{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:22:31Z","timestamp":1775881351358,"version":"3.50.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3394,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1016\/s0092-8674(04)00302-2","type":"journal-article","created":{"date-parts":[[2004,4,17]],"date-time":"2004-04-17T14:47:25Z","timestamp":1082213245000},"page":"225-237","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":737,"title":["I\u03baB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a"],"prefix":"10.1016","volume":"117","author":[{"given":"Mickey C.-T","family":"Hu","sequence":"first","affiliation":[]},{"given":"Dung-Fang","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Weiya","family":"Xia","sequence":"additional","affiliation":[]},{"given":"Leonard S","family":"Golfman","sequence":"additional","affiliation":[]},{"given":"Fu","family":"Ou-Yang","sequence":"additional","affiliation":[]},{"given":"Jer-Yen","family":"Yang","sequence":"additional","affiliation":[]},{"given":"Yiyu","family":"Zou","sequence":"additional","affiliation":[]},{"given":"Shilai","family":"Bao","sequence":"additional","affiliation":[]},{"given":"Norihisa","family":"Hanada","sequence":"additional","affiliation":[]},{"given":"Hitomi","family":"Saso","sequence":"additional","affiliation":[]},{"given":"Ryuji","family":"Kobayashi","sequence":"additional","affiliation":[]},{"given":"Mien-Chie","family":"Hung","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(04)00302-2_BIB1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/35099574","article-title":"Forkhead transcription factors contribute to execution of the mitotic programme in mammals","volume":"413","author":"Alvarez","year":"2001","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(04)00302-2_BIB2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0092-8674(00)80595-4","article-title":"Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor","volume":"96","author":"Brunet","year":"1999","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(04)00302-2_BIB3","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0968-0004(02)02113-8","article-title":"Cell cycle and death control","volume":"27","author":"Burgering","year":"2002","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/S0092-8674(04)00302-2_BIB4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.2002.0780","article-title":"Forkhead transcription factors","volume":"250","author":"Carlsson","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/S0092-8674(04)00302-2_BIB5","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/sj.onc.1200861","article-title":"The tumor suppression activity of E1A in HER-2 and neu-overexpressing breast cancer","volume":"14","author":"Chang","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(04)00302-2_BIB6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1535-6108(02)00154-X","article-title":"\u03b2-catenin interacts with and inhibits NF-\u03baB in human colon and breast cancer","volume":"2","author":"Deng","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/S0092-8674(04)00302-2_BIB7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(04)00302-2_BIB8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1359-6101(00)00018-6","article-title":"NF-\u03baB and cell-cycle regulation","volume":"12","author":"Joyce","year":"2001","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/S0092-8674(04)00302-2_BIB9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","article-title":"Phosphorylation meets Ub","volume":"18","author":"Karin","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/S0092-8674(04)00302-2_BIB10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nrc780","article-title":"NF-\u03baB in cancer","volume":"2","author":"Karin","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/S0092-8674(04)00302-2_BIB11","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1128\/MCB.22.7.2025-2036.2002","article-title":"Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors","volume":"22","author":"Kops","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(04)00302-2_BIB12","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/ncb0901-802","article-title":"Nuclear localization of EGF receptor and its potential new role as a transcription factor","volume":"3","author":"Lin","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/S0092-8674(04)00302-2_BIB13","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/35008115","article-title":"AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1","volume":"404","author":"Medema","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(04)00302-2_BIB14","doi-asserted-by":"crossref","first-page":"8969","DOI":"10.1128\/MCB.20.23.8969-8982.2000","article-title":"Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN","volume":"20","author":"Nakamura","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(04)00302-2_BIB15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0898-6568(01)00271-6","article-title":"The protein kinase B\/Akt signaling pathway in human malignancy","volume":"14","author":"Nicholson","year":"2002","journal-title":"Cell. Signal."},{"key":"10.1016\/S0092-8674(04)00302-2_BIB16","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1101\/gad.1098703","article-title":"Control of cell number by Drosophila FOXO","volume":"17","author":"Puig","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(04)00302-2_BIB17","first-page":"RE5","article-title":"The many forks in FOXO's road","volume":"172","author":"Tran","year":"2003","journal-title":"Sci STKE"},{"key":"10.1016\/S0092-8674(04)00302-2_BIB18","first-page":"M21","article-title":"The PTEN tumor suppressor protein","volume":"1470","author":"Vazquez","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0092-8674(04)00302-2_BIB19","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrc839","article-title":"The phosphatidylinositol 3-Kinase AKT pathway in human cancer","volume":"2","author":"Vivanco","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/S0092-8674(04)00302-2_BIB20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1046-2023(02)00006-3","article-title":"Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation","volume":"26","author":"Weinmann","year":"2002","journal-title":"Methods"},{"key":"10.1016\/S0092-8674(04)00302-2_BIB21","doi-asserted-by":"crossref","first-page":"8027","DOI":"10.1074\/jbc.275.11.8027","article-title":"HER-2\/neu blocks tumor necrosis factor-induced apoptosis via the Akt and NF-\u03baB pathway","volume":"275","author":"Zhou","year":"2000","journal-title":"J. Biol. Chem."}],"updated-by":[{"DOI":"10.1016\/j.cell.2007.06.006","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000}}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867404003022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867404003022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:49:07Z","timestamp":1758797347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867404003022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["S0092867404003022"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(04)00302-2","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1019381.218529","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2004,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"I\u03baB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0092-8674(04)00302-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Cell Press. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}