{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:52:45Z","timestamp":1759009965589},"reference-count":55,"publisher":"Elsevier BV","issue":"8492","license":[{"start":{"date-parts":[[1986,5,1]],"date-time":"1986-05-01T00:00:00Z","timestamp":515289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Lancet"],"published-print":{"date-parts":[[1986,5]]},"DOI":"10.1016\/s0140-6736(86)91395-4","type":"journal-article","created":{"date-parts":[[2003,9,17]],"date-time":"2003-09-17T01:14:15Z","timestamp":1063761255000},"page":"1256-1261","source":"Crossref","is-referenced-by-count":29,"title":["STRATEGIES FOR THE PREVENTION OF MALARIA IN TRAVELLERS: COMPARISON OF DRUG REGIMENS BY MEANS OF RISK-BENEFIT ANALYSIS"],"prefix":"10.1016","volume":"327","author":[{"given":"TimothyE.A.","family":"Peto","sequence":"first","affiliation":[]},{"given":"CharlesF.","family":"Gilks","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0140-6736(86)91395-4_BIB1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0140-6736(85)91092-X","article-title":"Bayesian diagnosis in presence of pre-existing disease","volume":"i","author":"Balla","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB2","series-title":"Imported malaria in Britain","author":"Malaria Reference Laboratory","year":"1984"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB3","first-page":"185","article-title":"Revised recommendations for preventing malaria in travellers to areas with chloroquine-resistant P falciparum","volume":"34","author":"Centers for Disease Control","year":"1985","journal-title":"MMWR"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB4","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/BF01951889","article-title":"Malaria prophylaxis in travellers: The current position","volume":"40","author":"Sturchler","year":"1984","journal-title":"Experientia"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/jramc-131-02-08","article-title":"Mosquitoes, malaria and war: Then and now","volume":"131","author":"Bruce-Chwatt","year":"1985","journal-title":"J R Army Med Corps"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB6","first-page":"915","article-title":"The analysis of malaria parasite rates in infants","volume":"47","author":"Macdonald","year":"1950","journal-title":"Trop Dis Bull"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB7","series-title":"The Garki project","author":"Molineaux","year":"1980"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB8","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0140-6736(01)86862-8","article-title":"Experimental proof of the mosquito-malaria theory","volume":"ii","author":"Manson","year":"1900","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB9","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0140-6736(84)91223-6","article-title":"Chemoprophylaxis of malaria in non-immune residents in Dar es Salaam, Tanzania","volume":"ii","author":"McLarty","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB10","first-page":"221","article-title":"Malaria risk in international travel","volume":"59","author":"World Health Organisation","year":"1984","journal-title":"Wkly Epidem Rec"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB11","first-page":"229","article-title":"Malaria risk in international travel. Part II","volume":"59","author":"World Health Organisation","year":"1984","journal-title":"Wkly Epidem Rec"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB12","first-page":"3","article-title":"Malaria prophylaxis for visitors to South-East Asia and South-West Pacific","volume":"35","author":"Colbourne","year":"1983","journal-title":"Commun Dis Rep"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB13","series-title":"Man's mastery of malaria","author":"Russell","year":"1955"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB14","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1136\/bmj.2.4633.891","article-title":"Malaria, with special reference to certain experimental, clinical and chemotherapeutic investigations","volume":"ii","author":"Fairley","year":"1949","journal-title":"Br Med J"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB15","first-page":"311","article-title":"Chemotherapeutic suppression and prophylaxis in malaria","volume":"38","author":"Fairley","year":"1945","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB16","first-page":"1114","article-title":"Prevention of malaria infections by drug prophylaxis","author":"Sapero","year":"1949"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB17","series-title":"Chemotherapy and drug resistance in malaria","author":"Peters","year":"1970"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB18","first-page":"105","article-title":"Researches on paludrine (M 4888) in malaria","volume":"40","author":"Fairley","year":"1946","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0035-9203(52)90091-6","article-title":"Proguanil and malaria among non-tolerant New Guinea natives","volume":"46","author":"Gunther","year":"1952","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/bmj.1.4646.147","article-title":"Proguanil-resistant falciparum malaria in Malaya","volume":"i","author":"Edeson","year":"1950","journal-title":"Br Med J"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB21","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0035-9203(63)90073-7","article-title":"Chloroquine-resistant falciparum malaria in Malaya","volume":"57","author":"Montgomery","year":"1963","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB22","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1136\/bmj.1.4758.564","article-title":"Proguanil-resistance in Malayan strains of Plasmodium vivax","volume":"i","author":"Wilson","year":"1952","journal-title":"Br Med J"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/00034983.1985.11811915","article-title":"A comparison of the pyrimethamine and cycloguanil sensitivities of the pre-erythrocytic and erythrocytic stages of drug-sensitive and -resistant strains of Plasmodium yoelii","volume":"79","author":"Howells","year":"1985","journal-title":"Ann Trop Med Parasitol"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB24","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0035-9203(57)90082-2","article-title":"Experiments with antimalarial drugs in man. IV","volume":"51","author":"Davey","year":"1957","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB25","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0035-9203(53)80011-8","article-title":"Resistance to proguanil in the gametocytes and pre-erythrocytic forms of Plasmodium falciparum","volume":"47","author":"Walker","year":"1953","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB26","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0035-9203(84)90122-6","article-title":"Concomitant resistance to pyrimethamine and cycloguanil of chloroquine-resistant falciparum from East Africa: An in vitro study of 12 isolates","volume":"78","author":"Schapira","year":"1984","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4269\/ajtmh.1971.20.1","article-title":"Prophylactic and sporontocidal treatment of chloroquine resistant Plasmodium falciparum from Vietnam","volume":"20","author":"Clyde","year":"1971","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB28","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/0035-9203(70)90102-1","article-title":"Prophylactic and sporontocidal treatment of chloroquine resistant Plasmodium falciparum from Malaya","volume":"64","author":"Clyde","year":"1970","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0035-9203(69)90063-7","article-title":"Drug resistance in malaria-a perspective","volume":"63","author":"Peters","year":"1969","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB30","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1136\/jramc-131-03-07","article-title":"Plasma paludrine levels-some observations in Commonwealth troops in the Far East 1970","volume":"131","author":"Worsley","year":"1985","journal-title":"J R Army Med Corps"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB31","series-title":"Malaria in Tanzania","author":"Clyde","year":"1967"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB32","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0035-9203(82)90181-X","article-title":"In vitro demonstration of pyrimethamine resistance of\"wild\" Plasmodium falciparum in the Gambia","volume":"76","author":"Smalley","year":"1982","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0140-6736(78)90616-5","article-title":"Persistence of drug-resistant malaria parasites","volume":"i","author":"Rosario","year":"1978","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB34","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/0035-9203(85)90108-7","article-title":"Drug-resistant malaria-changing patterns mean difficult decisions","volume":"79","author":"Spencer","year":"1985","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB35","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0140-6736(86)90846-9","article-title":"Is Plasmodium falciparum resistance to chloroquine reversible m absence of drug pressure?","volume":"i","author":"Onori","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB36","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/0035-9203(85)90070-7","article-title":"In vivo and in vitro assessment of the sensitivity of Plasmodium falciparum to chloroquine in the four districts of Tanya region, Tanzania","volume":"79","author":"Kilimali","year":"1985","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4269\/ajtmh.1982.31.1","article-title":"Sulphadoxme-pyrimethamine for the treatment of acute malaria in children in Papua New Guinea. I. Plasmodium falciparum","volume":"31","author":"Darlow","year":"1982","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB38","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0035-9203(84)90271-2","article-title":"Absence of malaria mortality in villagers with chloroquine-resistant Plasmodium falciparum treated with chloroquine","volume":"78","author":"Hoffman","year":"1984","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB39","first-page":"907","article-title":"An evaluation of five regimes for the outpatient treatment of falciparum malaria in Thailand 1980-81","volume":"60","author":"Pinichpongse","year":"1982","journal-title":"Bull WHO"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB40","first-page":"391","article-title":"The antimalarial action of primaquine against the blood and tissue stages of falciparum malaria","volume":"46","author":"Arnold","year":"1955","journal-title":"J Lab Clin Med"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB41","first-page":"303","article-title":"The haemolytic effect of various regimes of primaquine with chloroquine in American negroes with G6PD deficiency and lack of an effect of various antimalarial suppressive agents on erythrocytic metabolism","volume":"36","author":"Brewer","year":"1967","journal-title":"Bull WHO"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB42","year":"1981"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB43","series-title":"Advances in malaria chemotherapy","author":"World Health Organisation Scientific Group","year":"1984"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB44","doi-asserted-by":"crossref","first-page":"340","DOI":"10.5694\/j.1326-5377.1985.tb113407.x","article-title":"Inadequate prophylaxis of malaria with dapsone-pyrimethamine","volume":"142","author":"Cook","year":"1985","journal-title":"Med J Aust"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB45","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0140-6736(82)92295-4","article-title":"Pyrimethamine\/dapsone resistant falciparum malaria imported from Kenya","volume":"i","author":"Herzog","year":"1982","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB46","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1136\/bmj.291.6488.136","article-title":"Fansidar in malaria prophylaxis","volume":"291","author":"Bradley","year":"1985","journal-title":"Br Med J"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB47","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0140-6736(84)90410-0","article-title":"Effectiveness of amodiaquine as treatment for chloroquine-resistant Plasmodium falciparum infections in Kenya","volume":"i","author":"Watkins","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB48","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0140-6736(86)92371-8","article-title":"Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria","volume":"i","author":"Hatton","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB49","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0035-9203(37)90070-1","article-title":"A note on prognosis in relation to parasite counts in acute subtertian malaria","volume":"30","author":"Field","year":"1937","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB50","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0140-6736(85)92232-9","article-title":"Fatal malaria in US civilians","volume":"i","author":"Lobel","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB51","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S0140-6736(86)92825-4","article-title":"Severe cutaneous adverse reactions to sulfadoxme-pyrimethamine in Switzerland","volume":"i","author":"Steffen","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB52","first-page":"1460","year":"1982"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB53","first-page":"487","article-title":"Maloprim and agranulocytosis","volume":"ii","author":"Bruce-Chwatt","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB54","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1136\/bmj.283.6285.214","article-title":"Malaria prevention in travellers from the United Kingdom","volume":"283","author":"Ross Institute","year":"1981","journal-title":"Br Med J"},{"key":"10.1016\/S0140-6736(86)91395-4_BIB55","first-page":"181","article-title":"Malaria chemoprophylaxis: Problems associated with the chemoprophylaxis of malaria in travellers to endemic areas","volume":"60","author":"World Health Organisation","year":"1985","journal-title":"Wkly Epidem Rec"}],"container-title":["The Lancet"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673686913954?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673686913954?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T16:33:24Z","timestamp":1585154004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0140673686913954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,5]]},"references-count":55,"journal-issue":{"issue":"8492","published-print":{"date-parts":[[1986,5]]}},"alternative-id":["S0140673686913954"],"URL":"https:\/\/doi.org\/10.1016\/s0140-6736(86)91395-4","relation":{},"ISSN":["0140-6736"],"issn-type":[{"value":"0140-6736","type":"print"}],"subject":[],"published":{"date-parts":[[1986,5]]}}}