita","year":"1989","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB35","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0092-8674(00)81707-9","article-title":"Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body","volume":"95","author":"Odorizzi","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB36","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0092-8674(93)90412-J","article-title":"The torso receptor protein-tyrosine kinase signaling pathway","volume":"74","author":"Perrimon","year":"1993","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB37","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/genetics\/113.3.695","article-title":"X-linked female-sterile loci in Drosophila melanogaster","volume":"113","author":"Perrimon","year":"1986","journal-title":"Genetics"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB38","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1083\/jcb.131.3.603","article-title":"VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae","volume":"131","author":"Piper","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB39","doi-asserted-by":"crossref","first-page":"5008","DOI":"10.1093\/emboj\/20.17.5008","article-title":"Hrs recruits clathrin to early endosomes","volume":"20","author":"Raiborg","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB40","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1101\/gad.7.10.1937","article-title":"Establishment of ventral cell fates in the Drosophila embryonic ectoderm requires DER, the EGF receptor homolog","volume":"7","author":"Raz","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB41","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0168-9525(97)01091-3","article-title":"A thousand and one roles for the Drosophila EGF receptor","volume":"13","author":"Schweitzer","year":"1997","journal-title":"Trends Genet."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB42","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1101\/gad.9.12.1518","article-title":"Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination","volume":"9","author":"Schweitzer","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB43","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0955-0674(96)80034-2","article-title":"Receptor signalling and the regulation of endocytic membrane transport","volume":"8","author":"Seaman","year":"1996","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB44","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/28879","article-title":"EEA1 links PI(3)K function to Rab5 regulation of endosome fusion","volume":"394","author":"Simonsen","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB45","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0092-8674(00)81710-9","article-title":"Coiled coils in both intracellular vesicle and viral membrane fusion","volume":"95","author":"Skehel","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB46","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0092-8674(92)90394-R","article-title":"Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg","volume":"71","author":"Sprenger","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB47","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF00215114","article-title":"Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions","volume":"175","author":"Stewart","year":"1994","journal-title":"J. Comp. Physiol."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB48","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1242\/dev.120.9.2593","article-title":"Down-regulation of Drosophila Egfr mRNA levels following hyperactivated receptor signaling","volume":"120","author":"Sturtevant","year":"1994","journal-title":"Development"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB49","doi-asserted-by":"crossref","first-page":"7685","DOI":"10.1128\/MCB.20.20.7685-7692.2000","article-title":"Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate","volume":"20","author":"Urbe","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB50","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1432-1033.1990.tb15532.x","article-title":"Enhancement of tyrosine kinase activity of the Drosophila Egfr homolog by alterations of the transmembrane domain","volume":"189","author":"Wides","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB51","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/emboj\/17.1.127","article-title":"ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage-dependent manner","volume":"17","author":"Wu","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(02)00611-6_BIB52","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0896-6273(00)80811-9","article-title":"Syntaxin-1A interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo","volume":"23","author":"Wu","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/S0092-8674(02)00611-6_BIB53","doi-asserted-by":"crossref","first-page":"9129","DOI":"10.1074\/jbc.274.14.9129","article-title":"Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar\/lysosomal membrane trafficking pathways","volume":"274","author":"Wurmser","year":"1999","journal-title":"J. Biol. Chem."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867402006116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867402006116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:45:14Z","timestamp":1758797114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867402006116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["S0092867402006116"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(02)00611-6","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0092-8674(02)00611-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2002 Cell Press.  All rights reserved.","name":"copyright","label":"Copyright"}]}}