{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T11:18:01Z","timestamp":1774783081630,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[1999,6,1]],"date-time":"1999-06-01T00:00:00Z","timestamp":928195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computers & Chemistry"],"published-print":{"date-parts":[[1999,6]]},"DOI":"10.1016\/s0097-8485(99)00008-x","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T12:08:22Z","timestamp":1027598902000},"page":"317-331","source":"Crossref","is-referenced-by-count":49,"title":["Significance of Z-value statistics of Smith\u2013Waterman scores for protein alignments"],"prefix":"10.1016","volume":"23","author":[{"given":"J.P","family":"Comet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C","family":"Aude","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Gl\u00e9met","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.L","family":"Risler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"H\u00e9naut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.P","family":"Slonimski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.J","family":"Codani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0097-8485(99)00008-X_BIB1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/jmbi.1997.1287","article-title":"Do aligned sequences share the same fold?","volume":"273","author":"Abagyan","year":"1997","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB3","article-title":"Automatic analysis of large scale pairwise alignments of protein sequences","volume":"vol. 28","author":"Codani","year":"1999"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB4","unstructured":"Devereux, J., 1989. The GCG sequence analysis software package. Package, Version 6.0, Genetics Computer Group, Inc., University Research Park, 575 Science Drive, Suite B, Madison, Wisconsin, 53711, USA"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB5","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1093\/oxfordjournals.molbev.a025882","article-title":"Evolution of genes, evolution of species: the case of aminoacyl-tRNA synthetases","volume":"15(11)","author":"Diaz-Lazcoz","year":"1998","journal-title":"Mol. Biol. Evol"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB6","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/bioinformatics\/14.8.707","article-title":"Measurement of the effectiveness of transitive sequence comparison, through a third intermediate sequence","volume":"14","author":"Gerstein","year":"1998","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/S0097-8485(99)00008-X_BIB7","first-page":"137","article-title":"LASSAP: a large scale sequence comparison package","volume":"13","author":"Gl\u00e9met","year":"1997","journal-title":"Comp. Appl. BioSci"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB8","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1126\/science.1604319","article-title":"Exhaustive matching of the entire protein sequence database","volume":"256","author":"Gonnet","year":"1992","journal-title":"Science"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB9","series-title":"Statistics of Extremes","author":"Gumbel","year":"1958"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB10","doi-asserted-by":"crossref","first-page":"10915","DOI":"10.1073\/pnas.89.22.10915","article-title":"Amino acid substitution matrices from protein blocks","volume":"89","author":"Henikoff","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB11","series-title":"The Houghton Mifflin Series in Statistics","article-title":"Distribution in statistics: continuous univariate distributions\u20141","author":"Johnson","year":"1970"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB12","first-page":"2264","volume":"87","author":"Karlin","year":"1990","journal-title":"Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes. Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1214\/aos\/1176347616","article-title":"Statistical composition of high-scoring segments from molecular sequences","volume":"18","author":"Karlin","year":"1990","journal-title":"Ann. Stat"},{"issue":"14","key":"10.1016\/S0097-8485(99)00008-X_BIB14","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1093\/nar\/20.14.3631","article-title":"A comparaison of several similarity indices used in the classification of protein sequences: a multivariate analysis","volume":"20","author":"Land\u00e8s","year":"1992","journal-title":"Nucl. Acids. Res"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB15","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1126\/science.2983426","article-title":"Rapid and sensitive protein similarity searches","volume":"227","author":"Lipman","year":"1985","journal-title":"Science"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/nar\/12.1Part1.215","article-title":"On the statistical significance of nucleic acid similarities","volume":"12","author":"Lipman","year":"1984","journal-title":"Nucl. Acids Res"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0196-8858(91)90017-D","article-title":"A time-efficient, linear-space local similarity algorithm","volume":"12","author":"Miller","year":"1991","journal-title":"Adv. Appl. Math"},{"issue":"1","key":"10.1016\/S0097-8485(99)00008-X_BIB18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF02458620","article-title":"Maximum-likelihood estimation of the statistical distribution of Smith\u2013Waterman local sequence similarity scores","volume":"54","author":"Mott","year":"1992","journal-title":"Bull. Math. Biol"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0022-2836(70)90057-4","article-title":"A general method applicable to the search for similarities in the amino acid sequence of two proteins","volume":"48","author":"Needleman","year":"1970","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB20","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1006\/jmbi.1997.1288","article-title":"Intermediate sequences increase the detection of homology between sequences","volume":"273","author":"Park","year":"1997","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB21","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/bioinformatics\/14.2.144","article-title":"DIVCLUS: an automatic method in the GEANFAMMER package that finds homologous domains in single- and multi-domain proteins","volume":"14","author":"Park","year":"1998","journal-title":"Bioinformatics"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB22","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/pro.5560040613","article-title":"Comparison of methods for searching protein sequence databases","volume":"4","author":"Pearson","year":"1995","journal-title":"Protein Sci"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB23","unstructured":"Schwartz, R.M., Dayhoff, M.O., 1979. Matrices for detecting distant relationships. vol. 5, suppl 3, Nat. Biomed. Res. Found. Washington DC, Washington, pp. 353\u2013358"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB24","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/yea.320090902","article-title":"A database of chromosome III of Saccharomyces cerevisiae","volume":"9","author":"Slonimski","year":"1993","journal-title":"Yeast"},{"issue":"2","key":"10.1016\/S0097-8485(99)00008-X_BIB25","first-page":"46","article-title":"The first laws of genomics","volume":"3","author":"Slonimski","year":"1998","journal-title":"Comparative and Microbial Genomics"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0022-2836(81)90087-5","article-title":"Identification of common molecular subsequences","volume":"147","author":"Smith","year":"1981","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB27","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1126\/science.278.5338.631","article-title":"A genomic perspective on protein families","volume":"278","author":"Tatusov","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB28","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1006\/jmbi.1995.0340","article-title":"An assessment of amino acid exchange matrices in aligning protein sequences: the twilight zone revisited","volume":"249","author":"Vogt","year":"1995","journal-title":"J. Mol. Biol"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB29","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/0022-2836(87)90478-5","article-title":"A new algorithm for best subsequence alignments with application to tRNA-tRNA comparisons","volume":"197","author":"Waterman","year":"1987","journal-title":"J. Mol. Biol"},{"issue":"3","key":"10.1016\/S0097-8485(99)00008-X_BIB30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1214\/ss\/1177010382","article-title":"Sequence comparison significance and poisson approximation","volume":"9","author":"Waterman","year":"1994","journal-title":"Statistical Science"},{"key":"10.1016\/S0097-8485(99)00008-X_BIB31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2307\/253518","article-title":"Extreme value in business interruption insurance","volume":"63","author":"Zajdenweber","year":"1996","journal-title":"J. Risk and Insurance"}],"container-title":["Computers & Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009784859900008X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009784859900008X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T01:00:06Z","timestamp":1556672406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009784859900008X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6]]},"references-count":31,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[1999,6]]}},"alternative-id":["S009784859900008X"],"URL":"https:\/\/doi.org\/10.1016\/s0097-8485(99)00008-x","relation":{},"ISSN":["0097-8485"],"issn-type":[{"value":"0097-8485","type":"print"}],"subject":[],"published":{"date-parts":[[1999,6]]}}}