{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T16:06:57Z","timestamp":1776614817532,"version":"3.51.2"},"reference-count":12,"publisher":"Elsevier BV","issue":"9162","license":[{"start":{"date-parts":[[1999,4,1]],"date-time":"1999-04-01T00:00:00Z","timestamp":922924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Lancet"],"published-print":{"date-parts":[[1999,4]]},"DOI":"10.1016\/s0140-6736(98)07534-5","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T09:37:16Z","timestamp":1027589836000},"page":"1386-1389","source":"Crossref","is-referenced-by-count":2162,"title":["Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER)"],"prefix":"10.1016","volume":"353","author":[{"given":"Samuel Z","family":"Goldhaber","sequence":"first","affiliation":[]},{"given":"Luigi","family":"Visani","sequence":"additional","affiliation":[]},{"given":"Marisa","family":"De Rosa","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"suppl 2","key":"10.1016\/S0140-6736(98)07534-5_bib1","first-page":"1","article-title":"The urokinase pulmonary embolism trial: a national cooperative study","volume":"47","year":"1973","journal-title":"Circulation"},{"key":"10.1016\/S0140-6736(98)07534-5_bib2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0140-6736(93)90274-K","article-title":"Alteplase versus heparin in acute pulmonary embolism: randomised trial assessing right ventricular function and pulmonary perfusion","volume":"341","author":"Goldhaber","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/S0140-6736(98)07534-5_bib3","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1378\/chest.106.3.718","article-title":"Reduced dose bolus alteplase versus conventional alteplase infusion for pulmonary embolism thrombolysis: an international multicenter randomized trial","volume":"106","author":"Goldhaber","year":"1994","journal-title":"Chest"},{"key":"10.1016\/S0140-6736(98)07534-5_bib4","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/thx.42.7.481","article-title":"Recurrence of pulmonary embolism during anticoagulant treatment: a prospective study","volume":"42","author":"Girard","year":"1987","journal-title":"Thorax"},{"key":"10.1016\/S0140-6736(98)07534-5_bib5","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/0735-1097(92)90002-5","article-title":"PAIMS 2: alteplase combined with heparin versus heparin in the treatment of acute pulmonary embolism. Plasminogen Activator Italian Multicenter Study 2","volume":"20","author":"Dalla-Volta","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/S0140-6736(98)07534-5_bib6","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1001\/archinte.1997.00440410049005","article-title":"The importance of initial heparin treatment on long-term clinical outcomes of antithrombotic therapy: the emerging theme of delayed recurrence","volume":"157","author":"Hull","year":"1997","journal-title":"Arch Intern Med"},{"key":"10.1016\/S0140-6736(98)07534-5_bib7","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1378\/chest.111.5.1241","article-title":"Thrombolytic therapy for pulmonary embolism: frequency of intracranial hemorrhage and associated risk factors","volume":"111","author":"Kanter","year":"1997","journal-title":"Chest"},{"key":"10.1016\/S0140-6736(98)07534-5_bib8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1001\/jama.1995.03530040063042","article-title":"Prevalence of deep venous thrombosis among patients in medical intensive care","volume":"274","author":"Hirsch","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/S0140-6736(98)07534-5_bib9","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0002-9149(96)90069-7","article-title":"Cardiovascular risk stratification of pulmonary embolism","volume":"78","author":"Cannon","year":"1996","journal-title":"Am J Cardiol"},{"key":"10.1016\/S0140-6736(98)07534-5_bib10","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1136\/hrt.77.4.346","article-title":"Prognostic significance of right ventricular afterload stress detected by echocardiography in patients with clinically suspected pulmonary embolism","volume":"77","author":"Kasper","year":"1997","journal-title":"Heart"},{"key":"10.1016\/S0140-6736(98)07534-5_bib11","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0002-8703(97)70085-1","article-title":"Echocardiography doppler in pulmonary embolism: right ventricular dysfunction as a predictor of mortality","volume":"134","author":"Ribeiro","year":"1997","journal-title":"Am Heart"},{"key":"10.1016\/S0140-6736(98)07534-5_bib12","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S0735-1097(97)00319-7","article-title":"Management strategies and determinants of outcome in acute major pulmonary embolism: results of a multicenter registry","volume":"30","author":"Kasper","year":"1997","journal-title":"J Am Coll Cardiol"}],"container-title":["The Lancet"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673698075345?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140673698075345?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T03:57:36Z","timestamp":1556510256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0140673698075345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4]]},"references-count":12,"journal-issue":{"issue":"9162","published-print":{"date-parts":[[1999,4]]}},"alternative-id":["S0140673698075345"],"URL":"https:\/\/doi.org\/10.1016\/s0140-6736(98)07534-5","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.714147888.789652802","asserted-by":"object"}]},"ISSN":["0140-6736"],"issn-type":[{"value":"0140-6736","type":"print"}],"subject":[],"published":{"date-parts":[[1999,4]]}}}