{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:22:22Z","timestamp":1771003342108,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"8660","license":[{"start":{"date-parts":[[1989,8,1]],"date-time":"1989-08-01T00:00:00Z","timestamp":617932800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Lancet"],"published-print":{"date-parts":[[1989,8]]},"DOI":"10.1016\/s0140-6736(89)90591-6","type":"journal-article","created":{"date-parts":[[2003,9,22]],"date-time":"2003-09-22T16:37:44Z","timestamp":1064248664000},"page":"411-414","source":"Crossref","is-referenced-by-count":99,"title":["NEUTROPHIL-MEDIATED ENDOTHELIAL INJURY IN HAEMOLYTIC URAEMIC SYNDROME"],"prefix":"10.1016","volume":"334","author":[{"given":"KevinD","family":"Forsyth","sequence":"first","affiliation":[]},{"given":"MargaretM","family":"Fitzpatrick","sequence":"additional","affiliation":[]},{"given":"AnnaC","family":"Simpson","sequence":"additional","affiliation":[]},{"given":"T.Martin","family":"Barratt","sequence":"additional","affiliation":[]},{"given":"RolandJ","family":"Levinsky","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0140-6736(89)90591-6_BIB1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1136\/adc.59.5.397","article-title":"Haemolytic uraemic syndrome","volume":"59","author":"Levin","year":"1984","journal-title":"Arch Dis Child"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB2","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/S0046-8177(88)80093-5","article-title":"The histopathology of the hemolytic uremic syndrome associated with verocytotoxin producing Escherichia colt infections","volume":"19","author":"Richardson","year":"1988","journal-title":"Hum Pathol"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB3","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1136\/bmj.1.6126.1518","article-title":"Haemolytic uraemic syndrome complicating shigella dysentery in South Indian children","volume":"i","author":"Raghupathy","year":"1978","journal-title":"Br Med J"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB4","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1136\/bmj.2.5910.84","article-title":"Haemolytic uraemic syndrome in typhoid fever","volume":"ii","author":"Baker","year":"1974","journal-title":"Br Med J"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB5","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1542\/peds.46.3.378","article-title":"Enteroviruses associated with the hemolytic uremic syndrome","volume":"46","author":"Ray","year":"1970","journal-title":"Pediatrics"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB6","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0022-3476(64)80337-1","article-title":"The hemolytic uremic syndrome","volume":"64","author":"Gianantonio","year":"1964","journal-title":"J Pediatr"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0031-3955(16)31839-9","article-title":"The hemolytic uremic syndrome","volume":"13","author":"Piel","year":"1966","journal-title":"Pediatr Clin North Am"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB8","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1056\/NEJM197804272981702","article-title":"Hemolytic uremic syndrome after shigellosis: relation to endotoxemia and circulating immune complexes","volume":"298","author":"Koster","year":"1978","journal-title":"N Engl J Med"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB9","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/BF00852893","article-title":"The polymorphonuclear leucocyte count in childhood hemolytic uremic syndrome","volume":"3","author":"Walters","year":"1989","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB10","first-page":"265","article-title":"Role of the LFA-1 adhesion glycoprotein in neutrophil adhesion to endothelium and plastic surfaces","volume":"75","author":"Forsyth","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB11","doi-asserted-by":"crossref","unstructured":"Kd Forsyth, Ac Simpson, RJ. Levinsky, CD15 antibodies increase neutrophil adhesion to endothelium by an LFA-1 dependent mechanism, Eur J Immunol ((in press)).","DOI":"10.1002\/eji.1830190727"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0022-1759(87)90184-0","article-title":"A method for the determination of the adherence of granulocytes to microtitre plates","volume":"100","author":"Santini","year":"1987","journal-title":"J Immunol Method"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB13","first-page":"15","article-title":"Monoclonal antibodies that distinguish between human cellular and plasma fibronectin","volume":"2","author":"Keen","year":"1984","journal-title":"Mol Biol Med"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB14","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/infdis\/152.4.661","article-title":"Leucocyte adherence-related glycoproteins LFA-1, Mol, and p150,95: a new group of monoclonal antibodies, a new disease, and a possible opportunity to understand the molecular basis of leucocyte adherence","volume":"152","author":"Gallin","year":"1985","journal-title":"J Infect Dis"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB15","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1172\/JCI112869","article-title":"Tissue injury in inflammation oxidants, proteinases, and cationic proteins","volume":"79","author":"Henson","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB16","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1172\/JCI112731","article-title":"\u03b11 antitrypsin: molecular pathology, leucocytes and tissue damage","volume":"78","author":"Carrell","year":"1986","journal-title":"J Clin Invest"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1164\/ajrccm\/136.1.19","article-title":"Neutrophil mediated pulmonary vascular injury","volume":"136","author":"Worthen","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB18","first-page":"233","article-title":"The degradation of human glomerular basement membrane with purified lysosomal proteinases. evidence for the pathogenic role of the polymorphonuclear leucocyte in glomerulonephritis","volume":"54","author":"Davies","year":"1978","journal-title":"Clin Sci Mol Med"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB19","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1172\/JCI113241","article-title":"Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes","volume":"80","author":"Nathan","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB20","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1203\/00006450-198703000-00009","article-title":"Neutrophil function in an experimental model of hemolytic uremic syndrome","volume":"21","author":"Vedanarayanan","year":"1987","journal-title":"Pediator Res"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB21","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1172\/JCI113102","article-title":"Stimulated mobilization of monocyte Mac-1 and p150,95 adhesion glycoproteins from an intracellular vesicular compartment to the cell surface","volume":"80","author":"Miller","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/339061a0","article-title":"Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1","volume":"339","author":"Staunton","year":"1989","journal-title":"Nature"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB23","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1172\/JCI113788","article-title":"Recognition of an endothelial determinant for CD 18 dependent human neutrophil adherence and transendothelial migration","volume":"82","author":"Smith","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4049\/jimmunol.137.1.245","article-title":"Induction by IL1 and interferon gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1)","volume":"137","author":"Dustin","year":"1986","journal-title":"J Immunol"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB25","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.4049\/jimmunol.137.6.1893","article-title":"Activation of human endothelium by lymphokines: overlapping patterns of antigenic modulation by interleukin-1, tumor necrosis factor and immune interferon","volume":"137","author":"Pober","year":"1986","journal-title":"J Immunol"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB26","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1126\/science.2821619","article-title":"New perspectives in cell adhesion: RGD and integrins","volume":"238","author":"Ruoslahti","year":"1987","journal-title":"Science"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB27","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0092-8674(87)90233-9","article-title":"Integrins: a family of cell surface receptors","volume":"48","author":"Hynes","year":"1987","journal-title":"Cell"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB28","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/S0140-6736(84)91623-4","article-title":"A genetically engineered mutant of \u03b1-1 antitrypsin protects connective tissue from neutrophil damage, and may be useful in lung disease","volume":"ii","author":"George","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB29","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1182\/blood.V62.5.1063.1063","article-title":"Inflammed fibronectin: an altered fibronectin enhances neutrophil adhesion","volume":"62","author":"Vercellotti","year":"1983","journal-title":"Blood"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB30","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1172\/JCI113456","article-title":"Fibronectin degradation products containing the cytoadhesive tetrapeptide stimulate human neutrophil degranulation","volume":"81","author":"Wachtfogel","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB31","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1172\/JCI113407","article-title":"A monoclonal antibody to the adherence promoting leucocyte glycoprotein CD18 reduces organ injury and improves survival from hemorrhagic shock and resuscitation in rabbits","volume":"81","author":"Vedder","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1016\/S0140-6736(89)90591-6_BIB32","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1172\/JCI113364","article-title":"Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mol, anti CD11b) that inhibits leucocyte adhesion","volume":"81","author":"Simpson","year":"1988","journal-title":"J Clin Invest"}],"container-title":["The Lancet"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673689905916?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673689905916?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T19:47:54Z","timestamp":1682538474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0140673689905916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,8]]},"references-count":32,"journal-issue":{"issue":"8660","published-print":{"date-parts":[[1989,8]]}},"alternative-id":["S0140673689905916"],"URL":"https:\/\/doi.org\/10.1016\/s0140-6736(89)90591-6","relation":{},"ISSN":["0140-6736"],"issn-type":[{"value":"0140-6736","type":"print"}],"subject":[],"published":{"date-parts":[[1989,8]]}}}