{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T03:49:00Z","timestamp":1769312940145,"version":"3.49.0"},"reference-count":167,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2003,5]]},"DOI":"10.1016\/s0163-7258(03)00016-0","type":"journal-article","created":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:30:49Z","timestamp":1051749049000},"page":"129-142","source":"Crossref","is-referenced-by-count":121,"title":["The p38 mitogen-activated protein kinase pathway and its role in interferon signaling"],"prefix":"10.1016","volume":"98","author":[{"given":"Leonidas C.","family":"Platanias","sequence":"first","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/S0163-7258(03)00016-0_BIB1","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1002\/j.1460-2075.1994.tb06932.x","article-title":"Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and an associated surface protein in response to IFN\u03b1 and IFN\u03b2","volume":"13","author":"Abramovich","year":"1994","journal-title":"EMBO J"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000227327","article-title":"Interferons in the therapy of solid tumors","volume":"51","author":"Agarwala","year":"1994","journal-title":"Oncology"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB3","doi-asserted-by":"crossref","first-page":"29991","DOI":"10.1074\/jbc.272.48.29991","article-title":"The Type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein","volume":"272","author":"Ahmad","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB4","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.4049\/jimmunol.164.4.1800","article-title":"Interferon \u03b3 activates the C3G-Rap1 signaling pathway","volume":"164","author":"Alsayed","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB166","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1074\/jbc.M007431200","article-title":"Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to all-trans-retinoic acid","volume":"276","author":"Alsayed","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB5","doi-asserted-by":"crossref","first-page":"38716","DOI":"10.1074\/jbc.M008040200","article-title":"Growth regulation via p38 mitogen-activated protein kinase in developing liver","volume":"275","author":"Awad","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB6","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.immunol.15.1.563","article-title":"The IFN\u03b3 receptor: a paradigm for cytokine receptor signaling","volume":"15","author":"Bach","year":"1997","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB7","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.4049\/jimmunol.162.9.5367","article-title":"The role of p38 mitogen-activated protein kinase in IL-1b transcription","volume":"162","author":"Baldassare","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB8","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.7681220","article-title":"An osmosensing signal transduction pathway in yeast","volume":"259","author":"Brewater","year":"1993","journal-title":"Science"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB9","doi-asserted-by":"crossref","first-page":"24183","DOI":"10.1074\/jbc.272.39.24183","article-title":"Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons","volume":"272","author":"Burfoot","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB10","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1128\/MCB.20.5.1461-1477.2000","article-title":"Regulatory and signaling properties of the Vav family","volume":"20","author":"Bustelo","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB11","doi-asserted-by":"crossref","first-page":"7228","DOI":"10.1074\/jbc.273.13.7228","article-title":"Stimulation of \u201cstress-regulated\u201d mitogen-activated protein kinases (stress-activated kinases\/c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in perfused rat hearts and by oxidative and other stresses","volume":"273","author":"Clerk","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB12","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0079-6107(98)00056-X","article-title":"MAP kinase pathways","volume":"71","author":"Cobb","year":"1999","journal-title":"Prog Biophys Mol Biol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB13","doi-asserted-by":"crossref","first-page":"14843","DOI":"10.1074\/jbc.270.25.14843","article-title":"How MAP kinases are regulated","volume":"270","author":"Cobb","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB167","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.4049\/jimmunol.148.7.2126","article-title":"Multichain structure of the IFN-\u03b1 receptor on hematopoietic cells","volume":"48","author":"Colamonici","year":"1992","journal-title":"J Immunol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB14","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1002\/j.1460-2075.1993.tb06022.x","article-title":"RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts","volume":"12","author":"Cook","year":"1993","journal-title":"EMBO J"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB15","first-page":"95","article-title":"Mechanism of activation of the vav proto-oncogene","volume":"2","author":"Coppola","year":"1991","journal-title":"Cell Growth Differ"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/385169a0","article-title":"Phosphotyrosine-dependent activation of Rac-1 GDP\/GTP exchange by the vav proto-oncogene product","volume":"385","author":"Crespo","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB17","doi-asserted-by":"crossref","first-page":"33165","DOI":"10.1074\/jbc.271.52.33165","article-title":"The human type I interferon receptor. Identification of the interferon \u03b2-specific receptor-associated phosphoprotein","volume":"271","author":"Croze","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB18","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1126\/science.2406902","article-title":"Blast crisis in a murine model of chronic myelogenous leukemia","volume":"247","author":"Daley","year":"1990","journal-title":"Science"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB19","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.277.5332.1630","article-title":"Stats and gene regulation","volume":"277","author":"Darnell","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB20","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1089\/jir.1998.18.549","article-title":"Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway","volume":"18","author":"Darnell","year":"1998","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB21","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1126\/science.8197455","article-title":"Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular proteins","volume":"264","author":"Darnell","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB22","doi-asserted-by":"crossref","first-page":"7050","DOI":"10.1128\/MCB.15.12.7050","article-title":"Differential regulation of the alpha\/beta interferon stimulated Jak\/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1","volume":"15","author":"David","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB23","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1038\/sj.onc.1203481","article-title":"Serine phosphorylation of Stats","volume":"19","author":"Decker","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB24","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1126\/science.7839144","article-title":"Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms","volume":"267","author":"Derijard","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB25","doi-asserted-by":"crossref","first-page":"6168","DOI":"10.1073\/pnas.111027698","article-title":"Pro-apoptotic gene expression mediated by the p38 mitogen-activated protein kinase signal transduction pathway","volume":"98","author":"De Zutter","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB26","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1006\/geno.1994.1427","article-title":"Structure of the human Type I interferon gene cluster determined from a YAC clone contig","volume":"22","author":"Diaz","year":"1994","journal-title":"Genomics"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB27","doi-asserted-by":"crossref","first-page":"21606","DOI":"10.1074\/jbc.270.37.21606","article-title":"Cloning and expression of a long form of the \u03b2 subunit of the interferon \u03b1\/\u03b2 receptor that is required for signaling","volume":"270","author":"Domanski","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB28","doi-asserted-by":"crossref","first-page":"33167","DOI":"10.1074\/jbc.M003655200","article-title":"Engagement of the CrkL adapter in interleukin-5 signaling in eosinophils","volume":"275","author":"Du","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB29","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1074\/jbc.273.3.1741","article-title":"Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6","volume":"273","author":"Enslen","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB30","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1074\/jbc.274.2.571","article-title":"Activation of a CrkL-Stat5 signaling complex by Type I interferons","volume":"274","author":"Fish","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB31","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1074\/jbc.272.6.3296","article-title":"Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway","volume":"272","author":"Foltz","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB32","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/0092-8674(94)90278-X","article-title":"Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of the Hsp27","volume":"78","author":"Freshney","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB33","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1128\/MCB.16.7.3707","article-title":"Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members","volume":"16","author":"Frost","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB34","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1093\/emboj\/16.12.3563","article-title":"Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases","volume":"16","author":"Goebert","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB168","doi-asserted-by":"crossref","first-page":"5601","DOI":"10.1093\/emboj\/18.20.5601","article-title":"p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons","volume":"18","author":"Goh","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB35","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1128\/MCB.18.3.1725","article-title":"Signaling through CD5 activates a pathway involving phosphatidylinositol 3\u2032-kinase, Vav, and Rac1 in human mature T-lymphocytes","volume":"18","author":"Gringhuis","year":"1998","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB36","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0092-8674(84)90077-1","article-title":"Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22","volume":"36","author":"Groffen","year":"1984","journal-title":"Cell"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB37","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1046\/j.1365-2141.2001.02556.x","article-title":"Engagement of the CrkL adapter in interferon \u03b1 signaling in BCR-ABL expressing cells","volume":"112","author":"Grumbach","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB38","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/85855","article-title":"Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome","volume":"27","author":"Guris","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB39","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1073\/pnas.91.4.1198","article-title":"Cytokine therapeutics: lessons from interferon \u03b1","volume":"91","author":"Gutterman","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB40","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1126\/science.7914033","article-title":"A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells","volume":"265","author":"Han","year":"1994","journal-title":"Science"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB41","first-page":"2886","article-title":"Characterization the structure and function of a novel MAP kinase kinase (MKK6)","volume":"271","author":"Han","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB42","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/386296a0","article-title":"Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation","volume":"386","author":"Han","year":"1997","journal-title":"Nature"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB43","first-page":"95","article-title":"The genes of interferons and interferon-related factors: localization and relationships with chromosome aberrations in cancer","volume":"48","author":"Haus","year":"2000","journal-title":"Arch Immunol Ther Exp"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB44","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1126\/science.275.5296.90","article-title":"Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK\/JNK and p38 signaling pathways","volume":"275","author":"Ichijo","year":"1997","journal-title":"Science"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(08)60582-9","article-title":"The Janus protein tyrosine kinase family and its role in cytokine signaling","volume":"60","author":"Ihle","year":"1995","journal-title":"Adv Immunol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB46","doi-asserted-by":"crossref","first-page":"17920","DOI":"10.1074\/jbc.271.30.17920","article-title":"Characterization of the structure and function of a new mitogen-activated protein kinase (p38\u03b2)","volume":"271","author":"Jiang","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB47","doi-asserted-by":"crossref","first-page":"30122","DOI":"10.1074\/jbc.272.48.30122","article-title":"Characterization of the structure and function of the fourth member of p38 mitogen-activated protein kinases group, p38 delta","volume":"272","author":"Jiang","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB48","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1002\/j.1460-2075.1989.tb08354.x","article-title":"vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells","volume":"8","author":"Katzav","year":"1989","journal-title":"EMBO J"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB49","doi-asserted-by":"crossref","first-page":"6649","DOI":"10.1073\/pnas.87.17.6649","article-title":"Induction of chronic myelogenous leukemia-like syndrome in mice with V-abl and BCR-ABL","volume":"87","author":"Kelliher","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB50","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0092-8674(89)90985-9","article-title":"A ras-related gene with transformation suppressor activity","volume":"56","author":"Kitayama","year":"1989","journal-title":"Cell"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB51","doi-asserted-by":"crossref","first-page":"4284","DOI":"10.1073\/pnas.87.11.4284","article-title":"Genetic analysis of the Kirsten-ras-revertant 1 gene:potentiation of its tumor suppressor activity by specific point mutations","volume":"87","author":"Kitayama","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB52","doi-asserted-by":"crossref","first-page":"13956","DOI":"10.1073\/pnas.96.24.13956","article-title":"Stress-induced phosphorylation of Stat1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-\u03b3 uses a different pathway","volume":"96","author":"Kovarik","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB53","doi-asserted-by":"crossref","first-page":"27395","DOI":"10.1074\/jbc.270.46.27395","article-title":"Thrombin induces activation of p38 MAP kinase in human platelets","volume":"270","author":"Kramer","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB54","doi-asserted-by":"crossref","first-page":"19495","DOI":"10.1074\/jbc.273.31.19495","article-title":"Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon \u03b1 receptor","volume":"273","author":"Krishnan","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB169","doi-asserted-by":"crossref","first-page":"20490","DOI":"10.1074\/jbc.272.33.20490","article-title":"Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase","volume":"272","author":"Krumer","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB55","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1006\/bbrc.1997.6849","article-title":"Novel homologues of CSBP\/p38 Map kinase:activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles","volume":"235","author":"Kumar","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB56","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/jnci\/82.3.203","article-title":"Interferon alpha-2a combined with phototherapy in the treatment of cutaneous T-cell lymphoma","volume":"82","author":"Kuzel","year":"1990","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB57","doi-asserted-by":"crossref","first-page":"24313","DOI":"10.1074\/jbc.271.40.24313","article-title":"Sounding the alarm: protein kinase cascades activated by stress and inflammation","volume":"271","author":"Kyriakis","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB58","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0167-5699(88)91241-8","article-title":"Interferon receptors","volume":"9","author":"Langer","year":"1988","journal-title":"Immunol Today"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB59","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1073\/pnas.93.9.4355","article-title":"Erk6, a mitogen activated protein kinase involved in C2C12 myoblast differentiation","volume":"93","author":"Lechner","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB60","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/372739a0","article-title":"A protein kinase involved in the regulation of inflammatory cytokine biosynthesis","volume":"372","author":"Lee","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB61","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1006\/bbrc.2002.6516","article-title":"The CrkL adapter protein is required for Type I interferon-dependent gene transcription and activation of the small G-protein Rap1","volume":"291","author":"Lekmine","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB62","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1006\/bbrc.1996.1662","article-title":"The primary structure of p38\u03b3: a new member of the p38 group of MAP kinases","volume":"228","author":"Li","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB63","doi-asserted-by":"crossref","first-page":"296","DOI":"10.7326\/0003-4819-132-4-200002150-00008","article-title":"Pathogenesis, natural history, treatment, and prevention of hepatitis C","volume":"132","author":"Liang","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB64","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1126\/science.7716521","article-title":"Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2","volume":"268","author":"Lin","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB65","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.2408149","article-title":"Tyrosine kinase activity and transformation potency of bcr-abl oncogene products","volume":"247","author":"Lugo","year":"1990","journal-title":"Science"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB66","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.1002\/j.1460-2075.1995.tb00192.x","article-title":"Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster","volume":"14","author":"Lutfalla","year":"1995","journal-title":"EMBO J"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB67","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1056\/NEJM199005173222005","article-title":"Maintenance treatment with recombinant interferon alfa-2b in patients with multiple myeloma responding to conventional induction chemotherapy","volume":"322","author":"Mandelli","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB68","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/332272a0","article-title":"A novel viral oncogene with structural homology to phospholipase C","volume":"332","author":"Mayer","year":"1998","journal-title":"Nature"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB170","doi-asserted-by":"crossref","first-page":"28570","DOI":"10.1074\/jbc.M011685200","article-title":"The p38 MAP kinase pathway mediates the growth inhibitory effects of IFN\u03b1 in BCR-ABL expressing cells","volume":"276","author":"Mayer","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB69","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.2165\/00003495-200161110-00009","article-title":"Interferon alfacon-1: a review of its pharmacology and therapeutic efficacy in the treatment of chronic hepatitis C","volume":"61","author":"Melian","year":"2001","journal-title":"Drugs"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB70","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0014-5793(96)00255-4","article-title":"SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases","volume":"383","author":"Mertens","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB71","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/sj.onc.1203314","article-title":"p95Vav is associated to the IFN\u03b1\/\u03b2 receptor and contributes to the antiproliferative effect of IFN\u03b1 in megacaryocytic cell lines","volume":"19","author":"Micouin","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB72","doi-asserted-by":"crossref","first-page":"24832","DOI":"10.1074\/jbc.273.38.24832","article-title":"Regulation of interleukin 1\u03b2-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase","volume":"273","author":"Miyazawa","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB73","doi-asserted-by":"crossref","first-page":"13765","DOI":"10.1074\/jbc.271.23.13675","article-title":"A novel kinase cascade mediated by mitogen-activated protein kinase 6 and MKK3","volume":"271","author":"Moriguchi","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB74","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1074\/jbc.274.7.4045","article-title":"The proximal tyrosines of the cytoplasmic domain of the \u03b2 chain of the type I interferon receptor are essential for signal transducer and activator of transcription (Stat) 2 activation. Evidence that two Stat2 sites are required to reach a threshold of interferon \u03b1-induced Stat2 tyrosine phosphorylation that allows normal formation of interferon-stimulated gene factor 3","volume":"274","author":"Nadeau","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB75","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1182\/blood.V92.6.1859","article-title":"Activation of p38 MAP kinase and JNK but not ERK is required for erythropoietin-induced erythroid differentiation","volume":"92","author":"Nagata","year":"1998","journal-title":"Blood"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB76","doi-asserted-by":"crossref","first-page":"33361","DOI":"10.1074\/jbc.M105070200","article-title":"Roles of phosphatidyl-inositol 3-kinase in interferon-\u03b3-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression","volume":"276","author":"Nguyen","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB77","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1056\/NEJM200009283431307","article-title":"Multiple sclerosis","volume":"343","author":"Noseworthy","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB78","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0092-8674(94)90154-6","article-title":"The human interferon \u03b1\/\u03b2 receptor: characterization and molecular cloning","volume":"77","author":"Novick","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB79","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1182\/blood.V92.2.443","article-title":"Erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B in primary cultured human erythroid precursors","volume":"92","author":"Oda","year":"1998","journal-title":"Blood"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB80","doi-asserted-by":"crossref","first-page":"7561","DOI":"10.1073\/pnas.130502697","article-title":"Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation","volume":"97","author":"Okamoto","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB81","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1182\/blood.V99.4.1314","article-title":"The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cell chronic lymphocytic leukemia cells through a p38 mitogen activated protein-kinase-dependent mechanism","volume":"99","author":"Pedersen","year":"2002","journal-title":"Blood"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB82","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0076-6879(86)19004-5","article-title":"Interferon standards and general abbreviations","volume":"119","author":"Pestka","year":"1986","journal-title":"Methods Enzymol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB83","first-page":"S9-4","article-title":"The human interferon alpha species and hybrid proteins","volume":"24","author":"Pestka","year":"1997","journal-title":"Semin Oncol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB84","first-page":"S9-18","article-title":"The interferon receptors","volume":"24","author":"Pestka","year":"1997","journal-title":"Semin Oncol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB85","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/1097-0282(2000)55:4<254::AID-BIP1001>3.0.CO;2-1","article-title":"The human interferon \u03b1 species and receptors","volume":"55","author":"Pestka","year":"2000","journal-title":"Biopolymers"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB86","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1146\/annurev.bi.56.070187.003455","article-title":"Interferons and their actions","volume":"56","author":"Pestka","year":"1987","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB87","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S1359-6101(97)00009-9","article-title":"The interferon gamma (IFN-\u03b3) receptor: a paradigm for the multichain cytokine receptor","volume":"8","author":"Pestka","year":"1997","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB88","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/00001622-199511000-00015","article-title":"Interferons. Laboratory to clinic investigations","volume":"7","author":"Platanias","year":"1995","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB89","doi-asserted-by":"crossref","first-page":"24053","DOI":"10.1016\/S0021-9258(18)35944-1","article-title":"IFN\u03b1 induces rapid tyrosine phosphorylation of the \u03b1-subunit of its receptor","volume":"267","author":"Platanias","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB90","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/S0301-472X(99)00109-5","article-title":"Signaling pathways activated by interferons","volume":"27","author":"Platanias","year":"1999","journal-title":"Exp Hematol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB91","first-page":"820","article-title":"Hairy cell leukemia: the role of alpha-interferon","volume":"330","author":"Platanias","year":"1991","journal-title":"Eur J Cancer"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB92","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1016\/S0021-9258(17)41839-4","article-title":"Interferon \u03b1 induces rapid tyrosine phosphorylation of the vav proto-oncogene product in hematopoietic cells","volume":"269","author":"Platanias","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB93","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2141.1992.tb06464.x","article-title":"Expression of the IFN\u03b1 receptor in hairy cell leukemia cells","volume":"82","author":"Platanias","year":"1992","journal-title":"Br J Haematol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB94","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.4049\/jimmunol.150.8.3382","article-title":"Characterization of the \u03b1-subunit of the IFN\u03b1 receptor: evidence for N- and O-linked glycosylation and association with other surface proteins","volume":"150","author":"Platanias","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB95","doi-asserted-by":"crossref","first-page":"17761","DOI":"10.1016\/S0021-9258(17)32371-2","article-title":"Tyrosine phosphorylation of the \u03b1 and \u03b2 subunits of the Type I IFN receptor. Interferon-\u03b2 selectively induces tyrosine phosphorylation of an \u03b1 subunit-associated protein","volume":"269","author":"Platanias","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB96","doi-asserted-by":"crossref","first-page":"23630","DOI":"10.1074\/jbc.271.39.23630","article-title":"Differences in signaling between IFNs \u03b1 and \u03b2: IFN\u03b2 selectively induces the interaction of the \u03b1 and \u03b2L subunits of the Type I IFNR","volume":"271","author":"Platanias","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB97","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1074\/jbc.271.1.278","article-title":"The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2","volume":"271","author":"Platanias","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB99","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/S0301-472X(99)00060-0","article-title":"CrkL and CrkII participate in the generation of the growth inhibitory effects of interferons on primary hematopoietic progenitors","volume":"27","author":"Platanias","year":"1999","journal-title":"Exp Hematol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB100","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1080\/09537100075742","article-title":"Heat-shock proteins and platelet function","volume":"11","author":"Polanowska-Grabowska","year":"2002","journal-title":"Platelets"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB101","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.4049\/jimmunol.167.8.4553","article-title":"Phosphatidylinositol 3-kinase confers resistance to encephalomyocarditis and herpes simplex virus-induced cell death through the activation of distinct downstream effectors","volume":"167","author":"Prejean","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB102","doi-asserted-by":"crossref","first-page":"7420","DOI":"10.1074\/jbc.270.13.7420","article-title":"Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine","volume":"270","author":"Raingeaud","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB103","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1128\/MCB.16.3.1247","article-title":"MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway","volume":"16","author":"Raingeaud","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB104","first-page":"107","article-title":"Drug therapy for hepatitis B","volume":"46","author":"Regev","year":"2001","journal-title":"Adv Intern Med"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB105","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1089\/jir.1998.18.805","article-title":"The evolution of the type I interferons","volume":"18","author":"Roberts","year":"1998","journal-title":"J Interf Cyt Res"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB106","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0955-0674(97)80061-0","article-title":"Mitogen-activated protein kinase pathways","volume":"9","author":"Robinson","year":"1997","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB107","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/0092-8674(94)90277-1","article-title":"A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of small heat shock proteins","volume":"78","author":"Rouse","year":"1994","journal-title":"Cell"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB108","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1038\/sj.onc.1201380","article-title":"p38 Map kinase activation by endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells","volume":"15","author":"Rousseau","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB109","doi-asserted-by":"crossref","first-page":"17528","DOI":"10.1074\/jbc.270.29.17528","article-title":"The Jak kinases differentially associate with the \u03b1 and \u03b2 (accessory factor) chains of the interferon \u03b3 receptor to form a functional receptor unit capable of activating STAT transcription factors","volume":"270","author":"Sakatsume","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB110","doi-asserted-by":"crossref","first-page":"5309","DOI":"10.4049\/jimmunol.159.11.5309","article-title":"The p38 mitogen-activated protein kinase is activated by ligation of the T or B lymphocyte antigen receptors, Fas or CD40, but suppression of kinase activity does not inhibit apoptosis induced by antigen receptors","volume":"159","author":"Salmon","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB111","doi-asserted-by":"crossref","first-page":"844","DOI":"10.4049\/jimmunol.163.2.844","article-title":"TCR and CD28 are coupled via ZAP-70 to the activation of the Vav\/Rac-1-\/PAK-1\/p38 MAPK signaling pathway","volume":"163","author":"Salojin","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB112","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/372794a0","article-title":"Role of SAPK\/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun","volume":"372","author":"Sanchez","year":"1994","journal-title":"Nature"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB113","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/sj.leu.2401010","article-title":"Role of the adapter protein CrkL in signal transduction of normal hematopoietic and BCR\/ABL-transformed cells","volume":"12","author":"Sattler","year":"1998","journal-title":"Leukemia"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB114","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1128\/MCB.19.4.2435","article-title":"Mitogen-activated protein kinases: specific messages from ubiquitous messengers","volume":"19","author":"Schaeffer","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB115","doi-asserted-by":"crossref","first-page":"24173","DOI":"10.1074\/jbc.273.37.24173","article-title":"A role for the p38 mitogen-activated protein kinase\/Hsp27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini","volume":"273","author":"Schafer","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB116","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0301-472X(99)00154-X","article-title":"Thrombopoietin induces the generation of distinct Stat1, Stat3, Stat5a and Stat5b homo- and heterodimeric complexes with different kinetics in human platelets","volume":"28","author":"Schulze","year":"2000","journal-title":"Exp Hematol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB117","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1126\/science.272.5265.1179","article-title":"TAB1: an activator of the TAK-1 MAPKKK in TGF-\u03b2 signal transduction","volume":"272","author":"Shibuya","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB118","doi-asserted-by":"crossref","first-page":"8141","DOI":"10.1074\/jbc.272.13.8141","article-title":"TAK1 mediates the ceramide signaling to stress-activated protein kinase\/c-Jun N-terminal kinase","volume":"272","author":"Shirakabe","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB119","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1056\/NEJM199211053271902","article-title":"Interferon alfa combined with cytotoxic chemotherapy for patients with non-Hodgkin's lymphoma","volume":"327","author":"Smalley","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB120","first-page":"2565","article-title":"Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element","volume":"11","author":"Stadler","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB171","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev.biochem.67.1.227","article-title":"How cells respond to interferons","volume":"67","author":"Stark","year":"1998","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB121","doi-asserted-by":"crossref","first-page":"11427","DOI":"10.1074\/jbc.271.19.11427","article-title":"Cloning and characterization of MEK6, a novel member of the mitogen activated protein kinase kinase cascade","volume":"271","author":"Stein","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB122","doi-asserted-by":"crossref","first-page":"19509","DOI":"10.1074\/jbc.272.31.19509","article-title":"P38-2, a novel mitogen-activated protein kinase with distinct properties","volume":"272","author":"Stein","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB123","first-page":"5309","article-title":"Differential activation of ERK, JNK, and p38 mitogen-activated protein kinases by CD40 and the B cell antigen receptor","volume":"159","author":"Sutherland","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB124","doi-asserted-by":"crossref","first-page":"4629","DOI":"10.1002\/j.1460-2075.1996.tb00840.x","article-title":"FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2","volume":"15","author":"Tan","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB125","doi-asserted-by":"crossref","first-page":"27107","DOI":"10.1074\/jbc.271.43.27107","article-title":"Stimulation of stress-activated protein kinase and p38 HOG1 kinase in murine keratinocytes following photodynamic therapy with benzoporphyrin derivative","volume":"271","author":"Tao","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB126","first-page":"53","article-title":"Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia","volume":"27","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB127","doi-asserted-by":"crossref","first-page":"4779","DOI":"10.1093\/emboj\/18.17.4779","article-title":"The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3\/HMG-14 kinase","volume":"18","author":"Thompson","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB128","doi-asserted-by":"crossref","first-page":"20636","DOI":"10.1074\/jbc.273.32.20636","article-title":"p38 mitogen-activated protein kinase mediates the transcriptional induction of the atrial natriuretic factor gene through a serum response element","volume":"273","author":"Thureauf","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB129","doi-asserted-by":"crossref","first-page":"7026","DOI":"10.1002\/j.1460-2075.1996.tb01094.x","article-title":"Mlk-3 activates the SAPK\/JNK and p38\/RK pathways via SEK1 and MKK3\/6","volume":"15","author":"Tibbles","year":"1996","journal-title":"EMBO J"},{"issue":"suppl. 1","key":"10.1016\/S0163-7258(03)00016-0_BIB130","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000053596","article-title":"Tumor necrosis factor-alpha mediates antiapoptotic signals partially via p38 MAP kinase activation in human eosinophils","volume":"120","author":"Tsukahara","year":"1999","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB131","doi-asserted-by":"crossref","first-page":"24627","DOI":"10.1074\/jbc.270.42.24627","article-title":"Interaction of the transcriptional activator Stat-2 with the Type I IFN receptor","volume":"270","author":"Uddin","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB133","doi-asserted-by":"crossref","first-page":"15938","DOI":"10.1074\/jbc.270.27.15938","article-title":"Interferon \u03b1 engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3\u2032-kinase","volume":"270","author":"Uddin","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB135","first-page":"2574","article-title":"The IRS-pathway operates distinctively from the Stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or IFN\u03b1 receptors","volume":"90","author":"Uddin","year":"1997","journal-title":"Blood"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB136","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.4049\/jimmunol.158.5.2390","article-title":"Activation of the phosphatidylinositol 3\u2032-kinase serine kinase by IFN\u03b1","volume":"158","author":"Uddin","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB137","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0014-5793(97)00023-9","article-title":"The vav proto-oncogene product interacts with the Tyk-2 tyrosine kinase","volume":"403","author":"Uddin","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB139","first-page":"192","article-title":"Cellular pathways activated by interferons in hematopoietic cells","volume":"2","author":"Uddin","year":"1999","journal-title":"Haema"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB140","doi-asserted-by":"crossref","first-page":"30127","DOI":"10.1074\/jbc.274.42.30127","article-title":"Activation of the p38 Map kinase by Type I interferons","volume":"274","author":"Uddin","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB141","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1006\/bbrc.2000.2402","article-title":"Interferon \u03b1-dependent activation of the phosphatidylinositol 3\u2032-kinase serine kinase requires engagement of the IRS but not the Stat pathway","volume":"270","author":"Uddin","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB142","doi-asserted-by":"crossref","first-page":"27634","DOI":"10.1074\/jbc.M003170200","article-title":"The Rac1\/p38 Map kinase pathway is required for IFN\u03b1-dependent transcriptional activation but not serine phosphorylation of Stat proteins","volume":"275","author":"Uddin","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB143","doi-asserted-by":"crossref","first-page":"14408","DOI":"10.1074\/jbc.M109671200","article-title":"Protein kinase C-\u03b4 (PKC-\u03b4) is activated by Type I interferons and mediates phosphorylation of Stat1 on Serine 727","volume":"277","author":"Uddin","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB144","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0092-8674(90)90738-Z","article-title":"Genetic transfer of a functional human interferon receptor into mouse cells: cloning and expression of its cDNA","volume":"60","author":"Uz\u00e9","year":"1990","journal-title":"Cell"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB145","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1074\/jbc.273.6.3285","article-title":"p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-\u03baB p65 transactivation mediated by tumor necrosis factor","volume":"273","author":"Vanden Berghe","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB146","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/10428190290016782","article-title":"Signaling via the interferon-\u03b1 receptor in chronic myelogenous leukemia cells","volume":"43","author":"Verma","year":"2002","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB147","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.4049\/jimmunol.168.12.5984","article-title":"Cutting edge: activation of the p38 Map kinase signaling pathway mediates cytokine-induced hematopoietic suppression in aplastic anemia","volume":"168","author":"Verma","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB148","doi-asserted-by":"crossref","first-page":"7726","DOI":"10.1074\/jbc.M106640200","article-title":"Activation of the p38 Map kinase pathway mediates the suppressive effects of Type I interferons and transforming growth factor-\u03b2 on normal hematopoiesis","volume":"277","author":"Verma","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB149","first-page":"1326","article-title":"Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase","volume":"270","author":"Wang","year":"1996","journal-title":"Science"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB150","doi-asserted-by":"crossref","first-page":"401","DOI":"10.2165\/00003495-200059030-00002","article-title":"What is new in the treatment of multiple sclerosis","volume":"59","author":"Weinstock-Guttman","year":"2000","journal-title":"Drugs"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB151","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1093\/nar\/25.11.2062","article-title":"Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3","volume":"25","author":"Wen","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB152","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0092-8674(95)90311-9","article-title":"Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation","volume":"82","author":"Wen","year":"1995","journal-title":"Cell"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB153","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0002-9343(99)80189-2","article-title":"Interferon-\u03b1 therapy for chronic myelogenous leukemia","volume":"99","author":"Wetzler","year":"1995","journal-title":"Am J Med"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB154","first-page":"119","article-title":"The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action","volume":"53","author":"White","year":"1998","journal-title":"Recent Prog Horm Res"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9258(17)42297-6","article-title":"The insulin signaling system","volume":"269","author":"White","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB156","doi-asserted-by":"crossref","first-page":"24469","DOI":"10.1074\/jbc.274.35.24469","article-title":"Engagement of Gab1 and Gab2 in erythropoietin signalling","volume":"274","author":"Wickrema","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB157","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.270.5240.1326","article-title":"Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis","volume":"270","author":"Xia","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB158","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1128\/MCB.18.4.1946","article-title":"Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation","volume":"18","author":"Xin","year":"1998","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB159","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1126\/science.270.5244.2008","article-title":"Identification of a member of the MAPKKK family as a potential mediator of TGF-\u03b2 signal transduction","volume":"270","author":"Yamaguchi","year":"1995","journal-title":"Science"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB160","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1182\/blood.V91.2.641","article-title":"Suppression of cell proliferation and the expression of a bcr-abl fusion gene and apoptotic cell death in a new human chronic myelogenous leukemia cell line, KT-1, by interferon-\u03b1","volume":"91","author":"Yanagisawa","year":"1998","journal-title":"Blood"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB161","doi-asserted-by":"crossref","first-page":"18179","DOI":"10.1074\/jbc.270.31.18179","article-title":"Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase","volume":"270","author":"Yetter","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB162","doi-asserted-by":"crossref","first-page":"19943","DOI":"10.1074\/jbc.272.32.19943","article-title":"Tissue-specific pattern of stress kinase activation in ischemic\/reperfused heart and kidney","volume":"272","author":"Yin","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB163","doi-asserted-by":"crossref","first-page":"23934","DOI":"10.1074\/jbc.270.41.23934","article-title":"Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1","volume":"270","author":"Zhang","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB164","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1128\/MCB.19.1.21","article-title":"Regulation of the MEF2 family of transcription factors by p38","volume":"19","author":"Zhao","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/S0163-7258(03)00016-0_BIB165","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1128\/MCB.17.11.6618","article-title":"Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated Jak2 kinase","volume":"17","author":"Zhu","year":"1997","journal-title":"Mol Cell Biol"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725803000160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725803000160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T04:19:15Z","timestamp":1682482755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725803000160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5]]},"references-count":167,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,5]]}},"alternative-id":["S0163725803000160"],"URL":"https:\/\/doi.org\/10.1016\/s0163-7258(03)00016-0","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2003,5]]}}}