{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:12:18Z","timestamp":1776114738378,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"8647","license":[{"start":{"date-parts":[[1989,5,1]],"date-time":"1989-05-01T00:00:00Z","timestamp":609984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Lancet"],"published-print":{"date-parts":[[1989,5]]},"DOI":"10.1016\/s0140-6736(89)92394-5","type":"journal-article","created":{"date-parts":[[2003,10,9]],"date-time":"2003-10-09T07:06:15Z","timestamp":1065683175000},"page":"1122-1126","source":"Crossref","is-referenced-by-count":372,"title":["Peptide Regulatory Factors"],"prefix":"10.1016","volume":"333","author":[{"given":"KevinJ.","family":"Tracey","sequence":"first","affiliation":[]},{"given":"Helen","family":"Vlassara","sequence":"additional","affiliation":[]},{"given":"Anthony","family":"Cerami","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0140-6736(89)92394-5_BIB1","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1084\/jem.161.5.984","article-title":"Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells","volume":"161","author":"Beutler","year":"1985","journal-title":"J Exp Med"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB2","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1073\/pnas.72.9.3666","article-title":"An endotoxin-induced serum factor that causes necrosis of tumors","volume":"72","author":"Carswell","year":"1975","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB3","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1073\/pnas.83.6.1670","article-title":"Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators","volume":"83","author":"Caput","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB4","doi-asserted-by":"crossref","first-page":"6060","DOI":"10.1073\/pnas.82.18.6060","article-title":"Cloning and expression in E coli of the cDNA for murine tumor necrosis factor","volume":"82","author":"Pennica","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB5","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1084\/jem.164.5.1791","article-title":"Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of lpsd (endotoxin resistance) phenotype","volume":"164","author":"Beutler","year":"1986","journal-title":"J Exp Med"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0092-8674(88)90486-2","article-title":"A novel form of TNF\/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF","volume":"53","author":"Kriegler","year":"1988","journal-title":"Cell"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB7","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.4049\/jimmunol.140.4.1142","article-title":"Plasma membrane associated tumor necrosis factor: a non-integral membrane protein possibly bound to its own receptor","volume":"140","author":"Bakouche","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB8","first-page":"147","article-title":"Cytokine appearance in human endotoxemia and primate bacteremia","volume":"166","author":"Hesse","year":"1988","journal-title":"Surg Gynecol Obstet"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB9","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1126\/science.3764421","article-title":"Shock and tissue injury induced by recombinant human cachectin","volume":"234","author":"Tracey","year":"1986","journal-title":"Science"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB10","first-page":"415","article-title":"Cachectin\/tumor necrosis factor induces lethal shock and stress hormone responses in the dog","volume":"164","author":"Tracey","year":"1987","journal-title":"Surg Gynecol Obstet"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB11","first-page":"88","article-title":"Effects of tumour necrosis factor and related cytokines on vascular endothelial cells","author":"Pober","year":"1987"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB12","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1172\/JCI113241","article-title":"Neutrophil activation on biological surfaces: massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes","volume":"80","author":"Nathan","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB13","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1084\/jem.167.4.1472","article-title":"Tumor necrosis factor-alpha\/cachectin is a growth factor for thymocytes: synergistic interactions with other cytokines","volume":"167","author":"Ranges","year":"1988","journal-title":"J Exp Med"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB14_1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/330662a0","article-title":"Anti-cachectin\/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia","volume":"330","author":"Tracey","year":"1987","journal-title":"Nature"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB14_2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0140-6736(87)91728-4","article-title":"Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease","volume":"i","author":"Waage","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1056\/NEJM198808183190703","article-title":"Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura","volume":"319","author":"Girardin","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB16","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1084\/jem.167.3.1211","article-title":"Cachectin\/tumor necrosis factor induces cachexia, anemia, and inflammation","volume":"167","author":"Tracey","year":"1988","journal-title":"J Exp Med"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB17","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1126\/science.3839597","article-title":"A macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia","volume":"229","author":"Torti","year":"1985","journal-title":"Science"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB18","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1073\/pnas.84.9.2590","article-title":"Effect of endotoxin-induced monokines on glucose metabolism in the muscle cell line L6","volume":"84","author":"Lee","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB19","doi-asserted-by":"crossref","first-page":"8619","DOI":"10.1073\/pnas.84.23.8619","article-title":"Modulation of endogenous hormone action by recombinant human tumor necrosis factor","volume":"84","author":"Warren","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1084\/jem.168.1.95","article-title":"Tolerance to tumor necrosis factor in rats and the relationship to endotoxin tolerance and toxicity","volume":"168","author":"Fraker","year":"1988","journal-title":"J Exp Med"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB21","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0092-8674(87)90028-6","article-title":"Tumors secreting human TNF\/cachectin induce cachexia in mice","volume":"50","author":"Oliff","year":"1987","journal-title":"Cell"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB22","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0140-6736(87)91850-2","article-title":"Evidence for tumour necrosis factor\/cachectin production in cancer","volume":"ii","author":"Balkwill","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB23","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/jnci\/80.8.595","article-title":"Tumor necrosis factor not detectable in patients with clinical cancer cachexia","volume":"80","author":"Socher","year":"1988","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB24","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/S0140-6736(86)92007-6","article-title":"Raised serum levels of tumour necrosis factor in parasitic infections","volume":"ii","author":"Scuderi","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB25","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0002-9343(88)90576-1","article-title":"Elevated levels of circulating cachectin\/tumor necrosis factor in patients with acquired immunodeficiency syndrome","volume":"85","author":"Lahdevirta","year":"1988","journal-title":"Am J Med"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB26","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1084\/jem.163.6.1433","article-title":"Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1","volume":"163","author":"Dinarello","year":"1986","journal-title":"J Exp Med"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB27","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.4049\/jimmunol.141.11.4047","article-title":"Tumor necrosis factor induction by Candida albicans from human natural killer cells and monocytes","volume":"141","author":"Djeu","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB28","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/323816a0","article-title":"Antiviral effects of recombinant tumour necrosis factor in vitro","volume":"323","author":"Mestan","year":"1986","journal-title":"Nature"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB29","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/331356a0","article-title":"Tumour necrosis factor-alpha in murine autoimmune 'lupus' nephritis","volume":"331","author":"Jacob","year":"1988","journal-title":"Nature"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB30","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1084\/jem.166.5.1280","article-title":"Tumor necrosis factor\/rachectin is an effector of skin and gut lesions of the acute phase of graft-vs-host disease","volume":"166","author":"Piguet","year":"1987","journal-title":"J Exp Med"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB31","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1084\/jem.166.4.1132","article-title":"Raised serum levels of cachectin\/tumor necrosis factor alpha in renal allograft rejection","volume":"166","author":"Maury","year":"1987","journal-title":"J Exp Med"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.3175638","article-title":"Endothelial adhesiveness for blood neutrophils is inhibited by transforming growth factor-beta","volume":"242","author":"Gamble","year":"1988","journal-title":"Science"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB33","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/334260a0","article-title":"Deactivation of macrophages by transforming growth factor-beta","volume":"334","author":"Tsunawaki","year":"1988","journal-title":"Nature"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB34","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJM198805193182007","article-title":"Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications","volume":"318","author":"Brownlee","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB35","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1126\/science.3259727","article-title":"Cachectin\/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodeling","volume":"240","author":"Vlassara","year":"1988","journal-title":"Science"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB36","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1126\/science.2432664","article-title":"Angiogenic factors","volume":"235","author":"Folkman","year":"1988","journal-title":"Science"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB37","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1084\/jem.167.3.1067","article-title":"The antitumor function of tumor necrosis factor (TNF): I. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity","volume":"167","author":"Havell","year":"1988","journal-title":"J Exp Med"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB38","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1172\/JCI113341","article-title":"Tumor necrosis factor expression in human epithelial cells lines","volume":"81","author":"Spriggs","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1016\/S0140-6736(89)92394-5_BIB39","first-page":"206","article-title":"Clinical studies with tumour necrosis factor","author":"Spnggs","year":"1987"}],"container-title":["The Lancet"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673689923945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673689923945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T02:23:45Z","timestamp":1682562225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0140673689923945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,5]]},"references-count":40,"journal-issue":{"issue":"8647","published-print":{"date-parts":[[1989,5]]}},"alternative-id":["S0140673689923945"],"URL":"https:\/\/doi.org\/10.1016\/s0140-6736(89)92394-5","relation":{},"ISSN":["0140-6736"],"issn-type":[{"value":"0140-6736","type":"print"}],"subject":[],"published":{"date-parts":[[1989,5]]}}}