{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T08:56:13Z","timestamp":1774601773449,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"9387","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Lancet"],"published-print":{"date-parts":[[2003,9]]},"DOI":"10.1016\/s0140-6736(03)14342-5","type":"journal-article","created":{"date-parts":[[2003,9,17]],"date-time":"2003-09-17T02:31:56Z","timestamp":1063765916000},"page":"869-875","source":"Crossref","is-referenced-by-count":227,"title":["L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas"],"prefix":"10.1016","volume":"362","author":[{"given":"Mina","family":"Fogel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Gutwein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Mechtersheimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svenja","family":"Riedle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Stoeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asya","family":"Smirnov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"Edler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alon","family":"Ben-Arie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Huszar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Altevogt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0140-6736(03)14342-5_bib1","first-page":"305","article-title":"Prognostic factors in ovarian cancer","volume":"25","author":"Friedlander","year":"1998","journal-title":"Semin Oncol"},{"key":"10.1016\/S0140-6736(03)14342-5_bib2","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1097\/00000478-199206000-00008","article-title":"Uterine serous carcinoma. A morphologically diverse neoplasm with unifying clinicopathologic features","volume":"16","author":"Sherman","year":"1992","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/S0140-6736(03)14342-5_bib3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/scbi.2001.0416","article-title":"Critical determinants of metastasis","volume":"12","author":"Fidler","year":"2002","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/S0140-6736(03)14342-5_bib4","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0955-0674(97)80115-9","article-title":"Neural recognition molecules and synaptic plasticity","volume":"9","author":"Schachner","year":"1997","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/S0140-6736(03)14342-5_bib5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1006\/mcne.1998.0702","article-title":"Role of L1 in neural development: what the knockouts tell us","volume":"12","author":"Kamiguchi","year":"1998","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/S0140-6736(03)14342-5_bib6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0959-4388(98)80012-3","article-title":"Neural cell recognition molecule L1: from cell biology to human hereditary brain malformations","volume":"8","author":"Br\u00fcmmendorf","year":"1998","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/S0140-6736(03)14342-5_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/mcne.1999.0809","article-title":"Structural and functional evolution of the L1 family: are four adhesion molecules better than one?","volume":"15","author":"Hortsch","year":"2000","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/S0140-6736(03)14342-5_bib8","first-page":"2935","article-title":"A novel model of glioma cell invasion using organotypic brain slice culture","volume":"58","author":"Ohnishi","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/S0140-6736(03)14342-5_bib9","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1083\/jcb.200101099","article-title":"Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins","volume":"155","author":"Mechtersheimer","year":"2001","journal-title":"J Cell Biol"},{"key":"10.1016\/S0140-6736(03)14342-5_bib10","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1083\/jcb.132.3.475","article-title":"Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alpha vs beta 3","volume":"132","author":"Montgomery","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/S0140-6736(03)14342-5_bib11","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1242\/jcs.112.16.2667","article-title":"Metalloproteinase-mediated release of the ectodomain of L1 adhesion molecule","volume":"112","author":"Beer","year":"1999","journal-title":"J Cell Sci"},{"key":"10.1016\/S0140-6736(03)14342-5_bib12","doi-asserted-by":"crossref","first-page":"15490","DOI":"10.1074\/jbc.275.20.15490","article-title":"Role of Src kinases in the ADAM-mediated release of L1 adhesion molecule from human tumor cells","volume":"275","author":"Gutwein","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/S0140-6736(03)14342-5_bib13","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1096\/fj.02-0430fje","article-title":"ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles","volume":"17","author":"Gutwein","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/S0140-6736(03)14342-5_bib14","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1083\/jcb.200203024","article-title":"L1 endocytosis by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1","volume":"157","author":"Schaefer","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/S0140-6736(03)14342-5_bib15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0304-3835(02)00513-X","article-title":"L1 adhesion molecule (CD171) in development and progression of human malignant melanoma","volume":"189","author":"Fogel","year":"2003","journal-title":"Cancer Lett"},{"key":"10.1016\/S0140-6736(03)14342-5_bib16","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1002\/eji.1830261035","article-title":"L1 adhesion molecule on human lymphocytes and monocytes: expression and involvement in binding to alpha vs beta 3 integrin","volume":"26","author":"Ebeling","year":"1996","journal-title":"Eur J Immunol"},{"key":"10.1016\/S0140-6736(03)14342-5_bib17","first-page":"107","article-title":"Carcinoma of the ovary","volume":"6","author":"Heintz","year":"2001","journal-title":"J Epidemiol Biostat"},{"key":"10.1016\/S0140-6736(03)14342-5_bib18","first-page":"47","article-title":"Carcinoma of the corpus uteri","volume":"6","author":"Creasman","year":"2001","journal-title":"J Epidemiol Biostat"},{"key":"10.1016\/S0140-6736(03)14342-5_bib19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00000478-198203000-00002","article-title":"Uterine papillary serous carcinoma: a highly malignant form of endometrial adenocarcinoma","volume":"6","author":"Hendrickson","year":"1982","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/S0140-6736(03)14342-5_bib20","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/S0959-8049(02)00105-3","article-title":"Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma","volume":"38","author":"Thies","year":"2002","journal-title":"Eur J Cancer"},{"key":"10.1016\/S0140-6736(03)14342-5_bib21","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0168-9525(99)01926-5","article-title":"The ADAM gene family: surface proteins with adhesion and protease activity","volume":"16","author":"Primakoff","year":"2000","journal-title":"Trends Genet"},{"key":"10.1016\/S0140-6736(03)14342-5_bib22","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1101\/gad.1039703","article-title":"The ADAMs family of metalloproteinases: multidomain proteins with multiple functions","volume":"17","author":"Seals","year":"2003","journal-title":"Genes Dev"},{"key":"10.1016\/S0140-6736(03)14342-5_bib23","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1242\/jcs.112.21.3603","article-title":"Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding","volume":"112","author":"Schl\u00f6ndorff","year":"1999","journal-title":"J Cell Sci"},{"key":"10.1016\/S0140-6736(03)14342-5_bib24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrc745","article-title":"New functions for the matrix metalloproteinases in cancer progression","volume":"2","author":"Egeblad","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/S0140-6736(03)14342-5_bib25","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1093\/hmg\/11.21.2615","article-title":"The disintegrin\/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts","volume":"11","author":"Hartmann","year":"2002","journal-title":"Hum Mol Genet"},{"key":"10.1016\/S0140-6736(03)14342-5_bib26","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1073\/pnas.96.7.3922","article-title":"Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease","volume":"96","author":"Lammich","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0140-6736(03)14342-5_bib27","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1083\/jcb.200112026","article-title":"The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors","volume":"158","author":"Yan","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/S0140-6736(03)14342-5_bib28","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1523\/JNEUROSCI.22-12-04918.2002","article-title":"The neural cell adhesion molecule L1 potentiates integrin-dependent cell migration to extracellular matrix proteins","volume":"22","author":"Thelen","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/S0140-6736(03)14342-5_bib29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/(SICI)1097-4547(19980715)53:2<129::AID-JNR1>3.0.CO;2-9","article-title":"L1 neural cell adhesion molecule is a survival factor for fetal dopaminergic neurons","volume":"53","author":"Hulley","year":"1998","journal-title":"J Neurosci Res"}],"container-title":["The Lancet"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673603143425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673603143425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T06:25:58Z","timestamp":1623392758000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0140673603143425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":29,"journal-issue":{"issue":"9387","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["S0140673603143425"],"URL":"https:\/\/doi.org\/10.1016\/s0140-6736(03)14342-5","relation":{},"ISSN":["0140-6736"],"issn-type":[{"value":"0140-6736","type":"print"}],"subject":[],"published":{"date-parts":[[2003,9]]}}}