{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:10:00Z","timestamp":1780369800931,"version":"3.54.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3364,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[2004,5]]},"DOI":"10.1016\/s0092-8674(04)00419-2","type":"journal-article","created":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T09:31:40Z","timestamp":1086082300000},"page":"663-676","source":"Crossref","is-referenced-by-count":813,"title":["Stepwise Reprogramming of B Cells into Macrophages"],"prefix":"10.1016","volume":"117","author":[{"given":"Huafeng","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(04)00419-2_BIB1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0952-7915(99)00064-3","article-title":"Lymphoid precursors","volume":"12","author":"Akashi","year":"2000","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/35004599","article-title":"A clonogenic common myeloid progenitor that gives rise to all myeloid lineages","volume":"404","author":"Akashi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(04)00419-2_BIB3","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1128\/MCB.10.6.2703","article-title":"Macrophage lineage switching of murine early pre-B lymphoid cells expressing transduced fms genes","volume":"10","author":"Borzillo","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0959-437X(00)00226-4","article-title":"Hematopoietic development","volume":"11","author":"Cantor","year":"2001","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB5","first-page":"156","article-title":"Impaired generation of bone marrow B lymphocytes in mice deficient in C\/EBPbeta","volume":"90","author":"Chen","year":"1997","journal-title":"Blood"},{"key":"10.1016\/S0092-8674(04)00419-2_BIB6","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.4049\/jimmunol.168.11.5659","article-title":"A three-megabase yeast artificial chromosome contig spanning the C57BL mouse Igh locus","volume":"168","author":"Chevillard","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB7","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.4049\/jimmunol.153.11.5049","article-title":"Limited expression of C\/EBP family proteins during B lymphocyte development. Negative regulator Ig\/EBP predominates early and activator NF-IL-6 is induced later","volume":"153","author":"Cooper","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB8","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/ni973","article-title":"Regulation of macrophage and neutrophil cell fates by the PU.1:C\/EBPalpha ratio and granulocyte colony-stimulating factor","volume":"4","author":"Dahl","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB9","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1126\/science.288.5470.1439","article-title":"Regulation of B lymphocyte and macrophage development by graded expression of PU.1","volume":"288","author":"DeKoter","year":"2000","journal-title":"Science"},{"key":"10.1016\/S0092-8674(04)00419-2_BIB10","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0960-9822(00)00129-9","article-title":"Analysis of the B-cell progenitor compartment at the level of single cells","volume":"4","author":"Ehlich","year":"1994","journal-title":"Curr. Biol."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB11","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1038\/sj.onc.1205324","article-title":"Transcriptional regulation of granulocyte and monocyte development","volume":"21","author":"Friedman","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/S0092-8674(04)00419-2_BIB12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","article-title":"Blood monocytes consist of two principal subsets with distinct migratory properties","volume":"19","author":"Geissmann","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/S0092-8674(04)00419-2_BIB13","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1182\/blood.V99.9.3089","article-title":"Differentiation plasticity of hematopoietic cells","volume":"99","author":"Graf","year":"2002","journal-title":"Blood"},{"key":"10.1016\/S0092-8674(04)00419-2_BIB14","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0952-7915(03)00012-8","article-title":"B-cell commitment","volume":"15","author":"Hardy","year":"2003","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB15","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1093\/emboj\/cdg380","article-title":"Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C\/EBPalpha and GATA factors","volume":"22","author":"Heavey","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB16","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1093\/emboj\/cdf368","article-title":"Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells","volume":"21","author":"Heyworth","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB17","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1189\/jlb.72.4.621","article-title":"The mononuclear phagocyte system revisited","volume":"72","author":"Hume","year":"2002","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB18","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1074-7613(03)00242-5","article-title":"GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte\/erythrocyte lineages","volume":"19","author":"Iwasaki","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/S0092-8674(04)00419-2_BIB19","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1084\/jem.20021843","article-title":"Enforced granulocyte\/macrophage colony-stimulating factor signals do not support lymphopoiesis, but instruct lymphoid to myelomonocytic lineage conversion","volume":"197","author":"Iwasaki-Arai","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB20","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1182\/blood.V99.6.2032","article-title":"Expression of C\/EBPbeta from the C\/ebpalpha gene locus is sufficient for normal hematopoiesis in vivo","volume":"99","author":"Jones","year":"2002","journal-title":"Blood"},{"key":"10.1016\/S0092-8674(04)00419-2_BIB21","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nri721","article-title":"Redefinition of lymphoid progenitors","volume":"2","author":"Katsura","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB22","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0952-7915(00)00202-8","article-title":"Transcription factor regulation of B lineage commitment","volume":"13","author":"Kee","year":"2001","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB23","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1073\/pnas.072087899","article-title":"Lineage infidelity in myeloid cells with TCR gene rearrangement","volume":"99","author":"King","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(04)00419-2_BIB24","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0092-8674(88)90309-1","article-title":"Hemopoietic lineage switch","volume":"53","author":"Klinken","year":"1988","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(04)00419-2_BIB25","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/35030112","article-title":"Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines","volume":"407","author":"Kondo","year":"2000","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(04)00419-2_BIB26","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1128\/MCB.12.6.2662","article-title":"The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP","volume":"12","author":"Kozmik","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB27","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1101\/gad.9.10.1250","article-title":"GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts","volume":"9","author":"Kulessa","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/annonc\/13.S1.11","article-title":"Biology of Hodgkin's lymphoma","volume":"13","author":"Kuppers","year":"2002","journal-title":"Ann. Oncol."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1126\/science.1067518","article-title":"Reversion of B cell commitment upon loss of Pax5 expression","volume":"297","author":"Mikkola","year":"2002","journal-title":"Science"},{"key":"10.1016\/S0092-8674(04)00419-2_BIB30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1182\/blood.V68.2.597.597","article-title":"Mixed lineage leukemia","volume":"68","author":"Mirro","year":"1986","journal-title":"Blood"},{"key":"10.1016\/S0092-8674(04)00419-2_BIB31","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1101\/gad.12.15.2403","article-title":"PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors","volume":"12","author":"Nerlov","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB32","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1101\/gad.12.15.2413","article-title":"Distinct C\/EBP functions are required for eosinophil lineage commitment and maturation","volume":"12","author":"Nerlov","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB33","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/44076","article-title":"Commitment to the B-lymphoid lineage depends on the transcription factor Pax5","volume":"401","author":"Nutt","year":"1999","journal-title":"Nature"},{"key":"10.1016\/S0092-8674(04)00419-2_BIB34","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/35049577","article-title":"Diversification of haematopoietic stem cells to specific lineages","volume":"1","author":"Orkin","year":"2000","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB35","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1016\/S0021-9258(18)53496-7","article-title":"The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter","volume":"268","author":"Pahl","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB36","doi-asserted-by":"crossref","first-page":"29279","DOI":"10.1074\/jbc.273.45.29279","article-title":"The role of C\/EBP isoforms in the control of inflammatory and native immunity functions","volume":"273","author":"Poli","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB37","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.1128\/MCB.18.7.4301","article-title":"CCAAT\/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors","volume":"18","author":"Radomska","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB38","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0952-7915(02)00324-2","article-title":"Transcriptional control of B-cell development","volume":"14","author":"Schebesta","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB39","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1002\/j.1460-2075.1995.tb07185.x","article-title":"Lymphoproliferative disorder and imbalanced T-helper response in C\/EBP beta-deficient mice","volume":"14","author":"Screpanti","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB40","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0959-437X(98)80009-9","article-title":"A transcription factor party during blood cell differentiation","volume":"8","author":"Sieweke","year":"1998","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB41","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1073\/pnas.0337434100","article-title":"CCAAT\/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis","volume":"100","author":"Tang","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(04)00419-2_BIB42","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/intimm\/7.6.1013","article-title":"The status of Ig loci rearrangements in single cells from different stages of B cell development","volume":"7","author":"ten Boekel","year":"1995","journal-title":"Int. Immunol."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB43","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1182\/blood.V90.2.489","article-title":"Transcription factors, normal myeloid development, and leukemia","volume":"90","author":"Tenen","year":"1997","journal-title":"Blood"},{"key":"10.1016\/S0092-8674(04)00419-2_BIB44","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0952-7915(03)00011-6","article-title":"Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors","volume":"15","author":"Warren","year":"2003","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/S0092-8674(04)00419-2_BIB45","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S1074-7613(03)00299-1","article-title":"Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential","volume":"19","author":"Ye","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/S0092-8674(04)00419-2_BIB46","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1073\/pnas.94.2.569","article-title":"Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice","volume":"94","author":"Zhang","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867404004192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867404004192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T02:59:39Z","timestamp":1734404379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867404004192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["S0092867404004192"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(04)00419-2","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1019262.216547","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1019262.225435","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}