{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:00:13Z","timestamp":1777417213325,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computers & Chemistry"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1016\/s0097-8485(00)00070-x","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T14:10:41Z","timestamp":1027606241000},"page":"659-672","source":"Crossref","is-referenced-by-count":7,"title":["Regularities in mutational variability in selected protein families and the Markovian model of amino acid replacement"],"prefix":"10.1016","volume":"24","author":[{"given":"Jacek","family":"Leluk","sequence":"first","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0097-8485(00)00070-X_BIB1","unstructured":"Apweiler, R., Gateau, A., Contrino, S., Martin, M.J., Junker, V., O'Donovan, C., Lang, F., Mitaritonna, N., Kappus, S. and Bairoch, A. 1997. ISMB-97. Proceedings of the Fifth International Conference on Intelligent Systems for Molecular Biology, AAAI, Menlo Park, pp. 33\u201343."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB2","series-title":"Proteome Research: New Frontiers in Functional Genomics","first-page":"93","article-title":"Proteome databases","author":"Bairoch","year":"1997"},{"key":"10.1016\/S0097-8485(00)00070-X_BIB3","first-page":"312","volume":"75","author":"Bairoch","year":"1997","journal-title":"J. Mol. Med."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/nar\/27.1.49","volume":"27","author":"Bairoch","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB5","series-title":"Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology","first-page":"53","article-title":"ISMB\u201394","author":"Bucher","year":"1994"},{"key":"10.1016\/S0097-8485(00)00070-X_BIB6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/oxfordjournals.jbchem.a123863","volume":"112","author":"Chen","year":"1992","journal-title":"J. Biochem."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB7","doi-asserted-by":"crossref","first-page":"10881","DOI":"10.1093\/nar\/16.22.10881","volume":"16","author":"Corpet","year":"1988","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB8","first-page":"33","volume":"3","author":"Dayhoff","year":"1968"},{"key":"10.1016\/S0097-8485(00)00070-X_BIB9","first-page":"524","volume":"91","author":"Dayhoff","year":"1983"},{"key":"10.1016\/S0097-8485(00)00070-X_BIB10","unstructured":"Dayhoff, M.O., Schwartz, R.M., Orcutt, B.C., 1979. In: Dayhoff, M.O. (Ed.), Atlas of Protein Sequence and Structure, vol. 5, Suppl. 3. National Biomedical Research Foundation, Washington D.C., p. 345."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB11","first-page":"1","volume":"4","author":"Doolittle","year":"1979"},{"key":"10.1016\/S0097-8485(00)00070-X_BIB12","first-page":"164","volume":"5","author":"Felsenstein","year":"1989","journal-title":"Cladistics"},{"key":"10.1016\/S0097-8485(00)00070-X_BIB13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/BF02100085","volume":"21","author":"Feng","year":"1985","journal-title":"J. Mol. Evol."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-2836(66)80257-7","volume":"16","author":"Fitch","year":"1966","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0022-2836(66)80258-9","volume":"16","author":"Fitch","year":"1966","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1126\/science.155.3760.279","volume":"155","author":"Fitch","year":"1967","journal-title":"Science"},{"key":"10.1016\/S0097-8485(00)00070-X_BIB17","first-page":"337","volume":"183","author":"George","year":"1990"},{"key":"10.1016\/S0097-8485(00)00070-X_BIB18","first-page":"334","volume":"183","author":"George","year":"1990"},{"key":"10.1016\/S0097-8485(00)00070-X_BIB19","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1126\/science.1604319","volume":"256","author":"Gonnet","year":"1992","journal-title":"Science"},{"key":"10.1016\/S0097-8485(00)00070-X_BIB20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF01887398","volume":"15","author":"Haldar","year":"1996","journal-title":"J. Protein Chem."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB21","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/jb\/117.2.432","volume":"117","author":"Hamato","year":"1995","journal-title":"J. Biochem."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB22","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1271\/bbb1961.55.2641","volume":"55","author":"Hatakeyama","year":"1991","journal-title":"Agric. Biol. Chem."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB23","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/oxfordjournals.jbchem.a124621","volume":"116","author":"Hayashi","year":"1994","journal-title":"J. Biochem."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB24","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1021\/bi00432a009","volume":"28","author":"Heitz","year":"1989","journal-title":"Biochemistry"},{"key":"10.1016\/S0097-8485(00)00070-X_BIB25","doi-asserted-by":"crossref","first-page":"10915","DOI":"10.1073\/pnas.89.22.10915","volume":"89","author":"Henikoff","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0097-8485(00)00070-X_BIB26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/nar\/27.1.215","volume":"27","author":"Hofmann","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB27","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1006\/jmbi.1993.1548","volume":"233","author":"Johnson","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB28","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1006\/jmbi.1993.1323","volume":"231","author":"Johnson","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB29","first-page":"275","volume":"8","author":"Jones","year":"1992","journal-title":"CABIOS"},{"key":"10.1016\/S0097-8485(00)00070-X_BIB30","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/S0031-9422(00)80474-4","volume":"23","author":"Joubert","year":"1984","journal-title":"Phytochemistry"},{"key":"10.1016\/S0097-8485(00)00070-X_BIB31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/oxfordjournals.jbchem.a124875","volume":"118","author":"Lee","year":"1995","journal-title":"J. Biochem."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0097-8485(97)00035-1","volume":"22","author":"Leluk","year":"1998","journal-title":"Comput. Chem."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB33","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0021-9258(18)54006-0","volume":"268","author":"Ling","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB34","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0167-4838(92)90268-I","volume":"1120","author":"Matsuo","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/S0097-8485(00)00070-X_BIB35","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0022-2836(71)90390-1","volume":"61","author":"McLachlan","year":"1971","journal-title":"J. Mol. Biol."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB36","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1271\/bbb.56.1241","volume":"56","author":"Nishino","year":"1992","journal-title":"Biosci. Biotech. Biochem."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB37","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1515\/bchm3.1987.368.2.1505","volume":"368","author":"Otlewski","year":"1987","journal-title":"Biol. Chem. Hoppe-Seyler"},{"key":"10.1016\/S0097-8485(00)00070-X_BIB38","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1016\/S0021-9258(18)45659-1","volume":"262","author":"Scott","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB39","doi-asserted-by":"crossref","first-page":"507","DOI":"10.18388\/abp.1996_4484","volume":"43","author":"Stachowiak","year":"1996","journal-title":"Acta Biochim. Polon."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB40","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB41","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/0006-291X(85)90233-5","volume":"126","author":"Wieczorek","year":"1985","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/S0097-8485(00)00070-X_BIB42","first-page":"434","volume":"2","author":"Wilbur","year":"1985","journal-title":"Mol. Biol. Evol."}],"container-title":["Computers & Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009784850000070X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009784850000070X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T23:09:18Z","timestamp":1620342558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009784850000070X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S009784850000070X"],"URL":"https:\/\/doi.org\/10.1016\/s0097-8485(00)00070-x","relation":{},"ISSN":["0097-8485"],"issn-type":[{"value":"0097-8485","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}