{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:08:55Z","timestamp":1776056935009,"version":"3.50.1"},"reference-count":108,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4125,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[2002,4]]},"DOI":"10.1016\/s0092-8674(02)00675-x","type":"journal-article","created":{"date-parts":[[2004,4,15]],"date-time":"2004-04-15T09:36:43Z","timestamp":1082021803000},"page":"S45-S55","source":"Crossref","is-referenced-by-count":747,"special_numbering":"S1","title":["The Mechanism and Regulation of Chromosomal V(D)J Recombination"],"prefix":"10.1016","volume":"109","author":[{"given":"Craig H","family":"Bassing","sequence":"first","affiliation":[]},{"given":"Wojciech","family":"Swat","sequence":"additional","affiliation":[]},{"given":"Frederick W","family":"Alt","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(02)00675-X_BIB1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/29457","article-title":"Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system","volume":"394","author":"Agrawal","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0092-8674(80)90109-9","article-title":"Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain","volume":"21","author":"Alt","year":"1980","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB3","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/j.1460-2075.1984.tb01955.x","article-title":"Ordered rearrangement of immunoglobulin heavy chain variable region segments","volume":"3","author":"Alt","year":"1984","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB4","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0167-5699(92)90043-7","article-title":"VDJ recombination","volume":"13","author":"Alt","year":"1992","journal-title":"Immunol. Today"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1074-7613(00)80598-1","article-title":"Developmentally programmed rearrangement of T cell receptor V\u03b3 genes is controlled by sequences immediately upstream of the V\u03b3 genes","volume":"9","author":"Baker","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB6","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0960-9822(98)00021-9","article-title":"Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice","volume":"8","author":"Barnes","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB7","doi-asserted-by":"crossref","first-page":"893","DOI":"10.4049\/jimmunol.164.2.893","article-title":"Frequency and characterization of phenotypic Ig heavy chain allelically included IgM-expresssing B cells in mice","volume":"164","author":"Barreto","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB8","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/35014635","article-title":"Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12\/23 rule","volume":"405","author":"Bassing","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB9","doi-asserted-by":"crossref","first-page":"14066","DOI":"10.1073\/pnas.95.24.14066","article-title":"DNA end-joining catalyzed by human cell-free extracts","volume":"95","author":"Baumann","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1126\/science.281.5373.60","article-title":"Going the distance","volume":"281","author":"Blackwood","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB11","doi-asserted-by":"crossref","first-page":"7871","DOI":"10.1073\/pnas.93.15.7871","article-title":"Gene targeted deletion and replacement mutations of the T-cell receptor \u03b2 chain enhancer","volume":"93","author":"Bories","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.iy.09.040191.001543","article-title":"The SCID mouse mutant","volume":"9","author":"Bosma","year":"1991","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB13","doi-asserted-by":"crossref","first-page":"7877","DOI":"10.1073\/pnas.93.15.7877","article-title":"Deletion of the mouse T-cell receptor \u03b2 gene enhancer blocks \u03b1\u03b2 T-cell development","volume":"93","author":"Bouvier","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB14","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1126\/science.290.5498.1962","article-title":"Response to RAG-mediated V(D)J cleavage by NBS1 and \u03b3-H2AX","volume":"290","author":"Chen","year":"2000","journal-title":"Science"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB15","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1084\/jem.185.4.609","article-title":"Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development","volume":"185","author":"Constantinescu","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB16","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/S0960-9822(06)00258-2","article-title":"Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV","volume":"7","author":"Critchlow","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB17","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/35006670","article-title":"DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation","volume":"404","author":"Difilippantonio","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB18","doi-asserted-by":"crossref","first-page":"R920","DOI":"10.1016\/S0960-9822(01)00555-3","article-title":"DNA repair","volume":"11","author":"Doherty","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/380085a0","article-title":"Initiation of V(D)J recombination in vitro obeying the 12\/23 rule","volume":"380","author":"Eastman","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB20","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1038\/sj.onc.1204767","article-title":"DNA double-strand break repair and chromosomal translocation","volume":"20","author":"Ferguson","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/24172","article-title":"Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV","volume":"396","author":"Frank","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB22","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S1097-2765(00)80264-6","article-title":"DNA Ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway","volume":"5","author":"Frank","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB23","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1146\/annurev.immunol.18.1.495","article-title":"The RAG proteins and V(D)J recombination","volume":"18","author":"Fugmann","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1097-2765(00)80406-2","article-title":"Identification of two catalytic residues in RAG1 that define a single active site within the RAG1\/RAG2 protein complex","volume":"5","author":"Fugmann","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB25","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S1074-7613(00)80619-6","article-title":"A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for Ku in V(D)J recombination","volume":"9","author":"Gao","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB26","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0092-8674(00)81714-6","article-title":"A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis","volume":"95","author":"Gao","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB27","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/35009138","article-title":"Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability, and development","volume":"404","author":"Gao","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB28","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1074-7613(00)80053-9","article-title":"Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion","volume":"10","author":"Gartner","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB29","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1126\/science.8356452","article-title":"Mice lacking TdT","volume":"261","author":"Gilfillan","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB30","doi-asserted-by":"crossref","first-page":"3712","DOI":"10.1093\/emboj\/18.13.3712","article-title":"Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase","volume":"18","author":"Golding","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0065-2776(08)60607-0","article-title":"Regulation of immunoglobulin light chain isotype expression","volume":"69","author":"Gorman","year":"1998","journal-title":"Adv. Immunol."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB32","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/41358","article-title":"Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells","volume":"388","author":"Grawunder","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB33","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S1097-2765(00)80147-1","article-title":"DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes","volume":"2","author":"Grawunder","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB34","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1074-7613(00)80386-6","article-title":"Growth retardation and leaky SCID phenotype of Ku70-deficient mice","volume":"7","author":"Gu","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB35","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1073\/pnas.97.6.2668","article-title":"Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice","volume":"97","author":"Gu","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB36","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1126\/science.274.5295.2094","article-title":"Neoteny in lymphocytes","volume":"274","author":"Han","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB37","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1101\/gad.12.15.2305","article-title":"Enhancer control of V(D)J recombination at the TCR\u03b2 locus","volume":"12","author":"Hempel","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB38","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0065-2776(01)78004-2","article-title":"Factors and forces controlling V(D)J recombination","volume":"78","author":"Hesslein","year":"2001","journal-title":"Adv. Immunol."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB39","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1126\/science.274.5295.2092","article-title":"Re-expression of RAG-1 and RAG-2 genes in activated mature mouse B cells","volume":"274","author":"Hikida","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB40","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0092-8674(00)81587-1","article-title":"DNA transposition by the RAG1 and RAG2 proteins","volume":"94","author":"Hiom","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB41","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1074-7613(00)80070-9","article-title":"Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors","volume":"10","author":"Iritani","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB42","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0952-7915(00)00206-5","article-title":"Towards and understanding of somatic hypermutation","volume":"13","author":"Jacobs","year":"2001","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB43","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/85798","article-title":"DNA double-strand breaks","volume":"27","author":"Khanna","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB44","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0065-2776(08)60620-3","article-title":"Development and selection of T cells","volume":"58","author":"Kisielow","year":"1995","journal-title":"Adv. Immunol."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB45","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1101\/gad.13.23.3070","article-title":"Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase","volume":"13","author":"Kim","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB46","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1093\/emboj\/17.16.4881","article-title":"Dual role of RAG2 in V(D)J recombination","volume":"17","author":"Kirch","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB47","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1126\/science.8356451","article-title":"Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes","volume":"261","author":"Komori","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB48","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1073\/pnas.96.4.1403","article-title":"Catalytic subunit of DNA-dependent protein kinase","volume":"96","author":"Kurimasa","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB49","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1600-065X.1998.tb01236.x","article-title":"Developmental regulation of V(D)J recombination at the TCR\u03b1\/\u03b4 locus","volume":"165","author":"Krangel","year":"1998","journal-title":"Immunol. Rev."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB50","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S1097-2765(00)80297-X","article-title":"Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1","volume":"2","author":"Kwon","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB51","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S1097-2765(00)00102-7","article-title":"Histone acetylation and hSWI\/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA","volume":"6","author":"Kwon","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB52","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1101\/gad.13.23.3059","article-title":"Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination","volume":"13","author":"Landree","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB53","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S1074-7613(00)80151-X","article-title":"Cyclin A\/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair","volume":"11","author":"Lee","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB54","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0065-2776(08)60450-2","article-title":"The mechanism of V(D)J joining","volume":"56","author":"Lewis","year":"1994","journal-title":"Adv. Immunol."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB55","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1073\/pnas.022649699","article-title":"Ku86 is essential in human somatic cells","volume":"99","author":"Li","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB56","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/0092-8674(95)90135-3","article-title":"The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination","volume":"83","author":"Li","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB57","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1101\/gad.13.10.1246","article-title":"Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma","volume":"13","author":"Liao","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB58","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1084\/jem.192.8.1191","article-title":"Genetic modulation of T cell receptor gene segment usage during somatic recombination","volume":"192","author":"Livak","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB59","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0092-8674(02)00671-2","article-title":"Hairpin opening and overhang processing by an Artemis\/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination","volume":"108","author":"Ma","year":"2002","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB60","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1471-4906(01)02111-1","article-title":"Mechanism and control of IgH class-switch recombination","volume":"23","author":"Manis","year":"2002","journal-title":"Trends Immunol."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB61","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1084\/jem.192.5.625","article-title":"Chromatin remodeling by the T cell receptor (TCR)-\u03b2 gene enhancer during early T cell development","volume":"192","author":"Mathieu","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB62","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0092-8674(95)90116-7","article-title":"Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps","volume":"83","author":"McBlane","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB63","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1126\/science.287.5452.495","article-title":"A role for histone acetylation in the developmental regulation of V(D)J recombination","volume":"287","author":"McMurry","year":"2000","journal-title":"Science"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB64","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0092-8674(00)80874-0","article-title":"RAG1\/2-mediated resolution of transposition intermediates","volume":"101","author":"Melek","year":"2000","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB65","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1126\/science.280.5361.301","article-title":"Rejoining of DNA by the RAG1 and RAG2 proteins","volume":"280","author":"Melek","year":"1998","journal-title":"Science"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB66","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0092-8674(92)90030-G","article-title":"RAG-1-deficient mice have no mature B and T lymphocytes","volume":"68","author":"Mombaerts","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB67","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1074-7613(00)80095-3","article-title":"RAG2:gfp knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues","volume":"11","author":"Monroe","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB68","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0092-8674(01)00309-9","article-title":"Artemis, a novel DNA double-strand break repair\/V(D)J recombination protein, is mutated in human severe combined immune deficiency","volume":"105","author":"Moshous","year":"2001","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB69","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1101\/gad.12.12.1801","article-title":"\u03ba chain monoallelic demethylation and the establishment of allelic exclusion","volume":"12","author":"Mostoslavsky","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB70","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/35102606","article-title":"Asynchronous replication and allelic exclusion in the immune system","volume":"414","author":"Mostoslavsky","year":"2001","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB71","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1084\/jem.191.11.1813","article-title":"Revising B cell receptors","volume":"191","author":"Nemazee","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB72","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0952-7915(99)80073-9","article-title":"RAG and RAG defects","volume":"11","author":"Notarangelo","year":"1999","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB73","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/382551a0","article-title":"Requirement for Ku80 in growth and immunoglobulin V(D)J recombination","volume":"382","author":"Nussenzweig","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB74","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1126\/science.2360047","article-title":"RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination","volume":"248","author":"Oettinger","year":"1990","journal-title":"Science"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB75","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1084\/jem.186.6.921","article-title":"Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination in vivo","volume":"186","author":"Ouyang","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB76","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0092-8674(01)00591-8","article-title":"New glimpses of an old machine","volume":"107","author":"Paull","year":"2001","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB77","doi-asserted-by":"crossref","first-page":"29126","DOI":"10.1074\/jbc.M103797200","article-title":"Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints","volume":"276","author":"Raghavan","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB78","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/381751a0","article-title":"Clonal selection and learning in the antibody system","volume":"381","author":"Rajewsky","year":"1996","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB79","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1073\/pnas.96.4.1526","article-title":"Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain enhancer core region in the absence of the matrix attachment regions","volume":"96","author":"Sakai","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB80","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1034\/j.1600-065X.2000.17818.x","article-title":"The genetic and biochemical basis of Omenn syndrome","volume":"178","author":"Santagata","year":"2000","journal-title":"Immunol. Rev."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB81","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1615\/CritRevEukarGeneExpr.v9.i3-4.140","article-title":"MARs of antigen receptor and co-receptor genes","volume":"9","author":"Scheuermann","year":"1999","journal-title":"Crit. Rev. Euk. Gene Exp."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB82","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1097-2765(01)00155-1","article-title":"Joining-deficient RAG-1 mutants block V(D)J recombination in vivo and hairpin opening in vitro","volume":"7","author":"Schultz","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB83","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.274.5284.97","article-title":"RAG mutations in human B cell-negative SCID","volume":"274","author":"Schwarz","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB84","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S1097-2765(01)00423-3","article-title":"Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs","volume":"8","author":"Sekiguchi","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB85","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/intimm\/13.11.1405","article-title":"Limited effect of chromatin remodeling on D\u03b2-to-J\u03b2 recombination in CD4+CD8+ thymocyte","volume":"13","author":"Senoo","year":"2001","journal-title":"Int. Immunol."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB86","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(92)90029-C","article-title":"RAG-2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J recombination","volume":"68","author":"Shinkai","year":"1992","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB87","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/ni0901-848","article-title":"Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes","volume":"2","author":"Skok","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB88","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev.immunol.14.1.459","article-title":"Accessibility control of antigen-receptor variable-region gene assembly","volume":"14","author":"Sleckman","year":"1996","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB89","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S1074-7613(00)80372-6","article-title":"Function of the TCR\u03b1 enhancer in \u03b1\u03b2 and \u03b3\u03b4 T cells","volume":"7","author":"Sleckman","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB90","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1084\/jem.188.8.1465","article-title":"Assembly of productive TCR\u03b4 variable region genes exhibits allelic inclusion","volume":"188","author":"Sleckman","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB91","doi-asserted-by":"crossref","first-page":"7975","DOI":"10.1073\/pnas.130190597","article-title":"Mechanisms that direct ordered assembly of T cell receptor \u03b2 locus V, D, and J gene segments","volume":"97","author":"Sleckman","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB92","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0092-8674(00)81272-6","article-title":"Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro","volume":"85","author":"Stanhope-Baker","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB93","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/47412","article-title":"The language of covalent histone modifications","volume":"403","author":"Strahl","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB94","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1126\/science.8469973","article-title":"Impairment of V(D)J recombination in double-strand break repair mutants","volume":"260","author":"Taccioli","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB95","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1074-7613(00)80618-4","article-title":"Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity","volume":"9","author":"Taccioli","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB96","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1084\/jem.185.9.1549","article-title":"T cell receptor (TCR)-\u03b2 gene recombination","volume":"185","author":"Tourigny","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB97","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/302575a0","article-title":"Somatic generation of antibody diversity","volume":"302","author":"Tonegawa","year":"1983","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB98","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0092-8674(88)90425-4","article-title":"In transgenic mice the introduced functional T cell receptor \u03b2 gene prevents expression of endogenous \u03b2 genes","volume":"52","author":"Uematsu","year":"1988","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB99","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.271.5255.1592","article-title":"Similarities between initiation of V(D)J recombination and retroviral integration","volume":"271","author":"van Gent","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB100","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0092-8674(00)81086-7","article-title":"The RAG1 and RAG2 proteins establish the 12\/23 rule in V(D)J recombination","volume":"85","author":"van Gent","year":"1996","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB101","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0092-8674(00)81448-8","article-title":"Partial V(D)J recombination activity leads to Omenn syndrome","volume":"93","author":"Villa","year":"1998","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB102","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1074-7613(00)80259-9","article-title":"Defect in rearrangement of the most 5\u2032 TCR-J\u03b1 following targeted deletion of T early \u03b1 (TEA)","volume":"5","author":"Villey","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB103","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/35088000","article-title":"Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair","volume":"412","author":"Walker","year":"2001","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB104","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1074-7613(00)80031-X","article-title":"Control of V(D)J recombinational accessibility of the D\u03b21 gene segment at the TCR\u03b2 locus by a germline promoter","volume":"10","author":"Whitehurst","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB105","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0092-8674(85)90141-2","article-title":"Developmentally controlled and tissue-specific expression of unrearranged VH gene segments","volume":"40","author":"Yancopoulos","year":"1985","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB106","doi-asserted-by":"crossref","first-page":"6029","DOI":"10.4049\/jimmunol.162.10.6029","article-title":"Evidence that the Ig\u03ba gene MAR regulates the probability of premature V-J joining and somatic hypermutation","volume":"162","author":"Yi","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/S0092-8674(02)00675-X_BIB107","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/23287","article-title":"Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization","volume":"400","author":"Yu","year":"1999","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(02)00675-X_BIB108","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0092-8674(00)80111-7","article-title":"Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates","volume":"86","author":"Zhu","year":"1996","journal-title":"Cell"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286740200675X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286740200675X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T21:11:41Z","timestamp":1734297101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009286740200675X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":108,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["S009286740200675X"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(02)00675-x","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}