{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:52:10Z","timestamp":1779324730196,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"9137","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Lancet"],"published-print":{"date-parts":[[1998,10]]},"DOI":"10.1016\/s0140-6736(98)03086-4","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T21:04:53Z","timestamp":1027631093000},"page":"1347-1351","source":"Crossref","is-referenced-by-count":1073,"title":["Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial"],"prefix":"10.1016","volume":"352","author":[{"given":"Fran\u00e7oise","family":"Forette","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Laure","family":"Seux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan A","family":"Staessen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutgarde","family":"Thijs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem H","family":"Birkenh\u00e4ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija-Ruta","family":"Babarskiene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Speranta","family":"Babeanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Bossini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blas","family":"Gil-Extremera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Girerd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tovio","family":"Laks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil","family":"Lilov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentine","family":"Moisseyev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaakko","family":"Tuomilehto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannu","family":"Vanhanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Webster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yair","family":"Yodfat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Fagard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0140-6736(98)03086-4_bib1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0140-6736(96)09328-2","article-title":"Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study","volume":"349","author":"Hofman","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(98)03086-4_bib2","doi-asserted-by":"crossref","first-page":"14S","DOI":"10.1016\/0002-9343(91)90430-6","article-title":"Hypertension and risk of dementia in the elderly","volume":"90","author":"Forette","year":"1991","journal-title":"Am J Med"},{"key":"10.1016\/S0140-6736(98)03086-4_bib3","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1001\/jama.1991.03460240051027","article-title":"Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP)","volume":"265","year":"1991","journal-title":"JAMA"},{"key":"10.1016\/S0140-6736(98)03086-4_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF03324024","article-title":"A multicentre trial on the treatment of isolated systolic hypertension in the elderly: objectives, protocol, and organization","volume":"3","author":"Amery","year":"1991","journal-title":"Aging Clin Exp Res"},{"key":"10.1016\/S0140-6736(98)03086-4_bib5","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0140-6736(97)05381-6","article-title":"Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension","volume":"350","author":"Staessen","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(98)03086-4_bib6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/BF03324039","article-title":"Is prevention of vascular dementia possible? The Syst-Eur Vascular Dementia Project","volume":"3","author":"Forette","year":"1991","journal-title":"Aging Clin Exp Res"},{"key":"10.1016\/S0140-6736(98)03086-4_bib7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-Mental State\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1016\/S0140-6736(98)03086-4_bib8","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1532-5415.1985.tb07109.x","article-title":"The meaning of cognitive impairment in the elderly","volume":"33","author":"Folstein","year":"1985","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/S0140-6736(98)03086-4_bib9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000110764","article-title":"The validity of the Mini Mental State Examination as screening instrument for cognitive impairment and dementia in French elderly community residents","volume":"3","author":"Gagnon","year":"1990","journal-title":"Neuroepidemiology"},{"key":"10.1016\/S0140-6736(98)03086-4_bib10","series-title":"Diagnostic and statistical manual of mental disorders, 3rd edn, revised","year":"1987"},{"key":"10.1016\/S0140-6736(98)03086-4_bib11","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1093\/ije\/23.6.1256","article-title":"Incidence of dementia and Alzheimer's disease in elderly community residents of south-western France","volume":"23","author":"Letenneur","year":"1994","journal-title":"Int J Epidemiol"},{"issue":"suppl 1","key":"10.1016\/S0140-6736(98)03086-4_bib12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000110954","article-title":"Overview of incidence studies of dementia conducted in Europe","volume":"11","author":"Launer","year":"1992","journal-title":"Neuroepidemiology"},{"key":"10.1016\/S0140-6736(98)03086-4_bib13","series-title":"Alzheimer's disease: biology, diagnosis and therapeutics","first-page":"1","article-title":"The incidence of dementia in the Rotterdam study","author":"Ott","year":"1997"},{"key":"10.1016\/S0140-6736(98)03086-4_bib14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1161\/01.STR.14.3.399","article-title":"Diagnostic evaluation of degenerative and vascular dementia","volume":"14","author":"Loeb","year":"1983","journal-title":"Stroke"},{"key":"10.1016\/S0140-6736(98)03086-4_bib15","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1001\/archneur.1975.00490510088009","article-title":"Cerebral blood flow in dementia","volume":"32","author":"Hachinski","year":"1975","journal-title":"Arch Neurol"},{"key":"10.1016\/S0140-6736(98)03086-4_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/WNL.36.1.1","article-title":"Decreased cerebral blood flow precedes multi-infarct dementia but follows senile dementia of Alzheimer type","volume":"36","author":"Rogers","year":"1986","journal-title":"Neurology"},{"key":"10.1016\/S0140-6736(98)03086-4_bib17","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1136\/bmj.300.6719.230","article-title":"Analysis of serial measurements in medical research","volume":"300","author":"Matthews","year":"1990","journal-title":"BMJ"},{"key":"10.1016\/S0140-6736(98)03086-4_bib18","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1212\/WNL.42.3.473","article-title":"Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers","volume":"42","author":"Chui","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/S0140-6736(98)03086-4_bib19","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.2.250","article-title":"Vascular dementia: diagnostic criteria for research studies: report of the NINCDS-AIREN International Workshop","volume":"43","author":"Rom\u00e1n","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/S0140-6736(98)03086-4_bib20","series-title":"Diagnostic and statistical manual of mental disorders","year":"1994"},{"key":"10.1016\/S0140-6736(98)03086-4_bib21","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1056\/NEJM199712043372306","article-title":"The effect of different diagnostic criteria on the prevalence of dementia","volume":"337","author":"Erkinjuntti","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/S0140-6736(98)03086-4_bib22","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/j.1532-5415.1997.tb03191.x","article-title":"The association of antihypertensive agents with MRI white matter findings and the Modified Mini-Mental State Examination in older patients","volume":"45","author":"Heckbert","year":"1997","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/S0140-6736(98)03086-4_bib23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2165\/00044011-199611040-00001","article-title":"Nimodipine in the treatment of probable Alzheimer's disease: results of two multicentre trials","volume":"11","author":"Morich","year":"1996","journal-title":"Clin Drug Invest"},{"key":"10.1016\/S0140-6736(98)03086-4_bib24","series-title":"Treatment of dementias: a new generation of progress","first-page":"241","article-title":"Cellular mechanisms for nimodipine's reduction of aging related learning deficits","author":"Thompson","year":"1992"},{"key":"10.1016\/S0140-6736(98)03086-4_bib25","doi-asserted-by":"crossref","first-page":"752","DOI":"10.2165\/00003495-199753050-00003","article-title":"Cognitive enhancement therapy for Alzheimer's disease: the way forward","volume":"53","author":"Parneti","year":"1997","journal-title":"Drugs"},{"key":"10.1016\/S0140-6736(98)03086-4_bib26","first-page":"589","article-title":"The relationship between calcium antagonist-induced hypotension and central monoaminergic system in spontaneously hypertensive rats","volume":"11","author":"Hong","year":"1987","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"key":"10.1016\/S0140-6736(98)03086-4_bib27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0006-8993(85)90680-8","article-title":"Autoradiographic localization of calcium channel antagonist receptors in rat brain with [3H]nitrendipine","volume":"330","author":"Gould","year":"1985","journal-title":"Brain Res"}],"container-title":["The Lancet"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673698030864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673698030864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T01:26:22Z","timestamp":1555377982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0140673698030864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":27,"journal-issue":{"issue":"9137","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["S0140673698030864"],"URL":"https:\/\/doi.org\/10.1016\/s0140-6736(98)03086-4","relation":{},"ISSN":["0140-6736"],"issn-type":[{"value":"0140-6736","type":"print"}],"subject":[],"published":{"date-parts":[[1998,10]]}}}