{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:58:40Z","timestamp":1776185920190,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"8585","license":[{"start":{"date-parts":[[1988,3,1]],"date-time":"1988-03-01T00:00:00Z","timestamp":573177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Lancet"],"published-print":{"date-parts":[[1988,3]]},"DOI":"10.1016\/s0140-6736(88)91352-9","type":"journal-article","created":{"date-parts":[[2003,10,9]],"date-time":"2003-10-09T07:28:31Z","timestamp":1065684511000},"page":"554-558","source":"Crossref","is-referenced-by-count":215,"title":["REBOUND INCREASE IN BRONCHIAL RESPONSIVENESS AFTER TREATMENT WITH INHALED TERBUTALINE"],"prefix":"10.1016","volume":"331","author":[{"given":"A.S.","family":"Vathenen","sequence":"first","affiliation":[]},{"given":"B.G.","family":"Higgins","sequence":"additional","affiliation":[]},{"given":"A.J.","family":"Knox","sequence":"additional","affiliation":[]},{"given":"J.R.","family":"Britton","sequence":"additional","affiliation":[]},{"given":"A.E.","family":"Tattersfield","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0140-6736(88)91352-9_BIB1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1476-5381.1971.tb08070.x","article-title":"Resistance to beta-adrenoceptor stimulants (a possible explanation for the nse m asthma deaths)","volume":"43","author":"Conolly","year":"1971","journal-title":"Br J Pharmacol"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB2","first-page":"554","article-title":"Acute regulation of beta adrenergic catecholamine sensitivity in human lymphocytes","volume":"214","author":"Krall","year":"1980","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB3","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1056\/NEJM197810262991707","article-title":"Decreased beta-adrenergic receptors on polymorphonuclear leucocytes after adrenergic therapy","volume":"299","author":"Galant","year":"1978","journal-title":"N Engl J Med"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB4","first-page":"1194","article-title":"The effect of procaterol treatment on beta-adrenergic bronchodilatation and polymorphonuclear leucocyte responsiveness","volume":"132","author":"Busse","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB5","first-page":"185","article-title":"Subsensitization of beta-adrenoceptors in airways and lymphocytes of healthy and asthmatic subjects","volume":"125","author":"Tashkin","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB6","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0091-6749(82)90004-5","article-title":"Selective subtenitization of beta-adrenergic receptors in central airways of asthmatic and normal subjects during long-term therapy with inhaled salbutamol","volume":"70","author":"Conolly","year":"1982","journal-title":"J All Clin Immunol"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1042\/cs0720047","article-title":"Studies in vivo and in vitro of terbutalinemduced beta-adrenoceptor desensitization m healthy subjects","volume":"72","author":"Martinsson","year":"1987","journal-title":"Clin Sci"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB8","first-page":"1s","article-title":"Tolerance to beta-agonists","volume":"21","author":"Tattersfield","year":"1985","journal-title":"Bull Eur Physiopathol Respir"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB9","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1164\/ajrccm\/136.4_Pt_2.S64","article-title":"Effect of beta-agonists and anticholinergic drugs on bronchial reactivity","volume":"136","author":"Tattersfield","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB10","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1136\/thx.32.4.429","article-title":"Protective effect of drugs on histamine induced asthma","volume":"32","author":"Cockroft","year":"1977","journal-title":"Thorax"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB11","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1136\/thx.38.11.854","article-title":"Effect of aerosol fenoterol on the severity of bronchial hyperreactivity in patients with asthma","volume":"38","author":"Salome","year":"1983","journal-title":"Thorax"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB12","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1042\/cs0660665","article-title":"Methacholine dose-response curves in normal and asthmatic man Effect of starting conductance and pharmacological antagonism","volume":"66","author":"Chung","year":"1984","journal-title":"Clin Sci"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0007-0971(77)90091-2","article-title":"Do sympathomimetic amines prevent exercisemduced asthma by bronchodilatation alone?","volume":"71","author":"Hetzel","year":"1977","journal-title":"Br J Dis Chest"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB14","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1136\/thx.37.12.913","article-title":"Inhibition of the bronchial response to respiratory heat exchange by increasing doses of terbutaline sulphate","volume":"37","author":"O'Byrne","year":"1982","journal-title":"Thorax"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB15","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/0091-6749(85)90786-9","article-title":"Changes in bronchial reactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: a comparison between budesonide and terbutaline","volume":"76","author":"Kraan","year":"1985","journal-title":"J All Clin Immunol"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB16","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0091-6749(87)80163-X","article-title":"Effect of long term treatment with inhaled corticosteroids and beta-agonists on the bronchial responsiveness in children with asthma","volume":"79","author":"Kerrebijn","year":"1987","journal-title":"J All Clin Immunol"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000229248","article-title":"Changes during 24 hours in the lung function and histamine hyperreactivity of the bronchial tree in asthmatic and bronchitic patients","volume":"20","author":"De Vries","year":"1962","journal-title":"Int Arch Allergy"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB18","first-page":"139","article-title":"The circadian pattern of the bronchial reactivity to histamine in healthy subjects and in patients with obstructive lung disease","author":"Tammeling","year":"1977"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB19","first-page":"278","article-title":"Effect of circadian rhythm on bronchomotor tone after deep inspiration in normal and m asthmatic subjects","volume":"132","author":"Liu","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB20","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/thx.30.3.300","article-title":"A survey of asthma mortality in patients between ages 35 and 64 in Greater London hospitals in 1971","volume":"30","author":"Cochrane","year":"1975","journal-title":"Thorax"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB21","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1136\/bmj.1.6064.808","article-title":"Asthma Analysis of sudden deaths and ventilatory arrests in hospital","volume":"i","author":"Hetzel","year":"1977","journal-title":"Br Med J"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB22","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1136\/thx.38.10.760","article-title":"Rapid method for measurement of bronchial responsiveness","volume":"38","author":"Yan","year":"1983","journal-title":"Thorax"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0091-6749(77)90209-3","article-title":"Lack of bronchial beta adrenoceptor resistance in asthmatics during long-term treatment with terbutaline","volume":"59","author":"Larsson","year":"1977","journal-title":"J All Clin Immunol"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB24","first-page":"1014","article-title":"Tolerance to inhaled fenoterol","volume":"129","author":"Angelici","year":"1984","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB25","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1136\/thx.37.4.280","article-title":"Airway response to salbutamol Effect of regular salbutamol inhalations in normal, atopic and asthmatic subjects","volume":"37","author":"Harvey","year":"1982","journal-title":"Thorax"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB26","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0007-0971(78)90042-6","article-title":"Use of exercise challenge to investigate possible tolerance to beta-adrenoceptor stimulation in asthma","volume":"72","author":"Gibson","year":"1978","journal-title":"Br J Dis Chest"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB27","first-page":"973","article-title":"Effects of long term inhaled salbutamol therapy on the provocation of asthma by histamine","volume":"121","author":"Peel","year":"1980","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB28","first-page":"1289","article-title":"Neural control of human airways in health and disease","volume":"134","author":"Barnes","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB29","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-2125.1980.tb01782.x","article-title":"Tachyphylaxis to beta adrenoceptor agonists in human bronchial smooth muscle: Studies in vitro","volume":"10","author":"Davis","year":"1980","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB30","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1056\/NEJM196609152751103","article-title":"Bronchial response to beta-adrenergic blockade","volume":"27","author":"Zaid","year":"1966","journal-title":"N Engl J Med"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB31","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0091-6749(83)90069-6","article-title":"Asthma and increases in non-allergic bronchial responsiveness from seasonal pollen exposure","volume":"71","author":"Boulet","year":"1983","journal-title":"J All Clin Immunol"},{"key":"10.1016\/S0140-6736(88)91352-9_BIB32","first-page":"56","article-title":"Seasonal increase of carbachol airway responsiveness in patients allergic to grass pollen","volume":"130","author":"Sotomayor","year":"1984","journal-title":"Am Rev Respir Dis"}],"container-title":["The Lancet"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673688913529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673688913529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T23:33:13Z","timestamp":1734132793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0140673688913529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,3]]},"references-count":32,"journal-issue":{"issue":"8585","published-print":{"date-parts":[[1988,3]]}},"alternative-id":["S0140673688913529"],"URL":"https:\/\/doi.org\/10.1016\/s0140-6736(88)91352-9","relation":{},"ISSN":["0140-6736"],"issn-type":[{"value":"0140-6736","type":"print"}],"subject":[],"published":{"date-parts":[[1988,3]]}}}