{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T19:51:20Z","timestamp":1771012280153,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"8428","license":[{"start":{"date-parts":[[1985,3,1]],"date-time":"1985-03-01T00:00:00Z","timestamp":478483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Lancet"],"published-print":{"date-parts":[[1985,3]]},"DOI":"10.1016\/s0140-6736(85)91207-3","type":"journal-article","created":{"date-parts":[[2003,10,9]],"date-time":"2003-10-09T08:19:09Z","timestamp":1065687549000},"page":"545-549","source":"Crossref","is-referenced-by-count":288,"title":["RENAL, HAEMODYNAMIC, AND HORMONAL EFFECTS OF HUMAN ALPHA ATRIAL NATRIURETIC PEPTIDE IN HEALTHY VOLUNTEERS"],"prefix":"10.1016","volume":"325","author":[{"given":"A.M.","family":"Richards","sequence":"first","affiliation":[]},{"given":"H.","family":"Ikram","sequence":"additional","affiliation":[]},{"given":"T.G.","family":"Yandle","sequence":"additional","affiliation":[]},{"given":"M.G.","family":"Nicholls","sequence":"additional","affiliation":[]},{"given":"M.W.I.","family":"Webster","sequence":"additional","affiliation":[]},{"given":"E.A.","family":"Espiner","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0140-6736(85)91207-3_BIB1","first-page":"99","article-title":"Electron microscopy of the atrium of the heart: guinea pig","volume":"14","author":"Kisch","year":"1956","journal-title":"Exp Med Surg"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB2","first-page":"1257","article-title":"Le tissu de conduction du coeur chez la rat. Etude au microscope electronique","volume":"52","author":"Bompiani","year":"1959","journal-title":"Arch Mal Coeur"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB3","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3181\/00379727-161-40584","article-title":"Heart atria granularity effects of changes in water-electrolyte balance","volume":"161","author":"de Bold","year":"1979","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0024-3205(81)90370-2","article-title":"A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats","volume":"28","author":"de Bold","year":"1981","journal-title":"Life Sci"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1113\/jphysiol.1983.sp014484","article-title":"The effect of a natriutetic atrial extract on renal haemodynamics and urinary excretion in anaesthetized rats","volume":"334","author":"Borenstein","year":"1983","journal-title":"J Physiol"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB6","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1161\/01.RES.53.3.420","article-title":"Natriuretic activity of human and monkey atria","volume":"53","author":"Nemeh","year":"1983","journal-title":"Circ Res"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1126\/science.6857267","article-title":"Bioactive cardiac substances: potent vasorelaxant activity in mammalian atria","volume":"221","author":"Currie","year":"1983","journal-title":"Science"},{"issue":"suppl 1","key":"10.1016\/S0140-6736(85)91207-3_BIB8","first-page":"1","article-title":"Atrial natriuretic factor inhibits angiotensin norepinephrine, and potassium-induced vascular contractility","volume":"6","author":"Kleinert","year":"1984","journal-title":"Hypertension"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB9","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1126\/science.6326267","article-title":"Inhibition of aldosterone production by an atrial extract","volume":"224","author":"Atarashi","year":"1984","journal-title":"Science"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB10","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1126\/science.6538050","article-title":"Cardiac atria of BIO 14\u00b76 hamsters are deficient in natriuretic factor","volume":"223","author":"Chimoskey","year":"1984","journal-title":"Science"},{"issue":"suppl 1","key":"10.1016\/S0140-6736(85)91207-3_BIB11","first-page":"1","article-title":"Dahl S rats have increased natriuretic factor in atria but are markedly hyporesponsive to it","volume":"6","author":"Hirata","year":"1984","journal-title":"Hypertension"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB12","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1161\/01.HYP.5.5.672","article-title":"Atrial natriuretic factor: reduced cardiac content in spontaneously hypertensive rats","volume":"5","author":"Sonnenberg","year":"1983","journal-title":"Hypertension"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB13","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/309724a0","article-title":"Cloning and sequence analysis of cDNA encoding a precursor for human atrial natriuretic polypeptide","volume":"309","author":"Oikawa","year":"1984","journal-title":"Nature"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0006-291X(84)91077-5","article-title":"Purification and complete ammo acid sequence of \u03b1-human atrial natriuretic polypeptide (\u03b1-hANP)","volume":"118","author":"Kangawa","year":"1984","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB15","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/BF02442453","article-title":"New system for recording ambulatory blood pressure in man","volume":"16","author":"Millar-Craig","year":"1978","journal-title":"Med Biol Eng Comput"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1445-5994.1976.tb03306.x","article-title":"Outpatient screening tests for primary aldosteronism","volume":"6","author":"Dunn","year":"1976","journal-title":"Aust NZ J Med"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB17","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/clinchem\/29.2.268","article-title":"A direct radioimmunoassay for aldosterone in plasma","volume":"29","author":"Lun","year":"1983","journal-title":"Clin Chem"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB18","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0024-3205(77)90070-4","article-title":"Simultaneous single isotope radioenzymatic assays of plasma norepinephrine, epinephrine and dopamine","volume":"21","author":"Peuler","year":"1977","journal-title":"Life Sci"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB19","first-page":"959","article-title":"A sensitive radioimmunoassay for measuring plasma anti-diuretic hormone in man","volume":"96","author":"Sadler","year":"1983","journal-title":"NZ Med J"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB20","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/0024-3205(84)90179-6","article-title":"Actions of synthetic atrial natriuretic factor on bovine adrenal glomerulosa","volume":"35","author":"Goodfriend","year":"1984","journal-title":"Life Sci"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2125.1984.tb05023.x","article-title":"The influence of age on renal and extrarenal effects of frusemide","volume":"18","author":"Andreasen","year":"1984","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1365-2125.1984.tb05024.x","article-title":"The dose-response characteristics of the acute non-diuretic peripheral vascular effects of frusemide in normal subjects","volume":"18","author":"Johnston","year":"1984","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB23","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1136\/hrt.36.1.44","article-title":"Haemodynamic effects of frusemide in patients suspected of having acute myocardial infarction","volume":"36","author":"Mond","year":"1974","journal-title":"Br Heart J"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB24","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1136\/hrt.31.6.711","article-title":"Acute haemodynamic effects of frusemide in patients with normal and raised left atrial pressures","volume":"31","author":"Lal","year":"1969","journal-title":"Br Heart J"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB25","first-page":"246","article-title":"Effects of frusemide-induced plasma volume reduction on plasma antidiuretic hormone in normal and hypertensive subjects","volume":"15","author":"de Lima","year":"1981","journal-title":"Clin Nephrol"},{"key":"10.1016\/S0140-6736(85)91207-3_BIB26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1139\/y68-015","article-title":"Acute changes in plasma volume, renin activity, and free aldosterone levels in healthy subjects following frusemide administration","volume":"46","author":"Rosenthal","year":"1968","journal-title":"Canad J Physiol Pharmacol"}],"container-title":["The Lancet"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673685912073?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673685912073?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T23:20:09Z","timestamp":1585178409000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0140673685912073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3]]},"references-count":26,"journal-issue":{"issue":"8428","published-print":{"date-parts":[[1985,3]]}},"alternative-id":["S0140673685912073"],"URL":"https:\/\/doi.org\/10.1016\/s0140-6736(85)91207-3","relation":{},"ISSN":["0140-6736"],"issn-type":[{"value":"0140-6736","type":"print"}],"subject":[],"published":{"date-parts":[[1985,3]]}}}