{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T07:12:55Z","timestamp":1769584375716,"version":"3.49.0"},"reference-count":136,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2003,2]]},"DOI":"10.1016\/s0163-7258(02)00327-3","type":"journal-article","created":{"date-parts":[[2003,1,30]],"date-time":"2003-01-30T18:27:59Z","timestamp":1043951279000},"page":"139-152","source":"Crossref","is-referenced-by-count":394,"title":["The many roles of cytochrome b5"],"prefix":"10.1016","volume":"97","author":[{"given":"John B","family":"Schenkman","sequence":"first","affiliation":[]},{"given":"Ingela","family":"Jansson","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0163-7258(02)00327-3_BIB1","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1074\/jbc.273.6.3158","article-title":"Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer","volume":"273","author":"Auchus","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB2","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1749-6632.1973.tb47612.x","article-title":"The effect of high salt concentrations upon cytochrome c, cytochrome b5, and iron-EDTA reductase activities of liver microsomal NADPH-cytochrome c reductase","volume":"212","author":"Bilimoria","year":"1973","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB3","doi-asserted-by":"crossref","first-page":"9457","DOI":"10.1016\/S0021-9258(19)68784-3","article-title":"Direct evidence for electron transfer from ferrous cytochrome b5 to the oxyferrous intermediate of liver microsomal cytochrome P-450 LM2","volume":"256","author":"Bonfils","year":"1981","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB4","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1016\/S0021-9258(18)34594-0","article-title":"Association of cytochrome b5 and cytochrome P-450 reductase with cytochrome P-450 in the membrane of reconstituted vesicles","volume":"257","author":"B\u00f6sterling","year":"1982","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB5","doi-asserted-by":"crossref","first-page":"17036","DOI":"10.1074\/jbc.273.27.17036","article-title":"Identification of the binding site on cytochrome P450 2B4 for cytochrome b5 and cytochrome P450 reductase","volume":"273","author":"Bridges","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB6","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/0006-2952(85)90307-7","article-title":"Obligatory role of cytochrome b5 in the microsomal metabolism of methoxyflurane","volume":"34","author":"Canova-Davis","year":"1985","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB7","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/0003-9861(81)90502-6","article-title":"Interaction of purified microsomal cytochrome P-450 with cytochrome b5","volume":"211","author":"Chiang","year":"1981","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1074\/jbc.274.1.471","article-title":"Cloning, expression, and nutritional regulation of the mammalian \u03946-desaturase","volume":"274","author":"Cho","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB9","doi-asserted-by":"crossref","first-page":"37335","DOI":"10.1074\/jbc.274.52.37335","article-title":"Cloning, expression, and fatty acid regulation of the human \u0394-5 desaturase","volume":"274","author":"Cho","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB10","first-page":"628","article-title":"The metabolism of methylated aminoazo dyes. VI. Intracellular distribution and properties of the demethylase system","volume":"17","author":"Conney","year":"1957","journal-title":"Cancer Res"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB11","first-page":"470","article-title":"Reduced diphosphopyridine nucleotide synergism of the reduced triphosphopyridine nucleotide-dependent mixed-function oxidase system of hepatic microsomes. II. Role of the type I drug-binding site of cytochrome P-450","volume":"9","author":"Correia","year":"1973","journal-title":"Mol Pharmacol"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB12","doi-asserted-by":"crossref","first-page":"5388","DOI":"10.1016\/S0021-9258(18)50608-6","article-title":"Modification and identification of cytochrome b5 carboxyl groups involved in protein-protein interaction with cytochrome b5 reductase","volume":"254","author":"Dailey","year":"1979","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB13","doi-asserted-by":"crossref","first-page":"5184","DOI":"10.1016\/S0021-9258(19)70768-6","article-title":"Characterization of the interaction of amphipathic cytochrome b5 with stearyl coenzyme A desaturase and NADPH: cytochrome P-450 reductase","volume":"255","author":"Dailey","year":"1980","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB14","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0006-291X(85)90091-9","article-title":"Involvement of cytochrome b5 in the hepatic microsomal metabolism of benzo(A)pyrene","volume":"128","author":"DeMarco","year":"1985","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0005-2760(91)90298-V","article-title":"Evidence against cytochrome b5 involvement in liver microsomal fatty acid elongation","volume":"1082","author":"Demirkapi","year":"1991","journal-title":"Biochem Biophys Acta"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB16","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/0006-2952(77)90055-7","article-title":"Alteration of hepatic microsomal enzymes by griseofulvin treatment of mice","volume":"26","author":"Denk","year":"1977","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB17","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-0061(19980315)14:4<311::AID-YEA220>3.0.CO;2-B","article-title":"Synthesis of monohydroxylated inositolphosphorylceramide (IPC-C) in Saccharomyces cervesiae requires Scs7p, a protein with both a cytochrome b5-like domain and a hydroxylase\/desaturase domain","volume":"14","author":"Dunn","year":"1998","journal-title":"Yeast"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB18","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0003-9861(91)90128-6","article-title":"Cytochrome-P450 IIIA1 (P450p) requires cytochrome b5 and phospholipid with unsaturated fatty acids","volume":"291","author":"Eberhart","year":"1991","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB19","doi-asserted-by":"crossref","first-page":"8976","DOI":"10.1016\/S0021-9258(19)86797-2","article-title":"Cytochrome b5 reduction by NADPH-cytochrome P-450 reductase","volume":"254","author":"Enoch","year":"1979","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/0006-291X(71)90372-X","article-title":"A new spectral intermediate associated with cytochrome P-450 function in liver microsomes","volume":"42","author":"Estabrook","year":"1971","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB21","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.1016\/S0021-9258(19)85640-5","article-title":"Interactions of cytochrome P-450, NADPH-cytochrome P-450 reductase, phospholipid, and substrate in the reconstituted liver microsomal enzyme system","volume":"255","author":"French","year":"1980","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB22","doi-asserted-by":"crossref","first-page":"4822","DOI":"10.1016\/S0021-9258(19)69327-0","article-title":"Total enzymic synthesis of cholesterol from lanosterol. Cytochrome b5-dependence of 4-methyl sterol oxidase","volume":"256","author":"Fukushima","year":"1981","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB23","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0167-4781(95)00068-R","article-title":"Molecular cloning of human liver sulfite oxidase","volume":"1262","author":"Garrett","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB24","first-page":"89","article-title":"Effects of conditions for reconstitution with cytochrome b5 on the formation of products in cytochrome P-450-catalyzed reactions","volume":"14","author":"Gorsky","year":"1986","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB25","doi-asserted-by":"crossref","first-page":"6812","DOI":"10.1016\/S0021-9258(17)39800-9","article-title":"On the stoichiometry of the oxidase and monooxygenase reactions catalyzed by liver microsomal cytochrome P-450","volume":"259","author":"Gorsky","year":"1984","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0005-2728(76)90186-9","article-title":"Immunological similarity between NADH-cytochrome b5 reductase of erythrocytes and liver microsomes","volume":"423","author":"Goto-Tamura","year":"1976","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB27","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1021\/bi00281a007","article-title":"Oxidation-reduction properties of rat liver cytochromes P-450 and NADPH-cytochrome P-450 reductase related to catalysis in reconstituted systems","volume":"22","author":"Guengerich","year":"1983","journal-title":"Biochemistry"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB28","first-page":"951","article-title":"Spectral intermediates in the reaction of oxygen with purified liver microsomal cytochrome P-450","volume":"70","author":"Guengerich","year":"1976","journal-title":"Biochem Biophys Acta"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB29","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1016\/S0021-9258(19)89213-X","article-title":"Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism","volume":"261","author":"Guengerich","year":"1986","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB30","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1432-1033.1977.tb11379.x","article-title":"The \u201cb5-like\u201d domain from chicken-liver sulfite oxidase: a new case of common ancestral origin with liver cytochrome b5 and bakers' yeast cytochrome b2 core","volume":"74","author":"Guiard","year":"1977","journal-title":"Eur J Biochem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0009-2797(71)90036-6","article-title":"P450cam hydroxylase: substrate-effector and electron-transport reactions","volume":"4","author":"Gunsalus","year":"1971","journal-title":"Chem Biol Interact"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB32","doi-asserted-by":"crossref","first-page":"5018","DOI":"10.1021\/bi002305w","article-title":"Interaction of apo-cytochrome b5 with cytochromes P4503A4 and P45017A: relevance of heme transfer reactions","volume":"40","author":"Guryev","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB33","doi-asserted-by":"crossref","first-page":"26637","DOI":"10.1074\/jbc.271.43.26637","article-title":"Molecular cloning, overexpression in Escherichia coli, structural and functional characterization of house fly cytochrome b5","volume":"271","author":"Guzov","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB34","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0003-9861(90)90566-H","article-title":"Reconstitution of testosterone oxidation by purified rat cytochrome P450p(IIIA1)","volume":"277","author":"Halvorson","year":"1990","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/oxfordjournals.jbchem.a129469","article-title":"On functional role of cytochrome b5. I. NADH-linked cytochrome c reductase in microsomes","volume":"69","author":"Hara","year":"1971","journal-title":"J Biochem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB36","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0003-9861(71)90186-X","article-title":"Evidence for the participation of cytochrome b5 in hepatic microsomal mixed-function oxidation reactions","volume":"143","author":"Hildebrandt","year":"1971","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB37","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0003-9861(75)90047-8","article-title":"Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent formation and breakdown of hydrogen peroxide during mixed function oxidation reactions in liver microsomes","volume":"171","author":"Hildebrandt","year":"1975","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB38","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/0003-9861(84)90028-6","article-title":"On the function of cytochrome b5 in the cytochrome P-450-dependent oxygenase system","volume":"228","author":"Hlavica","year":"1984","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB39","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.1046\/j.1432-1327.2001.02412.x","article-title":"Allosteric phenomena in cytochrome P450-catalyzed monooxygenations","volume":"268","author":"Hlavica","year":"2001","journal-title":"Eur J Biochem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB40","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1432-1033.1980.tb04795.x","article-title":"Thyroid control over biomembranes. Liver-microsomal cytochrome b5 in hypothyroidism","volume":"109","author":"Hoch","year":"1980","journal-title":"Eur J Biochem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB41","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1021\/bi00770a005","article-title":"A requirement for cytochrome b5 in microsomal stearyl coenzyme A desaturation","volume":"11","author":"Holloway","year":"1972","journal-title":"Biochemistry"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB42","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1016\/S0021-9258(19)77170-1","article-title":"Requirement for reduced diphosphopyridine nucleotide-cytochrome b5 reductase in stearyl coenzyme A desaturation","volume":"245","author":"Holloway","year":"1970","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB43","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0003-9861(74)90171-4","article-title":"Reduced nicotinamide adenine dinucleotide-cytochrome b5 reductase and cytochrome b5 as electron carriers in NADH-supported cytochrome P-450-dependent enzyme activities in liver microsomes","volume":"165","author":"Hrycay","year":"1974","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB44","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0006-291X(74)90167-3","article-title":"Homogeneous cytochrome b5 from human erythrocytes","volume":"60","author":"Hultquist","year":"1974","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB45","doi-asserted-by":"crossref","first-page":"23542","DOI":"10.1016\/S0021-9258(18)54316-7","article-title":"The sequence of squash NADH:nitrate reductase and its relationship to the sequences of other flavoprotein oxidoreductases\u2014a family of flavoprotein pyridine nucleotide cytochrome reductases","volume":"266","author":"Hyde","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB46","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/oxfordjournals.jbchem.a133209","article-title":"The roles of cytochrome b5 in reconstituted monooxygenase systems containing various forms of hepatic microsomal cytochrome P-450","volume":"89","author":"Imai","year":"1981","journal-title":"J Biochem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB47","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/0006-291X(77)91059-2","article-title":"The roles of cytochrome b5 in a reconstituted N-demethylase system containing cytochrome P-450","volume":"75","author":"Imai","year":"1977","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB48","doi-asserted-by":"crossref","first-page":"6063","DOI":"10.1021\/bi00141a015","article-title":"Role of phospholipids in reconstituted cytochrome-P4503A form and mechanism of their activation of catalytic activity","volume":"31","author":"Imaoka","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB49","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/0006-291X(80)90303-4","article-title":"Cytochrome b5 as electron donor to rabbit liver cytochrome P-450LM2 in reconstituted phospholipid vesicles","volume":"97","author":"Ingelman-Sundberg","year":"1980","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB50","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/oxfordjournals.jbchem.a134613","article-title":"Contribution of cytochrome b5 to androgen synthesis in rat testicular microsomes","volume":"95","author":"Ishii-Ohba","year":"1984","journal-title":"J Biochem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB51","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/0006-291X(71)90373-1","article-title":"Oxygenated cytochrome P-450 and its possible role in enzymic hydroxylation","volume":"42","author":"Ishimura","year":"1971","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB52","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1021\/bi00705a023","article-title":"Redox properties of the reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 and reduced nicotinamide adenine dinucleotide-cytochrome b5 reductases","volume":"13","author":"Iyanagi","year":"1974","journal-title":"Biochemistry"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB53","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0300-483X(00)00378-4","article-title":"Cytochrome b5 plays a key role in human microsomal chromium (VI) reduction","volume":"159","author":"Jannetto","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB54","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0003-9861(77)90174-6","article-title":"Studies on three microsomal electron transfer systems. Specificity of electron flow pathways","volume":"178","author":"Jansson","year":"1977","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB55","first-page":"344","article-title":"Influence of cytochrome b5 on the stoichiometry of the different oxidative reactions catalyzed by liver microsomal cytochrome P450","volume":"15","author":"Jansson","year":"1987","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB56","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/abbi.1996.0033","article-title":"Substrate influence on interaction between cytochrome P450 and cytochrome b5 in microsomes","volume":"325","author":"Jansson","year":"1996","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB57","first-page":"453","article-title":"The interaction of cytochrome b5 with four cytochrome P450 enzymes from the untreated rat","volume":"13","author":"Jansson","year":"1985","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB58","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1016\/0024-3205(84)90524-1","article-title":"Selective induction of cytochrome b5 and NADH cytochrome b5 reductase by propylthiouracil","volume":"35","author":"Kariya","year":"1984","journal-title":"Life Sci"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB59","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0006-291X(82)91877-0","article-title":"Role of cytochrome b5 in the cytochrome P-450-mediated C21-steroid 17,20-lyase reaction","volume":"108","author":"Katagiri","year":"1982","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB60","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/0926-6569(63)90273-6","article-title":"The oxidation-reduction potential of cytochrome b5 in soluble and particulate form with reference to the role of lipid","volume":"67","author":"Kawai","year":"1963","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB61","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/oxfordjournals.jbchem.a133927","article-title":"Stimulatory effect of cytochrome b5 induced by p-nitroanisole and diisopropyl l,3-dithiol-2-ylidenemalonate on rat liver microsomal drug hydroxylations","volume":"92","author":"Kawata","year":"1982","journal-title":"J Biochem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB62","doi-asserted-by":"crossref","first-page":"7778","DOI":"10.1016\/S0021-9258(18)36015-0","article-title":"Rat liver microsomal elongation of fatty acids","volume":"254","author":"Keyes","year":"1979","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB63","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1432-1033.1982.tb06820.x","article-title":"Oxidase and oxygenase function of the microsomal cytochrome P450 monooxygenase system","volume":"126","author":"Kuthan","year":"1982","journal-title":"Eur J Biochem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB64","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/0006-291X(80)91352-2","article-title":"Different requirement for cytochrome b5 in NADPH-supported O-deethylation of p-nitrophenetole catalyzed by two types of microsomal cytochrome P-450","volume":"96","author":"Kuwahara","year":"1980","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB65","doi-asserted-by":"crossref","first-page":"9663","DOI":"10.1021\/ja00025a037","article-title":"Helix formation in apocytochrome-b5: the role of a neutral histidine at the N-cap position","volume":"113","author":"Lecomte","year":"1991","journal-title":"J Amer Chem Soc"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB66","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0003-9861(89)90576-6","article-title":"Methoxyflurane acts at the substrate binding site of cytochrome P450 LM2 to induce a dependence on cytochrome b5","volume":"268","author":"Lipka","year":"1989","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB67","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/S0021-9258(17)33808-5","article-title":"Autooxidation and hydroxylation reactions of oxygenated cytochrome P-450cam","volume":"251","author":"Lipscomb","year":"1976","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB68","doi-asserted-by":"crossref","first-page":"15699","DOI":"10.1016\/S0021-9258(17)36315-9","article-title":"Myoglobin: cytochrome b5 interactions and the kinetic mechanism of metmyoglobin reductase","volume":"260","author":"Livingston","year":"1985","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB69","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1006\/abbi.2000.2136","article-title":"The kinetic and spectral characterization of the E. coli-expressed mammalian CYP4A7: cytochrome b5 effects vary with substrate","volume":"385","author":"Loughran","year":"2001","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB70","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/S0006-291X(74)80432-8","article-title":"Liver microsomal electron transport systems. III. The involvement of cytochrome b5 in the NADPH-supported cytochrome P-450-dependent hydroxylation of chlorobenzene","volume":"61","author":"Lu","year":"1974","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB71","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1006\/jmbi.1995.0273","article-title":"Structural studies on corn nitrate reductase: refined structure of the cytochrome b reductase fragment at 2.5 \u00c5, its ADP complex and an active-site mutant and modeling of the cytochrome b domain","volume":"248","author":"Lu","year":"1995","journal-title":"J Mol Biol"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB72","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/0006-291X(74)90956-5","article-title":"Immunochemical evidence for the participation of cytochrome b5 in the NADH synergism of the NADPH-dependent mono-oxidase system of hepatic microsomes","volume":"57","author":"Mannering","year":"1974","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0079-6107(85)90004-5","article-title":"The structure, function and evolution of cytochromes","volume":"45","author":"Mathews","year":"1985","journal-title":"Prog Biophys Mol Biol"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB74","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1016\/0006-2952(85)90282-5","article-title":"Influence of chronic ethanol consumption on hamster liver microsomal o-dealkylase activities and cytochrome b5 content","volume":"34","author":"McCoy","year":"1985","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB75","doi-asserted-by":"crossref","first-page":"8357","DOI":"10.1021\/bi00098a012","article-title":"Similarities in structure between holocytochrome b5 and apocytochrome b5. NMR studies of the histidine residues","volume":"30","author":"Moore","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB76","first-page":"358","article-title":"Effects of cytochrome b5 on cytochrome P-450-catalyzed reactions. Studies with manganese-substituted cytochrome b5","volume":"12","author":"Morgan","year":"1984","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB77","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0006-2952(81)90131-3","article-title":"Changes in the rat hepatic mixed function oxidase system associated with chronic ethanol vapor inhalation","volume":"30","author":"Morgan","year":"1981","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB78","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/BF00239957","article-title":"Isolation of a cDNA encoding a cytochrome b5 specifically expressed in developing tobacco seeds","volume":"197","author":"Napier","year":"1995","journal-title":"Planta"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB79","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1021\/bi00642a006","article-title":"Effect of modification of individual cytochrome c lysines on the reaction with cytochrome b5","volume":"16","author":"Ng","year":"1977","journal-title":"Biochemistry"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB80","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/0003-9861(63)90508-3","article-title":"Cofactor requirements of the O-demethylating liver microsomal enzyme system","volume":"101","author":"Nilsson","year":"1963","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB81","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/0003-9861(85)90561-2","article-title":"NADPH-cytochrome P-450 reductase-cytochrome b5 interactions: crosslinking of the phospholipid vesicle-associated proteins by a water-soluble carbodiimide","volume":"241","author":"Nisimoto","year":"1985","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB82","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0006-291X(79)90604-1","article-title":"Immunochemical study on the participation of cytochrome b5 in drug oxidation reactions of mouse liver microsomes","volume":"91","author":"Noshiro","year":"1979","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB83","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1093\/oxfordjournals.jbchem.a133123","article-title":"Immunochemical study on the route of electron transfer from NADH and NADPH to cytochrome P-450 of liver microsomes","volume":"88","author":"Noshiro","year":"1980","journal-title":"J Biochem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB84","series-title":"Biochemistry, Biophysics and Regulation of Cytochrome P-450","first-page":"351","article-title":"The role of NADPH-cytochrome P450 reductase and cytochrome b5 in the transfer of electrons from NADPH and NADH to cytochrome P450","author":"Noshiro","year":"1980"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB85","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1432-1033.1981.tb05367.x","article-title":"Cytochrome b5 as electron donor for oxy-cytochrome P-450","volume":"116","author":"Noshiro","year":"1981","journal-title":"Eur J Biochem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB86","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/oxfordjournals.jbchem.a129248","article-title":"A new method for simultaneous purification of cytochrome b5 and NADPH-cytochrome c reductase from rat liver microsomes","volume":"67","author":"Omura","year":"1970","journal-title":"J Biochem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB87","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/0006-291X(82)90850-6","article-title":"Cytochrome b5 stimulates purified testicular microsomal cytochrome P-450 (C21 side chain cleavage)","volume":"108","author":"Onoda","year":"1982","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB88","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/oxfordjournals.jbchem.a129444","article-title":"A function of cytochrome b5 in fatty acid desaturation by rat liver microsomes","volume":"69","author":"Oshino","year":"1971","journal-title":"J Biochem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB89","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0167-4838(89)90143-X","article-title":"Structure of cytochrome b5 and its topology in the microsomal membrane","volume":"997","author":"Ozols","year":"1989","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB90","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1016\/S0021-9258(19)42782-8","article-title":"Evidence for the participation of cytochrome b5 in plasmalogen biosynthesis","volume":"249","author":"Paltauf","year":"1974","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB91","doi-asserted-by":"crossref","first-page":"11412","DOI":"10.1021\/bi980908q","article-title":"Electron shuttle between membrane-bound cytochrome P450 3A4 and b5 rules uncoupling mechanisms","volume":"37","author":"Perret","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB92","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1016\/S0021-9258(17)40177-3","article-title":"Evidence that purified liver microsomal cytochrome P-450 is a one-electron acceptor","volume":"252","author":"Peterson","year":"1977","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB93","doi-asserted-by":"crossref","first-page":"15377","DOI":"10.1016\/S0021-9258(17)42560-9","article-title":"On the mechanism of action of cytochrome P-450. Oxidation and reduction of the ferrous dioxygen complex of liver microsomal cytochrome P-450 by cytochrome b5","volume":"259","author":"Pompon","year":"1984","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB94","doi-asserted-by":"crossref","first-page":"14137","DOI":"10.1021\/bi9805036","article-title":"The influence of mutation at Glu44 and Glu56 of cytochrome b5 on the protein's stabilization and interaction between cytochrome c and cytochrome b5","volume":"37","author":"Qian","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB95","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1016\/S0021-9258(17)40432-7","article-title":"Mechanism of C-5 double bond introduction in the biosynthesis of cholesterol by rat liver microsomes. Evidence for the participation of microsomal cytochrome b5","volume":"252","author":"Reddy","year":"1977","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB96","doi-asserted-by":"crossref","first-page":"7516","DOI":"10.1021\/ja00390a021","article-title":"Oxidation-reduction equilibrium of cytochrome b5","volume":"104","author":"Reid","year":"1982","journal-title":"J Am Chem Soc"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB97","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/0022-2836(91)90945-3","article-title":"Mapping electrostatic interactions in macromolecular associations","volume":"221","author":"Rodgers","year":"1991","journal-title":"J Mol Biol"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB98","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0022-2836(76)90334-X","article-title":"An hypothetical structure for an intermolecular electron transfer complex of cytochromes c and b5","volume":"102","author":"Salemme","year":"1976","journal-title":"J Mol Biol"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB99","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0024-3205(74)90243-4","article-title":"The possible involvement of cytochrome b5 in the oxidation of lauric acid by microsomes from kidney cortex and liver of rats","volume":"14","author":"Sasame","year":"1974","journal-title":"Life Sci"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB100","first-page":"1624","article-title":"Effect of substrates on hepatic microsomal cytochrome P-450","volume":"349","author":"Schenkman","year":"1968","journal-title":"Hoppe-Seyler's Z Physiol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB101","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1081\/DMR-100101923","article-title":"Interactions between cytochrome P450 and cytochrome b5","volume":"31","author":"Schenkman","year":"1999","journal-title":"Drug Metab Rev"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB102","series-title":"Cytochrome P-450: New Trends","first-page":"59","article-title":"Interactions between cytochrome P-450 and other components of the microsomal electron transfer system","author":"Schenkman","year":"1987"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB103","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1006\/abbi.1994.1435","article-title":"Influence of ionic strength on the P450 monooxygenase reaction and role of cytochrome b5 in the process","volume":"314","author":"Schenkman","year":"1994","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB104","series-title":"Molecular and Appplied Aspects of Oxidative Drug Metabolizing Enzymes","first-page":"21","article-title":"Protein-protein interactions in the P450 monooxygenase system","author":"Schenkman","year":"1999"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB105","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1006\/abbi.1995.1235","article-title":"The effects of cytochrome b5, NADPH-P450 reductase, and lipid on the rate of 6\u03b2-hydroxylation of testosterone as catalyzed by a human P450 3A4 fusion protein","volume":"318","author":"Shet","year":"1995","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB106","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1093\/oxfordjournals.jbchem.a130004","article-title":"Reconstitution of hepatic microsomal stearoyl-coenzyme A desaturase system from solubilized components","volume":"72","author":"Shimakata","year":"1972","journal-title":"J Biochem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB107","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0005-2760(85)90263-2","article-title":"Studies on cytochrome P-450 (P-45017a,lyase) from guinea pig adrenal microsomes. Dual function of a single enzyme and effect of cytochrome b5","volume":"833","author":"Shinzawa","year":"1985","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB108","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0300-483X(01)00473-5","article-title":"Carbon tetrachloride changes the activity of cytochrome P450 system in the liver of male rats: role of antioxidants","volume":"169","author":"Shweita","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB109","doi-asserted-by":"crossref","first-page":"5399","DOI":"10.1021\/bi00669a029","article-title":"Coupling of spin, substrate, and redox equilibria in cytochrome P450","volume":"15","author":"Sligar","year":"1976","journal-title":"Biochemistry"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB110","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/0006-291X(79)91916-8","article-title":"Spin state control of the hepatic cytochrome P450 redox potential","volume":"90","author":"Sligar","year":"1979","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB111","first-page":"55","article-title":"The involvement of NADH-cytochrome b5 reductase and cytochrome b5 complex in microsomal NADH-cytochrome c reductase activity","volume":"21","author":"Staron","year":"1974","journal-title":"Acta Biochim Polon"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB112","doi-asserted-by":"crossref","first-page":"8201","DOI":"10.1021\/bi00446a035","article-title":"Putidaredoxin competitively inhibits cytochrome b5-cytochrome P-450cam association: a proposed molecular model for a cytochrome P-450cam electron-transfer complex","volume":"28","author":"Stayton","year":"1989","journal-title":"Biochemistry"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB113","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1073\/pnas.38.1.19","article-title":"A hemochromogen component of liver microsomes","volume":"38","author":"Strittmatter","year":"1952","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB114","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jcp.1030430105","article-title":"The intracellular distribution of cytochrome components and of oxidative enzyme activity in rat liver","volume":"43","author":"Strittmatter","year":"1954","journal-title":"J Cell Comp Physiol"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB115","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0021-9258(18)65245-7","article-title":"The isolation and properties of microsomal cytochrome","volume":"221","author":"Strittmatter","year":"1956","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB116","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0021-9258(18)65247-0","article-title":"A microsomal cytochrome reductase specific for diphosphopyridine nucleotide","volume":"221","author":"Strittmatter","year":"1956","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB117","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1073\/pnas.71.11.4565","article-title":"Purification and properties of rat liver microsomal stearyl coenzyme A desaturase","volume":"71","author":"Strittmatter","year":"1974","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB118","doi-asserted-by":"crossref","first-page":"21709","DOI":"10.1016\/S0021-9258(18)45798-5","article-title":"Characterization of the covalent cross-links of the active sites of amidinated cytochrome b5 and NADH:cytochrome b5 reductase","volume":"265","author":"Strittmatter","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB119","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1093\/oxfordjournals.jbchem.a132887","article-title":"NADH- and NADPH-dependent reconstituted p-nitroanisole 0-demethylation system containing cytochrome P-450 with high affinity for cytochrome b5","volume":"87","author":"Sugiyama","year":"1980","journal-title":"J Biochem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB120","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1093\/oxfordjournals.jbchem.a134109","article-title":"Interaction and electron transfer between cytochrome b5 and cytochrome P-450 in the reconstituted p-nitroanisole O-demethylase system","volume":"92","author":"Sugiyama","year":"1982","journal-title":"J Biochem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB121","doi-asserted-by":"crossref","first-page":"13444","DOI":"10.1016\/S0021-9258(17)43934-2","article-title":"Thermodynamic studies of the protein-protein interactions between cytochrome P-450 and cytochrome b5. Evidence for a central role of the cytochrome P-450 spin state in the coupling of substrate and cytochrome b5 binding to the terminal hemoprotein","volume":"258","author":"Tamburini","year":"1983","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB122","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/0003-9861(86)90244-4","article-title":"Mechanism of interaction between cytochromes P-450 RLM5 and b5: evidence for an electrostatic mechanism involving cytochrome b5 heme propionate groups","volume":"245","author":"Tamburini","year":"1986","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB123","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1073\/pnas.84.1.11","article-title":"Purification to homogeneity and enzymological characterization of a functional covalent complex composed of cytochromes P-450 isozyme 2 and b5 from rabbit liver","volume":"84","author":"Tamburini","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB124","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1016\/S0021-9258(18)89223-7","article-title":"Chemical characterization of protein-protein interactions between cytochrome P-450 and cytochrome b5","volume":"260","author":"Tamburini","year":"1985","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB125","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0006-291X(86)91229-5","article-title":"Differences in the spectral interactions between NADPH-cytochrome P-450 reductase and a series of cytochrome P-450 enzymes","volume":"137","author":"Tamburini","year":"1986","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB126","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0006-291X(86)80451-X","article-title":"Evidence of binary complex formation between cytochrome P-450, cytochrome b5 and NADPH-cytochrome P-450 reductase of hepatic microsomes","volume":"134","author":"Tamburini","year":"1986","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB127","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0304-4165(87)90208-X","article-title":"Modulation of the reductive metabolism of halothane by microsomal cytochrome b5 in rat liver","volume":"926","author":"Tamura","year":"1987","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB128","doi-asserted-by":"crossref","first-page":"11221","DOI":"10.1016\/S0021-9258(18)33745-1","article-title":"Hydroxylation of prostaglandins by inducible isozymes of rabbit liver microsomal cytochrome P-450","volume":"257","author":"Vatsis","year":"1982","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB129","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/0300-9084(96)88176-4","article-title":"Cytochrome b5, its functions, structure and membrane topology","volume":"77","author":"Verg\u00e8res","year":"1995","journal-title":"Biochimie"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB130","doi-asserted-by":"crossref","first-page":"15724","DOI":"10.1016\/S0021-9258(17)40741-1","article-title":"Quantitative analysis of electrostatic interactions between NADPH-cytochrome P450 reductase and cytochrome P450 enzymes","volume":"269","author":"Voznesensky","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB131","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.1016\/S0021-9258(20)81125-9","article-title":"Evidence for a mixed function oxidase in the biosynthesis of ethanolamine plasmalogens from 1-alkyl-2-acyl-sn-glycerol-3-phosphorylethanolamine","volume":"247","author":"Wykle","year":"1972","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB132","doi-asserted-by":"crossref","first-page":"8380","DOI":"10.1021\/bi00026a020","article-title":"Roles of divalent metal ions in oxidations catalyzed by recombinant cytochrome P450 3A4 and replacement of NADPH-cytochrome P450 reductase with other flavoproteins, ferredoxin, and oxygen surrogates","volume":"34","author":"Yamazaki","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB133","doi-asserted-by":"crossref","first-page":"27438","DOI":"10.1074\/jbc.271.44.27438","article-title":"Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4\/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5","volume":"271","author":"Yamazaki","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB134","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0006-2952(96)00208-0","article-title":"Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes","volume":"52","author":"Yamazaki","year":"1996","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB135","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1006\/abbi.1996.0022","article-title":"Roles of cytochrome b5 in the oxidation of testosterone and nifedipine by recombinant cytochrome P450 3A4 and by human liver microsomes","volume":"325","author":"Yamazaki","year":"1996","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S0163-7258(02)00327-3_BIB136","doi-asserted-by":"crossref","first-page":"30885","DOI":"10.1074\/jbc.M105011200","article-title":"Stimulation of cytochrome P450 reactions by apo-cytochrome b5. Evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase","volume":"276","author":"Yamazaki","year":"2001","journal-title":"J Biol Chem"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725802003273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725802003273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T13:52:44Z","timestamp":1622728364000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725802003273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":136,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["S0163725802003273"],"URL":"https:\/\/doi.org\/10.1016\/s0163-7258(02)00327-3","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2003,2]]}}}