{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:24:32Z","timestamp":1779344672744,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1988,2,1]],"date-time":"1988-02-01T00:00:00Z","timestamp":570672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1988,2]]},"DOI":"10.1016\/s0092-8674(88)80026-6","type":"journal-article","created":{"date-parts":[[2005,9,15]],"date-time":"2005-09-15T14:15:38Z","timestamp":1126793738000},"page":"329-341","source":"Crossref","is-referenced-by-count":632,"title":["The mannose 6-phosphate receptor and the biogenesis of lysosomes"],"prefix":"10.1016","volume":"52","author":[{"given":"Gareth","family":"Griffiths","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Hoflack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Simons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira","family":"Mellman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Kornfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0092-8674(88)80026-6_bib1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0092-8674(85)90212-0","article-title":"Vesicles and cisternae in the trans Golgi apparatus of human fibroblasts are acidic compartments","volume":"40","author":"Anderson","year":"1985","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(88)80026-6_bib2","first-page":"4838","article-title":"Visualization of acidic organelles in intact cells by electron microscopy","volume":"81","author":"Anderson","year":"1984"},{"key":"10.1016\/S0092-8674(88)80026-6_bib3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0092-8674(84)90195-8","article-title":"Direct visualization of protein transport and processing in the living cell by microinjection of specific antibodies","volume":"39","author":"Arnheiter","year":"1984","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(88)80026-6_bib4","doi-asserted-by":"crossref","first-page":"16755","DOI":"10.1016\/S0021-9258(18)66630-X","article-title":"Biosynthesis, glycosylation, movement through the Golgi system and transport to lysosomes by an N-linked carbohydrate-independent mechanism of three lysosomal integral membrane proteins","volume":"261","author":"Barriocanal","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(88)80026-6_bib5","first-page":"5135","article-title":"Accumulation of coated vesicles bearing mannose 6-phosphate receptors for lysosomal enzymes in the Golgi region of fibroblasts","volume":"81","author":"Brown","year":"1984"},{"key":"10.1016\/S0092-8674(88)80026-6_bib6","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0092-8674(84)90223-X","article-title":"The mannose 6-phosphate receptor for lysosomal enzymes is concentrated in cis Golgi cisternae","volume":"36","author":"Brown","year":"1984","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(88)80026-6_bib7","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1083\/jcb.99.1.320","article-title":"Redistribution of mannose 6-phosphate specific receptors induced by tunicamycin and chloroquine","volume":"99","author":"Brown","year":"1984","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(88)80026-6_bib8","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1083\/jcb.103.4.1235","article-title":"Mannose 6-phosphate receptors for lysosomal enzymes cycle between the Golgi complex and endosomes","volume":"103","author":"Brown","year":"1986","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(88)80026-6_bib9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0003-2697(81)90281-5","article-title":"Western blotting electrophoretic transfer of proteins from sodium docecylsulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic direction with antibody and radiolabeled protein A","volume":"112","author":"Burnette","year":"1981","journal-title":"Anal. Biochem."},{"key":"10.1016\/S0092-8674(88)80026-6_bib10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1083\/jcb.101.1.85","article-title":"Identification of two lysosomal membrane glycoproteins","volume":"101","author":"Chen","year":"1985","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(88)80026-6_bib11","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.1016\/S0021-9258(19)70726-1","article-title":"Low temperature selectively inhibits fusion between pinocytic vesicles and lysosomes during heterophagy of 125I asialofetuin by the perfused rat liver","volume":"255","author":"Dunn","year":"1980","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(88)80026-6_bib12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1083\/jcb.35.2.357","article-title":"Functions of coated vesicles during protein absorption in the rat vas deferens","volume":"35","author":"Friend","year":"1967","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(88)80026-6_bib13","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1083\/jcb.98.6.2047","article-title":"Ultrastructural localization of the mannose 6-phosphate receptor in rat liver","volume":"98","author":"Geuze","year":"1984","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(88)80026-6_bib14","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1083\/jcb.101.6.2253","article-title":"Possible pathways for lysosomal enzyme delivery","volume":"101","author":"Geuze","year":"1985","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(88)80026-6_bib15","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1083\/jcb.105.3.1227","article-title":"Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins","volume":"105","author":"Green","year":"1987","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(88)80026-6_bib16","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1177\/34.11.3534077","article-title":"Quantitation in immunocytochemistry: correlations of immunogold labeling to absolute number of membrane antigens","volume":"34","author":"Griffiths","year":"1986","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/S0092-8674(88)80026-6_bib17","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1126\/science.2945253","article-title":"The trans Golgi network: sorting at the exit site of the Golgi complex","volume":"234","author":"Griffiths","year":"1986","journal-title":"Science"},{"key":"10.1016\/S0092-8674(88)80026-6_bib18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0022-5320(84)80024-6","article-title":"On the preparation of cryosections for immunocytochemistry","volume":"89","author":"Griffiths","year":"1984","journal-title":"J. Ultrastruct Res."},{"key":"10.1016\/S0092-8674(88)80026-6_bib19","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1083\/jcb.101.3.949","article-title":"Exit of newly synthesized membrane proteins from the trans cisternae of the Golgi complex to the plasma membrane","volume":"101","author":"Griffiths","year":"1985","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(88)80026-6_bib20","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1083\/jcb.104.6.1743","article-title":"Lysosomal enzyme precursors in coated vesicles derived from the exocytic and endocytic pathways","volume":"104","author":"Lemansky","year":"1987","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(88)80026-6_bib21","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1083\/jcb.100.6.1839","article-title":"Glycoproteins of the lysosomal membrane","volume":"100","author":"Lewis","year":"1985","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(88)80026-6_bib22","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1083\/jcb.102.5.1593","article-title":"Lysosomal membrane dynamics: structure and interorganellar movement of a major lysosomal membrane glycoprotein","volume":"102","author":"Lippincott-Schwartz","year":"1986","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(88)80026-6_bib23","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0092-8674(87)90543-5","article-title":"Cycling of the integral membrane glycoprotein, LEP100, between plasma membrane and lysosomes: kinetic and morphological analysis","volume":"49","author":"Lippincott-Schwartz","year":"1987","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(88)80026-6_bib24","first-page":"4132","article-title":"Apical membrane aminopeptidase appears at sites of cell-cell contact in cultured kidney epithelial cells","volume":"77","author":"Louvard","year":"1980"},{"key":"10.1016\/S0092-8674(88)80026-6_bib25","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0092-8674(83)90078-8","article-title":"Penetration of Semliki Forest virus from acidic prelysosomal vacuoles","volume":"32","author":"Marsh","year":"1983","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(88)80026-6_bib26","first-page":"2899","article-title":"Three dimensional structure of endosomes in BHK-21-cells","volume":"83","author":"Marsh","year":"1986"},{"key":"10.1016\/S0092-8674(88)80026-6_bib27","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1146\/annurev.bi.55.070186.003311","article-title":"Acidification of the endocytic and exocytic pathways","volume":"55","author":"Mellman","year":"1986","journal-title":"Ann. Rev. Biochem."},{"key":"10.1016\/S0092-8674(88)80026-6_bib28","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1177\/33.11.2997327","article-title":"Intracellular transport of transferrin- and asialoorosomucoid-colloidal gold conjugates to lysosomes after receptor-mediated endocytosis","volume":"33","author":"Neutra","year":"1985","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/S0092-8674(88)80026-6_bib29","first-page":"7292","article-title":"Nucleotide sequence of rat preputial gland \u03b2-glucuronidase cDNA and in vitro insertion of its encoded polypeptide into microsomal membranes","volume":"83","author":"Nishimura","year":"1986"},{"key":"10.1016\/S0092-8674(88)80026-6_bib30","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1083\/jcb.103.6.2273","article-title":"Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles","volume":"103","author":"Orci","year":"1986","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(88)80026-6_bib31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1768-322X.1984.tb00300.x","article-title":"The mannose 6-phosphate receptor function. Biosynthesis and translocation","volume":"51","author":"Sahagian","year":"1984","journal-title":"Biol. Cell"},{"key":"10.1016\/S0092-8674(88)80026-6_bib32","doi-asserted-by":"crossref","first-page":"7121","DOI":"10.1016\/S0021-9258(18)32340-8","article-title":"Biosynthesis and turnover of the mannose 6-phosphate receptor in cultured Chinese hamster ovary cells","volume":"258","author":"Sahagian","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0092-8674(88)80026-6_bib33","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1083\/jcb.101.3.824","article-title":"Cathepsin D precursors in clathrin-coated organelles from human fibroblasts","volume":"101","author":"Schulze-Lohoff","year":"1985","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(88)80026-6_bib34","first-page":"87","article-title":"A novel method to make gold probes for multiple labeling cytochemistry","volume":"38","author":"Slot","year":"1985","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/S0092-8674(88)80026-6_bib35","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/jcb.1982.240180107","article-title":"The phosphomannosyl recognition system for intracellular and intercellular transport of lysosomal enzymes","volume":"18","author":"Sly","year":"1982","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/S0092-8674(88)80026-6_bib36","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0092-8674(82)90219-7","article-title":"Rapid acidification of endocytic vesicles containing \u03b12-macroglobulin","volume":"28","author":"Tycko","year":"1982","journal-title":"Cell"},{"key":"10.1016\/S0092-8674(88)80026-6_bib37","first-page":"6186","article-title":"Receptor mediated endocytosis of transferrin and the uptake of Fe in K562 cells: identification of a non-lysosomal acidic compartment","volume":"79","author":"van Renswoude","year":"1982"},{"key":"10.1016\/S0092-8674(88)80026-6_bib38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.biochem.55.1.167","article-title":"Lysosomal enzymes and their receptors","volume":"55","author":"von Figura","year":"1986","journal-title":"Ann. Rev. Biochem."},{"key":"10.1016\/S0092-8674(88)80026-6_bib39","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1002\/j.1460-2075.1984.tb01963.x","article-title":"Antibody to mannose 6-phosphate receptors induces receptor deficiency in human fibroblasts","volume":"3","author":"von Figura","year":"1984","journal-title":"EMBO J."},{"key":"10.1016\/S0092-8674(88)80026-6_bib40","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1083\/jcb.82.3.614","article-title":"\u03b12-macroglobulin binding to the plasma membrane of cultured fibroblasts","volume":"82","author":"Willingham","year":"1979","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0092-8674(88)80026-6_bib41","doi-asserted-by":"crossref","first-page":"6967","DOI":"10.1073\/pnas.78.11.6967","article-title":"Morphologic study of the internalization of a lysosomal enzyme by the mannose 6-phosphate receptor in cultured Chinese hamster ovary cells","volume":"78","author":"Willingham","year":"1981","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0092-8674(88)80026-6_bib42","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/0092-8674(84)90414-8","article-title":"Segregation of transferrin to a mildly acidic (pH 6.5) para-Golgi compartment in the recycling pathway","volume":"37","author":"Yamashiro","year":"1984","journal-title":"Cell"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867488800266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867488800266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T16:01:53Z","timestamp":1626537713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867488800266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,2]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1988,2]]}},"alternative-id":["S0092867488800266"],"URL":"https:\/\/doi.org\/10.1016\/s0092-8674(88)80026-6","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1988,2]]}}}