{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:36:25Z","timestamp":1780551385088,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"9464","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Lancet"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/s0140-6736(05)71142-9","type":"journal-article","created":{"date-parts":[[2005,3,19]],"date-time":"2005-03-19T18:18:26Z","timestamp":1111256306000},"page":"1054-1061","source":"Crossref","is-referenced-by-count":3824,"title":["Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders"],"prefix":"10.1016","volume":"365","author":[{"given":"E Joanna","family":"Baxter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda M","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"East","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasios","family":"Fourouclas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheila","family":"Swanton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George S","family":"Vassiliou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J","family":"Bench","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine M","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Curtin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike A","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy N","family":"Erber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony R","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0140-6736(05)71142-9_bib1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1182\/asheducation-2003.1.200","article-title":"Chronic myeloproliferative disorders","author":"Spivak","year":"2003","journal-title":"Hematology (Am Soc Hematol Educ Program)"},{"key":"10.1016\/S0140-6736(05)71142-9_bib2","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJM197610212951702","article-title":"Polycythemia vera: stem-cell and probable clonal origin of the disease","volume":"295","author":"Adamson","year":"1976","journal-title":"N Engl J Med"},{"key":"10.1016\/S0140-6736(05)71142-9_bib3","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1182\/blood.V58.5.916.916","article-title":"Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell","volume":"58","author":"Fialkow","year":"1981","journal-title":"Blood"},{"issue":"suppl 3","key":"10.1016\/S0140-6736(05)71142-9_bib4","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.1038\/sj.thj.6200438","article-title":"Management of the myeloproliferative disorders: distinguishing data from dogma","volume":"5","author":"Green","year":"2004","journal-title":"Hematol J"},{"issue":"suppl 3","key":"10.1016\/S0140-6736(05)71142-9_bib5","doi-asserted-by":"crossref","first-page":"S122","DOI":"10.1038\/sj.thj.6200437","article-title":"Chronic myeloproliferative disorders: molecular markers and pathogenesis","volume":"5","author":"Skoda","year":"2004","journal-title":"Hematol J"},{"key":"10.1016\/S0140-6736(05)71142-9_bib6","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1056\/NEJM197406132902419","article-title":"Letter: bone marrow responses in polycythemia vera","volume":"290","author":"Prchal","year":"1974","journal-title":"N Engl J Med"},{"key":"10.1016\/S0140-6736(05)71142-9_bib7","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1182\/blood.V80.4.891.891","article-title":"Polycythemia vera II: hypersensitivity of bone marrow erythroid, granulocyte-macrophage and megakaryocyte progenitor cells to interleukin-3 and granulocyte-macrophage colony stimulating factor","volume":"80","author":"Dai","year":"1992","journal-title":"Blood"},{"key":"10.1016\/S0140-6736(05)71142-9_bib8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1365-2141.1994.tb08300.x","article-title":"Spontaneous megakaryocyte colony formation in myeloproliferative disorders is not neutralizable by antibodies against IL3, IL6 and GM-CSF","volume":"87","author":"Li","year":"1994","journal-title":"Br J Haematol"},{"key":"10.1016\/S0140-6736(05)71142-9_bib9","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1365-2141.1993.tb04688.x","article-title":"Circulating megakaryocyte progenitors in myeloproliferative disorders are hypersensitive to interleukin-3","volume":"83","author":"Kobayashi","year":"1993","journal-title":"Br J Haematol"},{"key":"10.1016\/S0140-6736(05)71142-9_bib10","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1182\/blood.V96.10.3310","article-title":"Hypersensitivity of circulating progenitor cells to megakaryocyte growth and development factor (PEG-rHu MGDF) in essential thrombocythemia","volume":"96","author":"Axelrad","year":"2000","journal-title":"Blood"},{"key":"10.1016\/S0140-6736(05)71142-9_bib11","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0268-960X(97)90021-7","article-title":"Pathogenesis of polycythaemia vera","volume":"11","author":"Hinshelwood","year":"1997","journal-title":"Blood Rev"},{"key":"10.1016\/S0140-6736(05)71142-9_bib12","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1182\/blood.V96.10.3343","article-title":"The molecular biology of chronic myeloid leukemia","volume":"96","author":"Deininger","year":"2000","journal-title":"Blood"},{"key":"10.1016\/S0140-6736(05)71142-9_bib13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0268-960X(03)00024-9","article-title":"Receptor tyrosine kinases in normal and malignant haematopoiesis","volume":"17","author":"Reilly","year":"2003","journal-title":"Blood Rev"},{"key":"10.1016\/S0140-6736(05)71142-9_bib14","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1182\/blood-2003-11-3896","article-title":"After chronic myelogenous leukaemia: tyrosine kinase inhibitors in other hematologic malignancies","volume":"105","author":"Wadleigh","year":"2005","journal-title":"Blood"},{"key":"10.1016\/S0140-6736(05)71142-9_bib15","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0301-472X(03)00085-7","article-title":"Spontaneous STAT5 activation induces growth factor independence in idiopathic myelofibrosis: possible relationship with FKBP51 overexpression","volume":"31","author":"Komura","year":"2003","journal-title":"Exp Hematol"},{"key":"10.1016\/S0140-6736(05)71142-9_bib16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.exphem.2003.11.003","article-title":"Multiple signaling pathways are involved in erythropoietin-independent differentiation of erythroid progenitors in polycythemia vera","volume":"32","author":"Ugo","year":"2004","journal-title":"Exp Hematol"},{"key":"10.1016\/S0140-6736(05)71142-9_bib17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1056\/NEJMoa035572","article-title":"Efficacy and safety of low-dose aspirin in polycythemia vera","volume":"350","author":"Landolfi","year":"2004","journal-title":"N Engl J Med"},{"issue":"1 suppl 2","key":"10.1016\/S0140-6736(05)71142-9_bib18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0037-1963(01)90136-2","article-title":"Evaluation of diagnostic criteria in polycythemia vera","volume":"38","author":"Pearson","year":"2001","journal-title":"Semin Hematol"},{"key":"10.1016\/S0140-6736(05)71142-9_bib19","first-page":"29","article-title":"Experience of the polycythemia vera study group with essential thrombocythemia: a final report on diagnostic criteria, survival, and leukemic transition by treatment","volume":"34","author":"Murphy","year":"1997","journal-title":"Semin Hematol"},{"key":"10.1016\/S0140-6736(05)71142-9_bib20","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1046\/j.1365-2141.1999.01262.x","article-title":"The Italian consensus conference on diagnostic criteria for myelofibrosis with myeloid metaplasia","volume":"104","author":"Barosi","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1016\/S0140-6736(05)71142-9_bib21","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1038\/sj.onc.1203728","article-title":"Chromosome 20 deletions in myeloid malignancies: reduction of the common deleted region, generation of a PAC\/BAC contig and identification of candidate genes","volume":"19","author":"Bench","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/S0140-6736(05)71142-9_bib22","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1182\/blood.V6.4.372.372","article-title":"Some speculations on the myeloproliferative syndromes","volume":"6","author":"Dameshek","year":"1951","journal-title":"Blood"},{"key":"10.1016\/S0140-6736(05)71142-9_bib23","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s00277-004-0864-9","article-title":"PRV-1 mRNA expression discriminates two types of essential thrombocythemia","volume":"83","author":"Griesshammer","year":"2004","journal-title":"Ann Hematol"},{"key":"10.1016\/S0140-6736(05)71142-9_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.blre.2004.02.002","article-title":"Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders","volume":"19","author":"Kralovics","year":"2005","journal-title":"Blood Rev"},{"key":"10.1016\/S0140-6736(05)71142-9_bib25","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0889-8588(03)00082-0","article-title":"Essential thrombocythemia","volume":"17","author":"Harrison","year":"2003","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/S0140-6736(05)71142-9_bib26","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0301-472X(01)00789-5","article-title":"Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera","volume":"30","author":"Kralovics","year":"2002","journal-title":"Exp Hematol"},{"key":"10.1016\/S0140-6736(05)71142-9_bib27","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1182\/blood.V90.7.2535","article-title":"Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia","volume":"90","author":"Peeters","year":"1997","journal-title":"Blood"},{"key":"10.1016\/S0140-6736(05)71142-9_bib28","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.278.5341.1309","article-title":"A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia","volume":"278","author":"Lacronique","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0140-6736(05)71142-9_bib29","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1128\/MCB.20.10.3387-3395.2000","article-title":"Regulation of the Jak2 tyrosine kinase by its pseudokinase domain","volume":"20","author":"Saharinen","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0140-6736(05)71142-9_bib30","doi-asserted-by":"crossref","first-page":"47954","DOI":"10.1074\/jbc.M205156200","article-title":"The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction","volume":"277","author":"Saharinen","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/S0140-6736(05)71142-9_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/protein\/14.1.27","article-title":"Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation","volume":"14","author":"Lindauer","year":"2001","journal-title":"Protein Eng"},{"key":"10.1016\/S0140-6736(05)71142-9_bib32","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1128\/MCB.17.3.1562","article-title":"Mutation in the Jak kinase JH2 domain hyperactivates drosophila and mammalian Jak-Stat pathways","volume":"17","author":"Luo","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0140-6736(05)71142-9_bib33","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1056\/NEJM199802263380902","article-title":"Expression of Bcl-x in erythroid precursors from patients with polycythemia vera","volume":"338","author":"Silva","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/S0140-6736(05)71142-9_bib34","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1182\/blood-2003-03-0919","article-title":"Quantification of PRV-1 mRNA distinguishes polycythemia vera from secondary erythrocytosis","volume":"102","author":"Klippel","year":"2003","journal-title":"Blood"},{"key":"10.1016\/S0140-6736(05)71142-9_bib35","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1056\/NEJM199802263380903","article-title":"Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera","volume":"338","author":"Moliterno","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/S0140-6736(05)71142-9_bib36","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1182\/blood.V96.6.2269","article-title":"Bcr\/Abl activates transcription of the Bcl-X gene through STAT5","volume":"96","author":"Gesbert","year":"2000","journal-title":"Blood"}],"container-title":["The Lancet"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0140673605711429?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0140673605711429?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T07:40:02Z","timestamp":1586158802000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0140673605711429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":36,"aliases":["10.1016\/s0140-6736(05)74230-6","10.1016\/s0140-6736(05)74230-6"],"journal-issue":{"issue":"9464","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S0140673605711429"],"URL":"https:\/\/doi.org\/10.1016\/s0140-6736(05)71142-9","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.719900216.793516203","asserted-by":"object"}]},"ISSN":["0140-6736"],"issn-type":[{"value":"0140-6736","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}