{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:37:33Z","timestamp":1762864653560},"reference-count":24,"publisher":"Elsevier BV","issue":"8164","license":[{"start":{"date-parts":[[1980,2,1]],"date-time":"1980-02-01T00:00:00Z","timestamp":318211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Lancet"],"published-print":{"date-parts":[[1980,2]]},"DOI":"10.1016\/s0140-6736(80)90884-3","type":"journal-article","created":{"date-parts":[[2003,10,11]],"date-time":"2003-10-11T08:48:06Z","timestamp":1065862086000},"page":"333-336","source":"Crossref","is-referenced-by-count":156,"title":["GLUCOSE METABOLISM AND ACETYLCHOLINE SYNTHESIS IN RELATION TO NEURONAL ACTIVITY IN ALZHEIMER'S DISEASE"],"prefix":"10.1016","volume":"315","author":[{"given":"N.R.","family":"Sims","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.C.T.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.N.","family":"Davison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.M.","family":"Bowen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.H.A.","family":"Flack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.S.","family":"Snowden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Neary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0140-6736(80)90884-3_BIB1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/279372a0","article-title":"Dementia: an approaching epidemic","volume":"279","author":"Plum","year":"1979","journal-title":"Nature"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB2","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1111\/j.1471-4159.1976.tb02638.x","article-title":"Soluble proteins in normal and diseased human brain","volume":"27","author":"Smith","year":"1976","journal-title":"J Neurochem"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0006-8993(76)90757-5","article-title":"Biochemical indices of brain structure, function and \"hypoxia\" in cortex from baboons with middle cerebral artery occlusion","volume":"117","author":"Bowen","year":"1976","journal-title":"Brain Res"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB4","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/S0140-6736(74)90003-8","article-title":"Brain decarboxylase activities as indices of pathological change in senile dementia","volume":"i","author":"Bowen","year":"1974","journal-title":"Lancer"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB5","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/brain\/99.3.459","article-title":"Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies","volume":"99","author":"Bowen","year":"1976","journal-title":"Brain"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/brain\/100.3.427","article-title":"Chemical pathology of the organic dementias II. Quantitive estimation of cellular changes in post-mortem brains","volume":"100","author":"Bowen","year":"1977","journal-title":"Brain"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB7","first-page":"11","article-title":"Accelerated aging or selective neuron loss as an important cause of dementia?","volume":"i","author":"Bowen","year":"1979","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB8","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1136\/bmj.2.6150.1457","article-title":"Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia","volume":"ii","author":"Perry","year":"1978","journal-title":"Br Med J"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0022-510X(77)90073-9","article-title":"Neurotransmitter enzyme abnormalities in senile dementia\u2014choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue","volume":"34","author":"Perry","year":"1977","journal-title":"J Neurol Sci"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB10","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S0140-6736(77)92114-6","article-title":"Neocortical cholinergic neurones in elderly people","volume":"i","author":"White","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB11","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0006-8993(78)90562-0","article-title":"Pre- and post-synaptic neurochemical alterations in Alzheimer's disease","volume":"159","author":"Reisine","year":"1978","journal-title":"Brain Res"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0006-8993(79)90336-6","article-title":"Neurotransmitter-related enzymes in senile dementia of the Alzheimer type","volume":"171","author":"Davies","year":"1979","journal-title":"Brain Res"},{"year":"1978","series-title":"Acetylcholine synthesis in neurons","author":"Tucek","key":"10.1016\/S0140-6736(80)90884-3_BIB13"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB14","first-page":"77","article-title":"Relationship of choline uptake to acetylcholine synthesis and release","volume":"Vol 49","author":"Marchbanks","year":"1979"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB15","first-page":"441","article-title":"Regional cerebral blood flow in the dominant hemisphere in confirmed cases of Alzheimer's disease, Pick's disease and multi-infarct dementia: Relationship to clinical symptomatology and neuropathological findings","author":"Ingvar","year":"1978"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1471-4159.1975.tb11895.x","article-title":"A rapid radiochemical method for the determination of choline acetyltransferase","volume":"24","author":"Fonnum","year":"1975","journal-title":"J Neurochem"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/bj1480017","article-title":"Decreased synthesis of acetylcholine accompanying impaired oxidation of pyruvic acid in rat brain minces","volume":"148","author":"Gibson","year":"1975","journal-title":"Biochem J"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB18","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/j.1471-4159.1968.tb05921.x","article-title":"(14C) acetylcholine synthesis by cortex slices of rat brain","volume":"15","author":"Browning","year":"1968","journal-title":"J Neurochem"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB19","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1111\/j.1471-4159.1976.tb06988.x","article-title":"Inhibition of acetylcholine synthesis and of carbohydrate utilisation by maple-sugar-urine disease metabolites","volume":"26","author":"Gibson","year":"1976","journal-title":"J Neurochem"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB20","doi-asserted-by":"crossref","DOI":"10.1159\/000112381","article-title":"A morphological study of incubated slices of rat cerebellum in relation to postnatal age","author":"Garthwaite","year":"1980","journal-title":"Dev Neurosci"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/00005072-196504000-00004","article-title":"Chemical studies on Alzheimer's disease","volume":"24","author":"Suzuki","year":"1965","journal-title":"J Neuropath Exp Neurol"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB22","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/j.1471-4159.1978.tb00143.x","article-title":"Choline acetyltransferase and the high affinity uptake of choline in corpus striatum of reserpinised rats","volume":"31","author":"Burgess","year":"1978","journal-title":"J Neurochem"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB23","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1476-5381.1973.tb08379.x","article-title":"An analysis of the learning deficit following hyoscine administration to man","volume":"49","author":"Crow","year":"1973","journal-title":"Brit J Pharmacol"},{"key":"10.1016\/S0140-6736(80)90884-3_BIB24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1001\/archneur.1974.00490320001001","article-title":"Human memory and the cholinergic system","volume":"30","author":"Drachman","year":"1974","journal-title":"Arch Neurol (Chicago)"}],"container-title":["The Lancet"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673680908843?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673680908843?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T10:54:06Z","timestamp":1550660046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0140673680908843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,2]]},"references-count":24,"journal-issue":{"issue":"8164","published-print":{"date-parts":[[1980,2]]}},"alternative-id":["S0140673680908843"],"URL":"https:\/\/doi.org\/10.1016\/s0140-6736(80)90884-3","relation":{},"ISSN":["0140-6736"],"issn-type":[{"type":"print","value":"0140-6736"}],"subject":[],"published":{"date-parts":[[1980,2]]}}}